SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3l3f'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T9U_A_CPFA5002_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 3l3f PROTEIN DOA1
(Saccharomyces
cerevisiae) 		4 / 6 PHE X 580
ASN X 581
ASN X 676
GLN X 471
 None
 1.46A 1t9uA-3l3fX:
undetectable		 1t9uA-3l3fX:
16.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X70_A_715A801_2
(DIPEPTIDYL PEPTIDASE
IV)		 3l3f PROTEIN DOA1
(Saccharomyces
cerevisiae) 		3 / 3 ARG X 541
SER X 630
TYR X 629
 None
 0.77A 1x70A-3l3fX:
2.1		 1x70A-3l3fX:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2LH8_A_VIBA1_1
(MAJOR PRION PROTEIN)		 3l3f PROTEIN DOA1
(Saccharomyces
cerevisiae) 		4 / 6 PRO X 424
MET X 425
ASP X 429
TYR X 427
 None
 1.31A 2lh8A-3l3fX:
undetectable		 2lh8A-3l3fX:
13.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AF0_A_PAUA314_0
(PANTOTHENATE KINASE)		 3l3f PROTEIN DOA1
(Saccharomyces
cerevisiae) 		4 / 8 VAL X 469
ASP X 713
LEU X 714
GLY X 675
 None
 0.97A 3af0A-3l3fX:
undetectable		 3af0A-3l3fX:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NXU_B_RITB600_1
(CYTOCHROME P450 3A4)		 3l3f PROTEIN DOA1
(Saccharomyces
cerevisiae) 		5 / 12 LEU X 576
THR X 634
ILE X 603
ILE X 620
ALA X 666
 None
 1.18A 3nxuB-3l3fX:
undetectable		 3nxuB-3l3fX:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9V_B_DXCB323_0
(INVASIN IPAD)		 3l3f PROTEIN DOA1
(Saccharomyces
cerevisiae) 		4 / 7 ILE X 599
ILE X 603
VAL X 622
LEU X 625
 None
 0.68A 3r9vA-3l3fX:
undetectable
3r9vB-3l3fX:
undetectable		 3r9vA-3l3fX:
22.31
3r9vB-3l3fX:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RVG_A_ACTA504_0
(D-MYCAROSE
3-C-METHYLTRANSFERAS
E)		 3l3f PROTEIN DOA1
(Saccharomyces
cerevisiae) 		4 / 4 ALA X 536
LYS X 533
TYR X 556
GLU X 559
 None
 1.47A 4rvgA-3l3fX:
0.0		 4rvgA-3l3fX:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E5J_A_017A201_3
(PROTEASE)		 3l3f PROTEIN DOA1
(Saccharomyces
cerevisiae) 		3 / 3 ASP X 415
VAL X 431
LEU X 402
 None
 0.57A 5e5jB-3l3fX:
undetectable		 5e5jB-3l3fX:
15.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7P_H_CHDH401_0
(BILE SALT HYDROLASE)		 3l3f PROTEIN DOA1
(Saccharomyces
cerevisiae) 		5 / 10 ILE X 697
PHE X 711
LEU X 677
ALA X 678
LEU X 467
 None
 1.26A 5y7pH-3l3fX:
undetectable		 5y7pH-3l3fX:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA825_0
(GEPHYRIN)		 3l3f PROTEIN DOA1
(Saccharomyces
cerevisiae) 		3 / 3 LYS X 401
VAL X 388
ASP X 390
 None
 0.38A 6fgdA-3l3fX:
undetectable		 6fgdA-3l3fX:
23.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_C_PCFC607_0
(CYTOCHROME B)		 3l3f PROTEIN DOA1
(Saccharomyces
cerevisiae) 		5 / 10 TYR X 654
TYR X 660
THR X 605
PHE X 600
VAL X 646
 None
 1.49A 6hu9C-3l3fX:
2.4		 6hu9C-3l3fX:
20.64