SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3l2n'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y0X_X_T44X500_2
(THYROID HORMONE
RECEPTOR BETA-1)		 3l2n PEPTIDASE M14,
CARBOXYPEPTIDASE A
(Shewanella
denitrificans) 		4 / 5 ILE A 275
ARG A 227
LEU A 316
ASN A 321
 None
UNL  A 378 ( 2.8A)
None
None
 1.17A 1y0xX-3l2nA:
undetectable		 1y0xX-3l2nA:
26.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BNN_A_FCNA1199_1
(EPOXIDASE)		 3l2n PEPTIDASE M14,
CARBOXYPEPTIDASE A
(Shewanella
denitrificans) 		5 / 9 ARG A 227
LEU A 216
ASN A 226
GLU A 169
HIS A 259
 UNL  A 378 ( 2.8A)
None
UNL  A 378 ( 4.4A)
CA  A 377 (-2.1A)
CA  A 377 (-3.2A)
 1.48A 2bnnA-3l2nA:
2.0
2bnnB-3l2nA:
0.8		 2bnnA-3l2nA:
21.43
2bnnB-3l2nA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA4_B_ACHB603_0
(ACETYLCHOLINESTERASE)		 3l2n PEPTIDASE M14,
CARBOXYPEPTIDASE A
(Shewanella
denitrificans) 		4 / 7 TYR A  63
GLU A 169
HIS A 259
GLY A 260
 None
CA  A 377 (-2.1A)
CA  A 377 (-3.2A)
None
 1.22A 2ha4B-3l2nA:
4.3		 2ha4B-3l2nA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNI_A_MTKA501_2
(CYTOCHROME P450 2C8)		 3l2n PEPTIDASE M14,
CARBOXYPEPTIDASE A
(Shewanella
denitrificans) 		5 / 8 ILE A  12
ILE A   3
ILE A 104
ILE A  55
ALA A  45
 None
 1.14A 2nniA-3l2nA:
undetectable		 2nniA-3l2nA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2TSR_C_D16C509_1
(THYMIDYLATE SYNTHASE)		 3l2n PEPTIDASE M14,
CARBOXYPEPTIDASE A
(Shewanella
denitrificans) 		5 / 10 ARG A  83
PHE A 109
GLU A 169
GLY A 263
PHE A 338
 None
None
CA  A 377 (-2.1A)
None
None
 1.24A 2tsrC-3l2nA:
undetectable		 2tsrC-3l2nA:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_B_HSMB1162_1
(ALLERGEN ARG R 1)		 3l2n PEPTIDASE M14,
CARBOXYPEPTIDASE A
(Shewanella
denitrificans) 		3 / 3 GLU A 262
HIS A 166
GLU A 169
 None
CA  A 377 (-3.2A)
CA  A 377 (-2.1A)
 0.70A 2x45B-3l2nA:
undetectable		 2x45B-3l2nA:
16.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_B_HSMB1162_1
(ALLERGEN ARG R 1)		 3l2n PEPTIDASE M14,
CARBOXYPEPTIDASE A
(Shewanella
denitrificans) 		3 / 3 GLU A 335
HIS A 166
GLU A 169
 UNL  A 378 ( 3.3A)
CA  A 377 (-3.2A)
CA  A 377 (-2.1A)
 0.80A 2x45B-3l2nA:
undetectable		 2x45B-3l2nA:
16.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_C_HSMC1162_1
(ALLERGEN ARG R 1)		 3l2n PEPTIDASE M14,
CARBOXYPEPTIDASE A
(Shewanella
denitrificans) 		3 / 3 GLU A 262
HIS A 166
GLU A 169
 None
CA  A 377 (-3.2A)
CA  A 377 (-2.1A)
 0.72A 2x45C-3l2nA:
undetectable		 2x45C-3l2nA:
16.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_C_HSMC1162_1
(ALLERGEN ARG R 1)		 3l2n PEPTIDASE M14,
CARBOXYPEPTIDASE A
(Shewanella
denitrificans) 		3 / 3 GLU A 335
HIS A 166
GLU A 169
 UNL  A 378 ( 3.3A)
CA  A 377 (-3.2A)
CA  A 377 (-2.1A)
 0.83A 2x45C-3l2nA:
undetectable		 2x45C-3l2nA:
16.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZS9_A_PAUA603_0
(PANTOTHENATE KINASE)		 3l2n PEPTIDASE M14,
CARBOXYPEPTIDASE A
(Shewanella
denitrificans) 		4 / 6 VAL A 318
ASP A 309
TYR A 306
ASN A 226
 None
None
None
UNL  A 378 ( 4.4A)
 1.26A 2zs9A-3l2nA:
undetectable		 2zs9A-3l2nA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG2_W_CHDW1059_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 3l2n PEPTIDASE M14,
CARBOXYPEPTIDASE A
(Shewanella
denitrificans) 		4 / 7 ILE A 104
LEU A  99
ARG A  83
THR A  86
 None
 1.04A 3ag2N-3l2nA:
undetectable
3ag2W-3l2nA:
undetectable		 3ag2N-3l2nA:
21.32
3ag2W-3l2nA:
9.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG3_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 3l2n PEPTIDASE M14,
CARBOXYPEPTIDASE A
(Shewanella
denitrificans) 		4 / 7 ILE A 104
LEU A  99
ARG A  83
THR A  86
 None
 0.93A 3ag3A-3l2nA:
undetectable
3ag3J-3l2nA:
undetectable		 3ag3A-3l2nA:
21.32
3ag3J-3l2nA:
9.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG4_W_CHDW1059_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 3l2n PEPTIDASE M14,
CARBOXYPEPTIDASE A
(Shewanella
denitrificans) 		4 / 7 ILE A 104
LEU A  99
ARG A  83
THR A  86
 None
 0.90A 3ag4N-3l2nA:
undetectable
3ag4W-3l2nA:
undetectable		 3ag4N-3l2nA:
21.32
3ag4W-3l2nA:
9.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASO_W_CHDW1059_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1)		 3l2n PEPTIDASE M14,
CARBOXYPEPTIDASE A
(Shewanella
denitrificans) 		4 / 8 ILE A 104
LEU A  99
ARG A  83
THR A  86
 None
 0.92A 3asoN-3l2nA:
undetectable
3asoW-3l2nA:
undetectable		 3asoN-3l2nA:
21.32
3asoW-3l2nA:
9.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_B_SAMB300_1
(SAM-DEPENDENT
METHYLTRANSFERASE)		 3l2n PEPTIDASE M14,
CARBOXYPEPTIDASE A
(Shewanella
denitrificans) 		3 / 3 TYR A 358
ASP A 299
ASP A 346
 None
 0.98A 3ou7B-3l2nA:
undetectable		 3ou7B-3l2nA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RUK_D_AERD601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 3l2n PEPTIDASE M14,
CARBOXYPEPTIDASE A
(Shewanella
denitrificans) 		5 / 11 ALA A 366
PHE A 289
ILE A 161
GLY A 360
VAL A 267
 None
 1.19A 3rukD-3l2nA:
undetectable		 3rukD-3l2nA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WG7_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3l2n PEPTIDASE M14,
CARBOXYPEPTIDASE A
(Shewanella
denitrificans) 		4 / 6 ILE A 104
LEU A  99
ARG A  83
THR A  86
 None
 1.17A 3wg7A-3l2nA:
undetectable
3wg7J-3l2nA:
undetectable		 3wg7A-3l2nA:
21.32
3wg7J-3l2nA:
9.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1G_B_LNLB701_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3l2n PEPTIDASE M14,
CARBOXYPEPTIDASE A
(Shewanella
denitrificans) 		4 / 7 VAL A 149
VAL A 147
LEU A 146
MET A 206
 None
 1.00A 4e1gB-3l2nA:
undetectable		 4e1gB-3l2nA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJG_A_NCTA501_1
(CYTOCHROME P450 2A13)		 3l2n PEPTIDASE M14,
CARBOXYPEPTIDASE A
(Shewanella
denitrificans) 		4 / 7 PHE A 300
PHE A 359
ALA A 366
LEU A 334
 None
 0.95A 4ejgA-3l2nA:
undetectable		 4ejgA-3l2nA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJG_B_NCTB501_1
(CYTOCHROME P450 2A13)		 3l2n PEPTIDASE M14,
CARBOXYPEPTIDASE A
(Shewanella
denitrificans) 		4 / 8 PHE A 300
PHE A 359
ALA A 366
LEU A 334
 None
 0.92A 4ejgB-3l2nA:
undetectable		 4ejgB-3l2nA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G77_A_TLFA711_0
(LACTOTRANSFERRIN)		 3l2n PEPTIDASE M14,
CARBOXYPEPTIDASE A
(Shewanella
denitrificans) 		4 / 7 ILE A  95
LEU A  93
ALA A  72
VAL A  73
 None
 0.74A 4g77A-3l2nA:
undetectable		 4g77A-3l2nA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M11_A_MXMA606_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3l2n PEPTIDASE M14,
CARBOXYPEPTIDASE A
(Shewanella
denitrificans) 		5 / 12 LEU A 269
VAL A 370
LEU A 330
ALA A 292
LEU A 293
 None
 1.34A 4m11A-3l2nA:
undetectable		 4m11A-3l2nA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NTX_A_AMRA509_1
(ACID-SENSING ION
CHANNEL 1
BASIC PHOSPHOLIPASE
A2 HOMOLOG TX-BETA)		 3l2n PEPTIDASE M14,
CARBOXYPEPTIDASE A
(Shewanella
denitrificans) 		4 / 6 ASP A 257
GLU A 169
ASN A 224
ARG A 227
 None
CA  A 377 (-2.1A)
UNL  A 378 (-4.7A)
UNL  A 378 ( 2.8A)
 1.29A 4ntxA-3l2nA:
undetectable
4ntxC-3l2nA:
undetectable		 4ntxA-3l2nA:
21.30
4ntxC-3l2nA:
14.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FLC_C_RAPC999_1
(SERINE/THREONINE-PRO
TEIN KINASE MTOR
FKBP)		 3l2n PEPTIDASE M14,
CARBOXYPEPTIDASE A
(Shewanella
denitrificans) 		4 / 8 GLU A 228
GLY A 210
THR A 145
TYR A 242
 None
 1.00A 5flcB-3l2nA:
undetectable		 5flcB-3l2nA:
15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FLC_G_RAPG999_1
(SERINE/THREONINE-PRO
TEIN KINASE MTOR
FKBP)		 3l2n PEPTIDASE M14,
CARBOXYPEPTIDASE A
(Shewanella
denitrificans) 		4 / 8 GLU A 228
GLY A 210
THR A 145
TYR A 242
 None
 1.00A 5flcF-3l2nA:
undetectable		 5flcF-3l2nA:
15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I9Y_A_1N1A1001_2
(EPHRIN TYPE-A
RECEPTOR 2)		 3l2n PEPTIDASE M14,
CARBOXYPEPTIDASE A
(Shewanella
denitrificans) 		3 / 3 ILE A  23
ILE A  12
MET A   1
 None
 0.63A 5i9yA-3l2nA:
undetectable		 5i9yA-3l2nA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDQ_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3l2n PEPTIDASE M14,
CARBOXYPEPTIDASE A
(Shewanella
denitrificans) 		4 / 7 ILE A 104
LEU A  99
ARG A  83
THR A  86
 None
 0.91A 5xdqN-3l2nA:
undetectable
5xdqW-3l2nA:
undetectable		 5xdqN-3l2nA:
21.32
5xdqW-3l2nA:
9.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDX_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT VIIA-HEART)		 3l2n PEPTIDASE M14,
CARBOXYPEPTIDASE A
(Shewanella
denitrificans) 		4 / 7 ILE A 104
LEU A  99
ARG A  83
THR A  86
 None
 0.90A 5xdxA-3l2nA:
undetectable
5xdxJ-3l2nA:
undetectable		 5xdxA-3l2nA:
21.32
5xdxJ-3l2nA:
9.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIO_A_HFGA801_1
(PROLINE-TRNA
SYNTHETASE CLASS II
AARS (YBAK RNA
BINDING DOMAIN PLUS
TRNA SYNTHETASE))		 3l2n PEPTIDASE M14,
CARBOXYPEPTIDASE A
(Shewanella
denitrificans) 		3 / 3 THR A 333
GLU A 335
HIS A 166
 UNL  A 378 ( 4.8A)
UNL  A 378 ( 3.3A)
CA  A 377 (-3.2A)
 0.93A 5xioA-3l2nA:
2.1		 5xioA-3l2nA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCP_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3l2n PEPTIDASE M14,
CARBOXYPEPTIDASE A
(Shewanella
denitrificans) 		4 / 8 ILE A 104
LEU A  99
ARG A  83
THR A  86
 None
 0.94A 5zcpN-3l2nA:
undetectable
5zcpW-3l2nA:
undetectable		 5zcpN-3l2nA:
21.32
5zcpW-3l2nA:
9.44