SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3l2p'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C4D_B_DVAB8_0
(GRAMICIDIN A)		 3l2p DNA LIGASE 3
(Homo
sapiens) 		3 / 3 TRP A 729
VAL A 607
TRP A 636
 None
 1.26A 1c4dA-3l2pA:
undetectable
1c4dB-3l2pA:
undetectable		 1c4dA-3l2pA:
2.32
1c4dB-3l2pA:
2.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK3_A_T44A3004_1
(SERUM ALBUMIN)		 3l2p DNA LIGASE 3
(Homo
sapiens) 		4 / 7 GLU A 178
LEU A 176
VAL A 290
LEU A 218
 None
 0.84A 1hk3A-3l2pA:
undetectable		 1hk3A-3l2pA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E5D_A_NCAA1501_0
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)		 3l2p DNA LIGASE 3
(Homo
sapiens) 		4 / 7 ARG A 426
ASP A 509
ASP A 471
TYR A 579
 AMP  A 901 (-3.8A)
None
None
None
 1.08A 2e5dA-3l2pA:
undetectable
2e5dB-3l2pA:
undetectable		 2e5dA-3l2pA:
22.37
2e5dB-3l2pA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E5D_B_NCAB1502_0
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)		 3l2p DNA LIGASE 3
(Homo
sapiens) 		4 / 7 ASP A 471
TYR A 579
ARG A 426
ASP A 509
 None
None
AMP  A 901 (-3.8A)
None
 1.10A 2e5dA-3l2pA:
undetectable
2e5dB-3l2pA:
undetectable		 2e5dA-3l2pA:
22.37
2e5dB-3l2pA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D41_A_FCNA4001_1
(FOMA PROTEIN)		 3l2p DNA LIGASE 3
(Homo
sapiens) 		5 / 8 GLY A 699
ILE A 697
SER A 714
SER A 703
THR A 640
 None
 0.92A 3d41A-3l2pA:
undetectable		 3d41A-3l2pA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K37_B_BCZB468_1
(NEURAMINIDASE)		 3l2p DNA LIGASE 3
(Homo
sapiens) 		3 / 3 ARG A 527
GLU A 536
TYR A 422
 None
None
AMP  A 901 (-4.6A)
 0.88A 3k37B-3l2pA:
undetectable		 3k37B-3l2pA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QWU_A_ADNA501_1
(DNA LIGASE)		 3l2p DNA LIGASE 3
(Homo
sapiens) 		5 / 12 GLU A 419
ARG A 441
GLU A 473
VAL A 571
LYS A 588
 AMP  A 901 (-3.7A)
None
AMP  A 901 ( 3.7A)
AMP  A 901 ( 4.8A)
AMP  A 901 (-2.9A)
 0.84A 3qwuA-3l2pA:
11.8		 3qwuA-3l2pA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QWU_A_ADNA501_1
(DNA LIGASE)		 3l2p DNA LIGASE 3
(Homo
sapiens) 		6 / 12 GLU A 419
GLU A 473
PHE A 508
VAL A 571
LYS A 573
LYS A 588
 AMP  A 901 (-3.7A)
AMP  A 901 ( 3.7A)
AMP  A 901 (-3.3A)
AMP  A 901 ( 4.8A)
AMP  A 901 (-3.1A)
AMP  A 901 (-2.9A)
 0.72A 3qwuA-3l2pA:
11.8		 3qwuA-3l2pA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QWU_A_ADNA501_1
(DNA LIGASE)		 3l2p DNA LIGASE 3
(Homo
sapiens) 		5 / 12 GLU A 419
LYS A 421
ARG A 441
VAL A 571
LYS A 588
 AMP  A 901 (-3.7A)
AMP  A 901 (-2.2A)
None
AMP  A 901 ( 4.8A)
AMP  A 901 (-2.9A)
 1.04A 3qwuA-3l2pA:
11.8		 3qwuA-3l2pA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QWU_A_ADNA501_1
(DNA LIGASE)		 3l2p DNA LIGASE 3
(Homo
sapiens) 		5 / 12 GLU A 419
LYS A 421
VAL A 571
LYS A 573
LYS A 588
 AMP  A 901 (-3.7A)
AMP  A 901 (-2.2A)
AMP  A 901 ( 4.8A)
AMP  A 901 (-3.1A)
AMP  A 901 (-2.9A)
 0.97A 3qwuA-3l2pA:
11.8		 3qwuA-3l2pA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QWU_B_ADNB501_1
(DNA LIGASE)		 3l2p DNA LIGASE 3
(Homo
sapiens) 		6 / 11 GLU A 419
LYS A 421
GLU A 473
PHE A 508
VAL A 571
LYS A 573
 AMP  A 901 (-3.7A)
AMP  A 901 (-2.2A)
AMP  A 901 ( 3.7A)
AMP  A 901 (-3.3A)
AMP  A 901 ( 4.8A)
AMP  A 901 (-3.1A)
 0.89A 3qwuB-3l2pA:
5.6		 3qwuB-3l2pA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SMT_A_ACTA500_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD3)		 3l2p DNA LIGASE 3
(Homo
sapiens) 		3 / 3 PHE A 270
SER A 274
GLN A 273
 None
 0.96A 3smtA-3l2pA:
undetectable		 3smtA-3l2pA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_B_W9TB513_1
(HEMOLYTIC LECTIN
CEL-III)		 3l2p DNA LIGASE 3
(Homo
sapiens) 		4 / 6 CYH A 628
THR A 733
ASN A 734
ILE A 713
 None
 1.41A 3w9tB-3l2pA:
undetectable		 3w9tB-3l2pA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECM_A_LEUA602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 3l2p DNA LIGASE 3
(Homo
sapiens) 		4 / 5 THR A 638
ALA A 710
THR A 709
HIS A 708
 None
 1.34A 5ecmA-3l2pA:
undetectable		 5ecmA-3l2pA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NWV_A_ACAA18_2
(SCRFP-TAG,GP41)		 3l2p DNA LIGASE 3
(Homo
sapiens) 		4 / 7 GLN A 197
ASP A 344
ALA A 350
LEU A 384
 None
 0.82A 5nwvA-3l2pA:
undetectable		 5nwvA-3l2pA:
5.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X24_A_LSNA502_1
(CYTOCHROME P450 2C9)		 3l2p DNA LIGASE 3
(Homo
sapiens) 		5 / 12 ALA A 643
PHE A 611
VAL A 607
GLY A 627
THR A 709
 None
 1.18A 5x24A-3l2pA:
undetectable		 5x24A-3l2pA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BAA_E_GBME2001_2
(ATP-BINDING CASSETTE
SUB-FAMILY C MEMBER
8)		 3l2p DNA LIGASE 3
(Homo
sapiens) 		3 / 3 LEU A 744
THR A 733
ASN A 734
 None
 0.62A 6baaE-3l2pA:
undetectable		 6baaE-3l2pA:
17.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BAA_F_GBMF2001_2
(ATP-BINDING CASSETTE
SUB-FAMILY C MEMBER
8)		 3l2p DNA LIGASE 3
(Homo
sapiens) 		3 / 3 LEU A 744
THR A 733
ASN A 734
 None
 0.62A 6baaF-3l2pA:
undetectable		 6baaF-3l2pA:
17.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BAA_G_GBMG2001_2
(ATP-BINDING CASSETTE
SUB-FAMILY C MEMBER
8)		 3l2p DNA LIGASE 3
(Homo
sapiens) 		3 / 3 LEU A 744
THR A 733
ASN A 734
 None
 0.62A 6baaG-3l2pA:
undetectable		 6baaG-3l2pA:
17.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BAA_H_GBMH2001_2
(ATP-BINDING CASSETTE
SUB-FAMILY C MEMBER
8)		 3l2p DNA LIGASE 3
(Homo
sapiens) 		3 / 3 LEU A 744
THR A 733
ASN A 734
 None
 0.62A 6baaH-3l2pA:
undetectable		 6baaH-3l2pA:
17.04