SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3l1c'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_J_TRPJ81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 3l1c KINESIN-14 NCD
(Drosophila
melanogaster) 		4 / 8 SER A 666
ALA A 665
ALA A 664
ILE A 645
 None
 0.72A 1gtnI-3l1cA:
undetectable
1gtnJ-3l1cA:
undetectable		 1gtnI-3l1cA:
10.65
1gtnJ-3l1cA:
10.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y0X_X_T44X500_2
(THYROID HORMONE
RECEPTOR BETA-1)		 3l1c KINESIN-14 NCD
(Drosophila
melanogaster) 		4 / 5 ILE A 599
SER A 660
LEU A 603
ASN A 600
 None
 1.20A 1y0xX-3l1cA:
undetectable		 1y0xX-3l1cA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDY_A_HCYA1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 3l1c KINESIN-14 NCD
(Drosophila
melanogaster) 		5 / 12 SER A 416
VAL A 415
ILE A 411
SER A 406
PHE A 644
 None
 1.47A 2vdyA-3l1cA:
undetectable		 2vdyA-3l1cA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VUF_A_FUAA2002_1
(SERUM ALBUMIN)		 3l1c KINESIN-14 NCD
(Drosophila
melanogaster) 		4 / 9 ILE A 349
PHE A 663
ALA A 664
VAL A 667
 None
 0.78A 2vufA-3l1cA:
undetectable		 2vufA-3l1cA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CKZ_A_ZMRA469_2
(NEURAMINIDASE)		 3l1c KINESIN-14 NCD
(Drosophila
melanogaster) 		4 / 6 ARG A 350
ILE A 411
ARG A 354
SER A 407
 None
None
ADP  A 998 (-2.9A)
None
 1.31A 3ckzA-3l1cA:
undetectable		 3ckzA-3l1cA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDW_A_RITA100_2
(PROTEASE)		 3l1c KINESIN-14 NCD
(Drosophila
melanogaster) 		5 / 9 ARG A 350
ASP A 580
ILE A 454
GLY A 452
ILE A 430
 None
MG  A 996 ( 3.8A)
None
None
None
 1.04A 3ndwB-3l1cA:
undetectable		 3ndwB-3l1cA:
14.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_B_HCYB1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 3l1c KINESIN-14 NCD
(Drosophila
melanogaster) 		5 / 12 SER A 416
VAL A 415
ILE A 411
SER A 406
PHE A 644
 None
 1.46A 4c49B-3l1cA:
undetectable		 4c49B-3l1cA:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_C_HCYC1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 3l1c KINESIN-14 NCD
(Drosophila
melanogaster) 		5 / 12 SER A 416
VAL A 415
ILE A 411
SER A 406
PHE A 644
 None
 1.47A 4c49C-3l1cA:
undetectable		 4c49C-3l1cA:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JTQ_A_FLPA401_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 3l1c KINESIN-14 NCD
(Drosophila
melanogaster) 		5 / 10 VAL A 415
VAL A 453
ILE A 454
LEU A 561
LEU A 461
 None
 1.29A 4jtqA-3l1cA:
undetectable		 4jtqA-3l1cA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NFP_A_8W5A804_2
(GLUCOCORTICOID
RECEPTOR)		 3l1c KINESIN-14 NCD
(Drosophila
melanogaster) 		4 / 4 LEU A 611
MET A 643
ILE A 620
LEU A 606
 None
 1.33A 5nfpA-3l1cA:
undetectable		 5nfpA-3l1cA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TT3_F_EZLF302_1
(ALPHA-CARBONIC
ANHYDRASE)		 3l1c KINESIN-14 NCD
(Drosophila
melanogaster) 		4 / 8 HIS A 554
VAL A 556
VAL A 579
LEU A 631
 None
 0.85A 5tt3F-3l1cA:
undetectable		 5tt3F-3l1cA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCG_A_08YA602_2
(CYTOCHROME P450 3A4)		 3l1c KINESIN-14 NCD
(Drosophila
melanogaster) 		3 / 3 ARG A 306
ARG A 312
ARG A 304
 None
 1.00A 5vcgA-3l1cA:
undetectable		 5vcgA-3l1cA:
21.92