SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3l4i'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N4H_A_REAA500_1
(NUCLEAR RECEPTOR
ROR-BETA)		 3l4i HEAT SHOCK 70
(HSP70) PROTEIN
(Cryptosporidium
parvum) 		5 / 11 GLN A 141
ILE A 180
ALA A 181
VAL A  57
ALA A  85
 None
 1.19A 1n4hA-3l4iA:
undetectable		 1n4hA-3l4iA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZZ_A_SAMA635_0
(ACLACINOMYCIN-10-HYD
ROXYLASE)		 3l4i HEAT SHOCK 70
(HSP70) PROTEIN
(Cryptosporidium
parvum) 		5 / 12 GLY A 246
GLY A 218
GLY A 219
LEU A 244
ASN A 251
 ADP  A 401 (-3.3A)
ADP  A 401 (-3.3A)
None
None
None
 0.87A 1qzzA-3l4iA:
2.2		 1qzzA-3l4iA:
24.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDS_A_SAMA5635_0
(PROTEIN RDMB)		 3l4i HEAT SHOCK 70
(HSP70) PROTEIN
(Cryptosporidium
parvum) 		5 / 12 GLY A 246
GLY A 218
GLY A 219
LEU A 244
ASN A 251
 ADP  A 401 (-3.3A)
ADP  A 401 (-3.3A)
None
None
None
 0.91A 1xdsA-3l4iA:
undetectable		 1xdsA-3l4iA:
24.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDS_B_SAMB9635_0
(PROTEIN RDMB)		 3l4i HEAT SHOCK 70
(HSP70) PROTEIN
(Cryptosporidium
parvum) 		5 / 12 GLY A 246
GLY A 218
GLY A 219
LEU A 244
ASN A 251
 ADP  A 401 (-3.3A)
ADP  A 401 (-3.3A)
None
None
None
 0.88A 1xdsB-3l4iA:
undetectable		 1xdsB-3l4iA:
24.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8L_A_SAMA400_0
(HYPOTHETICAL PROTEIN
LMO1582)		 3l4i HEAT SHOCK 70
(HSP70) PROTEIN
(Cryptosporidium
parvum) 		5 / 12 ALA A 387
VAL A  35
ASP A  42
GLY A  23
ASP A 383
 None
 1.00A 2f8lA-3l4iA:
undetectable		 2f8lA-3l4iA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGQ_A_PCFA1275_0
(WNT INHIBITORY
FACTOR 1)		 3l4i HEAT SHOCK 70
(HSP70) PROTEIN
(Cryptosporidium
parvum) 		5 / 12 ILE A 314
LEU A 291
ILE A 360
PRO A 361
PHE A 327
 None
None
ADP  A 401 ( 4.9A)
None
None
 1.07A 2ygqA-3l4iA:
undetectable		 2ygqA-3l4iA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_R_TFPR201_1
(PROTEIN S100-A4)		 3l4i HEAT SHOCK 70
(HSP70) PROTEIN
(Cryptosporidium
parvum) 		5 / 10 GLY A 240
ILE A 367
PHE A 319
GLY A 245
PHE A 249
 EDO  A 403 (-3.7A)
None
None
None
None
 1.43A 3ko0R-3l4iA:
undetectable
3ko0T-3l4iA:
undetectable		 3ko0R-3l4iA:
12.40
3ko0T-3l4iA:
12.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ME6_A_CGEA501_1
(CYTOCHROME P450 2B4)		 3l4i HEAT SHOCK 70
(HSP70) PROTEIN
(Cryptosporidium
parvum) 		5 / 10 ILE A 228
ALA A 194
ILE A 213
VAL A 352
VAL A 211
 None
 0.99A 3me6A-3l4iA:
undetectable		 3me6A-3l4iA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QF1_A_PZEA6951_1
(LACTOPEROXIDASE)		 3l4i HEAT SHOCK 70
(HSP70) PROTEIN
(Cryptosporidium
parvum) 		3 / 3 HIS A 349
ARG A 209
GLU A 208
 None
 1.03A 3qf1A-3l4iA:
undetectable		 3qf1A-3l4iA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_D_W9TD507_1
(HEMOLYTIC LECTIN
CEL-III)		 3l4i HEAT SHOCK 70
(HSP70) PROTEIN
(Cryptosporidium
parvum) 		4 / 5 ASP A 248
GLU A 247
GLY A 219
ASP A 241
 None
 1.26A 3w9tD-3l4iA:
undetectable		 3w9tD-3l4iA:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_A_ACTA506_0
(RNA POLYMERASE
3D-POL)		 3l4i HEAT SHOCK 70
(HSP70) PROTEIN
(Cryptosporidium
parvum) 		3 / 3 VAL A  57
GLY A  67
LYS A  71
 None
 0.71A 4k50A-3l4iA:
undetectable		 4k50A-3l4iA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_E_ACTE504_0
(RNA POLYMERASE
3D-POL)		 3l4i HEAT SHOCK 70
(HSP70) PROTEIN
(Cryptosporidium
parvum) 		3 / 3 VAL A  57
GLY A  67
LYS A  71
 None
 0.78A 4k50E-3l4iA:
undetectable		 4k50E-3l4iA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_I_ACTI504_0
(RNA POLYMERASE
3D-POL)		 3l4i HEAT SHOCK 70
(HSP70) PROTEIN
(Cryptosporidium
parvum) 		3 / 3 VAL A  57
GLY A  67
LYS A  71
 None
 0.67A 4k50I-3l4iA:
undetectable		 4k50I-3l4iA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_B_GCSB307_1
(CHITOSANASE)		 3l4i HEAT SHOCK 70
(HSP70) PROTEIN
(Cryptosporidium
parvum) 		4 / 7 GLU A 191
THR A  28
GLY A  27
THR A  29
 PO4  A 402 (-3.0A)
PO4  A 402 ( 3.3A)
PO4  A 402 ( 3.0A)
ADP  A 401 (-3.5A)
 0.95A 4qwpB-3l4iA:
undetectable		 4qwpB-3l4iA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCI_A_ADNA2414_1
(RNA-DIRECTED RNA
POLYMERASE L)		 3l4i HEAT SHOCK 70
(HSP70) PROTEIN
(Cryptosporidium
parvum) 		4 / 6 PHE A 319
ARG A 252
PHE A 249
TYR A 326
 None
 1.07A 4uciA-3l4iA:
undetectable		 4uciA-3l4iA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCI_B_ADNB2415_1
(RNA-DIRECTED RNA
POLYMERASE L)		 3l4i HEAT SHOCK 70
(HSP70) PROTEIN
(Cryptosporidium
parvum) 		4 / 7 PHE A 319
ARG A 252
PHE A 249
TYR A 326
 None
 1.07A 4uciB-3l4iA:
undetectable		 4uciB-3l4iA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YJI_A_TYLA502_1
(ARYL ACYLAMIDASE)		 3l4i HEAT SHOCK 70
(HSP70) PROTEIN
(Cryptosporidium
parvum) 		4 / 7 LEU A 140
GLY A  23
ALA A 158
ILE A 189
 None
 0.72A 4yjiA-3l4iA:
undetectable		 4yjiA-3l4iA:
23.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4G_A_IPHA903_0
(PROTEIN ARGONAUTE-2)		 3l4i HEAT SHOCK 70
(HSP70) PROTEIN
(Cryptosporidium
parvum) 		4 / 6 LEU A  88
LYS A 116
PRO A 117
GLU A 133
 None
 1.14A 4z4gA-3l4iA:
7.4		 4z4gA-3l4iA:
18.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AQF_A_ADNA1382_1
(HEAT SHOCK COGNATE
71 KDA PROTEIN)		 3l4i HEAT SHOCK 70
(HSP70) PROTEIN
(Cryptosporidium
parvum) 		9 / 10 GLY A 217
GLY A 246
LYS A 288
ARG A 289
SER A 292
GLY A 356
SER A 357
ARG A 359
ILE A 360
 ADP  A 401 (-3.4A)
ADP  A 401 (-3.3A)
ADP  A 401 (-2.7A)
ADP  A 401 (-3.7A)
ADP  A 401 (-2.6A)
ADP  A 401 (-3.2A)
ADP  A 401 (-3.7A)
ADP  A 401 (-4.2A)
ADP  A 401 ( 4.9A)
 1.01A 5aqfA-3l4iA:
57.0		 5aqfA-3l4iA:
72.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AQF_A_ADNA1382_1
(HEAT SHOCK COGNATE
71 KDA PROTEIN)		 3l4i HEAT SHOCK 70
(HSP70) PROTEIN
(Cryptosporidium
parvum) 		10 / 10 GLY A 218
GLY A 246
GLU A 285
LYS A 288
ARG A 289
SER A 292
GLY A 356
SER A 357
ARG A 359
ILE A 360
 ADP  A 401 (-3.3A)
ADP  A 401 (-3.3A)
ADP  A 401 (-2.6A)
ADP  A 401 (-2.7A)
ADP  A 401 (-3.7A)
ADP  A 401 (-2.6A)
ADP  A 401 (-3.2A)
ADP  A 401 (-3.7A)
ADP  A 401 (-4.2A)
ADP  A 401 ( 4.9A)
 0.58A 5aqfA-3l4iA:
57.0		 5aqfA-3l4iA:
72.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AQF_A_ADNA1382_1
(HEAT SHOCK COGNATE
71 KDA PROTEIN)		 3l4i HEAT SHOCK 70
(HSP70) PROTEIN
(Cryptosporidium
parvum) 		6 / 10 GLY A 245
GLY A 246
LYS A 288
SER A 292
SER A 357
ILE A 360
 None
ADP  A 401 (-3.3A)
ADP  A 401 (-2.7A)
ADP  A 401 (-2.6A)
ADP  A 401 (-3.7A)
ADP  A 401 ( 4.9A)
 1.43A 5aqfA-3l4iA:
57.0		 5aqfA-3l4iA:
72.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AQF_C_ADNC1382_1
(HEAT SHOCK COGNATE
71 KDA PROTEIN)		 3l4i HEAT SHOCK 70
(HSP70) PROTEIN
(Cryptosporidium
parvum) 		9 / 10 GLY A 217
GLY A 246
LYS A 288
ARG A 289
SER A 292
GLY A 356
SER A 357
ARG A 359
ILE A 360
 ADP  A 401 (-3.4A)
ADP  A 401 (-3.3A)
ADP  A 401 (-2.7A)
ADP  A 401 (-3.7A)
ADP  A 401 (-2.6A)
ADP  A 401 (-3.2A)
ADP  A 401 (-3.7A)
ADP  A 401 (-4.2A)
ADP  A 401 ( 4.9A)
 1.03A 5aqfC-3l4iA:
56.5		 5aqfC-3l4iA:
72.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AQF_C_ADNC1382_1
(HEAT SHOCK COGNATE
71 KDA PROTEIN)		 3l4i HEAT SHOCK 70
(HSP70) PROTEIN
(Cryptosporidium
parvum) 		10 / 10 GLY A 218
GLY A 246
GLU A 285
LYS A 288
ARG A 289
SER A 292
GLY A 356
SER A 357
ARG A 359
ILE A 360
 ADP  A 401 (-3.3A)
ADP  A 401 (-3.3A)
ADP  A 401 (-2.6A)
ADP  A 401 (-2.7A)
ADP  A 401 (-3.7A)
ADP  A 401 (-2.6A)
ADP  A 401 (-3.2A)
ADP  A 401 (-3.7A)
ADP  A 401 (-4.2A)
ADP  A 401 ( 4.9A)
 0.60A 5aqfC-3l4iA:
56.5		 5aqfC-3l4iA:
72.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AQF_C_ADNC1382_1
(HEAT SHOCK COGNATE
71 KDA PROTEIN)		 3l4i HEAT SHOCK 70
(HSP70) PROTEIN
(Cryptosporidium
parvum) 		6 / 10 GLY A 245
GLY A 246
LYS A 288
SER A 292
SER A 357
ILE A 360
 None
ADP  A 401 (-3.3A)
ADP  A 401 (-2.7A)
ADP  A 401 (-2.6A)
ADP  A 401 (-3.7A)
ADP  A 401 ( 4.9A)
 1.42A 5aqfC-3l4iA:
56.5		 5aqfC-3l4iA:
72.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AQY_A_ADNA1389_1
(HEAT SHOCK 70 KDA
PROTEIN 1A)		 3l4i HEAT SHOCK 70
(HSP70) PROTEIN
(Cryptosporidium
parvum) 		6 / 10 GLY A 217
GLY A 245
GLY A 356
SER A 357
ARG A 359
ILE A 360
 ADP  A 401 (-3.4A)
None
ADP  A 401 (-3.2A)
ADP  A 401 (-3.7A)
ADP  A 401 (-4.2A)
ADP  A 401 ( 4.9A)
 1.17A 5aqyA-3l4iA:
59.2		 5aqyA-3l4iA:
72.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AQY_A_ADNA1389_1
(HEAT SHOCK 70 KDA
PROTEIN 1A)		 3l4i HEAT SHOCK 70
(HSP70) PROTEIN
(Cryptosporidium
parvum) 		9 / 10 GLY A 217
GLY A 246
LYS A 288
ARG A 289
SER A 292
GLY A 356
SER A 357
ARG A 359
ILE A 360
 ADP  A 401 (-3.4A)
ADP  A 401 (-3.3A)
ADP  A 401 (-2.7A)
ADP  A 401 (-3.7A)
ADP  A 401 (-2.6A)
ADP  A 401 (-3.2A)
ADP  A 401 (-3.7A)
ADP  A 401 (-4.2A)
ADP  A 401 ( 4.9A)
 0.98A 5aqyA-3l4iA:
59.2		 5aqyA-3l4iA:
72.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AQY_A_ADNA1389_1
(HEAT SHOCK 70 KDA
PROTEIN 1A)		 3l4i HEAT SHOCK 70
(HSP70) PROTEIN
(Cryptosporidium
parvum) 		6 / 10 GLY A 218
GLY A 245
GLY A 356
SER A 357
ARG A 359
ILE A 360
 ADP  A 401 (-3.3A)
None
ADP  A 401 (-3.2A)
ADP  A 401 (-3.7A)
ADP  A 401 (-4.2A)
ADP  A 401 ( 4.9A)
 1.09A 5aqyA-3l4iA:
59.2		 5aqyA-3l4iA:
72.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AQY_A_ADNA1389_1
(HEAT SHOCK 70 KDA
PROTEIN 1A)		 3l4i HEAT SHOCK 70
(HSP70) PROTEIN
(Cryptosporidium
parvum) 		10 / 10 GLY A 218
GLY A 246
GLU A 285
LYS A 288
ARG A 289
SER A 292
GLY A 356
SER A 357
ARG A 359
ILE A 360
 ADP  A 401 (-3.3A)
ADP  A 401 (-3.3A)
ADP  A 401 (-2.6A)
ADP  A 401 (-2.7A)
ADP  A 401 (-3.7A)
ADP  A 401 (-2.6A)
ADP  A 401 (-3.2A)
ADP  A 401 (-3.7A)
ADP  A 401 (-4.2A)
ADP  A 401 ( 4.9A)
 0.56A 5aqyA-3l4iA:
59.2		 5aqyA-3l4iA:
72.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AQY_A_ADNA1389_1
(HEAT SHOCK 70 KDA
PROTEIN 1A)		 3l4i HEAT SHOCK 70
(HSP70) PROTEIN
(Cryptosporidium
parvum) 		6 / 10 GLY A 245
GLY A 246
LYS A 288
SER A 292
SER A 357
ILE A 360
 None
ADP  A 401 (-3.3A)
ADP  A 401 (-2.7A)
ADP  A 401 (-2.6A)
ADP  A 401 (-3.7A)
ADP  A 401 ( 4.9A)
 1.45A 5aqyA-3l4iA:
59.2		 5aqyA-3l4iA:
72.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M50_E_TA1E502_1
(TUBULIN BETA-2B
CHAIN)		 3l4i HEAT SHOCK 70
(HSP70) PROTEIN
(Cryptosporidium
parvum) 		5 / 12 ASP A  25
LEU A 212
ARG A 359
GLY A 217
LEU A 216
 ADP  A 401 ( 4.7A)
None
ADP  A 401 (-4.2A)
ADP  A 401 (-3.4A)
None
 1.23A 5m50E-3l4iA:
undetectable		 5m50E-3l4iA:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UL4_A_SAMA803_0
(OXSB PROTEIN)		 3l4i HEAT SHOCK 70
(HSP70) PROTEIN
(Cryptosporidium
parvum) 		5 / 12 PHE A 249
GLY A 217
GLY A 356
ILE A 360
LEU A 253
 None
ADP  A 401 (-3.4A)
ADP  A 401 (-3.2A)
ADP  A 401 ( 4.9A)
None
 1.06A 5ul4A-3l4iA:
2.1		 5ul4A-3l4iA:
20.05