SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3l22'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CEA_B_ACAB90_1
(PLASMINOGEN)		 3l22 SUSD SUPERFAMILY
PROTEIN
(Bacteroides
fragilis) 		4 / 7 ARG A 232
ASP A  73
TYR A 153
TYR A  69
 EDO  A  22 (-4.1A)
None
None
None
 1.28A 1ceaB-3l22A:
undetectable		 1ceaB-3l22A:
11.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1G60_A_SAMA500_0
(ADENINE-SPECIFIC
METHYLTRANSFERASE
MBOIIA)		 3l22 SUSD SUPERFAMILY
PROTEIN
(Bacteroides
fragilis) 		5 / 12 ASN A  94
GLY A 441
SER A 443
MET A  95
TYR A 447
 None
ACT  A  12 (-3.5A)
ACT  A  12 (-2.6A)
None
None
 1.32A 1g60A-3l22A:
undetectable		 1g60A-3l22A:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N4F_A_ASRA140_0
(LYSOZYME C)		 3l22 SUSD SUPERFAMILY
PROTEIN
(Bacteroides
fragilis) 		3 / 3 ASN A  49
ALA A  53
ASN A 282
 None
 0.70A 1n4fA-3l22A:
undetectable		 1n4fA-3l22A:
15.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_A_BEZA501_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 3l22 SUSD SUPERFAMILY
PROTEIN
(Bacteroides
fragilis) 		4 / 7 PHE A 412
ALA A 351
ILE A 262
GLU A 271
 None
 1.15A 1oniA-3l22A:
undetectable
1oniB-3l22A:
undetectable		 1oniA-3l22A:
18.80
1oniB-3l22A:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_I_BEZI517_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 3l22 SUSD SUPERFAMILY
PROTEIN
(Bacteroides
fragilis) 		4 / 7 ILE A 262
GLU A 271
PHE A 412
ALA A 351
 None
 1.05A 1oniG-3l22A:
undetectable
1oniI-3l22A:
undetectable		 1oniG-3l22A:
18.80
1oniI-3l22A:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UPF_A_URFA999_1
(URACIL
PHOSPHORIBOSYLTRANSF
ERASE)		 3l22 SUSD SUPERFAMILY
PROTEIN
(Bacteroides
fragilis) 		4 / 5 MET A 228
ALA A 224
TYR A 350
ILE A 273
 None
 1.00A 1upfA-3l22A:
undetectable		 1upfA-3l22A:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UPF_C_URFC999_1
(URACIL
PHOSPHORIBOSYLTRANSF
ERASE)		 3l22 SUSD SUPERFAMILY
PROTEIN
(Bacteroides
fragilis) 		4 / 5 MET A 228
ALA A 224
TYR A 350
ILE A 273
 None
 1.09A 1upfC-3l22A:
undetectable		 1upfC-3l22A:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UPF_D_URFD999_1
(URACIL
PHOSPHORIBOSYLTRANSF
ERASE)		 3l22 SUSD SUPERFAMILY
PROTEIN
(Bacteroides
fragilis) 		4 / 4 MET A 228
ALA A 224
TYR A 350
ILE A 273
 None
 1.02A 1upfD-3l22A:
undetectable		 1upfD-3l22A:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VOU_A_ACTA1397_0
(2,6-DIHYDROXYPYRIDIN
E HYDROXYLASE)		 3l22 SUSD SUPERFAMILY
PROTEIN
(Bacteroides
fragilis) 		3 / 3 PRO A 161
GLY A 426
TYR A 447
 None
 0.66A 2vouA-3l22A:
undetectable		 2vouA-3l22A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VOU_B_ACTB1391_0
(2,6-DIHYDROXYPYRIDIN
E HYDROXYLASE)		 3l22 SUSD SUPERFAMILY
PROTEIN
(Bacteroides
fragilis) 		3 / 3 PRO A 161
GLY A 426
TYR A 447
 None
 0.56A 2vouB-3l22A:
undetectable		 2vouB-3l22A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VOU_C_ACTC1391_0
(2,6-DIHYDROXYPYRIDIN
E HYDROXYLASE)		 3l22 SUSD SUPERFAMILY
PROTEIN
(Bacteroides
fragilis) 		3 / 3 PRO A 161
GLY A 426
TYR A 447
 None
 0.55A 2vouC-3l22A:
undetectable		 2vouC-3l22A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XRZ_A_ACTA1467_0
(DEOXYRIBODIPYRIMIDIN
E PHOTOLYASE)		 3l22 SUSD SUPERFAMILY
PROTEIN
(Bacteroides
fragilis) 		4 / 5 ARG A 425
ASP A 421
ILE A 417
GLU A 359
 None
EDO  A  22 (-3.7A)
EDO  A  22 ( 4.4A)
None
 1.42A 2xrzA-3l22A:
undetectable
2xrzB-3l22A:
undetectable		 2xrzA-3l22A:
22.98
2xrzB-3l22A:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YFB_A_ACTA501_0
(METHYL-ACCEPTING
CHEMOTAXIS
TRANSDUCER)		 3l22 SUSD SUPERFAMILY
PROTEIN
(Bacteroides
fragilis) 		4 / 7 ARG A 174
VAL A 171
ILE A 451
TYR A 112
 None
 1.14A 2yfbA-3l22A:
undetectable		 2yfbA-3l22A:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YFB_B_ACTB501_0
(METHYL-ACCEPTING
CHEMOTAXIS
TRANSDUCER)		 3l22 SUSD SUPERFAMILY
PROTEIN
(Bacteroides
fragilis) 		4 / 6 ARG A 174
VAL A 171
ILE A 451
TYR A 112
 None
 1.17A 2yfbB-3l22A:
undetectable		 2yfbB-3l22A:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQA_C_DX4C270_0
(PTERIDINE REDUCTASE
1)		 3l22 SUSD SUPERFAMILY
PROTEIN
(Bacteroides
fragilis) 		4 / 6 PHE A 335
ASP A  73
TYR A 294
PRO A 346
 None
 1.26A 3jqaC-3l22A:
undetectable		 3jqaC-3l22A:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQA_D_DX4D270_0
(PTERIDINE REDUCTASE
1)		 3l22 SUSD SUPERFAMILY
PROTEIN
(Bacteroides
fragilis) 		4 / 6 PHE A 335
ASP A  73
TYR A 294
PRO A 346
 None
 1.29A 3jqaD-3l22A:
undetectable		 3jqaD-3l22A:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PHN_A_ACTA108_0
(PROTEIN P-30)		 3l22 SUSD SUPERFAMILY
PROTEIN
(Bacteroides
fragilis) 		3 / 3 THR A  39
SER A  40
ARG A  43
 None
 0.75A 3phnA-3l22A:
undetectable		 3phnA-3l22A:
13.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUF_B_SUEB1201_2
(NS3 PROTEASE, NS4A
PROTEIN)		 3l22 SUSD SUPERFAMILY
PROTEIN
(Bacteroides
fragilis) 		3 / 3 TYR A  93
LEU A  63
ARG A  75
 None
 0.65A 3sufB-3l22A:
undetectable		 3sufB-3l22A:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3S_A_9PLA1_1
(CYTOCHROME P450 2A13)		 3l22 SUSD SUPERFAMILY
PROTEIN
(Bacteroides
fragilis) 		5 / 9 PHE A 274
PHE A 348
ALA A 226
ALA A 148
LEU A 208
 None
 1.25A 3t3sA-3l22A:
undetectable		 3t3sA-3l22A:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WXO_A_NIZA802_1
(CATALASE-PEROXIDASE)		 3l22 SUSD SUPERFAMILY
PROTEIN
(Bacteroides
fragilis) 		4 / 8 LEU A 332
ILE A 302
GLY A 307
ILE A 308
 None
 0.82A 3wxoA-3l22A:
undetectable		 3wxoA-3l22A:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D35_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3l22 SUSD SUPERFAMILY
PROTEIN
(Bacteroides
fragilis) 		4 / 6 VAL A 378
ARG A 349
PHE A 412
GLU A 407
 None
 1.20A 4d35A-3l22A:
undetectable
4d35B-3l22A:
0.0		 4d35A-3l22A:
21.46
4d35B-3l22A:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FU9_A_ACTA311_0
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 3l22 SUSD SUPERFAMILY
PROTEIN
(Bacteroides
fragilis) 		3 / 3 GLN A 288
THR A  60
THR A  58
 None
 0.71A 4fu9A-3l22A:
undetectable		 4fu9A-3l22A:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FUF_A_ACTA310_0
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 3l22 SUSD SUPERFAMILY
PROTEIN
(Bacteroides
fragilis) 		3 / 3 GLN A 288
THR A  60
THR A  58
 None
 0.74A 4fufA-3l22A:
undetectable		 4fufA-3l22A:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCN_B_MTLB805_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3l22 SUSD SUPERFAMILY
PROTEIN
(Bacteroides
fragilis) 		4 / 6 ARG A 425
GLU A 402
ASP A  78
ARG A 418
 None
 1.21A 4kcnB-3l22A:
undetectable		 4kcnB-3l22A:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_B_STRB601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 3l22 SUSD SUPERFAMILY
PROTEIN
(Bacteroides
fragilis) 		4 / 5 ILE A 194
LEU A 173
ASP A 201
GLU A 196
 None
ACT  A  10 (-4.7A)
None
None
 1.02A 4nkxB-3l22A:
undetectable		 4nkxB-3l22A:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RKU_A_PQNA5001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 3l22 SUSD SUPERFAMILY
PROTEIN
(Bacteroides
fragilis) 		4 / 8 PHE A 348
ALA A 148
LEU A 149
PHE A 429
 None
 0.93A 4rkuA-3l22A:
1.3
4rkuJ-3l22A:
undetectable		 4rkuA-3l22A:
19.54
4rkuJ-3l22A:
6.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XE5_A_OBNA1104_2
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 3l22 SUSD SUPERFAMILY
PROTEIN
(Bacteroides
fragilis) 		4 / 6 PRO A 442
VAL A 191
THR A 448
ARG A 418
 ACT  A  12 (-3.9A)
None
None
None
 1.14A 4xe5A-3l22A:
undetectable		 4xe5A-3l22A:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YO9_B_ACTB401_0
(3C-LIKE PROTEINASE)		 3l22 SUSD SUPERFAMILY
PROTEIN
(Bacteroides
fragilis) 		3 / 3 ARG A 321
ASP A 319
TYR A 314
 None
 0.95A 4yo9B-3l22A:
undetectable		 4yo9B-3l22A:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZDY_A_1YNA602_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3l22 SUSD SUPERFAMILY
PROTEIN
(Bacteroides
fragilis) 		3 / 3 ALA A 291
TYR A 294
PRO A 346
 None
 0.54A 4zdyA-3l22A:
undetectable		 4zdyA-3l22A:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IY5_P_CHDP307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3l22 SUSD SUPERFAMILY
PROTEIN
(Bacteroides
fragilis) 		4 / 5 LEU A  70
PHE A  72
LEU A 290
PHE A 335
 None
 1.25A 5iy5P-3l22A:
2.0
5iy5W-3l22A:
undetectable		 5iy5P-3l22A:
21.03
5iy5W-3l22A:
9.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_G_CVIG301_1
(REGULATORY PROTEIN
TETR)		 3l22 SUSD SUPERFAMILY
PROTEIN
(Bacteroides
fragilis) 		4 / 7 GLY A 426
TYR A 152
ASP A 421
TYR A 405
 None
None
EDO  A  22 (-3.7A)
None
 1.24A 5vlmG-3l22A:
undetectable		 5vlmG-3l22A:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y9Y_A_ACTA412_0
(UNCHARACTERIZED
PROTEIN KDOO)		 3l22 SUSD SUPERFAMILY
PROTEIN
(Bacteroides
fragilis) 		3 / 3 ARG A 381
PHE A 412
ARG A 349
 None
 0.97A 5y9yA-3l22A:
undetectable		 5y9yA-3l22A:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZJI_A_PQNA844_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 3l22 SUSD SUPERFAMILY
PROTEIN
(Bacteroides
fragilis) 		5 / 10 PHE A 348
ILE A 198
ALA A 148
LEU A 149
PHE A 429
 None
 1.04A 5zjiA-3l22A:
0.8
5zjiJ-3l22A:
undetectable		 5zjiA-3l22A:
15.20
5zjiJ-3l22A:
6.73