SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3l5j'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_H_BEZH515_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 3l5j INTERLEUKIN-6
RECEPTOR SUBUNIT
BETA
(Homo
sapiens) 		4 / 6 ALA A 495
TYR A 491
ILE A 529
PRO A 497
 None
 1.13A 1oniH-3l5jA:
undetectable
1oniI-3l5jA:
undetectable		 1oniH-3l5jA:
21.76
1oniI-3l5jA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F3T_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 3l5j INTERLEUKIN-6
RECEPTOR SUBUNIT
BETA
(Homo
sapiens) 		4 / 6 LEU A 392
TYR A 374
LEU A 327
TYR A 312
 None
 1.14A 4f3tA-3l5jA:
undetectable		 4f3tA-3l5jA:
16.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WCX_C_SAMC503_0
(BIOTIN AND THIAMIN
SYNTHESIS ASSOCIATED)		 3l5j INTERLEUKIN-6
RECEPTOR SUBUNIT
BETA
(Homo
sapiens) 		5 / 12 TYR A 470
GLY A 527
LEU A 464
LEU A 460
ALA A 410
 None
 1.14A 4wcxC-3l5jA:
undetectable		 4wcxC-3l5jA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JMN_C_FUAC1101_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 3l5j INTERLEUKIN-6
RECEPTOR SUBUNIT
BETA
(Homo
sapiens) 		3 / 3 VAL A 474
HIS A 456
VAL A 455
 None
 0.71A 5jmnC-3l5jA:
undetectable		 5jmnC-3l5jA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KI6_A_IPHA901_0
(PROTEIN ARGONAUTE-2)		 3l5j INTERLEUKIN-6
RECEPTOR SUBUNIT
BETA
(Homo
sapiens) 		4 / 5 LEU A 392
TYR A 374
LEU A 327
TYR A 312
 None
 1.28A 5ki6A-3l5jA:
undetectable		 5ki6A-3l5jA:
16.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6N7F_A_RBFA502_0
(PUTATIVE GLUTATHIONE
REDUCTASE (GR))		 3l5j INTERLEUKIN-6
RECEPTOR SUBUNIT
BETA
(Homo
sapiens) 		4 / 7 GLY A 500
ASN A 526
GLU A 576
GLY A 577
 None
 0.82A 6n7fA-3l5jA:
undetectable		 6n7fA-3l5jA:
13.57