SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3l3b'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_H_ACTH3006_0
(BETA-CARBONIC
ANHYDRASE)		 3l3b ES1 FAMILY PROTEIN
(Ehrlichia
chaffeensis) 		4 / 6 GLN A  46
ASP A  16
VAL A  58
HIS A  52
 None
 1.38A 1ekjG-3l3bA:
undetectable
1ekjH-3l3bA:
undetectable		 1ekjG-3l3bA:
22.22
1ekjH-3l3bA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GX8_A_RTLA1163_0
(BETA-LACTOGLOBULIN)		 3l3b ES1 FAMILY PROTEIN
(Ehrlichia
chaffeensis) 		5 / 9 LEU A 146
LEU A  90
GLU A 125
ILE A   8
VAL A  98
 None
 1.21A 1gx8A-3l3bA:
undetectable		 1gx8A-3l3bA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_B_BEZB504_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 3l3b ES1 FAMILY PROTEIN
(Ehrlichia
chaffeensis) 		4 / 7 LEU A  90
ILE A 133
ALA A 122
ILE A 115
 None
 0.84A 1oniB-3l3bA:
undetectable
1oniC-3l3bA:
undetectable		 1oniB-3l3bA:
20.63
1oniC-3l3bA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YC2_D_NCAD510_0
(NAD-DEPENDENT
DEACETYLASE 2)		 3l3b ES1 FAMILY PROTEIN
(Ehrlichia
chaffeensis) 		4 / 5 ALA A 151
ASN A 186
ILE A 188
ASP A 183
 None
 0.98A 1yc2D-3l3bA:
5.6		 1yc2D-3l3bA:
25.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNH_A_9CRA501_1
(CYTOCHROME P450 2C8)		 3l3b ES1 FAMILY PROTEIN
(Ehrlichia
chaffeensis) 		5 / 11 GLY A  97
SER A 139
ILE A   8
ALA A 122
ILE A 115
 None
 1.00A 2nnhA-3l3bA:
undetectable		 2nnhA-3l3bA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z0Y_A_SAMA300_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN TTHA0657)		 3l3b ES1 FAMILY PROTEIN
(Ehrlichia
chaffeensis) 		5 / 9 ALA A 193
VAL A 136
GLY A  94
GLY A  95
LEU A  25
 None
 0.99A 2z0yA-3l3bA:
2.7		 2z0yA-3l3bA:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KW4_A_TICA600_1
(CYTOCHROME P450 2B4)		 3l3b ES1 FAMILY PROTEIN
(Ehrlichia
chaffeensis) 		6 / 11 SER A  18
GLU A  22
ILE A 138
VAL A 142
VAL A  98
GLY A  95
 None
 1.50A 3kw4A-3l3bA:
undetectable		 3kw4A-3l3bA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RV5_C_DXCC92_0
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 3l3b ES1 FAMILY PROTEIN
(Ehrlichia
chaffeensis) 		4 / 4 VAL A  76
PHE A  40
PHE A 119
VAL A  98
 None
 1.34A 3rv5C-3l3bA:
undetectable
3rv5D-3l3bA:
undetectable		 3rv5C-3l3bA:
15.66
3rv5D-3l3bA:
15.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UG8_A_IMNA2001_2
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 3l3b ES1 FAMILY PROTEIN
(Ehrlichia
chaffeensis) 		3 / 3 TYR A  96
GLU A  22
TYR A 194
 None
 0.99A 3ug8A-3l3bA:
undetectable		 3ug8A-3l3bA:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IIL_A_RBFA401_2
(MEMBRANE LIPOPROTEIN
TPN38(B))		 3l3b ES1 FAMILY PROTEIN
(Ehrlichia
chaffeensis) 		4 / 8 VAL A  91
PRO A 140
ILE A 207
MET A 214
 None
 1.10A 4iilA-3l3bA:
4.5		 4iilA-3l3bA:
23.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KIC_A_SAMA401_0
(METHYLTRANSFERASE
MPPJ)		 3l3b ES1 FAMILY PROTEIN
(Ehrlichia
chaffeensis) 		5 / 12 GLY A  11
GLY A  13
ARG A  62
ALA A  23
ALA A  41
 None
 1.11A 4kicA-3l3bA:
2.9		 4kicA-3l3bA:
24.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NPT_A_017A401_1
(PROTEASE)		 3l3b ES1 FAMILY PROTEIN
(Ehrlichia
chaffeensis) 		5 / 9 ILE A 207
GLY A 206
ILE A 178
MET A 210
ILE A 157
 None
 1.01A 4nptA-3l3bA:
undetectable		 4nptA-3l3bA:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZVM_B_DM2B303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 3l3b ES1 FAMILY PROTEIN
(Ehrlichia
chaffeensis) 		5 / 11 VAL A 136
PHE A 119
GLY A  17
GLY A  11
ILE A  71
 None
 1.32A 4zvmA-3l3bA:
4.3
4zvmB-3l3bA:
6.3		 4zvmA-3l3bA:
20.72
4zvmB-3l3bA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_A_SAMA902_0
(MRNA CAPPING ENZYME
P5)		 3l3b ES1 FAMILY PROTEIN
(Ehrlichia
chaffeensis) 		5 / 12 LEU A  30
GLY A 134
PRO A  93
PRO A 140
VAL A 181
 None
 1.28A 5x6yA-3l3bA:
undetectable		 5x6yA-3l3bA:
15.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGC_A_ACTA811_0
(GEPHYRIN)		 3l3b ES1 FAMILY PROTEIN
(Ehrlichia
chaffeensis) 		3 / 3 LEU A  25
LEU A 200
ARG A  21
 None
 0.51A 6fgcA-3l3bA:
4.1		 6fgcA-3l3bA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA810_0
(GEPHYRIN)		 3l3b ES1 FAMILY PROTEIN
(Ehrlichia
chaffeensis) 		3 / 3 LEU A  25
LEU A 200
ARG A  21
 None
 0.52A 6fgdA-3l3bA:
3.3		 6fgdA-3l3bA:
21.70