SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3l2e'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_C_SAMC2293_0
(GLYCINE
N-METHYLTRANSFERASE)		 3l2e GLYCOCYAMINE KINASE
ALPHA CHAIN
(Namalycastis
sp.
ST01) 		5 / 12 ILE A 246
VAL A 238
ALA A 304
GLY A 267
LEU A 127
 None
 1.11A 1kiaC-3l2eA:
undetectable		 1kiaC-3l2eA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_A_NOVA400_2
(DNA GYRASE SUBUNIT B)		 3l2e GLYCOCYAMINE KINASE
ALPHA CHAIN
(Namalycastis
sp.
ST01) 		3 / 3 ASN A 349
PHE A 264
VAL A 302
 None
 0.83A 1kijA-3l2eA:
undetectable		 1kijA-3l2eA:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_B_SAMB1293_0
(GLYCINE
N-METHYLTRANSFERASE)		 3l2e GLYCOCYAMINE KINASE
ALPHA CHAIN
(Namalycastis
sp.
ST01) 		5 / 12 ILE A 246
VAL A 238
ALA A 304
GLY A 267
LEU A 127
 None
 1.10A 1nbhB-3l2eA:
undetectable		 1nbhB-3l2eA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NW5_A_SAMA401_1
(MODIFICATION
METHYLASE RSRI)		 3l2e GLYCOCYAMINE KINASE
ALPHA CHAIN
(Namalycastis
sp.
ST01) 		3 / 3 ASP A 194
HIS A 230
ASP A 201
 None
 0.73A 1nw5A-3l2eA:
undetectable		 1nw5A-3l2eA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QWX_B_ML1B233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 3l2e GLYCOCYAMINE KINASE
ALPHA CHAIN
(Namalycastis
sp.
ST01) 		4 / 7 GLY A  71
GLY A  89
PHE A 101
PHE A 100
 None
 0.82A 2qwxA-3l2eA:
undetectable
2qwxB-3l2eA:
undetectable		 2qwxA-3l2eA:
20.37
2qwxB-3l2eA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VN1_A_FK5A501_2
(70 KDA
PEPTIDYLPROLYL
ISOMERASE)		 3l2e GLYCOCYAMINE KINASE
ALPHA CHAIN
(Namalycastis
sp.
ST01) 		4 / 6 LEU A  45
SER A  93
PHE A  88
ASP A  90
 None
 1.24A 2vn1B-3l2eA:
undetectable		 2vn1B-3l2eA:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XKK_E_MFXE1100_1
(TOPOISOMERASE IV
DNA)		 3l2e GLYCOCYAMINE KINASE
ALPHA CHAIN
(Namalycastis
sp.
ST01) 		3 / 3 ARG A 220
GLU A 166
SER A 216
 None
 0.83A 2xkkA-3l2eA:
undetectable
2xkkC-3l2eA:
undetectable		 2xkkA-3l2eA:
20.23
2xkkC-3l2eA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZD1_A_T27A557_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 3l2e GLYCOCYAMINE KINASE
ALPHA CHAIN
(Namalycastis
sp.
ST01) 		5 / 12 PRO A 120
LEU A 122
VAL A 248
VAL A 302
TYR A 290
 None
 1.16A 2zd1A-3l2eA:
3.1		 2zd1A-3l2eA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MEE_A_T27A561_1
(P66 REVERSE
TRANSCRIPTASE)		 3l2e GLYCOCYAMINE KINASE
ALPHA CHAIN
(Namalycastis
sp.
ST01) 		5 / 12 PRO A 120
LEU A 122
VAL A 248
VAL A 302
TYR A 290
 None
 1.27A 3meeA-3l2eA:
3.3		 3meeA-3l2eA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MEG_A_T27A561_1
(P66 REVERSE
TRANSCRIPTASE)		 3l2e GLYCOCYAMINE KINASE
ALPHA CHAIN
(Namalycastis
sp.
ST01) 		5 / 12 PRO A 120
LEU A 122
VAL A 248
VAL A 302
TYR A 290
 None
 1.25A 3megA-3l2eA:
undetectable		 3megA-3l2eA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G1Q_A_T27A601_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 3l2e GLYCOCYAMINE KINASE
ALPHA CHAIN
(Namalycastis
sp.
ST01) 		5 / 12 PRO A 120
LEU A 122
VAL A 248
VAL A 302
TYR A 290
 None
 1.16A 4g1qA-3l2eA:
2.6		 4g1qA-3l2eA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ICL_A_T27A601_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 3l2e GLYCOCYAMINE KINASE
ALPHA CHAIN
(Namalycastis
sp.
ST01) 		5 / 12 PRO A 120
LEU A 122
VAL A 248
VAL A 302
TYR A 290
 None
 1.16A 4iclA-3l2eA:
3.2		 4iclA-3l2eA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ID5_A_T27A601_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 3l2e GLYCOCYAMINE KINASE
ALPHA CHAIN
(Namalycastis
sp.
ST01) 		5 / 12 PRO A 120
LEU A 122
VAL A 248
VAL A 302
TYR A 290
 None
 1.16A 4id5A-3l2eA:
3.8		 4id5A-3l2eA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IDK_A_T27A601_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 3l2e GLYCOCYAMINE KINASE
ALPHA CHAIN
(Namalycastis
sp.
ST01) 		5 / 12 PRO A 120
LEU A 122
VAL A 248
VAL A 302
TYR A 290
 None
 1.15A 4idkA-3l2eA:
3.8		 4idkA-3l2eA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IFV_A_T27A601_1
(EXORIBONUCLEASE H,
P66 RT)		 3l2e GLYCOCYAMINE KINASE
ALPHA CHAIN
(Namalycastis
sp.
ST01) 		5 / 12 PRO A 120
LEU A 122
VAL A 248
VAL A 302
TYR A 290
 None
 1.15A 4ifvA-3l2eA:
3.0		 4ifvA-3l2eA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IFY_A_T27A601_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 3l2e GLYCOCYAMINE KINASE
ALPHA CHAIN
(Namalycastis
sp.
ST01) 		5 / 12 PRO A 120
LEU A 122
VAL A 248
VAL A 302
TYR A 290
 None
 1.16A 4ifyA-3l2eA:
3.8		 4ifyA-3l2eA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IG3_A_T27A601_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 3l2e GLYCOCYAMINE KINASE
ALPHA CHAIN
(Namalycastis
sp.
ST01) 		5 / 12 PRO A 120
LEU A 122
VAL A 248
VAL A 302
TYR A 290
 None
 1.18A 4ig3A-3l2eA:
3.2		 4ig3A-3l2eA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KFB_A_T27A607_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H,
EXORIBONUCLEA P66 RT)		 3l2e GLYCOCYAMINE KINASE
ALPHA CHAIN
(Namalycastis
sp.
ST01) 		5 / 12 PRO A 120
LEU A 122
VAL A 248
VAL A 302
TYR A 290
 None
 1.22A 4kfbA-3l2eA:
3.0		 4kfbA-3l2eA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ACL_A_SASA1111_1
(MCG)		 3l2e GLYCOCYAMINE KINASE
ALPHA CHAIN
(Namalycastis
sp.
ST01) 		4 / 7 SER A  93
TYR A  97
TYR A  92
GLU A  91
 None
 1.14A 5aclA-3l2eA:
undetectable		 5aclA-3l2eA:
14.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CYM_A_T27A601_1
(HIV-1 REVERSE
TRANSCRIPTASE, P66
SUBUNIT)		 3l2e GLYCOCYAMINE KINASE
ALPHA CHAIN
(Namalycastis
sp.
ST01) 		5 / 12 PRO A 120
LEU A 122
VAL A 248
VAL A 302
TYR A 290
 None
 1.14A 5cymA-3l2eA:
3.3		 5cymA-3l2eA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CYQ_A_T27A601_1
(HIV-1 REVERSE
TRANSCRIPTASE, P66
SUBUNIT)		 3l2e GLYCOCYAMINE KINASE
ALPHA CHAIN
(Namalycastis
sp.
ST01) 		5 / 12 PRO A 120
LEU A 122
VAL A 248
VAL A 302
TYR A 290
 None
 1.15A 5cyqA-3l2eA:
3.0		 5cyqA-3l2eA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J2T_C_VLBC503_2
(TUBULIN ALPHA-1B
CHAIN)		 3l2e GLYCOCYAMINE KINASE
ALPHA CHAIN
(Namalycastis
sp.
ST01) 		6 / 12 VAL A 368
ASN A 369
ILE A 372
ALA A 373
LYS A 376
VAL A 137
 None
 0.80A 5j2tC-3l2eA:
undetectable		 5j2tC-3l2eA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U4S_B_BEZB301_0
(PUTATIVE SHORT CHAIN
DEHYDROGENASE)		 3l2e GLYCOCYAMINE KINASE
ALPHA CHAIN
(Namalycastis
sp.
ST01) 		4 / 8 ILE A 291
LEU A 288
LEU A 353
PRO A 295
 None
 1.03A 5u4sB-3l2eA:
undetectable		 5u4sB-3l2eA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X23_A_LSNA503_1
(CYTOCHROME P450 2C9)		 3l2e GLYCOCYAMINE KINASE
ALPHA CHAIN
(Namalycastis
sp.
ST01) 		4 / 5 GLY A  85
THR A  84
ASN A  39
LYS A  83
 None
 0.95A 5x23A-3l2eA:
undetectable		 5x23A-3l2eA:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X24_A_LSNA503_1
(CYTOCHROME P450 2C9)		 3l2e GLYCOCYAMINE KINASE
ALPHA CHAIN
(Namalycastis
sp.
ST01) 		4 / 6 GLY A  85
THR A  84
ASN A  39
LYS A  83
 None
 0.89A 5x24A-3l2eA:
undetectable		 5x24A-3l2eA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XXI_A_LSNA502_1
(CYTOCHROME P450 2C9)		 3l2e GLYCOCYAMINE KINASE
ALPHA CHAIN
(Namalycastis
sp.
ST01) 		4 / 6 GLY A  85
THR A  84
ASN A  39
LYS A  83
 None
 0.67A 5xxiA-3l2eA:
undetectable		 5xxiA-3l2eA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ELI_A_T27A701_1
(REVERSE
TRANSCRIPTASE)		 3l2e GLYCOCYAMINE KINASE
ALPHA CHAIN
(Namalycastis
sp.
ST01) 		5 / 12 PRO A 120
LEU A 122
VAL A 248
VAL A 302
TYR A 290
 None
 1.17A 6eliA-3l2eA:
3.4		 6eliA-3l2eA:
13.90