SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3l2k'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C4D_B_DVAB8_0
(GRAMICIDIN A)		 3l2k EHPF
(Pantoea
agglomerans) 		3 / 3 TRP A 112
VAL A 107
TRP A 321
 None
 1.27A 1c4dA-3l2kA:
undetectable
1c4dB-3l2kA:
undetectable		 1c4dA-3l2kA:
3.68
1c4dB-3l2kA:
3.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDT_A_ESTA350_1
(17-BETA-HYDROXYSTERO
ID-DEHYDROGENASE)		 3l2k EHPF
(Pantoea
agglomerans) 		5 / 11 VAL A 296
LEU A 347
GLU A 329
TYR A 262
GLU A 351
 None
 1.36A 1fdtA-3l2kA:
4.1		 1fdtA-3l2kA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM4_A_DXCA1001_0
(MAJOR POLLEN
ALLERGEN BET V 1-L)		 3l2k EHPF
(Pantoea
agglomerans) 		5 / 12 PRO A 320
PHE A 291
PRO A 290
ALA A  26
MET A  28
 None
 1.40A 1fm4A-3l2kA:
undetectable		 1fm4A-3l2kA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM4_A_DXCA1001_0
(MAJOR POLLEN
ALLERGEN BET V 1-L)		 3l2k EHPF
(Pantoea
agglomerans) 		5 / 12 PRO A 320
PHE A 291
PRO A 290
ILE A  59
ALA A  26
 None
 1.41A 1fm4A-3l2kA:
undetectable		 1fm4A-3l2kA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1K5Q_B_PACB559_0
(PENICILLIN G ACYLASE
ALPHA SUBUNIT
PENICILLIN G ACYLASE
BETA SUBUNIT)		 3l2k EHPF
(Pantoea
agglomerans) 		4 / 7 SER A 289
ALA A  15
SER A 340
ALA A 343
 None
 1.02A 1k5qA-3l2kA:
undetectable
1k5qB-3l2kA:
undetectable		 1k5qA-3l2kA:
20.95
1k5qB-3l2kA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXE_B_1FLB2003_1
(SERUM ALBUMIN)		 3l2k EHPF
(Pantoea
agglomerans) 		5 / 10 LEU A 198
LEU A 216
LEU A 213
ILE A 233
ALA A 138
 None
 1.09A 2bxeB-3l2kA:
undetectable		 2bxeB-3l2kA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXP_A_P1ZA3001_1
(SERUM ALBUMIN)		 3l2k EHPF
(Pantoea
agglomerans) 		5 / 12 LEU A 198
LEU A 216
LEU A 213
ILE A 233
ALA A 138
 None
 1.03A 2bxpA-3l2kA:
undetectable		 2bxpA-3l2kA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXQ_A_P1ZA2002_1
(SERUM ALBUMIN)		 3l2k EHPF
(Pantoea
agglomerans) 		5 / 12 LEU A 198
LEU A 216
LEU A 213
ILE A 233
ALA A 138
 None
 0.98A 2bxqA-3l2kA:
undetectable		 2bxqA-3l2kA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO5_A_CHDA501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3l2k EHPF
(Pantoea
agglomerans) 		5 / 12 LEU A 136
LEU A 198
ILE A 139
LEU A 217
VAL A 212
 None
 1.15A 2po5A-3l2kA:
2.5		 2po5A-3l2kA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AY0_A_ADNA401_1
(UNCHARACTERIZED
PROTEIN MJ0883)		 3l2k EHPF
(Pantoea
agglomerans) 		5 / 10 PHE A  50
ASP A  51
ILE A  53
VAL A  56
PHE A  65
 None
 1.36A 3ay0A-3l2kA:
3.2		 3ay0A-3l2kA:
23.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CKZ_A_ZMRA469_2
(NEURAMINIDASE)		 3l2k EHPF
(Pantoea
agglomerans) 		4 / 6 ASP A 349
ARG A 310
ILE A 284
SER A 280
 None
 1.24A 3ckzA-3l2kA:
undetectable		 3ckzA-3l2kA:
23.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_B_CHDB152_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 3l2k EHPF
(Pantoea
agglomerans) 		4 / 8 ILE A 139
PRO A 140
VAL A 270
GLY A 263
 None
 0.76A 3em0B-3l2kA:
undetectable		 3em0B-3l2kA:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MB5_A_SAMA301_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 3l2k EHPF
(Pantoea
agglomerans) 		5 / 12 ILE A 292
SER A 264
ALA A 267
LEU A 268
ILE A 139
 None
 1.06A 3mb5A-3l2kA:
undetectable		 3mb5A-3l2kA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3N_A_DLUA398_1
(PFV INTEGRASE)		 3l2k EHPF
(Pantoea
agglomerans) 		4 / 8 ASP A 286
GLY A 344
TYR A 307
GLN A 282
 None
 1.00A 3s3nA-3l2kA:
undetectable		 3s3nA-3l2kA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCK_A_SAMA2409_1
(RNA-DIRECTED RNA
POLYMERASE L)		 3l2k EHPF
(Pantoea
agglomerans) 		3 / 3 SER A 280
ASP A 345
ASP A 349
 None
 0.82A 4uckA-3l2kA:
undetectable		 4uckA-3l2kA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B6I_A_ADNA302_1
(FLUORINASE)		 3l2k EHPF
(Pantoea
agglomerans) 		4 / 7 THR A 316
TYR A 324
PRO A 325
SER A 266
 None
 1.07A 5b6iA-3l2kA:
2.3		 5b6iA-3l2kA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M54_B_TA1B502_1
(TUBULIN BETA-2B
CHAIN)		 3l2k EHPF
(Pantoea
agglomerans) 		5 / 12 ALA A 249
SER A 250
PHE A 258
THR A 208
LEU A 217
 None
 1.46A 5m54B-3l2kA:
undetectable		 5m54B-3l2kA:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X23_A_LSNA503_1
(CYTOCHROME P450 2C9)		 3l2k EHPF
(Pantoea
agglomerans) 		4 / 5 PRO A  82
GLY A  37
THR A  36
LYS A  34
 None
 1.06A 5x23A-3l2kA:
undetectable		 5x23A-3l2kA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X80_A_SALA201_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		 3l2k EHPF
(Pantoea
agglomerans) 		4 / 5 VAL A 296
ARG A 335
GLY A 308
TYR A 307
 None
 1.42A 5x80A-3l2kA:
undetectable
5x80B-3l2kA:
undetectable		 5x80A-3l2kA:
18.03
5x80B-3l2kA:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XXI_A_LSNA502_1
(CYTOCHROME P450 2C9)		 3l2k EHPF
(Pantoea
agglomerans) 		4 / 6 PRO A  82
GLY A  37
THR A  36
LYS A  34
 None
 1.04A 5xxiA-3l2kA:
undetectable		 5xxiA-3l2kA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_A_EY4A502_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 3l2k EHPF
(Pantoea
agglomerans) 		4 / 7 ALA A 260
TYR A 262
GLN A 282
VAL A 283
 None
 0.94A 6cduA-3l2kA:
undetectable
6cduE-3l2kA:
undetectable		 6cduA-3l2kA:
23.25
6cduE-3l2kA:
23.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_H_EY4H500_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 3l2k EHPF
(Pantoea
agglomerans) 		4 / 7 GLN A 282
VAL A 283
ALA A 260
TYR A 262
 None
 0.92A 6cduH-3l2kA:
undetectable
6cduI-3l2kA:
undetectable		 6cduH-3l2kA:
23.25
6cduI-3l2kA:
23.25