SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3l4k'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KYV_A_RBFA501_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 3l4k DNA TOPOISOMERASE 2
(Saccharomyces
cerevisiae) 		5 / 12 GLY A 959
GLU A 962
ILE A 890
ILE A 967
LEU A 966
 None
 1.26A 1kyvA-3l4kA:
undetectable
1kyvE-3l4kA:
undetectable		 1kyvA-3l4kA:
12.17
1kyvE-3l4kA:
12.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KYV_C_RBFC503_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 3l4k DNA TOPOISOMERASE 2
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 967
LEU A 966
GLY A 959
GLU A 962
ILE A 890
 None
 1.27A 1kyvB-3l4kA:
2.4
1kyvC-3l4kA:
undetectable		 1kyvB-3l4kA:
12.17
1kyvC-3l4kA:
12.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KYV_D_RBFD504_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 3l4k DNA TOPOISOMERASE 2
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 967
LEU A 966
GLY A 959
GLU A 962
ILE A 890
 None
 1.25A 1kyvC-3l4kA:
undetectable
1kyvD-3l4kA:
2.4		 1kyvC-3l4kA:
12.17
1kyvD-3l4kA:
12.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KYV_E_RBFE505_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 3l4k DNA TOPOISOMERASE 2
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 967
LEU A 966
GLY A 959
GLU A 962
ILE A 890
 None
 1.25A 1kyvD-3l4kA:
2.4
1kyvE-3l4kA:
undetectable		 1kyvD-3l4kA:
12.17
1kyvE-3l4kA:
12.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MCN_P_DHIP1_0
(IMMUNOGLOBULIN
LAMBDA DIMER MCG
(LIGHT CHAIN)
PEPTIDE
N-ACETYL-D-HIS-L-PRO
-NH2)		 3l4k DNA TOPOISOMERASE 2
(Saccharomyces
cerevisiae) 		3 / 3 PHE A 869
TYR A 840
PRO A 843
 None
 0.87A 1mcnA-3l4kA:
undetectable
1mcnB-3l4kA:
undetectable
1mcnP-3l4kA:
undetectable		 1mcnA-3l4kA:
14.13
1mcnB-3l4kA:
14.13
1mcnP-3l4kA:
0.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJL_B_SAMB400_0
(METHIONINE REPRESSOR
PROTEIN METJ)		 3l4k DNA TOPOISOMERASE 2
(Saccharomyces
cerevisiae) 		5 / 9 GLU A 558
LEU A 624
HIS A 520
PHE A 627
GLY A 554
 None
 1.21A 1mjlA-3l4kA:
undetectable
1mjlB-3l4kA:
undetectable		 1mjlA-3l4kA:
9.20
1mjlB-3l4kA:
9.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_A_BEZA502_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 3l4k DNA TOPOISOMERASE 2
(Saccharomyces
cerevisiae) 		4 / 6 PHE A 752
ASN A 751
ILE A 746
GLY A 747
 None
 1.02A 1oniA-3l4kA:
undetectable
1oniB-3l4kA:
undetectable		 1oniA-3l4kA:
10.82
1oniB-3l4kA:
10.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_D_BEZD508_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 3l4k DNA TOPOISOMERASE 2
(Saccharomyces
cerevisiae) 		4 / 6 PHE A 752
ASN A 751
ILE A 746
GLY A 747
 None
 1.01A 1oniD-3l4kA:
1.1
1oniF-3l4kA:
undetectable		 1oniD-3l4kA:
10.82
1oniF-3l4kA:
10.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A8T_B_ADNB252_1
(U8 SNORNA-BINDING
PROTEIN X29)		 3l4k DNA TOPOISOMERASE 2
(Saccharomyces
cerevisiae) 		4 / 8 GLY A 832
PHE A 683
ILE A 833
SER A 838
 None
 1.01A 2a8tB-3l4kA:
undetectable		 2a8tB-3l4kA:
14.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F78_A_BEZA1001_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 3l4k DNA TOPOISOMERASE 2
(Saccharomyces
cerevisiae) 		5 / 9 LEU A 790
ILE A 758
PHE A1162
LEU A 822
ILE A 821
 None
 1.26A 2f78A-3l4kA:
undetectable		 2f78A-3l4kA:
15.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2P02_A_SAMA2_0
(S-ADENOSYLMETHIONINE
SYNTHETASE ISOFORM
TYPE-2)		 3l4k DNA TOPOISOMERASE 2
(Saccharomyces
cerevisiae) 		4 / 8 HIS A 533
ASP A 530
SER A 740
ASP A 687
 None
 1.21A 2p02A-3l4kA:
undetectable		 2p02A-3l4kA:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_C_RIMC399_1
(MATRIX PROTEIN 2)		 3l4k DNA TOPOISOMERASE 2
(Saccharomyces
cerevisiae) 		4 / 6 LEU A 966
LEU A 903
ILE A 890
ARG A 889
 None
 0.89A 2rlfC-3l4kA:
undetectable
2rlfD-3l4kA:
undetectable		 2rlfC-3l4kA:
4.40
2rlfD-3l4kA:
4.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3B_B_FOLB401_1
(DIHYDROFOLATE
REDUCTASE)		 3l4k DNA TOPOISOMERASE 2
(Saccharomyces
cerevisiae) 		3 / 3 GLU A 814
GLN A 807
ARG A 588
 None
 0.77A 2w3bB-3l4kA:
undetectable		 2w3bB-3l4kA:
13.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3B_B_FOLB401_1
(DIHYDROFOLATE
REDUCTASE)		 3l4k DNA TOPOISOMERASE 2
(Saccharomyces
cerevisiae) 		3 / 3 GLU A 816
GLN A 807
ARG A 588
 None
 0.94A 2w3bB-3l4kA:
undetectable		 2w3bB-3l4kA:
13.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9S_A_TOPA1160_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 3l4k DNA TOPOISOMERASE 2
(Saccharomyces
cerevisiae) 		5 / 11 ALA A 435
LEU A 445
ASP A 431
LEU A 429
ILE A 423
 None
 0.87A 2w9sA-3l4kA:
undetectable		 2w9sA-3l4kA:
12.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9S_B_TOPB1160_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 3l4k DNA TOPOISOMERASE 2
(Saccharomyces
cerevisiae) 		5 / 11 ALA A 435
LEU A 445
ASP A 431
LEU A 429
ILE A 423
 None
 0.90A 2w9sB-3l4kA:
undetectable		 2w9sB-3l4kA:
12.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YVL_A_SAMA601_0
(HYPOTHETICAL PROTEIN)		 3l4k DNA TOPOISOMERASE 2
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 745
GLY A 709
SER A 729
ALA A 725
VAL A 813
 None
 1.11A 2yvlA-3l4kA:
undetectable		 2yvlA-3l4kA:
15.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3F33_A_PFLA2001_1
(FERRITIN LIGHT CHAIN)		 3l4k DNA TOPOISOMERASE 2
(Saccharomyces
cerevisiae) 		4 / 6 LEU A1124
SER A1123
TYR A1129
LEU A1132
 None
 0.98A 3f33A-3l4kA:
3.0		 3f33A-3l4kA:
13.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GCS_A_BAXA401_2
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 3l4k DNA TOPOISOMERASE 2
(Saccharomyces
cerevisiae) 		4 / 6 MET A 865
VAL A 990
ILE A 849
ILE A 993
 None
 0.96A 3gcsA-3l4kA:
undetectable		 3gcsA-3l4kA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_D_SAMD301_0
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 3l4k DNA TOPOISOMERASE 2
(Saccharomyces
cerevisiae) 		5 / 12 GLY A 536
PHE A 683
ASP A 530
ILE A 534
LEU A 537
 None
 1.28A 3iv6D-3l4kA:
undetectable		 3iv6D-3l4kA:
16.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LD6_B_KKKB602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3l4k DNA TOPOISOMERASE 2
(Saccharomyces
cerevisiae) 		5 / 12 PHE A 617
PHE A 559
GLY A 460
ALA A 457
THR A 448
 None
 1.00A 3ld6B-3l4kA:
undetectable		 3ld6B-3l4kA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P4W_C_DSFC320_1
(GLR4197 PROTEIN)		 3l4k DNA TOPOISOMERASE 2
(Saccharomyces
cerevisiae) 		4 / 8 ILE A 495
ILE A 498
VAL A 481
ILE A 538
 None
 0.72A 3p4wC-3l4kA:
undetectable		 3p4wC-3l4kA:
16.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QXV_D_MTXD2000_2
(ANTI-METHOTREXATE
CDR1-4 GRAFT VHH)		 3l4k DNA TOPOISOMERASE 2
(Saccharomyces
cerevisiae) 		3 / 3 LEU A 790
ARG A 854
ASN A 845
 None
 0.64A 3qxvD-3l4kA:
undetectable		 3qxvD-3l4kA:
11.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B53_B_ACTB1445_0
(IG GAMMA-4 CHAIN C
REGION)		 3l4k DNA TOPOISOMERASE 2
(Saccharomyces
cerevisiae) 		3 / 3 GLU A 738
GLY A 737
SER A 729
 None
 0.51A 4b53B-3l4kA:
undetectable		 4b53B-3l4kA:
10.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9N_A_CAMA1419_0
(CYTOCHROME P450)		 3l4k DNA TOPOISOMERASE 2
(Saccharomyces
cerevisiae) 		4 / 8 THR A 561
LEU A 605
GLY A 606
VAL A 613
 None
 0.85A 4c9nA-3l4kA:
undetectable		 4c9nA-3l4kA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ECK_B_FOLB703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3l4k DNA TOPOISOMERASE 2
(Saccharomyces
cerevisiae) 		5 / 12 VAL A 463
LEU A 624
PHE A 617
MET A 524
LEU A 456
 None
 1.19A 4eckB-3l4kA:
undetectable		 4eckB-3l4kA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FU8_A_ACTA304_0
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 3l4k DNA TOPOISOMERASE 2
(Saccharomyces
cerevisiae) 		3 / 3 ARG A1008
HIS A 796
TYR A1005
 None
 0.88A 4fu8A-3l4kA:
undetectable		 4fu8A-3l4kA:
14.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FU9_A_ACTA312_0
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 3l4k DNA TOPOISOMERASE 2
(Saccharomyces
cerevisiae) 		3 / 3 ARG A1008
HIS A 796
TYR A1005
 None
 0.95A 4fu9A-3l4kA:
undetectable		 4fu9A-3l4kA:
14.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I90_A_ACTA500_0
(1-PHOSPHATIDYLINOSIT
OL PHOSPHODIESTERASE)		 3l4k DNA TOPOISOMERASE 2
(Saccharomyces
cerevisiae) 		3 / 3 LYS A 954
ARG A 963
TRP A 929
 None
 1.30A 4i90A-3l4kA:
undetectable		 4i90A-3l4kA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K4Y_A_ACTA502_0
(RNA-DEPENDENT RNA
POLYMERASE)		 3l4k DNA TOPOISOMERASE 2
(Saccharomyces
cerevisiae) 		4 / 5 LEU A 719
GLU A 786
LEU A 715
LYS A 713
 None
 1.32A 4k4yA-3l4kA:
undetectable		 4k4yA-3l4kA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K4Y_I_ACTI503_0
(RNA-DEPENDENT RNA
POLYMERASE)		 3l4k DNA TOPOISOMERASE 2
(Saccharomyces
cerevisiae) 		4 / 5 LEU A 719
GLU A 786
LEU A 715
LYS A 713
 None
 1.32A 4k4yI-3l4kA:
undetectable		 4k4yI-3l4kA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NDN_C_SAMC405_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 3l4k DNA TOPOISOMERASE 2
(Saccharomyces
cerevisiae) 		4 / 7 HIS A 533
ASP A 530
SER A 740
ASP A 687
 None
 1.24A 4ndnC-3l4kA:
undetectable		 4ndnC-3l4kA:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODR_A_FK5A201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD,
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP1A CHIMERA)		 3l4k DNA TOPOISOMERASE 2
(Saccharomyces
cerevisiae) 		5 / 12 LEU A1170
LEU A 847
ILE A 850
ILE A 794
ILE A 821
 None
 0.97A 4odrA-3l4kA:
undetectable
4odrB-3l4kA:
undetectable		 4odrA-3l4kA:
9.25
4odrB-3l4kA:
9.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZU_D_ACTD201_0
(RETINOL-BINDING
PROTEIN 2)		 3l4k DNA TOPOISOMERASE 2
(Saccharomyces
cerevisiae) 		3 / 3 ASP A1158
HIS A 796
LYS A 793
 None
 0.83A 4qzuD-3l4kA:
undetectable		 4qzuD-3l4kA:
10.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RZV_A_032A801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 3l4k DNA TOPOISOMERASE 2
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 537
SER A 643
PHE A 642
GLY A 536
GLY A 531
 None
 0.97A 4rzvA-3l4kA:
undetectable		 4rzvA-3l4kA:
17.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4USW_A_ACTA1470_0
(ADENYLATE CYCLASE
TYPE 10)		 3l4k DNA TOPOISOMERASE 2
(Saccharomyces
cerevisiae) 		4 / 6 LEU A 682
LEU A 663
VAL A 662
PHE A 675
 None
 1.12A 4uswA-3l4kA:
undetectable		 4uswA-3l4kA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z2E_H_TR6H101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
SYMMETRIZED E-SITE
DNA)		 3l4k DNA TOPOISOMERASE 2
(Saccharomyces
cerevisiae) 		3 / 5 GLY A 450
GLY A 476
GLU A 494
 None
 0.50A 4z2eA-3l4kA:
25.7
4z2eD-3l4kA:
18.3		 4z2eA-3l4kA:
19.58
4z2eD-3l4kA:
16.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CZY_A_SAMA603_0
(LEGIONELLA EFFECTOR
LEGAS4)		 3l4k DNA TOPOISOMERASE 2
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 504
GLY A 503
ARG A 517
TYR A 518
LEU A 549
 None
 1.34A 5czyA-3l4kA:
undetectable		 5czyA-3l4kA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DSG_A_0HKA1201_2
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M4,ENDOLYSIN,ENDOLYS
IN,MUSCARINIC
ACETYLCHOLINE
RECEPTOR M4)		 3l4k DNA TOPOISOMERASE 2
(Saccharomyces
cerevisiae) 		3 / 3 ASN A 540
LEU A 630
PHE A 546
 None
 0.78A 5dsgA-3l4kA:
undetectable		 5dsgA-3l4kA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_B_RCXB601_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3l4k DNA TOPOISOMERASE 2
(Saccharomyces
cerevisiae) 		4 / 4 LEU A 760
ARG A 792
ILE A 794
PHE A 795
 None
 1.17A 5kirB-3l4kA:
undetectable		 5kirB-3l4kA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NWV_A_ACAA18_2
(SCRFP-TAG,GP41)		 3l4k DNA TOPOISOMERASE 2
(Saccharomyces
cerevisiae) 		4 / 7 GLN A1167
LEU A1170
ASP A1173
ALA A1176
 None
 0.84A 5nwvA-3l4kA:
undetectable		 5nwvA-3l4kA:
4.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OV9_B_CVIB603_0
(ACETYLCHOLINESTERASE)		 3l4k DNA TOPOISOMERASE 2
(Saccharomyces
cerevisiae) 		4 / 7 TYR A 708
GLN A 807
HIS A 735
TYR A 727
 None
None
ZN  A   1 (-3.1A)
None
 1.33A 5ov9B-3l4kA:
undetectable		 5ov9B-3l4kA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7P_B_ACRB1421_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 3l4k DNA TOPOISOMERASE 2
(Saccharomyces
cerevisiae) 		4 / 6 TYR A1067
GLU A1021
TYR A1068
GLY A1069
 None
 0.90A 5x7pB-3l4kA:
undetectable		 5x7pB-3l4kA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7P_E_CHDE401_0
(BILE SALT HYDROLASE)		 3l4k DNA TOPOISOMERASE 2
(Saccharomyces
cerevisiae) 		4 / 8 ILE A 538
LEU A 474
LEU A 454
ALA A 453
 None
 0.82A 5y7pE-3l4kA:
undetectable		 5y7pE-3l4kA:
17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E8Q_A_X2NA602_0
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3l4k DNA TOPOISOMERASE 2
(Saccharomyces
cerevisiae) 		5 / 12 GLY A 660
ILE A 523
PHE A 675
GLY A 536
THR A 661
 None
 1.23A 6e8qA-3l4kA:
1.0		 6e8qA-3l4kA:
7.79