SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3l2o'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FCN_B_DVAB35_0
(UBIQUITIN)		 3l2o F-BOX ONLY PROTEIN 4
(Homo
sapiens) 		4 / 6 ARG B 338
LEU B 328
GLU B 363
ILE B 331
 None
 0.79A 2fcnA-3l2oB:
undetectable
2fcnB-3l2oB:
undetectable		 2fcnA-3l2oB:
11.80
2fcnB-3l2oB:
11.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SU9_A_ACTA426_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 3l2o F-BOX ONLY PROTEIN 4
(Homo
sapiens) 		3 / 3 GLN B 224
GLU B 176
LYS B 230
 None
 1.14A 3su9A-3l2oB:
undetectable		 3su9A-3l2oB:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N49_A_SAMA601_0
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)		 3l2o F-BOX ONLY PROTEIN 4
(Homo
sapiens) 		5 / 12 GLY B 183
PRO B 184
GLY B 185
LEU B 236
ILE B 233
 None
 1.02A 4n49A-3l2oB:
undetectable		 4n49A-3l2oB:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1K_B_LOCB502_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 3l2o F-BOX ONLY PROTEIN 4
(Homo
sapiens) 		5 / 12 VAL B 292
LEU B 350
LEU B 358
THR B 362
ALA B 345
 None
 0.99A 4x1kA-3l2oB:
3.4
4x1kB-3l2oB:
3.7		 4x1kA-3l2oB:
19.50
4x1kB-3l2oB:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B8I_C_FK5C201_3
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)		 3l2o F-BOX ONLY PROTEIN 4
(Homo
sapiens) 		5 / 12 PHE B 318
VAL B 275
ILE B 276
LEU B 234
ILE B 217
 None
 1.25A 5b8iC-3l2oB:
undetectable		 5b8iC-3l2oB:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FSA_A_X2NA590_2
(CYP51 VARIANT1)		 3l2o F-BOX ONLY PROTEIN 4
(Homo
sapiens) 		3 / 3 PRO B 205
ILE B 214
SER B 199
 None
 0.77A 5fsaA-3l2oB:
undetectable		 5fsaA-3l2oB:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FSA_A_X2NA590_2
(CYP51 VARIANT1)		 3l2o F-BOX ONLY PROTEIN 4
(Homo
sapiens) 		3 / 3 PRO B 205
ILE B 217
SER B 200
 None
 0.73A 5fsaA-3l2oB:
undetectable		 5fsaA-3l2oB:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRF_D_EVPD101_1
()		 3l2o F-BOX ONLY PROTEIN 4
(Homo
sapiens) 		4 / 5 GLY B 288
ASP B 287
ARG B 178
MET B 198
 None
 1.29A 5zrfB-3l2oB:
2.9		 5zrfB-3l2oB:
16.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRF_F_EVPF1301_1
()		 3l2o F-BOX ONLY PROTEIN 4
(Homo
sapiens) 		4 / 4 GLY B 288
ASP B 287
ARG B 178
MET B 198
 None
 1.26A 5zrfA-3l2oB:
2.4		 5zrfA-3l2oB:
16.52