SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3l4c'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FSL_B_NIOB145_1
(LEGHEMOGLOBIN A)		 3l4c DEDICATOR OF
CYTOKINESIS PROTEIN
1
(Homo
sapiens) 		4 / 8 ILE A 499
HIS A 508
LEU A 509
VAL A 497
 None
 0.75A 1fslB-3l4cA:
undetectable		 1fslB-3l4cA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N61_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE)		 3l4c DEDICATOR OF
CYTOKINESIS PROTEIN
1
(Homo
sapiens) 		4 / 7 PHE A 602
SER A 605
VAL A 430
VAL A 433
 None
 1.29A 3n61A-3l4cA:
undetectable
3n61B-3l4cA:
undetectable		 3n61A-3l4cA:
19.95
3n61B-3l4cA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_C_DXCC1478_0
(MJ0495-LIKE PROTEIN)		 3l4c DEDICATOR OF
CYTOKINESIS PROTEIN
1
(Homo
sapiens) 		4 / 7 ASP A 550
GLY A 547
THR A 606
PHE A 602
 None
 1.02A 4ac9C-3l4cA:
undetectable		 4ac9C-3l4cA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJJ_D_NCTD501_1
(CYTOCHROME P450 2A6)		 3l4c DEDICATOR OF
CYTOKINESIS PROTEIN
1
(Homo
sapiens) 		4 / 7 PHE A 513
ILE A 604
LEU A 432
PHE A 602
 None
 0.83A 4ejjD-3l4cA:
undetectable		 4ejjD-3l4cA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EQB_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3l4c DEDICATOR OF
CYTOKINESIS PROTEIN
1
(Homo
sapiens) 		5 / 12 GLY A 459
PHE A 437
PHE A 513
GLY A 435
HIS A 508
 None
 1.09A 5eqbA-3l4cA:
undetectable		 5eqbA-3l4cA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KLA_A_ACTA1505_0
(MATERNAL PROTEIN
PUMILIO)		 3l4c DEDICATOR OF
CYTOKINESIS PROTEIN
1
(Homo
sapiens) 		3 / 3 HIS A 508
LYS A 535
PHE A 533
 None
 1.49A 5klaA-3l4cA:
undetectable		 5klaA-3l4cA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_C_ADNC502_1
(ADENOSYLHOMOCYSTEINA
SE)		 3l4c DEDICATOR OF
CYTOKINESIS PROTEIN
1
(Homo
sapiens) 		3 / 3 LEU A 432
GLY A 435
PHE A 529
 None
 0.56A 6exiC-3l4cA:
undetectable		 6exiC-3l4cA:
17.48