SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3l4g'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_A_TRPA81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 3l4g PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN
(Homo
sapiens) 		5 / 9 GLY A 458
THR A 328
HIS A 327
ILE A 373
SER A 332
 PHE  A 509 (-3.6A)
None
None
None
None
 1.42A 1c9sA-3l4gA:
undetectable
1c9sK-3l4gA:
undetectable		 1c9sA-3l4gA:
9.81
1c9sK-3l4gA:
9.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_B_TRPB81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 3l4g PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN
(Homo
sapiens) 		5 / 9 SER A 332
GLY A 458
THR A 328
HIS A 327
ILE A 373
 None
PHE  A 509 (-3.6A)
None
None
None
 1.43A 1c9sA-3l4gA:
undetectable
1c9sB-3l4gA:
undetectable		 1c9sA-3l4gA:
9.81
1c9sB-3l4gA:
9.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_D_TRPD81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 3l4g PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN
(Homo
sapiens) 		5 / 9 SER A 332
GLY A 458
THR A 328
HIS A 327
ILE A 373
 None
PHE  A 509 (-3.6A)
None
None
None
 1.44A 1c9sC-3l4gA:
undetectable
1c9sD-3l4gA:
undetectable		 1c9sC-3l4gA:
9.81
1c9sD-3l4gA:
9.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_E_TRPE81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 3l4g PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN
(Homo
sapiens) 		5 / 9 SER A 332
GLY A 458
THR A 328
HIS A 327
ILE A 373
 None
PHE  A 509 (-3.6A)
None
None
None
 1.42A 1c9sD-3l4gA:
undetectable
1c9sE-3l4gA:
undetectable		 1c9sD-3l4gA:
9.81
1c9sE-3l4gA:
9.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_F_TRPF81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 3l4g PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN
(Homo
sapiens) 		5 / 9 SER A 332
GLY A 458
THR A 328
HIS A 327
ILE A 373
 None
PHE  A 509 (-3.6A)
None
None
None
 1.43A 1c9sE-3l4gA:
undetectable
1c9sF-3l4gA:
undetectable		 1c9sE-3l4gA:
9.81
1c9sF-3l4gA:
9.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_G_TRPG81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 3l4g PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN
(Homo
sapiens) 		5 / 9 SER A 332
GLY A 458
THR A 328
HIS A 327
ILE A 373
 None
PHE  A 509 (-3.6A)
None
None
None
 1.43A 1c9sF-3l4gA:
undetectable
1c9sG-3l4gA:
undetectable		 1c9sF-3l4gA:
9.81
1c9sG-3l4gA:
9.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_H_TRPH81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 3l4g PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN
(Homo
sapiens) 		5 / 10 SER A 332
GLY A 458
THR A 328
HIS A 327
ILE A 373
 None
PHE  A 509 (-3.6A)
None
None
None
 1.43A 1c9sG-3l4gA:
undetectable
1c9sH-3l4gA:
undetectable		 1c9sG-3l4gA:
9.81
1c9sH-3l4gA:
9.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_I_TRPI81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 3l4g PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN
(Homo
sapiens) 		5 / 9 SER A 332
GLY A 458
THR A 328
HIS A 327
ILE A 373
 None
PHE  A 509 (-3.6A)
None
None
None
 1.43A 1c9sH-3l4gA:
undetectable
1c9sI-3l4gA:
undetectable		 1c9sH-3l4gA:
9.81
1c9sI-3l4gA:
9.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_K_TRPK81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 3l4g PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN
(Homo
sapiens) 		5 / 9 SER A 332
GLY A 458
THR A 328
HIS A 327
ILE A 373
 None
PHE  A 509 (-3.6A)
None
None
None
 1.42A 1c9sJ-3l4gA:
undetectable
1c9sK-3l4gA:
undetectable		 1c9sJ-3l4gA:
9.81
1c9sK-3l4gA:
9.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_L_TRPL81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 3l4g PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN
(Homo
sapiens) 		5 / 9 GLY A 458
THR A 328
HIS A 327
ILE A 373
SER A 332
 PHE  A 509 (-3.6A)
None
None
None
None
 1.46A 1c9sL-3l4gA:
undetectable
1c9sM-3l4gA:
undetectable		 1c9sL-3l4gA:
9.81
1c9sM-3l4gA:
9.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_M_TRPM81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 3l4g PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN
(Homo
sapiens) 		5 / 9 GLY A 458
THR A 328
HIS A 327
ILE A 373
SER A 332
 PHE  A 509 (-3.6A)
None
None
None
None
 1.45A 1c9sM-3l4gA:
undetectable
1c9sN-3l4gA:
undetectable		 1c9sM-3l4gA:
9.81
1c9sN-3l4gA:
9.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_O_TRPO81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 3l4g PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN
(Homo
sapiens) 		5 / 9 GLY A 458
THR A 328
HIS A 327
ILE A 373
SER A 332
 PHE  A 509 (-3.6A)
None
None
None
None
 1.45A 1c9sO-3l4gA:
undetectable
1c9sP-3l4gA:
undetectable		 1c9sO-3l4gA:
9.81
1c9sP-3l4gA:
9.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_S_TRPS81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 3l4g PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN
(Homo
sapiens) 		5 / 9 GLY A 458
THR A 328
HIS A 327
ILE A 373
SER A 332
 PHE  A 509 (-3.6A)
None
None
None
None
 1.45A 1c9sS-3l4gA:
undetectable
1c9sT-3l4gA:
undetectable		 1c9sS-3l4gA:
9.81
1c9sT-3l4gA:
9.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_A_TRPA81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 3l4g PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN
(Homo
sapiens) 		5 / 9 GLY A 458
THR A 328
HIS A 327
ILE A 373
SER A 332
 PHE  A 509 (-3.6A)
None
None
None
None
 1.43A 1gtfA-3l4gA:
undetectable
1gtfK-3l4gA:
undetectable		 1gtfA-3l4gA:
9.81
1gtfK-3l4gA:
9.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_B_TRPB81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 3l4g PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN
(Homo
sapiens) 		5 / 9 SER A 332
GLY A 458
THR A 328
HIS A 327
ILE A 373
 None
PHE  A 509 (-3.6A)
None
None
None
 1.42A 1gtfA-3l4gA:
undetectable
1gtfB-3l4gA:
undetectable		 1gtfA-3l4gA:
9.81
1gtfB-3l4gA:
9.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_C_TRPC81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 3l4g PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN
(Homo
sapiens) 		5 / 9 SER A 332
GLY A 458
THR A 328
HIS A 327
ILE A 373
 None
PHE  A 509 (-3.6A)
None
None
None
 1.42A 1gtfB-3l4gA:
undetectable
1gtfC-3l4gA:
undetectable		 1gtfB-3l4gA:
9.81
1gtfC-3l4gA:
9.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_F_TRPF81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 3l4g PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN
(Homo
sapiens) 		5 / 9 SER A 332
GLY A 458
THR A 328
HIS A 327
ILE A 373
 None
PHE  A 509 (-3.6A)
None
None
None
 1.45A 1gtfE-3l4gA:
undetectable
1gtfF-3l4gA:
undetectable		 1gtfE-3l4gA:
9.81
1gtfF-3l4gA:
9.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_G_TRPG81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 3l4g PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN
(Homo
sapiens) 		5 / 9 SER A 332
GLY A 458
THR A 328
HIS A 327
ILE A 373
 None
PHE  A 509 (-3.6A)
None
None
None
 1.43A 1gtfF-3l4gA:
undetectable
1gtfG-3l4gA:
undetectable		 1gtfF-3l4gA:
9.81
1gtfG-3l4gA:
9.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_H_TRPH81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 3l4g PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN
(Homo
sapiens) 		5 / 10 SER A 332
GLY A 458
THR A 328
HIS A 327
ILE A 373
 None
PHE  A 509 (-3.6A)
None
None
None
 1.43A 1gtfG-3l4gA:
undetectable
1gtfH-3l4gA:
undetectable		 1gtfG-3l4gA:
9.81
1gtfH-3l4gA:
9.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_J_TRPJ81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 3l4g PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN
(Homo
sapiens) 		5 / 9 SER A 332
GLY A 458
THR A 328
HIS A 327
ILE A 373
 None
PHE  A 509 (-3.6A)
None
None
None
 1.44A 1gtfI-3l4gA:
undetectable
1gtfJ-3l4gA:
undetectable		 1gtfI-3l4gA:
9.81
1gtfJ-3l4gA:
9.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_O_TRPO81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 3l4g PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN
(Homo
sapiens) 		5 / 9 GLY A 458
THR A 328
HIS A 327
ILE A 373
SER A 332
 PHE  A 509 (-3.6A)
None
None
None
None
 1.46A 1gtfO-3l4gA:
undetectable
1gtfP-3l4gA:
undetectable		 1gtfO-3l4gA:
9.81
1gtfP-3l4gA:
9.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_P_TRPP81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 3l4g PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN
(Homo
sapiens) 		5 / 10 GLY A 458
THR A 328
HIS A 327
ILE A 373
SER A 332
 PHE  A 509 (-3.6A)
None
None
None
None
 1.45A 1gtfP-3l4gA:
undetectable
1gtfQ-3l4gA:
undetectable		 1gtfP-3l4gA:
9.81
1gtfQ-3l4gA:
9.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_B_TRPB81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 3l4g PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN
(Homo
sapiens) 		5 / 8 SER A 332
GLY A 458
THR A 328
HIS A 327
ILE A 373
 None
PHE  A 509 (-3.6A)
None
None
None
 1.38A 1gtnA-3l4gA:
undetectable
1gtnB-3l4gA:
undetectable		 1gtnA-3l4gA:
9.81
1gtnB-3l4gA:
9.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_L_TRPL81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 3l4g PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN
PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN
(Homo
sapiens;
Homo
sapiens) 		5 / 9 VAL B 318
GLY A 385
HIS A 386
THR B 380
ILE B 377
 None
 1.19A 1gtnL-3l4gB:
undetectable
1gtnM-3l4gB:
undetectable		 1gtnL-3l4gB:
9.95
1gtnM-3l4gB:
9.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_R_TRPR81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 3l4g PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN
(Homo
sapiens) 		5 / 9 GLY A 458
THR A 328
HIS A 327
ILE A 373
SER A 332
 PHE  A 509 (-3.6A)
None
None
None
None
 1.45A 1gtnR-3l4gA:
undetectable
1gtnS-3l4gA:
undetectable		 1gtnR-3l4gA:
9.81
1gtnS-3l4gA:
9.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		 3l4g PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN
(Homo
sapiens) 		4 / 8 CYH B  76
LEU B  11
ALA B  14
LEU B  15
 None
 0.82A 1hwiB-3l4gB:
3.5		 1hwiB-3l4gB:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_2
(HMG-COA REDUCTASE)		 3l4g PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN
(Homo
sapiens) 		4 / 8 CYH B  76
LEU B  11
ALA B  14
LEU B  15
 None
 0.79A 1hwiD-3l4gB:
3.7		 1hwiD-3l4gB:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_1
(HMG-COA REDUCTASE)		 3l4g PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN
(Homo
sapiens) 		4 / 8 CYH B  76
LEU B  11
ALA B  14
LEU B  15
 None
 0.80A 1hwiC-3l4gB:
3.7		 1hwiC-3l4gB:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L2I_B_CCSB417_0
(ESTROGEN RECEPTOR)		 3l4g PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN
(Homo
sapiens) 		4 / 6 PRO B 170
PHE B 171
GLN B 106
VAL B 289
 None
 0.91A 1l2iB-3l4gB:
undetectable		 1l2iB-3l4gB:
19.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_A_TRPA81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3l4g PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN
(Homo
sapiens) 		5 / 9 GLY A 458
THR A 328
HIS A 327
ILE A 373
SER A 332
 PHE  A 509 (-3.6A)
None
None
None
None
 1.42A 1utdA-3l4gA:
undetectable
1utdB-3l4gA:
undetectable		 1utdA-3l4gA:
9.81
1utdB-3l4gA:
9.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_B_TRPB81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3l4g PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN
(Homo
sapiens) 		5 / 8 GLY A 458
THR A 328
HIS A 327
ILE A 373
SER A 332
 PHE  A 509 (-3.6A)
None
None
None
None
 1.43A 1utdB-3l4gA:
undetectable
1utdC-3l4gA:
undetectable		 1utdB-3l4gA:
9.81
1utdC-3l4gA:
9.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_C_TRPC81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3l4g PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN
(Homo
sapiens) 		5 / 9 GLY A 458
THR A 328
HIS A 327
ILE A 373
SER A 332
 PHE  A 509 (-3.6A)
None
None
None
None
 1.44A 1utdC-3l4gA:
undetectable
1utdD-3l4gA:
undetectable		 1utdC-3l4gA:
9.81
1utdD-3l4gA:
9.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_D_TRPD81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3l4g PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN
(Homo
sapiens) 		5 / 9 GLY A 458
THR A 328
HIS A 327
ILE A 373
SER A 332
 PHE  A 509 (-3.6A)
None
None
None
None
 1.44A 1utdD-3l4gA:
undetectable
1utdE-3l4gA:
undetectable		 1utdD-3l4gA:
9.81
1utdE-3l4gA:
9.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_F_TRPF81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3l4g PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN
(Homo
sapiens) 		5 / 8 GLY A 458
THR A 328
HIS A 327
ILE A 373
SER A 332
 PHE  A 509 (-3.6A)
None
None
None
None
 1.44A 1utdF-3l4gA:
undetectable
1utdG-3l4gA:
undetectable		 1utdF-3l4gA:
9.81
1utdG-3l4gA:
9.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_G_TRPG81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3l4g PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN
(Homo
sapiens) 		5 / 9 GLY A 458
THR A 328
HIS A 327
ILE A 373
SER A 332
 PHE  A 509 (-3.6A)
None
None
None
None
 1.47A 1utdG-3l4gA:
undetectable
1utdH-3l4gA:
undetectable		 1utdG-3l4gA:
9.81
1utdH-3l4gA:
9.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_J_TRPJ81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3l4g PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN
(Homo
sapiens) 		5 / 8 GLY A 458
THR A 328
HIS A 327
ILE A 373
SER A 332
 PHE  A 509 (-3.6A)
None
None
None
None
 1.45A 1utdJ-3l4gA:
undetectable
1utdK-3l4gA:
undetectable		 1utdJ-3l4gA:
9.81
1utdK-3l4gA:
9.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_K_TRPK81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3l4g PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN
(Homo
sapiens) 		5 / 9 SER A 332
GLY A 458
THR A 328
HIS A 327
ILE A 373
 None
PHE  A 509 (-3.6A)
None
None
None
 1.44A 1utdA-3l4gA:
undetectable
1utdK-3l4gA:
undetectable		 1utdA-3l4gA:
9.81
1utdK-3l4gA:
9.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_N_TRPN81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3l4g PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN
(Homo
sapiens) 		5 / 10 GLY A 458
THR A 328
HIS A 327
ILE A 373
SER A 332
 PHE  A 509 (-3.6A)
None
None
None
None
 1.45A 1utdN-3l4gA:
undetectable
1utdO-3l4gA:
undetectable		 1utdN-3l4gA:
9.81
1utdO-3l4gA:
9.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_R_TRPR81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3l4g PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN
(Homo
sapiens) 		5 / 10 GLY A 458
THR A 328
HIS A 327
ILE A 373
SER A 332
 PHE  A 509 (-3.6A)
None
None
None
None
 1.45A 1utdR-3l4gA:
undetectable
1utdS-3l4gA:
undetectable		 1utdR-3l4gA:
9.81
1utdS-3l4gA:
9.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_B_TFPB203_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 3l4g PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN
(Homo
sapiens) 		4 / 6 VAL A 390
LEU A 387
PHE A 238
SER A 332
 None
 0.97A 1wrlB-3l4gA:
undetectable		 1wrlB-3l4gA:
11.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZQ9_A_SAMA4000_1
(PROBABLE
DIMETHYLADENOSINE
TRANSFERASE)		 3l4g PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN
(Homo
sapiens) 		3 / 3 GLY B 507
GLU B 509
ASN B 503
 None
 0.73A 1zq9A-3l4gB:
undetectable		 1zq9A-3l4gB:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HS2_B_017B203_1
(PROTEASE)		 3l4g PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN
(Homo
sapiens) 		4 / 6 LEU B 313
LYS B 316
ARG B 321
GLY B 319
 None
 1.03A 2hs2B-3l4gB:
undetectable		 2hs2B-3l4gB:
11.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QWX_A_ML1A233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 3l4g PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN
(Homo
sapiens) 		4 / 8 PHE B 588
ILE B 583
MET B 404
ILE B 511
 None
 0.84A 2qwxA-3l4gB:
undetectable
2qwxB-3l4gB:
undetectable		 2qwxA-3l4gB:
16.64
2qwxB-3l4gB:
16.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XRZ_A_ACTA1467_0
(DEOXYRIBODIPYRIMIDIN
E PHOTOLYASE)		 3l4g PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN
PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN
(Homo
sapiens;
Homo
sapiens) 		4 / 5 ARG A 439
ASP B 363
ILE B 358
GLU A 441
 None
 1.20A 2xrzA-3l4gA:
undetectable
2xrzB-3l4gA:
undetectable		 2xrzA-3l4gA:
20.73
2xrzB-3l4gA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_B_ACHB1210_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 3l4g PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN
(Homo
sapiens) 		4 / 7 VAL B 271
TYR B 277
CYH B 278
ILE B 251
 None
 1.01A 2xz5B-3l4gB:
undetectable
2xz5E-3l4gB:
undetectable		 2xz5B-3l4gB:
15.46
2xz5E-3l4gB:
15.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y69_N_CHDN1517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3l4g PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN
(Homo
sapiens) 		4 / 8 LEU B  35
ASP B  21
THR B  20
TYR B  19
 None
 1.17A 2y69C-3l4gB:
undetectable
2y69N-3l4gB:
1.2
2y69P-3l4gB:
undetectable		 2y69C-3l4gB:
17.25
2y69N-3l4gB:
20.39
2y69P-3l4gB:
17.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKV_A_478A200_2
(PROTEASE)		 3l4g PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN
PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN
(Homo
sapiens) 		5 / 9 ASP A 379
GLY B 319
ILE B 377
PRO A 415
ILE A 455
 None
 1.08A 3ekvB-3l4gA:
undetectable		 3ekvB-3l4gA:
11.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MBG_A_ACTA207_0
(FAD-LINKED
SULFHYDRYL OXIDASE
ALR)		 3l4g PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN
(Homo
sapiens) 		4 / 7 GLU A 360
ASP A 275
ARG A 358
ALA A 270
 None
 1.27A 3mbgA-3l4gA:
undetectable
3mbgB-3l4gA:
undetectable		 3mbgA-3l4gA:
15.46
3mbgB-3l4gA:
15.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NU4_B_478B401_1
(PROTEASE)		 3l4g PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN
PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN
(Homo
sapiens) 		5 / 9 ASP A 379
GLY B 319
ILE B 377
PRO A 415
ILE A 455
 None
 1.05A 3nu4A-3l4gA:
undetectable		 3nu4A-3l4gA:
13.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NUO_B_478B478_1
(PROTEASE)		 3l4g PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN
PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN
(Homo
sapiens) 		5 / 9 ASP A 379
GLY B 319
ILE B 377
PRO A 415
ILE A 455
 None
 1.06A 3nuoA-3l4gA:
undetectable		 3nuoA-3l4gA:
13.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S8P_A_SAMA500_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 3l4g PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN
(Homo
sapiens) 		3 / 3 HIS A 327
SER A 352
GLU A 374
 None
None
PHE  A 509 (-3.6A)
 0.68A 3s8pA-3l4gA:
undetectable		 3s8pA-3l4gA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TEG_A_DAHA416_1
(PHENYLALANYL-TRNA
SYNTHETASE,
MITOCHONDRIAL)		 3l4g PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN
(Homo
sapiens) 		7 / 12 ARG A 358
GLN A 372
GLU A 374
THR A 413
GLY A 436
ALA A 456
GLY A 458
 None
PHE  A 509 (-3.4A)
PHE  A 509 (-3.6A)
PHE  A 509 (-3.7A)
PHE  A 509 (-4.0A)
PHE  A 509 ( 4.1A)
PHE  A 509 (-3.6A)
 0.93A 3tegA-3l4gA:
20.8		 3tegA-3l4gA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TEH_A_DAHA351_1
(PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN)		 3l4g PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN
(Homo
sapiens) 		6 / 9 HIS A 327
ARG A 358
GLN A 372
GLU A 374
ALA A 456
GLY A 458
 None
None
PHE  A 509 (-3.4A)
PHE  A 509 (-3.6A)
PHE  A 509 ( 4.1A)
PHE  A 509 (-3.6A)
 0.97A 3tehA-3l4gA:
22.8		 3tehA-3l4gA:
27.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TPX_E_ACTE204_0
(E3 UBIQUITIN-PROTEIN
LIGASE MDM2)		 3l4g PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN
(Homo
sapiens) 		3 / 3 LYS B 217
PRO B 218
LEU B 219
 None
 0.72A 3tpxE-3l4gB:
undetectable		 3tpxE-3l4gB:
10.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WG7_P_CHDP307_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3l4g PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN
(Homo
sapiens) 		4 / 8 LEU B  35
ASP B  21
THR B  20
TYR B  19
 None
 1.24A 3wg7C-3l4gB:
undetectable
3wg7N-3l4gB:
undetectable
3wg7P-3l4gB:
undetectable		 3wg7C-3l4gB:
17.25
3wg7N-3l4gB:
20.39
3wg7P-3l4gB:
17.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B9Z_A_ACRA1818_1
(ALPHA-GLUCOSIDASE,
PUTATIVE, ADG31B)		 3l4g PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN
PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN
(Homo
sapiens) 		5 / 12 TYR A 409
LEU B  75
ILE B 269
ASP B  73
ARG B 355
 None
 1.39A 4b9zA-3l4gA:
undetectable		 4b9zA-3l4gA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G1B_A_ECNA403_1
(FLAVOHEMOGLOBIN)		 3l4g PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN
(Homo
sapiens) 		5 / 12 PHE B 299
ALA B 263
LEU B 267
VAL B 289
ILE B 223
 None
 1.12A 4g1bA-3l4gB:
undetectable		 4g1bA-3l4gB:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G5J_A_0WMA1102_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 3l4g PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN
(Homo
sapiens) 		4 / 7 PHE B 282
TYR B  96
TYR B 335
PRO B  94
 None
 0.86A 4g5jA-3l4gB:
undetectable		 4g5jA-3l4gB:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JQ4_A_IMNA401_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 3l4g PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN
(Homo
sapiens) 		5 / 10 VAL B   4
VAL B  67
GLU B  78
LEU B  10
LEU B  11
 None
 1.29A 4jq4A-3l4gB:
undetectable		 4jq4A-3l4gB:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KUK_A_RBFA201_2
(BLUE-LIGHT
PHOTORECEPTOR)		 3l4g PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN
(Homo
sapiens) 		5 / 9 LEU B  77
VAL B  67
ARG B  71
ILE B  65
PHE B  87
 None
 1.08A 4kukA-3l4gB:
undetectable		 4kukA-3l4gB:
13.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q1W_A_017A104_2
(ASPARTYL PROTEASE)		 3l4g PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN
PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN
(Homo
sapiens) 		5 / 10 ASP A 379
GLY B 319
ILE B 377
PRO A 415
ILE A 455
 None
 1.08A 4q1wB-3l4gA:
undetectable		 4q1wB-3l4gA:
11.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA0_A_SHHA404_2
(HISTONE DEACETYLASE
8)		 3l4g PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN
(Homo
sapiens) 		3 / 3 PRO B 221
MET B 233
TYR B 220
 None
 1.11A 4qa0B-3l4gB:
undetectable		 4qa0B-3l4gB:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA0_B_SHHB404_1
(HISTONE DEACETYLASE
8)		 3l4g PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN
(Homo
sapiens) 		3 / 3 PRO B 221
MET B 233
TYR B 220
 None
 1.11A 4qa0A-3l4gB:
undetectable		 4qa0A-3l4gB:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_A_RBFA201_2
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 3l4g PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN
(Homo
sapiens) 		4 / 8 LEU B  77
VAL B  67
ILE B  65
PHE B  87
 None
 0.80A 4r38A-3l4gB:
undetectable		 4r38A-3l4gB:
14.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XO7_A_ASDA402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 3l4g PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN
PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN
(Homo
sapiens) 		4 / 7 VAL B 481
ILE B 480
HIS A 371
LEU B 413
 None
 0.95A 4xo7A-3l4gB:
undetectable		 4xo7A-3l4gB:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_A_HISA302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 3l4g PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN
(Homo
sapiens) 		5 / 10 VAL A 376
GLU A 374
THR A 413
VAL A 454
SER A 332
 None
PHE  A 509 (-3.6A)
PHE  A 509 (-3.7A)
None
None
 1.25A 4yb6A-3l4gA:
undetectable
4yb6E-3l4gA:
undetectable		 4yb6A-3l4gA:
20.63
4yb6E-3l4gA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_A_HISA302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 3l4g PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN
(Homo
sapiens) 		5 / 10 VAL A 376
GLU A 374
VAL A 454
SER A 332
LEU A 336
 None
PHE  A 509 (-3.6A)
None
None
None
 1.14A 4yb6A-3l4gA:
undetectable
4yb6E-3l4gA:
undetectable		 4yb6A-3l4gA:
20.63
4yb6E-3l4gA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_B_HISB302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 3l4g PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN
(Homo
sapiens) 		5 / 10 GLU A 253
THR A 276
VAL A 356
LEU A 323
SER A 330
 None
 1.23A 4yb6B-3l4gA:
undetectable
4yb6C-3l4gA:
undetectable		 4yb6B-3l4gA:
20.63
4yb6C-3l4gA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_B_HISB302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 3l4g PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN
(Homo
sapiens) 		5 / 10 VAL A 376
GLU A 374
THR A 413
VAL A 454
SER A 332
 None
PHE  A 509 (-3.6A)
PHE  A 509 (-3.7A)
None
None
 1.24A 4yb6B-3l4gA:
undetectable
4yb6C-3l4gA:
undetectable		 4yb6B-3l4gA:
20.63
4yb6C-3l4gA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_B_HISB302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 3l4g PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN
(Homo
sapiens) 		5 / 10 VAL A 376
GLU A 374
VAL A 454
SER A 332
LEU A 336
 None
PHE  A 509 (-3.6A)
None
None
None
 1.13A 4yb6B-3l4gA:
undetectable
4yb6C-3l4gA:
undetectable		 4yb6B-3l4gA:
20.63
4yb6C-3l4gA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_C_HISC302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 3l4g PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN
(Homo
sapiens) 		5 / 10 VAL A 376
GLU A 374
THR A 413
VAL A 454
SER A 332
 None
PHE  A 509 (-3.6A)
PHE  A 509 (-3.7A)
None
None
 1.26A 4yb6C-3l4gA:
undetectable
4yb6F-3l4gA:
undetectable		 4yb6C-3l4gA:
20.63
4yb6F-3l4gA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_C_HISC302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 3l4g PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN
(Homo
sapiens) 		5 / 10 VAL A 376
GLU A 374
VAL A 454
SER A 332
LEU A 336
 None
PHE  A 509 (-3.6A)
None
None
None
 1.14A 4yb6C-3l4gA:
undetectable
4yb6F-3l4gA:
undetectable		 4yb6C-3l4gA:
20.63
4yb6F-3l4gA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_D_HISD302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 3l4g PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN
(Homo
sapiens) 		5 / 10 SER A 332
LEU A 336
VAL A 376
GLU A 374
VAL A 454
 None
None
None
PHE  A 509 (-3.6A)
None
 1.12A 4yb6A-3l4gA:
undetectable
4yb6D-3l4gA:
undetectable		 4yb6A-3l4gA:
20.63
4yb6D-3l4gA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_D_HISD302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 3l4g PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN
(Homo
sapiens) 		5 / 10 SER A 332
VAL A 376
GLU A 374
THR A 413
VAL A 454
 None
None
PHE  A 509 (-3.6A)
PHE  A 509 (-3.7A)
None
 1.27A 4yb6A-3l4gA:
undetectable
4yb6D-3l4gA:
undetectable		 4yb6A-3l4gA:
20.63
4yb6D-3l4gA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_E_HISE302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 3l4g PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN
(Homo
sapiens) 		5 / 10 LEU A 323
SER A 330
GLU A 253
THR A 276
VAL A 356
 None
 1.22A 4yb6D-3l4gA:
undetectable
4yb6E-3l4gA:
undetectable		 4yb6D-3l4gA:
20.63
4yb6E-3l4gA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_E_HISE302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 3l4g PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN
(Homo
sapiens) 		5 / 10 SER A 332
LEU A 336
VAL A 376
GLU A 374
VAL A 454
 None
None
None
PHE  A 509 (-3.6A)
None
 1.13A 4yb6D-3l4gA:
undetectable
4yb6E-3l4gA:
undetectable		 4yb6D-3l4gA:
20.63
4yb6E-3l4gA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_E_HISE302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 3l4g PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN
(Homo
sapiens) 		5 / 10 SER A 332
VAL A 376
GLU A 374
THR A 413
VAL A 454
 None
None
PHE  A 509 (-3.6A)
PHE  A 509 (-3.7A)
None
 1.25A 4yb6D-3l4gA:
undetectable
4yb6E-3l4gA:
undetectable		 4yb6D-3l4gA:
20.63
4yb6E-3l4gA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_F_HISF302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 3l4g PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN
(Homo
sapiens) 		5 / 10 SER A 332
LEU A 336
VAL A 376
GLU A 374
VAL A 454
 None
None
None
PHE  A 509 (-3.6A)
None
 1.16A 4yb6B-3l4gA:
undetectable
4yb6F-3l4gA:
undetectable		 4yb6B-3l4gA:
20.63
4yb6F-3l4gA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_A_TRPA101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3l4g PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN
(Homo
sapiens) 		5 / 9 SER A 332
GLY A 458
THR A 328
HIS A 327
ILE A 373
 None
PHE  A 509 (-3.6A)
None
None
None
 1.41A 5eeuA-3l4gA:
undetectable
5eeuB-3l4gA:
undetectable		 5eeuA-3l4gA:
9.81
5eeuB-3l4gA:
9.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_B_TRPB101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3l4g PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN
(Homo
sapiens) 		5 / 9 SER A 332
GLY A 458
THR A 328
HIS A 327
ILE A 373
 None
PHE  A 509 (-3.6A)
None
None
None
 1.42A 5eeuB-3l4gA:
undetectable
5eeuC-3l4gA:
undetectable		 5eeuB-3l4gA:
9.81
5eeuC-3l4gA:
9.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_C_TRPC101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3l4g PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN
(Homo
sapiens) 		5 / 9 SER A 332
GLY A 458
THR A 328
HIS A 327
ILE A 373
 None
PHE  A 509 (-3.6A)
None
None
None
 1.42A 5eeuC-3l4gA:
undetectable
5eeuD-3l4gA:
undetectable		 5eeuC-3l4gA:
9.81
5eeuD-3l4gA:
9.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_E_TRPE101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3l4g PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN
(Homo
sapiens) 		5 / 9 SER A 332
GLY A 458
THR A 328
HIS A 327
ILE A 373
 None
PHE  A 509 (-3.6A)
None
None
None
 1.41A 5eeuE-3l4gA:
undetectable
5eeuF-3l4gA:
undetectable		 5eeuE-3l4gA:
9.81
5eeuF-3l4gA:
9.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_H_TRPH101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3l4g PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN
(Homo
sapiens) 		5 / 10 SER A 332
GLY A 458
THR A 328
HIS A 327
ILE A 373
 None
PHE  A 509 (-3.6A)
None
None
None
 1.42A 5eeuH-3l4gA:
undetectable
5eeuI-3l4gA:
undetectable		 5eeuH-3l4gA:
9.81
5eeuI-3l4gA:
9.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_K_TRPK101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3l4g PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN
(Homo
sapiens) 		5 / 9 GLY A 458
THR A 328
HIS A 327
ILE A 373
SER A 332
 PHE  A 509 (-3.6A)
None
None
None
None
 1.42A 5eeuA-3l4gA:
undetectable
5eeuK-3l4gA:
undetectable		 5eeuA-3l4gA:
9.81
5eeuK-3l4gA:
9.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_O_TRPO101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3l4g PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN
(Homo
sapiens) 		5 / 10 GLY A 458
THR A 328
HIS A 327
ILE A 373
SER A 332
 PHE  A 509 (-3.6A)
None
None
None
None
 1.45A 5eeuN-3l4gA:
undetectable
5eeuO-3l4gA:
undetectable		 5eeuN-3l4gA:
9.81
5eeuO-3l4gA:
9.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_V_TRPV101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3l4g PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN
(Homo
sapiens) 		5 / 10 GLY A 458
THR A 328
HIS A 327
ILE A 373
SER A 332
 PHE  A 509 (-3.6A)
None
None
None
None
 1.43A 5eeuU-3l4gA:
undetectable
5eeuV-3l4gA:
undetectable		 5eeuU-3l4gA:
9.81
5eeuV-3l4gA:
9.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_B_TRPB101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3l4g PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN
(Homo
sapiens) 		5 / 9 SER A 332
GLY A 458
THR A 328
HIS A 327
ILE A 373
 None
PHE  A 509 (-3.6A)
None
None
None
 1.42A 5eevB-3l4gA:
undetectable
5eevC-3l4gA:
undetectable		 5eevB-3l4gA:
9.81
5eevC-3l4gA:
9.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_C_TRPC101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3l4g PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN
(Homo
sapiens) 		5 / 9 SER A 332
GLY A 458
THR A 328
HIS A 327
ILE A 373
 None
PHE  A 509 (-3.6A)
None
None
None
 1.42A 5eevC-3l4gA:
undetectable
5eevD-3l4gA:
undetectable		 5eevC-3l4gA:
9.81
5eevD-3l4gA:
9.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_E_TRPE101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3l4g PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN
(Homo
sapiens) 		5 / 9 SER A 332
GLY A 458
THR A 328
HIS A 327
ILE A 373
 None
PHE  A 509 (-3.6A)
None
None
None
 1.41A 5eevE-3l4gA:
undetectable
5eevF-3l4gA:
undetectable		 5eevE-3l4gA:
9.81
5eevF-3l4gA:
9.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_H_TRPH101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3l4g PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN
(Homo
sapiens) 		5 / 9 SER A 332
GLY A 458
THR A 328
HIS A 327
ILE A 373
 None
PHE  A 509 (-3.6A)
None
None
None
 1.42A 5eevH-3l4gA:
undetectable
5eevI-3l4gA:
undetectable		 5eevH-3l4gA:
9.81
5eevI-3l4gA:
9.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_K_TRPK101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3l4g PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN
(Homo
sapiens) 		5 / 9 GLY A 458
THR A 328
HIS A 327
ILE A 373
SER A 332
 PHE  A 509 (-3.6A)
None
None
None
None
 1.42A 5eevA-3l4gA:
undetectable
5eevK-3l4gA:
undetectable		 5eevA-3l4gA:
9.81
5eevK-3l4gA:
9.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_O_TRPO101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3l4g PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN
(Homo
sapiens) 		5 / 10 GLY A 458
THR A 328
HIS A 327
ILE A 373
SER A 332
 PHE  A 509 (-3.6A)
None
None
None
None
 1.45A 5eevN-3l4gA:
undetectable
5eevO-3l4gA:
undetectable		 5eevN-3l4gA:
9.81
5eevO-3l4gA:
9.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_U_TRPU101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3l4g PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN
(Homo
sapiens) 		5 / 10 GLY A 458
THR A 328
HIS A 327
ILE A 373
SER A 332
 PHE  A 509 (-3.6A)
None
None
None
None
 1.45A 5eevT-3l4gA:
undetectable
5eevU-3l4gA:
undetectable		 5eevT-3l4gA:
9.81
5eevU-3l4gA:
9.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_V_TRPV101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3l4g PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN
(Homo
sapiens) 		5 / 10 GLY A 458
THR A 328
HIS A 327
ILE A 373
SER A 332
 PHE  A 509 (-3.6A)
None
None
None
None
 1.42A 5eevU-3l4gA:
undetectable
5eevV-3l4gA:
undetectable		 5eevU-3l4gA:
9.81
5eevV-3l4gA:
9.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_B_TRPB101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3l4g PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN
(Homo
sapiens) 		5 / 9 SER A 332
GLY A 458
THR A 328
HIS A 327
ILE A 373
 None
PHE  A 509 (-3.6A)
None
None
None
 1.42A 5eewB-3l4gA:
undetectable
5eewC-3l4gA:
undetectable		 5eewB-3l4gA:
9.81
5eewC-3l4gA:
9.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_C_TRPC101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3l4g PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN
(Homo
sapiens) 		5 / 9 SER A 332
GLY A 458
THR A 328
HIS A 327
ILE A 373
 None
PHE  A 509 (-3.6A)
None
None
None
 1.42A 5eewC-3l4gA:
undetectable
5eewD-3l4gA:
undetectable		 5eewC-3l4gA:
9.81
5eewD-3l4gA:
9.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_E_TRPE101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3l4g PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN
(Homo
sapiens) 		5 / 9 SER A 332
GLY A 458
THR A 328
HIS A 327
ILE A 373
 None
PHE  A 509 (-3.6A)
None
None
None
 1.41A 5eewE-3l4gA:
undetectable
5eewF-3l4gA:
undetectable		 5eewE-3l4gA:
9.81
5eewF-3l4gA:
9.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_G_TRPG101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3l4g PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN
(Homo
sapiens) 		5 / 10 SER A 332
GLY A 458
THR A 328
HIS A 327
ILE A 373
 None
PHE  A 509 (-3.6A)
None
None
None
 1.45A 5eewG-3l4gA:
undetectable
5eewH-3l4gA:
undetectable		 5eewG-3l4gA:
9.81
5eewH-3l4gA:
9.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_K_TRPK101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3l4g PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN
(Homo
sapiens) 		5 / 9 GLY A 458
THR A 328
HIS A 327
ILE A 373
SER A 332
 PHE  A 509 (-3.6A)
None
None
None
None
 1.42A 5eewA-3l4gA:
undetectable
5eewK-3l4gA:
undetectable		 5eewA-3l4gA:
9.81
5eewK-3l4gA:
9.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_O_TRPO101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3l4g PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN
(Homo
sapiens) 		5 / 10 GLY A 458
THR A 328
HIS A 327
ILE A 373
SER A 332
 PHE  A 509 (-3.6A)
None
None
None
None
 1.45A 5eewN-3l4gA:
undetectable
5eewO-3l4gA:
undetectable		 5eewN-3l4gA:
9.81
5eewO-3l4gA:
9.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_U_TRPU101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3l4g PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN
(Homo
sapiens) 		5 / 10 GLY A 458
THR A 328
HIS A 327
ILE A 373
SER A 332
 PHE  A 509 (-3.6A)
None
None
None
None
 1.45A 5eewT-3l4gA:
undetectable
5eewU-3l4gA:
undetectable		 5eewT-3l4gA:
9.81
5eewU-3l4gA:
9.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_B_TRPB101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3l4g PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN
(Homo
sapiens) 		5 / 9 SER A 332
GLY A 458
THR A 328
HIS A 327
ILE A 373
 None
PHE  A 509 (-3.6A)
None
None
None
 1.42A 5eexB-3l4gA:
undetectable
5eexC-3l4gA:
undetectable		 5eexB-3l4gA:
9.81
5eexC-3l4gA:
9.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_C_TRPC101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3l4g PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN
(Homo
sapiens) 		5 / 9 SER A 332
GLY A 458
THR A 328
HIS A 327
ILE A 373
 None
PHE  A 509 (-3.6A)
None
None
None
 1.42A 5eexC-3l4gA:
undetectable
5eexD-3l4gA:
undetectable		 5eexC-3l4gA:
9.81
5eexD-3l4gA:
9.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_D_TRPD101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3l4g PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN
(Homo
sapiens) 		5 / 10 SER A 332
GLY A 458
THR A 328
HIS A 327
ILE A 373
 None
PHE  A 509 (-3.6A)
None
None
None
 1.42A 5eexD-3l4gA:
undetectable
5eexE-3l4gA:
undetectable		 5eexD-3l4gA:
9.81
5eexE-3l4gA:
9.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_E_TRPE101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3l4g PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN
(Homo
sapiens) 		5 / 9 SER A 332
GLY A 458
THR A 328
HIS A 327
ILE A 373
 None
PHE  A 509 (-3.6A)
None
None
None
 1.41A 5eexE-3l4gA:
undetectable
5eexF-3l4gA:
undetectable		 5eexE-3l4gA:
9.81
5eexF-3l4gA:
9.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_G_TRPG101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3l4g PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN
(Homo
sapiens) 		5 / 10 SER A 332
GLY A 458
THR A 328
HIS A 327
ILE A 373
 None
PHE  A 509 (-3.6A)
None
None
None
 1.46A 5eexG-3l4gA:
undetectable
5eexH-3l4gA:
undetectable		 5eexG-3l4gA:
9.81
5eexH-3l4gA:
9.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_K_TRPK101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3l4g PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN
(Homo
sapiens) 		5 / 10 GLY A 458
THR A 328
HIS A 327
ILE A 373
SER A 332
 PHE  A 509 (-3.6A)
None
None
None
None
 1.42A 5eexA-3l4gA:
undetectable
5eexK-3l4gA:
undetectable		 5eexA-3l4gA:
9.81
5eexK-3l4gA:
9.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_O_TRPO101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3l4g PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN
(Homo
sapiens) 		5 / 10 GLY A 458
THR A 328
HIS A 327
ILE A 373
SER A 332
 PHE  A 509 (-3.6A)
None
None
None
None
 1.44A 5eexN-3l4gA:
undetectable
5eexO-3l4gA:
undetectable		 5eexN-3l4gA:
9.81
5eexO-3l4gA:
9.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_R_TRPR101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3l4g PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN
(Homo
sapiens) 		5 / 9 GLY A 458
THR A 328
HIS A 327
ILE A 373
SER A 332
 PHE  A 509 (-3.6A)
None
None
None
None
 1.45A 5eexQ-3l4gA:
undetectable
5eexR-3l4gA:
undetectable		 5eexQ-3l4gA:
9.81
5eexR-3l4gA:
9.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_U_TRPU101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3l4g PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN
(Homo
sapiens) 		5 / 10 GLY A 458
THR A 328
HIS A 327
ILE A 373
SER A 332
 PHE  A 509 (-3.6A)
None
None
None
None
 1.45A 5eexT-3l4gA:
undetectable
5eexU-3l4gA:
undetectable		 5eexT-3l4gA:
9.81
5eexU-3l4gA:
9.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_V_TRPV101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3l4g PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN
(Homo
sapiens) 		5 / 10 GLY A 458
THR A 328
HIS A 327
ILE A 373
SER A 332
 PHE  A 509 (-3.6A)
None
None
None
None
 1.42A 5eexU-3l4gA:
undetectable
5eexV-3l4gA:
undetectable		 5eexU-3l4gA:
9.81
5eexV-3l4gA:
9.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_B_TRPB101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3l4g PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN
(Homo
sapiens) 		5 / 9 SER A 332
GLY A 458
THR A 328
HIS A 327
ILE A 373
 None
PHE  A 509 (-3.6A)
None
None
None
 1.42A 5eeyB-3l4gA:
undetectable
5eeyC-3l4gA:
undetectable		 5eeyB-3l4gA:
9.81
5eeyC-3l4gA:
9.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_C_TRPC101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3l4g PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN
(Homo
sapiens) 		5 / 9 SER A 332
GLY A 458
THR A 328
HIS A 327
ILE A 373
 None
PHE  A 509 (-3.6A)
None
None
None
 1.42A 5eeyC-3l4gA:
undetectable
5eeyD-3l4gA:
undetectable		 5eeyC-3l4gA:
9.81
5eeyD-3l4gA:
9.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_D_TRPD101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3l4g PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN
(Homo
sapiens) 		5 / 10 SER A 332
GLY A 458
THR A 328
HIS A 327
ILE A 373
 None
PHE  A 509 (-3.6A)
None
None
None
 1.42A 5eeyD-3l4gA:
undetectable
5eeyE-3l4gA:
undetectable		 5eeyD-3l4gA:
9.81
5eeyE-3l4gA:
9.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_E_TRPE101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3l4g PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN
(Homo
sapiens) 		5 / 9 SER A 332
GLY A 458
THR A 328
HIS A 327
ILE A 373
 None
PHE  A 509 (-3.6A)
None
None
None
 1.41A 5eeyE-3l4gA:
undetectable
5eeyF-3l4gA:
undetectable		 5eeyE-3l4gA:
9.81
5eeyF-3l4gA:
9.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_G_TRPG101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3l4g PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN
(Homo
sapiens) 		5 / 10 SER A 332
GLY A 458
THR A 328
HIS A 327
ILE A 373
 None
PHE  A 509 (-3.6A)
None
None
None
 1.46A 5eeyG-3l4gA:
undetectable
5eeyH-3l4gA:
undetectable		 5eeyG-3l4gA:
9.81
5eeyH-3l4gA:
9.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_H_TRPH101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3l4g PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN
(Homo
sapiens) 		5 / 9 SER A 332
GLY A 458
THR A 328
HIS A 327
ILE A 373
 None
PHE  A 509 (-3.6A)
None
None
None
 1.42A 5eeyH-3l4gA:
undetectable
5eeyI-3l4gA:
undetectable		 5eeyH-3l4gA:
9.81
5eeyI-3l4gA:
9.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_K_TRPK101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3l4g PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN
(Homo
sapiens) 		5 / 9 GLY A 458
THR A 328
HIS A 327
ILE A 373
SER A 332
 PHE  A 509 (-3.6A)
None
None
None
None
 1.42A 5eeyA-3l4gA:
undetectable
5eeyK-3l4gA:
undetectable		 5eeyA-3l4gA:
9.81
5eeyK-3l4gA:
9.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_O_TRPO101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3l4g PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN
(Homo
sapiens) 		5 / 10 GLY A 458
THR A 328
HIS A 327
ILE A 373
SER A 332
 PHE  A 509 (-3.6A)
None
None
None
None
 1.45A 5eeyN-3l4gA:
undetectable
5eeyO-3l4gA:
undetectable		 5eeyN-3l4gA:
9.81
5eeyO-3l4gA:
9.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_R_TRPR101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3l4g PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN
(Homo
sapiens) 		5 / 9 GLY A 458
THR A 328
HIS A 327
ILE A 373
SER A 332
 PHE  A 509 (-3.6A)
None
None
None
None
 1.45A 5eeyQ-3l4gA:
undetectable
5eeyR-3l4gA:
undetectable		 5eeyQ-3l4gA:
9.81
5eeyR-3l4gA:
9.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_U_TRPU101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3l4g PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN
(Homo
sapiens) 		5 / 10 GLY A 458
THR A 328
HIS A 327
ILE A 373
SER A 332
 PHE  A 509 (-3.6A)
None
None
None
None
 1.45A 5eeyT-3l4gA:
undetectable
5eeyU-3l4gA:
undetectable		 5eeyT-3l4gA:
9.81
5eeyU-3l4gA:
9.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_B_TRPB101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3l4g PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN
(Homo
sapiens) 		5 / 9 SER A 332
GLY A 458
THR A 328
HIS A 327
ILE A 373
 None
PHE  A 509 (-3.6A)
None
None
None
 1.42A 5eezB-3l4gA:
undetectable
5eezC-3l4gA:
undetectable		 5eezB-3l4gA:
9.81
5eezC-3l4gA:
9.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_C_TRPC101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3l4g PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN
(Homo
sapiens) 		5 / 9 SER A 332
GLY A 458
THR A 328
HIS A 327
ILE A 373
 None
PHE  A 509 (-3.6A)
None
None
None
 1.42A 5eezC-3l4gA:
undetectable
5eezD-3l4gA:
undetectable		 5eezC-3l4gA:
9.81
5eezD-3l4gA:
9.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_D_TRPD101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3l4g PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN
(Homo
sapiens) 		5 / 10 SER A 332
GLY A 458
THR A 328
HIS A 327
ILE A 373
 None
PHE  A 509 (-3.6A)
None
None
None
 1.43A 5eezD-3l4gA:
undetectable
5eezE-3l4gA:
undetectable		 5eezD-3l4gA:
9.81
5eezE-3l4gA:
9.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_E_TRPE101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3l4g PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN
(Homo
sapiens) 		5 / 9 SER A 332
GLY A 458
THR A 328
HIS A 327
ILE A 373
 None
PHE  A 509 (-3.6A)
None
None
None
 1.41A 5eezE-3l4gA:
undetectable
5eezF-3l4gA:
undetectable		 5eezE-3l4gA:
9.81
5eezF-3l4gA:
9.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_G_TRPG101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3l4g PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN
(Homo
sapiens) 		5 / 10 SER A 332
GLY A 458
THR A 328
HIS A 327
ILE A 373
 None
PHE  A 509 (-3.6A)
None
None
None
 1.46A 5eezG-3l4gA:
undetectable
5eezH-3l4gA:
undetectable		 5eezG-3l4gA:
9.81
5eezH-3l4gA:
9.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_H_TRPH101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3l4g PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN
(Homo
sapiens) 		5 / 9 SER A 332
GLY A 458
THR A 328
HIS A 327
ILE A 373
 None
PHE  A 509 (-3.6A)
None
None
None
 1.42A 5eezH-3l4gA:
undetectable
5eezI-3l4gA:
undetectable		 5eezH-3l4gA:
9.81
5eezI-3l4gA:
9.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_J_TRPJ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3l4g PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN
(Homo
sapiens) 		5 / 9 SER A 332
GLY A 458
THR A 328
HIS A 327
ILE A 373
 None
PHE  A 509 (-3.6A)
None
None
None
 1.41A 5eezJ-3l4gA:
undetectable
5eezK-3l4gA:
undetectable		 5eezJ-3l4gA:
9.81
5eezK-3l4gA:
9.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_K_TRPK101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3l4g PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN
(Homo
sapiens) 		5 / 9 GLY A 458
THR A 328
HIS A 327
ILE A 373
SER A 332
 PHE  A 509 (-3.6A)
None
None
None
None
 1.42A 5eezA-3l4gA:
undetectable
5eezK-3l4gA:
undetectable		 5eezA-3l4gA:
9.81
5eezK-3l4gA:
9.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_O_TRPO101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3l4g PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN
(Homo
sapiens) 		5 / 10 GLY A 458
THR A 328
HIS A 327
ILE A 373
SER A 332
 PHE  A 509 (-3.6A)
None
None
None
None
 1.45A 5eezN-3l4gA:
undetectable
5eezO-3l4gA:
undetectable		 5eezN-3l4gA:
9.81
5eezO-3l4gA:
9.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_R_TRPR101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3l4g PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN
(Homo
sapiens) 		5 / 9 GLY A 458
THR A 328
HIS A 327
ILE A 373
SER A 332
 PHE  A 509 (-3.6A)
None
None
None
None
 1.44A 5eezQ-3l4gA:
undetectable
5eezR-3l4gA:
undetectable		 5eezQ-3l4gA:
9.81
5eezR-3l4gA:
9.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_U_TRPU101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3l4g PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN
(Homo
sapiens) 		5 / 10 GLY A 458
THR A 328
HIS A 327
ILE A 373
SER A 332
 PHE  A 509 (-3.6A)
None
None
None
None
 1.45A 5eezT-3l4gA:
undetectable
5eezU-3l4gA:
undetectable		 5eezT-3l4gA:
9.81
5eezU-3l4gA:
9.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_B_TRPB101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3l4g PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN
(Homo
sapiens) 		5 / 9 SER A 332
GLY A 458
THR A 328
HIS A 327
ILE A 373
 None
PHE  A 509 (-3.6A)
None
None
None
 1.42A 5ef0B-3l4gA:
undetectable
5ef0C-3l4gA:
undetectable		 5ef0B-3l4gA:
9.81
5ef0C-3l4gA:
9.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_C_TRPC101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3l4g PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN
(Homo
sapiens) 		5 / 9 SER A 332
GLY A 458
THR A 328
HIS A 327
ILE A 373
 None
PHE  A 509 (-3.6A)
None
None
None
 1.42A 5ef0C-3l4gA:
undetectable
5ef0D-3l4gA:
undetectable		 5ef0C-3l4gA:
9.81
5ef0D-3l4gA:
9.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_D_TRPD101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3l4g PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN
(Homo
sapiens) 		5 / 10 SER A 332
GLY A 458
THR A 328
HIS A 327
ILE A 373
 None
PHE  A 509 (-3.6A)
None
None
None
 1.43A 5ef0D-3l4gA:
undetectable
5ef0E-3l4gA:
undetectable		 5ef0D-3l4gA:
9.81
5ef0E-3l4gA:
9.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_E_TRPE101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3l4g PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN
(Homo
sapiens) 		5 / 9 SER A 332
GLY A 458
THR A 328
HIS A 327
ILE A 373
 None
PHE  A 509 (-3.6A)
None
None
None
 1.42A 5ef0E-3l4gA:
undetectable
5ef0F-3l4gA:
undetectable		 5ef0E-3l4gA:
9.81
5ef0F-3l4gA:
9.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_G_TRPG101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3l4g PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN
(Homo
sapiens) 		5 / 10 SER A 332
GLY A 458
THR A 328
HIS A 327
ILE A 373
 None
PHE  A 509 (-3.6A)
None
None
None
 1.46A 5ef0G-3l4gA:
undetectable
5ef0H-3l4gA:
undetectable		 5ef0G-3l4gA:
9.81
5ef0H-3l4gA:
9.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_H_TRPH101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3l4g PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN
(Homo
sapiens) 		5 / 9 SER A 332
GLY A 458
THR A 328
HIS A 327
ILE A 373
 None
PHE  A 509 (-3.6A)
None
None
None
 1.42A 5ef0H-3l4gA:
undetectable
5ef0I-3l4gA:
undetectable		 5ef0H-3l4gA:
9.81
5ef0I-3l4gA:
9.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_J_TRPJ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3l4g PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN
(Homo
sapiens) 		5 / 9 SER A 332
GLY A 458
THR A 328
HIS A 327
ILE A 373
 None
PHE  A 509 (-3.6A)
None
None
None
 1.42A 5ef0J-3l4gA:
undetectable
5ef0K-3l4gA:
undetectable		 5ef0J-3l4gA:
9.81
5ef0K-3l4gA:
9.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_K_TRPK101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3l4g PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN
(Homo
sapiens) 		5 / 10 GLY A 458
THR A 328
HIS A 327
ILE A 373
SER A 332
 PHE  A 509 (-3.6A)
None
None
None
None
 1.42A 5ef0A-3l4gA:
undetectable
5ef0K-3l4gA:
undetectable		 5ef0A-3l4gA:
9.81
5ef0K-3l4gA:
9.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_O_TRPO101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3l4g PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN
(Homo
sapiens) 		5 / 10 GLY A 458
THR A 328
HIS A 327
ILE A 373
SER A 332
 PHE  A 509 (-3.6A)
None
None
None
None
 1.44A 5ef0N-3l4gA:
undetectable
5ef0O-3l4gA:
undetectable		 5ef0N-3l4gA:
9.81
5ef0O-3l4gA:
9.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_R_TRPR101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3l4g PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN
(Homo
sapiens) 		5 / 9 GLY A 458
THR A 328
HIS A 327
ILE A 373
SER A 332
 PHE  A 509 (-3.6A)
None
None
None
None
 1.44A 5ef0Q-3l4gA:
undetectable
5ef0R-3l4gA:
undetectable		 5ef0Q-3l4gA:
9.81
5ef0R-3l4gA:
9.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_U_TRPU101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3l4g PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN
(Homo
sapiens) 		5 / 10 GLY A 458
THR A 328
HIS A 327
ILE A 373
SER A 332
 PHE  A 509 (-3.6A)
None
None
None
None
 1.45A 5ef0T-3l4gA:
undetectable
5ef0U-3l4gA:
undetectable		 5ef0T-3l4gA:
9.81
5ef0U-3l4gA:
9.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_V_TRPV101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3l4g PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN
(Homo
sapiens) 		5 / 10 GLY A 458
THR A 328
HIS A 327
ILE A 373
SER A 332
 PHE  A 509 (-3.6A)
None
None
None
None
 1.42A 5ef0U-3l4gA:
undetectable
5ef0V-3l4gA:
undetectable		 5ef0U-3l4gA:
9.81
5ef0V-3l4gA:
9.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_B_TRPB101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3l4g PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN
(Homo
sapiens) 		5 / 9 SER A 332
GLY A 458
THR A 328
HIS A 327
ILE A 373
 None
PHE  A 509 (-3.6A)
None
None
None
 1.42A 5ef1B-3l4gA:
undetectable
5ef1C-3l4gA:
undetectable		 5ef1B-3l4gA:
9.81
5ef1C-3l4gA:
9.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_C_TRPC101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3l4g PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN
(Homo
sapiens) 		5 / 9 SER A 332
GLY A 458
THR A 328
HIS A 327
ILE A 373
 None
PHE  A 509 (-3.6A)
None
None
None
 1.42A 5ef1C-3l4gA:
undetectable
5ef1D-3l4gA:
undetectable		 5ef1C-3l4gA:
9.81
5ef1D-3l4gA:
9.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_D_TRPD101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3l4g PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN
(Homo
sapiens) 		5 / 10 SER A 332
GLY A 458
THR A 328
HIS A 327
ILE A 373
 None
PHE  A 509 (-3.6A)
None
None
None
 1.43A 5ef1D-3l4gA:
undetectable
5ef1E-3l4gA:
undetectable		 5ef1D-3l4gA:
9.81
5ef1E-3l4gA:
9.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_E_TRPE101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3l4g PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN
(Homo
sapiens) 		5 / 9 SER A 332
GLY A 458
THR A 328
HIS A 327
ILE A 373
 None
PHE  A 509 (-3.6A)
None
None
None
 1.42A 5ef1E-3l4gA:
undetectable
5ef1F-3l4gA:
undetectable		 5ef1E-3l4gA:
9.81
5ef1F-3l4gA:
9.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_G_TRPG101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3l4g PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN
(Homo
sapiens) 		5 / 10 SER A 332
GLY A 458
THR A 328
HIS A 327
ILE A 373
 None
PHE  A 509 (-3.6A)
None
None
None
 1.46A 5ef1G-3l4gA:
undetectable
5ef1H-3l4gA:
undetectable		 5ef1G-3l4gA:
9.81
5ef1H-3l4gA:
9.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_H_TRPH101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3l4g PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN
(Homo
sapiens) 		5 / 9 SER A 332
GLY A 458
THR A 328
HIS A 327
ILE A 373
 None
PHE  A 509 (-3.6A)
None
None
None
 1.42A 5ef1H-3l4gA:
undetectable
5ef1I-3l4gA:
undetectable		 5ef1H-3l4gA:
9.81
5ef1I-3l4gA:
9.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_J_TRPJ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3l4g PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN
(Homo
sapiens) 		5 / 9 SER A 332
GLY A 458
THR A 328
HIS A 327
ILE A 373
 None
PHE  A 509 (-3.6A)
None
None
None
 1.42A 5ef1J-3l4gA:
undetectable
5ef1K-3l4gA:
undetectable		 5ef1J-3l4gA:
9.81
5ef1K-3l4gA:
9.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_K_TRPK101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3l4g PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN
(Homo
sapiens) 		5 / 9 GLY A 458
THR A 328
HIS A 327
ILE A 373
SER A 332
 PHE  A 509 (-3.6A)
None
None
None
None
 1.42A 5ef1A-3l4gA:
undetectable
5ef1K-3l4gA:
undetectable		 5ef1A-3l4gA:
9.81
5ef1K-3l4gA:
9.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_O_TRPO101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3l4g PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN
(Homo
sapiens) 		5 / 10 GLY A 458
THR A 328
HIS A 327
ILE A 373
SER A 332
 PHE  A 509 (-3.6A)
None
None
None
None
 1.45A 5ef1N-3l4gA:
undetectable
5ef1O-3l4gA:
undetectable		 5ef1N-3l4gA:
9.81
5ef1O-3l4gA:
9.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_R_TRPR101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3l4g PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN
(Homo
sapiens) 		5 / 9 GLY A 458
THR A 328
HIS A 327
ILE A 373
SER A 332
 PHE  A 509 (-3.6A)
None
None
None
None
 1.45A 5ef1Q-3l4gA:
undetectable
5ef1R-3l4gA:
undetectable		 5ef1Q-3l4gA:
9.81
5ef1R-3l4gA:
9.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_U_TRPU101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3l4g PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN
(Homo
sapiens) 		5 / 10 GLY A 458
THR A 328
HIS A 327
ILE A 373
SER A 332
 PHE  A 509 (-3.6A)
None
None
None
None
 1.45A 5ef1T-3l4gA:
undetectable
5ef1U-3l4gA:
undetectable		 5ef1T-3l4gA:
9.81
5ef1U-3l4gA:
9.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_B_TRPB101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3l4g PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN
(Homo
sapiens) 		5 / 9 SER A 332
GLY A 458
THR A 328
HIS A 327
ILE A 373
 None
PHE  A 509 (-3.6A)
None
None
None
 1.42A 5ef2B-3l4gA:
undetectable
5ef2C-3l4gA:
undetectable		 5ef2B-3l4gA:
9.81
5ef2C-3l4gA:
9.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_C_TRPC101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3l4g PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN
(Homo
sapiens) 		5 / 9 SER A 332
GLY A 458
THR A 328
HIS A 327
ILE A 373
 None
PHE  A 509 (-3.6A)
None
None
None
 1.42A 5ef2C-3l4gA:
undetectable
5ef2D-3l4gA:
undetectable		 5ef2C-3l4gA:
9.81
5ef2D-3l4gA:
9.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_D_TRPD101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3l4g PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN
(Homo
sapiens) 		5 / 10 SER A 332
GLY A 458
THR A 328
HIS A 327
ILE A 373
 None
PHE  A 509 (-3.6A)
None
None
None
 1.43A 5ef2D-3l4gA:
undetectable
5ef2E-3l4gA:
undetectable		 5ef2D-3l4gA:
9.81
5ef2E-3l4gA:
9.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_E_TRPE101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3l4g PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN
(Homo
sapiens) 		5 / 9 SER A 332
GLY A 458
THR A 328
HIS A 327
ILE A 373
 None
PHE  A 509 (-3.6A)
None
None
None
 1.42A 5ef2E-3l4gA:
undetectable
5ef2F-3l4gA:
undetectable		 5ef2E-3l4gA:
9.81
5ef2F-3l4gA:
9.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_G_TRPG101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3l4g PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN
(Homo
sapiens) 		5 / 10 SER A 332
GLY A 458
THR A 328
HIS A 327
ILE A 373
 None
PHE  A 509 (-3.6A)
None
None
None
 1.46A 5ef2G-3l4gA:
undetectable
5ef2H-3l4gA:
undetectable		 5ef2G-3l4gA:
9.81
5ef2H-3l4gA:
9.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_H_TRPH101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3l4g PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN
(Homo
sapiens) 		5 / 9 SER A 332
GLY A 458
THR A 328
HIS A 327
ILE A 373
 None
PHE  A 509 (-3.6A)
None
None
None
 1.42A 5ef2H-3l4gA:
undetectable
5ef2I-3l4gA:
undetectable		 5ef2H-3l4gA:
9.81
5ef2I-3l4gA:
9.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_J_TRPJ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3l4g PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN
(Homo
sapiens) 		5 / 9 SER A 332
GLY A 458
THR A 328
HIS A 327
ILE A 373
 None
PHE  A 509 (-3.6A)
None
None
None
 1.42A 5ef2J-3l4gA:
undetectable
5ef2K-3l4gA:
undetectable		 5ef2J-3l4gA:
9.81
5ef2K-3l4gA:
9.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_K_TRPK101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3l4g PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN
(Homo
sapiens) 		5 / 9 GLY A 458
THR A 328
HIS A 327
ILE A 373
SER A 332
 PHE  A 509 (-3.6A)
None
None
None
None
 1.43A 5ef2A-3l4gA:
undetectable
5ef2K-3l4gA:
undetectable		 5ef2A-3l4gA:
9.81
5ef2K-3l4gA:
9.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_O_TRPO101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3l4g PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN
(Homo
sapiens) 		5 / 10 GLY A 458
THR A 328
HIS A 327
ILE A 373
SER A 332
 PHE  A 509 (-3.6A)
None
None
None
None
 1.44A 5ef2N-3l4gA:
undetectable
5ef2O-3l4gA:
undetectable		 5ef2N-3l4gA:
9.81
5ef2O-3l4gA:
9.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_R_TRPR101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3l4g PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN
(Homo
sapiens) 		5 / 9 GLY A 458
THR A 328
HIS A 327
ILE A 373
SER A 332
 PHE  A 509 (-3.6A)
None
None
None
None
 1.44A 5ef2Q-3l4gA:
undetectable
5ef2R-3l4gA:
undetectable		 5ef2Q-3l4gA:
9.81
5ef2R-3l4gA:
9.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_U_TRPU101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3l4g PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN
(Homo
sapiens) 		5 / 10 GLY A 458
THR A 328
HIS A 327
ILE A 373
SER A 332
 PHE  A 509 (-3.6A)
None
None
None
None
 1.45A 5ef2T-3l4gA:
undetectable
5ef2U-3l4gA:
undetectable		 5ef2T-3l4gA:
9.81
5ef2U-3l4gA:
9.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_B_TRPB101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3l4g PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN
(Homo
sapiens) 		5 / 9 SER A 332
GLY A 458
THR A 328
HIS A 327
ILE A 373
 None
PHE  A 509 (-3.6A)
None
None
None
 1.43A 5ef3B-3l4gA:
undetectable
5ef3C-3l4gA:
undetectable		 5ef3B-3l4gA:
9.81
5ef3C-3l4gA:
9.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_C_TRPC101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3l4g PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN
(Homo
sapiens) 		5 / 9 SER A 332
GLY A 458
THR A 328
HIS A 327
ILE A 373
 None
PHE  A 509 (-3.6A)
None
None
None
 1.42A 5ef3C-3l4gA:
undetectable
5ef3D-3l4gA:
undetectable		 5ef3C-3l4gA:
9.81
5ef3D-3l4gA:
9.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_D_TRPD101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3l4g PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN
(Homo
sapiens) 		5 / 10 SER A 332
GLY A 458
THR A 328
HIS A 327
ILE A 373
 None
PHE  A 509 (-3.6A)
None
None
None
 1.43A 5ef3D-3l4gA:
undetectable
5ef3E-3l4gA:
undetectable		 5ef3D-3l4gA:
9.81
5ef3E-3l4gA:
9.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_E_TRPE101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3l4g PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN
(Homo
sapiens) 		5 / 9 SER A 332
GLY A 458
THR A 328
HIS A 327
ILE A 373
 None
PHE  A 509 (-3.6A)
None
None
None
 1.42A 5ef3E-3l4gA:
undetectable
5ef3F-3l4gA:
undetectable		 5ef3E-3l4gA:
9.81
5ef3F-3l4gA:
9.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_G_TRPG101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3l4g PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN
(Homo
sapiens) 		5 / 10 SER A 332
GLY A 458
THR A 328
HIS A 327
ILE A 373
 None
PHE  A 509 (-3.6A)
None
None
None
 1.46A 5ef3G-3l4gA:
undetectable
5ef3H-3l4gA:
undetectable		 5ef3G-3l4gA:
9.81
5ef3H-3l4gA:
9.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_H_TRPH101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3l4g PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN
(Homo
sapiens) 		5 / 9 SER A 332
GLY A 458
THR A 328
HIS A 327
ILE A 373
 None
PHE  A 509 (-3.6A)
None
None
None
 1.42A 5ef3H-3l4gA:
undetectable
5ef3I-3l4gA:
undetectable		 5ef3H-3l4gA:
9.81
5ef3I-3l4gA:
9.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_J_TRPJ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3l4g PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN
(Homo
sapiens) 		5 / 9 SER A 332
GLY A 458
THR A 328
HIS A 327
ILE A 373
 None
PHE  A 509 (-3.6A)
None
None
None
 1.42A 5ef3J-3l4gA:
undetectable
5ef3K-3l4gA:
undetectable		 5ef3J-3l4gA:
9.81
5ef3K-3l4gA:
9.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_K_TRPK101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3l4g PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN
(Homo
sapiens) 		5 / 10 GLY A 458
THR A 328
HIS A 327
ILE A 373
SER A 332
 PHE  A 509 (-3.6A)
None
None
None
None
 1.43A 5ef3A-3l4gA:
undetectable
5ef3K-3l4gA:
undetectable		 5ef3A-3l4gA:
9.81
5ef3K-3l4gA:
9.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_O_TRPO101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3l4g PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN
(Homo
sapiens) 		5 / 10 GLY A 458
THR A 328
HIS A 327
ILE A 373
SER A 332
 PHE  A 509 (-3.6A)
None
None
None
None
 1.44A 5ef3N-3l4gA:
undetectable
5ef3O-3l4gA:
undetectable		 5ef3N-3l4gA:
9.81
5ef3O-3l4gA:
9.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_R_TRPR101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3l4g PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN
(Homo
sapiens) 		5 / 9 GLY A 458
THR A 328
HIS A 327
ILE A 373
SER A 332
 PHE  A 509 (-3.6A)
None
None
None
None
 1.45A 5ef3Q-3l4gA:
undetectable
5ef3R-3l4gA:
undetectable		 5ef3Q-3l4gA:
9.81
5ef3R-3l4gA:
9.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_U_TRPU101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3l4g PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN
(Homo
sapiens) 		5 / 10 GLY A 458
THR A 328
HIS A 327
ILE A 373
SER A 332
 PHE  A 509 (-3.6A)
None
None
None
None
 1.45A 5ef3T-3l4gA:
undetectable
5ef3U-3l4gA:
undetectable		 5ef3T-3l4gA:
9.81
5ef3U-3l4gA:
9.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KMD_C_6UBC1304_1
(ION TRANSPORT
PROTEIN)		 3l4g PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN
(Homo
sapiens) 		4 / 5 TYR B 374
LEU B  33
GLY B  32
PHE B  31
 None
 0.89A 5kmdC-3l4gB:
undetectable
5kmdD-3l4gB:
undetectable		 5kmdC-3l4gB:
18.84
5kmdD-3l4gB:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR0_A_478A101_1
(PROTEASE E35D-APV)		 3l4g PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN
PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN
(Homo
sapiens) 		5 / 9 ASP A 379
GLY B 319
ILE B 377
PRO A 415
ILE A 455
 None
 1.14A 5kr0A-3l4gA:
undetectable		 5kr0A-3l4gA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z84_C_CHDC301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3l4g PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN
(Homo
sapiens) 		4 / 8 ASP B  21
THR B  20
TYR B  19
LEU B  35
 None
 1.21A 5z84A-3l4gB:
1.0
5z84C-3l4gB:
undetectable
5z84P-3l4gB:
undetectable		 5z84A-3l4gB:
20.39
5z84C-3l4gB:
17.25
5z84P-3l4gB:
17.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z85_C_CHDC301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3l4g PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN
(Homo
sapiens) 		4 / 8 ASP B  21
THR B  20
TYR B  19
LEU B  35
 None
 1.20A 5z85A-3l4gB:
undetectable
5z85C-3l4gB:
undetectable
5z85P-3l4gB:
undetectable		 5z85A-3l4gB:
20.39
5z85C-3l4gB:
17.25
5z85P-3l4gB:
17.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z85_P_CHDP301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3l4g PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN
(Homo
sapiens) 		4 / 7 LEU B  35
ASP B  21
THR B  20
TYR B  19
 None
 1.25A 5z85C-3l4gB:
undetectable
5z85N-3l4gB:
undetectable
5z85P-3l4gB:
undetectable		 5z85C-3l4gB:
17.25
5z85N-3l4gB:
20.39
5z85P-3l4gB:
17.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BZO_C_FI8C1201_0
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 3l4g PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN
PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN
(Homo
sapiens;
Homo
sapiens) 		5 / 12 ILE B 320
VAL A 419
SER A 416
VAL A 437
GLU A 414
 None
 1.35A 6bzoC-3l4gB:
undetectable		 6bzoC-3l4gB:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GB9_A_ACTA508_0
(MOLYBDOPTERIN
BIOSYNTHESIS PROTEIN
CNX1)		 3l4g PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN
(Homo
sapiens) 		3 / 3 VAL B 449
ALA B 436
GLN B 420
 None
 0.63A 6gb9A-3l4gB:
undetectable		 6gb9A-3l4gB:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6IFT_A_SAMA301_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE A)		 3l4g PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN
(Homo
sapiens) 		5 / 12 LEU B 413
ILE B 480
GLY B 457
ILE B 423
ASP B 422
 None
 0.83A 6iftA-3l4gB:
undetectable		 6iftA-3l4gB:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN5_E_LLLE301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 3l4g PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN
(Homo
sapiens) 		4 / 7 ASP B  21
ARG B   8
TYR B  63
ASP B   9
 None
 1.35A 6mn5E-3l4gB:
undetectable		 6mn5E-3l4gB:
10.64