SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3l49'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AV2_D_DVAD6_0
(GRAMICIDIN A)		 3l49 ABC SUGAR (RIBOSE)
TRANSPORTER,
PERIPLASMIC
SUBSTRATE-BINDING
SUBUNIT
(Rhodobacter
sphaeroides) 		3 / 3 TRP A 222
ALA A 220
VAL A 156
 None
 0.99A 1av2C-3l49A:
undetectable
1av2D-3l49A:
undetectable		 1av2C-3l49A:
10.11
1av2D-3l49A:
10.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RKF_A_AB1A501_1
(PROTEASE RETROPEPSIN)		 3l49 ABC SUGAR (RIBOSE)
TRANSPORTER,
PERIPLASMIC
SUBSTRATE-BINDING
SUBUNIT
(Rhodobacter
sphaeroides) 		5 / 12 LEU A 105
ILE A 113
GLY A  35
ILE A  36
ILE A 108
 None
 0.82A 2rkfA-3l49A:
undetectable		 2rkfA-3l49A:
16.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RKF_A_AB1A501_2
(PROTEASE RETROPEPSIN)		 3l49 ABC SUGAR (RIBOSE)
TRANSPORTER,
PERIPLASMIC
SUBSTRATE-BINDING
SUBUNIT
(Rhodobacter
sphaeroides) 		5 / 12 LEU A 105
ILE A 113
GLY A  35
ILE A  36
ILE A 108
 None
 0.81A 2rkfB-3l49A:
undetectable		 2rkfB-3l49A:
16.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L8L_B_DVAB6_0
(GRAMICIDIN D)		 3l49 ABC SUGAR (RIBOSE)
TRANSPORTER,
PERIPLASMIC
SUBSTRATE-BINDING
SUBUNIT
(Rhodobacter
sphaeroides) 		3 / 3 TRP A 222
ALA A 220
VAL A 156
 None
 0.97A 3l8lA-3l49A:
undetectable
3l8lB-3l49A:
undetectable		 3l8lA-3l49A:
10.11
3l8lB-3l49A:
11.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NU4_B_478B401_2
(PROTEASE)		 3l49 ABC SUGAR (RIBOSE)
TRANSPORTER,
PERIPLASMIC
SUBSTRATE-BINDING
SUBUNIT
(Rhodobacter
sphaeroides) 		5 / 9 LEU A 105
ILE A 113
GLY A  35
ILE A  36
ILE A 108
 None
 0.89A 3nu4B-3l49A:
undetectable		 3nu4B-3l49A:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S43_A_478A401_2
(PROTEASE)		 3l49 ABC SUGAR (RIBOSE)
TRANSPORTER,
PERIPLASMIC
SUBSTRATE-BINDING
SUBUNIT
(Rhodobacter
sphaeroides) 		5 / 10 LEU A 105
ILE A 113
GLY A  35
ILE A  36
ILE A 108
 None
 0.85A 3s43B-3l49A:
undetectable		 3s43B-3l49A:
17.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S53_A_017A201_2
(PROTEASE)		 3l49 ABC SUGAR (RIBOSE)
TRANSPORTER,
PERIPLASMIC
SUBSTRATE-BINDING
SUBUNIT
(Rhodobacter
sphaeroides) 		5 / 11 LEU A 105
ILE A 113
GLY A  35
ILE A  36
ILE A 108
 None
 0.89A 3s53B-3l49A:
undetectable		 3s53B-3l49A:
17.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UT5_D_LOCD502_1
(TUBULIN BETA CHAIN)		 3l49 ABC SUGAR (RIBOSE)
TRANSPORTER,
PERIPLASMIC
SUBSTRATE-BINDING
SUBUNIT
(Rhodobacter
sphaeroides) 		5 / 12 LEU A  47
GLN A  94
ALA A  49
ALA A  66
ALA A  38
 None
 1.08A 3ut5D-3l49A:
3.9		 3ut5D-3l49A:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QTU_B_SAMB301_0
(PUTATIVE
METHYLTRANSFERASE
BUD23)		 3l49 ABC SUGAR (RIBOSE)
TRANSPORTER,
PERIPLASMIC
SUBSTRATE-BINDING
SUBUNIT
(Rhodobacter
sphaeroides) 		5 / 12 GLY A 248
SER A 252
ILE A 221
ALA A 223
TRP A 225
 None
None
None
None
UNL  A   1 ( 4.7A)
 1.14A 4qtuB-3l49A:
3.6		 4qtuB-3l49A:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QTU_D_SAMD301_0
(PUTATIVE
METHYLTRANSFERASE
BUD23)		 3l49 ABC SUGAR (RIBOSE)
TRANSPORTER,
PERIPLASMIC
SUBSTRATE-BINDING
SUBUNIT
(Rhodobacter
sphaeroides) 		5 / 12 GLY A 248
SER A 252
ILE A 221
ALA A 223
TRP A 225
 None
None
None
None
UNL  A   1 ( 4.7A)
 1.07A 4qtuD-3l49A:
3.2		 4qtuD-3l49A:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XP6_A_B40A601_1
(TRANSPORTER)		 3l49 ABC SUGAR (RIBOSE)
TRANSPORTER,
PERIPLASMIC
SUBSTRATE-BINDING
SUBUNIT
(Rhodobacter
sphaeroides) 		4 / 5 ASP A  42
ASP A  73
PHE A 160
GLY A  96
 None
None
UNL  A   1 ( 4.4A)
None
 1.11A 4xp6A-3l49A:
undetectable		 4xp6A-3l49A:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E5J_A_017A201_2
(PROTEASE)		 3l49 ABC SUGAR (RIBOSE)
TRANSPORTER,
PERIPLASMIC
SUBSTRATE-BINDING
SUBUNIT
(Rhodobacter
sphaeroides) 		5 / 12 LEU A 105
ILE A 113
GLY A  35
ILE A  36
ILE A 108
 None
 0.86A 5e5jB-3l49A:
undetectable		 5e5jB-3l49A:
17.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E5K_B_017B201_1
(HIV-1 PROTEASE)		 3l49 ABC SUGAR (RIBOSE)
TRANSPORTER,
PERIPLASMIC
SUBSTRATE-BINDING
SUBUNIT
(Rhodobacter
sphaeroides) 		5 / 12 LEU A 105
ILE A 113
GLY A  35
ILE A  36
ILE A 108
 None
 0.79A 5e5kA-3l49A:
undetectable		 5e5kA-3l49A:
17.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GWX_A_SAMA301_0
(GLYCINE SARCOSINE
N-METHYLTRANSFERASE)		 3l49 ABC SUGAR (RIBOSE)
TRANSPORTER,
PERIPLASMIC
SUBSTRATE-BINDING
SUBUNIT
(Rhodobacter
sphaeroides) 		5 / 12 ALA A 270
GLY A 248
GLY A 251
SER A 252
GLY A 137
 None
 1.06A 5gwxA-3l49A:
undetectable		 5gwxA-3l49A:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O4Y_D_CCSD14_0
(PHE-MAA-ASN-PRO-HIS-
LEU-SER-TRP-SER-TRP-
9KK-9KK-ARG-CCS-GLY-
NH2
PROGRAMMED CELL
DEATH 1 LIGAND 1)		 3l49 ABC SUGAR (RIBOSE)
TRANSPORTER,
PERIPLASMIC
SUBSTRATE-BINDING
SUBUNIT
(Rhodobacter
sphaeroides) 		5 / 12 LEU A 304
GLY A 248
GLY A 267
VAL A 259
THR A 306
 None
 1.33A 5o4yD-3l49A:
undetectable
5o4yE-3l49A:
undetectable		 5o4yD-3l49A:
3.55
5o4yE-3l49A:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T8H_B_478B401_1
(PROTEASE)		 3l49 ABC SUGAR (RIBOSE)
TRANSPORTER,
PERIPLASMIC
SUBSTRATE-BINDING
SUBUNIT
(Rhodobacter
sphaeroides) 		5 / 12 LEU A 105
ILE A 113
GLY A  35
ILE A  36
ILE A 108
 None
 0.84A 5t8hA-3l49A:
undetectable		 5t8hA-3l49A:
17.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7P_A_ACRA1471_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 3l49 ABC SUGAR (RIBOSE)
TRANSPORTER,
PERIPLASMIC
SUBSTRATE-BINDING
SUBUNIT
(Rhodobacter
sphaeroides) 		5 / 12 ASP A 250
LEU A  95
ARG A 169
ASN A 128
THR A 130
 UNL  A   1 ( 2.9A)
UNL  A   1 ( 4.5A)
UNL  A   1 ( 2.8A)
None
None
 1.30A 5x7pA-3l49A:
0.0		 5x7pA-3l49A:
12.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7P_B_ACRB1471_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 3l49 ABC SUGAR (RIBOSE)
TRANSPORTER,
PERIPLASMIC
SUBSTRATE-BINDING
SUBUNIT
(Rhodobacter
sphaeroides) 		5 / 12 ASP A 250
LEU A  95
ARG A 169
ASN A 128
THR A 130
 UNL  A   1 ( 2.9A)
UNL  A   1 ( 4.5A)
UNL  A   1 ( 2.8A)
None
None
 1.26A 5x7pB-3l49A:
1.7		 5x7pB-3l49A:
12.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YK2_A_ERYA501_0
(PROBABLE CONSERVED
ATP-BINDING PROTEIN
ABC TRANSPORTER)		 3l49 ABC SUGAR (RIBOSE)
TRANSPORTER,
PERIPLASMIC
SUBSTRATE-BINDING
SUBUNIT
(Rhodobacter
sphaeroides) 		5 / 11 GLU A  58
ARG A  59
GLY A 278
ALA A  52
ILE A  92
 None
 1.15A 5yk2A-3l49A:
undetectable		 5yk2A-3l49A:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CJK_C_ACTC301_0
(IMMUNOGLOBULIN FAB
LIGHT CHAIN)		 3l49 ABC SUGAR (RIBOSE)
TRANSPORTER,
PERIPLASMIC
SUBSTRATE-BINDING
SUBUNIT
(Rhodobacter
sphaeroides) 		4 / 4 VAL A 256
GLY A 251
ASP A 226
ASP A  44
 None
 1.36A 6cjkC-3l49A:
undetectable		 6cjkC-3l49A:
21.00