SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3l5a'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXQ_A_IMNA2001_1
(SERUM ALBUMIN)		 3l5a NADH/FLAVIN
OXIDOREDUCTASE/NADH
OXIDASE
(Staphylococcus
aureus) 		5 / 10 SER A 185
ALA A 194
ALA A 201
LEU A 205
LEU A 249
 None
 1.08A 2bxqA-3l5aA:
undetectable		 2bxqA-3l5aA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD5_B_CHDB1103_0
(FERROCHELATASE)		 3l5a NADH/FLAVIN
OXIDOREDUCTASE/NADH
OXIDASE
(Staphylococcus
aureus) 		4 / 8 LEU A 349
SER A  53
VAL A 323
GLY A 324
 None
 1.00A 2qd5B-3l5aA:
undetectable		 2qd5B-3l5aA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XAT_A_CLMA301_0
(XENOBIOTIC
ACETYLTRANSFERASE)		 3l5a NADH/FLAVIN
OXIDOREDUCTASE/NADH
OXIDASE
(Staphylococcus
aureus) 		3 / 3 GLY A 240
TYR A 241
SER A 182
 None
 0.65A 2xatA-3l5aA:
undetectable		 2xatA-3l5aA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN5_A_FUNA1356_2
(THYROXINE-BINDING
GLOBULIN)		 3l5a NADH/FLAVIN
OXIDOREDUCTASE/NADH
OXIDASE
(Staphylococcus
aureus) 		3 / 3 LEU A 175
ARG A 228
ILE A 177
 None
 0.55A 2xn5B-3l5aA:
undetectable		 2xn5B-3l5aA:
7.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y6R_B_CTCB1385_0
(TETX2 PROTEIN)		 3l5a NADH/FLAVIN
OXIDOREDUCTASE/NADH
OXIDASE
(Staphylococcus
aureus) 		4 / 8 GLY A 226
PRO A  14
GLY A  16
MET A 322
 None
 0.92A 2y6rB-3l5aA:
undetectable		 2y6rB-3l5aA:
25.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J6G_B_TA1B502_1
(TUBULIN BETA CHAIN)		 3l5a NADH/FLAVIN
OXIDOREDUCTASE/NADH
OXIDASE
(Staphylococcus
aureus) 		5 / 10 VAL A 253
ASP A 255
PHE A 181
THR A 242
LEU A 197
 None
 1.07A 3j6gB-3l5aA:
4.3		 3j6gB-3l5aA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J6G_D_TA1D502_1
(TUBULIN BETA CHAIN)		 3l5a NADH/FLAVIN
OXIDOREDUCTASE/NADH
OXIDASE
(Staphylococcus
aureus) 		5 / 10 VAL A 253
ASP A 255
PHE A 181
THR A 242
LEU A 197
 None
 1.07A 3j6gD-3l5aA:
4.3		 3j6gD-3l5aA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J6G_F_TA1F502_1
(TUBULIN BETA CHAIN)		 3l5a NADH/FLAVIN
OXIDOREDUCTASE/NADH
OXIDASE
(Staphylococcus
aureus) 		5 / 10 VAL A 253
ASP A 255
PHE A 181
THR A 242
LEU A 197
 None
 1.07A 3j6gF-3l5aA:
4.1		 3j6gF-3l5aA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J6G_H_TA1H502_1
(TUBULIN BETA CHAIN)		 3l5a NADH/FLAVIN
OXIDOREDUCTASE/NADH
OXIDASE
(Staphylococcus
aureus) 		5 / 10 VAL A 253
ASP A 255
PHE A 181
THR A 242
LEU A 197
 None
 1.07A 3j6gH-3l5aA:
0.0		 3j6gH-3l5aA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J6G_J_TA1J502_1
(TUBULIN BETA CHAIN)		 3l5a NADH/FLAVIN
OXIDOREDUCTASE/NADH
OXIDASE
(Staphylococcus
aureus) 		5 / 10 VAL A 253
ASP A 255
PHE A 181
THR A 242
LEU A 197
 None
 1.07A 3j6gJ-3l5aA:
undetectable		 3j6gJ-3l5aA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J6G_L_TA1L502_1
(TUBULIN BETA CHAIN)		 3l5a NADH/FLAVIN
OXIDOREDUCTASE/NADH
OXIDASE
(Staphylococcus
aureus) 		5 / 10 VAL A 253
ASP A 255
PHE A 181
THR A 242
LEU A 197
 None
 1.07A 3j6gL-3l5aA:
2.8		 3j6gL-3l5aA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J6G_N_TA1N502_1
(TUBULIN BETA CHAIN)		 3l5a NADH/FLAVIN
OXIDOREDUCTASE/NADH
OXIDASE
(Staphylococcus
aureus) 		5 / 10 VAL A 253
ASP A 255
PHE A 181
THR A 242
LEU A 197
 None
 1.07A 3j6gN-3l5aA:
4.3		 3j6gN-3l5aA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J6G_P_TA1P502_1
(TUBULIN BETA CHAIN)		 3l5a NADH/FLAVIN
OXIDOREDUCTASE/NADH
OXIDASE
(Staphylococcus
aureus) 		5 / 10 VAL A 253
ASP A 255
PHE A 181
THR A 242
LEU A 197
 None
 1.07A 3j6gP-3l5aA:
4.3		 3j6gP-3l5aA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J6G_R_TA1R502_1
(TUBULIN BETA CHAIN)		 3l5a NADH/FLAVIN
OXIDOREDUCTASE/NADH
OXIDASE
(Staphylococcus
aureus) 		5 / 10 VAL A 253
ASP A 255
PHE A 181
THR A 242
LEU A 197
 None
 1.07A 3j6gR-3l5aA:
4.3		 3j6gR-3l5aA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDV_A_CL6A506_1
(CHOLESTEROL
24-HYDROXYLASE)		 3l5a NADH/FLAVIN
OXIDOREDUCTASE/NADH
OXIDASE
(Staphylococcus
aureus) 		5 / 9 LEU A 262
PHE A 227
LEU A 249
ILE A 171
ALA A 172
 None
 1.10A 3mdvA-3l5aA:
undetectable		 3mdvA-3l5aA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T01_A_PPFA503_1
(PHOSPHONOACETATE
HYDROLASE)		 3l5a NADH/FLAVIN
OXIDOREDUCTASE/NADH
OXIDASE
(Staphylococcus
aureus) 		4 / 7 ASP A 190
HIS A 191
ILE A 145
HIS A 142
 None
 1.13A 3t01A-3l5aA:
undetectable		 3t01A-3l5aA:
23.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BBO_C_ACTC1113_0
(BLR5658 PROTEIN)		 3l5a NADH/FLAVIN
OXIDOREDUCTASE/NADH
OXIDASE
(Staphylococcus
aureus) 		4 / 4 ASN A 186
ALA A 194
GLY A 193
THR A 189
 None
 0.90A 4bboC-3l5aA:
undetectable		 4bboC-3l5aA:
15.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BUP_B_SAMB500_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 3l5a NADH/FLAVIN
OXIDOREDUCTASE/NADH
OXIDASE
(Staphylococcus
aureus) 		3 / 3 HIS A 191
GLU A 206
ASN A 146
 None
 0.55A 4bupB-3l5aA:
undetectable		 4bupB-3l5aA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DV1_A_SRYA1601_1
(16S RRNA
RIBOSOMAL PROTEIN
S12)		 3l5a NADH/FLAVIN
OXIDOREDUCTASE/NADH
OXIDASE
(Staphylococcus
aureus) 		3 / 3 LYS A   1
LYS A   5
PRO A   6
 None
 1.26A 4dv1L-3l5aA:
undetectable		 4dv1L-3l5aA:
13.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2X_G_TMQG202_1
(DIHYDROFOLATE
REDUCTASE)		 3l5a NADH/FLAVIN
OXIDOREDUCTASE/NADH
OXIDASE
(Staphylococcus
aureus) 		5 / 12 ILE A 271
GLN A 318
LEU A   7
PRO A   6
ILE A 307
 None
 0.89A 4m2xG-3l5aA:
undetectable		 4m2xG-3l5aA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0D_A_MTXA604_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3l5a NADH/FLAVIN
OXIDOREDUCTASE/NADH
OXIDASE
(Staphylococcus
aureus) 		5 / 12 VAL A 256
ALA A 210
LEU A 203
ILE A 171
LEU A 249
 None
 1.17A 4q0dA-3l5aA:
undetectable		 4q0dA-3l5aA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0D_B_MTXB604_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3l5a NADH/FLAVIN
OXIDOREDUCTASE/NADH
OXIDASE
(Staphylococcus
aureus) 		5 / 12 VAL A 256
ALA A 210
LEU A 203
ILE A 171
LEU A 249
 None
 1.17A 4q0dB-3l5aA:
undetectable		 4q0dB-3l5aA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0D_E_MTXE604_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3l5a NADH/FLAVIN
OXIDOREDUCTASE/NADH
OXIDASE
(Staphylococcus
aureus) 		5 / 12 VAL A 256
ALA A 210
LEU A 203
ILE A 171
LEU A 249
 None
 1.17A 4q0dE-3l5aA:
undetectable		 4q0dE-3l5aA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESL_A_1YNA701_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3l5a NADH/FLAVIN
OXIDOREDUCTASE/NADH
OXIDASE
(Staphylococcus
aureus) 		5 / 12 GLY A 378
TYR A  63
ILE A  64
THR A 179
PHE A  71
 None
 1.18A 5eslA-3l5aA:
undetectable		 5eslA-3l5aA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I9Y_A_1N1A1001_2
(EPHRIN TYPE-A
RECEPTOR 2)		 3l5a NADH/FLAVIN
OXIDOREDUCTASE/NADH
OXIDASE
(Staphylococcus
aureus) 		3 / 3 ILE A 299
ILE A 224
MET A 254
 None
 0.58A 5i9yA-3l5aA:
undetectable		 5i9yA-3l5aA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR2_A_ROCA101_2
(PROTEASE PR5-SQV)		 3l5a NADH/FLAVIN
OXIDOREDUCTASE/NADH
OXIDASE
(Staphylococcus
aureus) 		5 / 11 ARG A  22
GLY A 226
ILE A 224
PRO A 300
ILE A 302
 None
 0.88A 5kr2B-3l5aA:
undetectable		 5kr2B-3l5aA:
13.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NUN_A_Z80A201_1
(BETA-LACTOGLOBULIN)		 3l5a NADH/FLAVIN
OXIDOREDUCTASE/NADH
OXIDASE
(Staphylococcus
aureus) 		5 / 9 ALA A 172
ILE A 250
LEU A 249
ILE A 259
ALA A 265
 None
 1.00A 5nunA-3l5aA:
undetectable		 5nunA-3l5aA:
15.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WBV_A_SAMA402_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
KMT5B)		 3l5a NADH/FLAVIN
OXIDOREDUCTASE/NADH
OXIDASE
(Staphylococcus
aureus) 		3 / 3 HIS A 191
GLU A 206
ASN A 146
 None
 0.64A 5wbvA-3l5aA:
undetectable		 5wbvA-3l5aA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WBV_B_SAMB402_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
KMT5B)		 3l5a NADH/FLAVIN
OXIDOREDUCTASE/NADH
OXIDASE
(Staphylococcus
aureus) 		3 / 3 HIS A 191
GLU A 206
ASN A 146
 None
 0.64A 5wbvB-3l5aA:
undetectable		 5wbvB-3l5aA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6R2E_A_FFOA403_0
(THYMIDYLATE SYNTHASE)		 3l5a NADH/FLAVIN
OXIDOREDUCTASE/NADH
OXIDASE
(Staphylococcus
aureus) 		5 / 12 ILE A 215
ASN A  15
LEU A  13
ASP A 165
GLY A 166
 None
 1.21A 6r2eA-3l5aA:
undetectable		 6r2eA-3l5aA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6R2E_C_FFOC404_0
(THYMIDYLATE SYNTHASE)		 3l5a NADH/FLAVIN
OXIDOREDUCTASE/NADH
OXIDASE
(Staphylococcus
aureus) 		5 / 10 ILE A 215
ASN A  15
LEU A  13
ASP A 165
GLY A 166
 None
 1.24A 6r2eC-3l5aA:
undetectable		 6r2eC-3l5aA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6R2E_D_FFOD403_0
(THYMIDYLATE SYNTHASE)		 3l5a NADH/FLAVIN
OXIDOREDUCTASE/NADH
OXIDASE
(Staphylococcus
aureus) 		5 / 10 ILE A 215
ASN A  15
LEU A  13
ASP A 165
GLY A 166
 None
 1.30A 6r2eD-3l5aA:
undetectable		 6r2eD-3l5aA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6R2E_G_FFOG403_0
(THYMIDYLATE SYNTHASE)		 3l5a NADH/FLAVIN
OXIDOREDUCTASE/NADH
OXIDASE
(Staphylococcus
aureus) 		5 / 11 ILE A 215
ASN A  15
LEU A  13
ASP A 165
GLY A 166
 None
 1.28A 6r2eG-3l5aA:
undetectable		 6r2eG-3l5aA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6R2E_H_FFOH403_0
(THYMIDYLATE SYNTHASE)		 3l5a NADH/FLAVIN
OXIDOREDUCTASE/NADH
OXIDASE
(Staphylococcus
aureus) 		5 / 12 ILE A 215
ASN A  15
LEU A  13
ASP A 165
GLY A 166
 None
 1.30A 6r2eH-3l5aA:
undetectable		 6r2eH-3l5aA:
21.92