SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3l5h'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTB_A_PZQA901_0
(GLUTATHIONE
S-TRANSFERASE)		 3l5h INTERLEUKIN-6
RECEPTOR SUBUNIT
BETA
(Homo
sapiens) 		3 / 3 GLN A 356
TYR A 374
ARG A 373
 None
None
SO4  A 592 (-3.0A)
 0.89A 1gtbA-3l5hA:
undetectable		 1gtbA-3l5hA:
16.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2D55_C_DVAC8_0
(ACTINOMYCIN D)		 3l5h INTERLEUKIN-6
RECEPTOR SUBUNIT
BETA
(Homo
sapiens) 		3 / 3 PRO A 308
THR A 331
PRO A 333
 None
 0.80A 2d55C-3l5hA:
undetectable		 2d55C-3l5hA:
2.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRE_D_CHDD702_0
(FERROCHELATASE)		 3l5h INTERLEUKIN-6
RECEPTOR SUBUNIT
BETA
(Homo
sapiens) 		3 / 3 ARG A 373
GLY A 481
PRO A 482
 SO4  A 592 (-3.0A)
None
None
 0.77A 2hreD-3l5hA:
undetectable		 2hreD-3l5hA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3A_A_TOPA1190_1
(DIHYDROFOLATE
REDUCTASE)		 3l5h INTERLEUKIN-6
RECEPTOR SUBUNIT
BETA
(Homo
sapiens) 		5 / 11 ALA A  73
PHE A  69
THR A  47
ILE A  52
PRO A  53
 None
 1.05A 2w3aA-3l5hA:
undetectable		 2w3aA-3l5hA:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2N_A_X2NA1480_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 3l5h INTERLEUKIN-6
RECEPTOR SUBUNIT
BETA
(Homo
sapiens) 		5 / 12 TYR A 536
PHE A 586
TYR A 566
ALA A 571
ALA A 513
 None
 1.32A 2x2nA-3l5hA:
undetectable		 2x2nA-3l5hA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_A_HSMA1161_1
(ALLERGEN ARG R 1)		 3l5h INTERLEUKIN-6
RECEPTOR SUBUNIT
BETA
(Homo
sapiens) 		4 / 5 TYR A 555
VAL A 548
ASP A 549
SER A 551
 None
 1.20A 2x45A-3l5hA:
undetectable		 2x45A-3l5hA:
12.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_C_HSMC1161_1
(ALLERGEN ARG R 1)		 3l5h INTERLEUKIN-6
RECEPTOR SUBUNIT
BETA
(Homo
sapiens) 		4 / 5 TYR A 555
VAL A 548
ASP A 549
SER A 551
 None
 1.15A 2x45C-3l5hA:
undetectable		 2x45C-3l5hA:
12.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F3T_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 3l5h INTERLEUKIN-6
RECEPTOR SUBUNIT
BETA
(Homo
sapiens) 		4 / 6 LEU A 392
TYR A 374
LEU A 327
TYR A 312
 None
 1.19A 4f3tA-3l5hA:
undetectable		 4f3tA-3l5hA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCI_A_ADNA2414_1
(RNA-DIRECTED RNA
POLYMERASE L)		 3l5h INTERLEUKIN-6
RECEPTOR SUBUNIT
BETA
(Homo
sapiens) 		4 / 6 GLU A 583
PHE A 584
PHE A 586
TYR A 566
 None
 1.48A 4uciA-3l5hA:
undetectable		 4uciA-3l5hA:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCI_B_ADNB2415_1
(RNA-DIRECTED RNA
POLYMERASE L)		 3l5h INTERLEUKIN-6
RECEPTOR SUBUNIT
BETA
(Homo
sapiens) 		4 / 7 GLU A 583
PHE A 584
PHE A 586
TYR A 566
 None
 1.48A 4uciB-3l5hA:
undetectable		 4uciB-3l5hA:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WCX_C_SAMC503_0
(BIOTIN AND THIAMIN
SYNTHESIS ASSOCIATED)		 3l5h INTERLEUKIN-6
RECEPTOR SUBUNIT
BETA
(Homo
sapiens) 		5 / 12 TYR A 470
GLY A 527
LEU A 464
LEU A 460
ALA A 410
 None
 1.17A 4wcxC-3l5hA:
undetectable		 4wcxC-3l5hA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WOZ_B_MN9B401_0
(N-ACETYLNEURAMINATE
LYASE)		 3l5h INTERLEUKIN-6
RECEPTOR SUBUNIT
BETA
(Homo
sapiens) 		4 / 6 THR A 544
SER A 558
LEU A 557
LEU A 560
 None
 1.03A 4wozA-3l5hA:
undetectable
4wozB-3l5hA:
undetectable		 4wozA-3l5hA:
20.34
4wozB-3l5hA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CNK_A_NCTA405_1
(NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
ALPHA-4)		 3l5h INTERLEUKIN-6
RECEPTOR SUBUNIT
BETA
(Homo
sapiens) 		4 / 6 TYR A 235
TRP A 222
THR A 223
THR A 221
 None
 1.22A 6cnkA-3l5hA:
0.7
6cnkB-3l5hA:
1.6		 6cnkA-3l5hA:
11.48
6cnkB-3l5hA:
11.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD6_A_STIA603_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3l5h INTERLEUKIN-6
RECEPTOR SUBUNIT
BETA
(Homo
sapiens) 		4 / 5 LEU A 392
TYR A 312
ILE A 472
GLY A 481
 None
 1.08A 6hd6A-3l5hA:
undetectable		 6hd6A-3l5hA:
9.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6N7F_A_RBFA502_0
(PUTATIVE GLUTATHIONE
REDUCTASE (GR))		 3l5h INTERLEUKIN-6
RECEPTOR SUBUNIT
BETA
(Homo
sapiens) 		4 / 7 GLY A 500
ASN A 526
GLU A 576
GLY A 577
 None
None
NAG  A 607 (-3.7A)
NAG  A 607 ( 3.9A)
 0.95A 6n7fA-3l5hA:
undetectable		 6n7fA-3l5hA:
8.41