SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3l4e'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TT6_A_DESA129_1
(TRANSTHYRETIN)		 3l4e UNCHARACTERIZED
PEPTIDASE LMO0363
(Listeria
monocytogenes) 		4 / 4 LYS A  27
LEU A  24
LEU A  55
SER A  54
 None
 1.46A 1tt6A-3l4eA:
undetectable		 1tt6A-3l4eA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FJ1_A_CTCA222_0
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS D)		 3l4e UNCHARACTERIZED
PEPTIDASE LMO0363
(Listeria
monocytogenes) 		5 / 12 PHE A  91
THR A  85
VAL A  84
LEU A 150
ILE A 124
 None
 1.20A 2fj1A-3l4eA:
undetectable		 2fj1A-3l4eA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FJ1_A_CTCA222_0
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS D)		 3l4e UNCHARACTERIZED
PEPTIDASE LMO0363
(Listeria
monocytogenes) 		5 / 12 SER A  36
THR A  85
VAL A  84
LEU A 150
ILE A 124
 None
 1.18A 2fj1A-3l4eA:
undetectable		 2fj1A-3l4eA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H42_C_VIAC903_2
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 3l4e UNCHARACTERIZED
PEPTIDASE LMO0363
(Listeria
monocytogenes) 		3 / 3 ASN A 162
ILE A 173
MET A 135
 None
 0.84A 2h42C-3l4eA:
undetectable		 2h42C-3l4eA:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OKC_B_SAMB500_1
(TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN)		 3l4e UNCHARACTERIZED
PEPTIDASE LMO0363
(Listeria
monocytogenes) 		4 / 6 THR A 170
THR A 134
ASP A 136
THR A  89
 None
None
SO4  A 207 ( 4.8A)
None
 1.11A 2okcB-3l4eA:
undetectable		 2okcB-3l4eA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_C_KLNC1498_1
(CYTOCHROME P450 3A4)		 3l4e UNCHARACTERIZED
PEPTIDASE LMO0363
(Listeria
monocytogenes) 		5 / 12 LEU A  92
ILE A 105
ALA A 101
THR A  99
GLU A  61
 None
 1.16A 2v0mC-3l4eA:
undetectable		 2v0mC-3l4eA:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A3Y_A_OBNA6000_1
(NA, K-ATPASE ALPHA
SUBUNIT)		 3l4e UNCHARACTERIZED
PEPTIDASE LMO0363
(Listeria
monocytogenes) 		5 / 10 GLU A  21
PHE A  17
ALA A  47
PHE A  10
THR A  85
 None
 1.39A 3a3yA-3l4eA:
2.8		 3a3yA-3l4eA:
12.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARR_A_PNXA607_1
(CHITINASE A)		 3l4e UNCHARACTERIZED
PEPTIDASE LMO0363
(Listeria
monocytogenes) 		4 / 7 VAL A 123
SER A 126
THR A  89
LEU A  93
 None
 1.15A 3arrA-3l4eA:
undetectable		 3arrA-3l4eA:
16.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MBS_A_MRVA1101_2
(CHIMERA PROTEIN OF
C-C CHEMOKINE
RECEPTOR TYPE 5 AND
RUBREDOXIN)		 3l4e UNCHARACTERIZED
PEPTIDASE LMO0363
(Listeria
monocytogenes) 		4 / 7 TYR A  83
THR A 170
LEU A 158
THR A 125
 None
 1.13A 4mbsA-3l4eA:
undetectable		 4mbsA-3l4eA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MBS_B_MRVB1101_2
(CHIMERA PROTEIN OF
C-C CHEMOKINE
RECEPTOR TYPE 5 AND
RUBREDOXIN)		 3l4e UNCHARACTERIZED
PEPTIDASE LMO0363
(Listeria
monocytogenes) 		4 / 5 TYR A  83
THR A 170
LEU A 158
THR A 125
 None
 1.13A 4mbsB-3l4eA:
undetectable		 4mbsB-3l4eA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_B_STRB601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 3l4e UNCHARACTERIZED
PEPTIDASE LMO0363
(Listeria
monocytogenes) 		6 / 12 LEU A  24
PHE A  17
ALA A  51
ILE A 116
VAL A  29
VAL A  59
 None
 1.40A 4nkxB-3l4eA:
undetectable		 4nkxB-3l4eA:
17.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOI_A_ML1A303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 3l4e UNCHARACTERIZED
PEPTIDASE LMO0363
(Listeria
monocytogenes) 		4 / 8 PHE A  31
PHE A  17
GLY A 117
ILE A 124
 None
 1.00A 4qoiA-3l4eA:
4.6
4qoiB-3l4eA:
4.7		 4qoiA-3l4eA:
24.49
4qoiB-3l4eA:
24.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z91_F_4LEF401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 3l4e UNCHARACTERIZED
PEPTIDASE LMO0363
(Listeria
monocytogenes) 		4 / 7 THR A 125
LEU A 150
THR A  89
LEU A  92
 None
 0.82A 4z91F-3l4eA:
undetectable
4z91G-3l4eA:
undetectable
4z91H-3l4eA:
undetectable
4z91I-3l4eA:
undetectable
4z91J-3l4eA:
undetectable		 4z91F-3l4eA:
20.72
4z91G-3l4eA:
20.72
4z91H-3l4eA:
20.72
4z91I-3l4eA:
20.72
4z91J-3l4eA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESL_A_1YNA701_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3l4e UNCHARACTERIZED
PEPTIDASE LMO0363
(Listeria
monocytogenes) 		4 / 5 ALA A 130
TYR A 131
GLY A 112
LEU A   6
 None
 0.96A 5eslA-3l4eA:
undetectable		 5eslA-3l4eA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GWZ_D_010D6_0
(N-[(5-METHYLISOXAZOL
-3-YL)CARBONYL]ALANY
L-L-VALYL-N~1~-((1R,
2Z)-4-(BENZYLOXY)-4-
OXO-1-{[(3R)-2-OXOPY
RROLIDIN-3-YL]METHYL
}BUT-2-ENYL)-L-LEUCI
NAMIDE
PEDV MAIN PROTEASE)		 3l4e UNCHARACTERIZED
PEPTIDASE LMO0363
(Listeria
monocytogenes) 		3 / 3 MET A 135
HIS A 160
GLY A  87
 None
 0.74A 5gwzB-3l4eA:
undetectable		 5gwzB-3l4eA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I71_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 3l4e UNCHARACTERIZED
PEPTIDASE LMO0363
(Listeria
monocytogenes) 		5 / 12 ASP A 136
ILE A 124
ALA A 149
GLY A 117
VAL A  84
 SO4  A 207 ( 4.8A)
None
None
None
None
 0.97A 5i71A-3l4eA:
undetectable		 5i71A-3l4eA:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I75_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 3l4e UNCHARACTERIZED
PEPTIDASE LMO0363
(Listeria
monocytogenes) 		5 / 12 ASP A 136
ILE A 124
ALA A 149
GLY A 117
VAL A  84
 SO4  A 207 ( 4.8A)
None
None
None
None
 0.96A 5i75A-3l4eA:
undetectable		 5i75A-3l4eA:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KPC_A_SAMA401_1
(PAVINE
N-METHYLTRANSFERASE)		 3l4e UNCHARACTERIZED
PEPTIDASE LMO0363
(Listeria
monocytogenes) 		4 / 5 PHE A  90
SER A 137
GLN A  94
ASP A  63
 None
SO4  A 207 (-4.4A)
None
None
 1.35A 5kpcA-3l4eA:
undetectable		 5kpcA-3l4eA:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UHC_C_RFPC1201_2
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 3l4e UNCHARACTERIZED
PEPTIDASE LMO0363
(Listeria
monocytogenes) 		3 / 3 PHE A  10
ASP A  12
LEU A 158
 None
 0.74A 5uhcC-3l4eA:
undetectable		 5uhcC-3l4eA:
10.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A94_A_ZOTA3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		 3l4e UNCHARACTERIZED
PEPTIDASE LMO0363
(Listeria
monocytogenes) 		5 / 12 LEU A  57
VAL A  29
PHE A 193
PHE A  10
VAL A  14
 None
 1.25A 6a94A-3l4eA:
undetectable		 6a94A-3l4eA:
20.63