SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3l5k'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_B_DIFB1376_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 3l5k HALOACID
DEHALOGENASE-LIKE
HYDROLASE
DOMAIN-CONTAINING
PROTEIN 1A
(Homo
sapiens) 		4 / 7 GLY A  94
ALA A  95
LEU A  91
SER A 213
 None
 0.87A 2wekB-3l5kA:
4.0		 2wekB-3l5kA:
23.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7K_A_SALA1303_1
(LYSR-TYPE REGULATORY
PROTEIN)		 3l5k HALOACID
DEHALOGENASE-LIKE
HYDROLASE
DOMAIN-CONTAINING
PROTEIN 1A
(Homo
sapiens) 		4 / 7 SER A 114
PHE A 155
ILE A 154
GLY A 180
 None
 0.97A 2y7kA-3l5kA:
undetectable		 2y7kA-3l5kA:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_Q_TFPQ201_1
(PROTEIN S100-A4)		 3l5k HALOACID
DEHALOGENASE-LIKE
HYDROLASE
DOMAIN-CONTAINING
PROTEIN 1A
(Homo
sapiens) 		4 / 8 PHE A 130
MET A  15
PHE A  13
PHE A 134
 None
 0.89A 3ko0O-3l5kA:
undetectable
3ko0Q-3l5kA:
undetectable		 3ko0O-3l5kA:
18.44
3ko0Q-3l5kA:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_S_TFPS201_1
(PROTEIN S100-A4)		 3l5k HALOACID
DEHALOGENASE-LIKE
HYDROLASE
DOMAIN-CONTAINING
PROTEIN 1A
(Homo
sapiens) 		4 / 7 PHE A 130
MET A  15
PHE A  13
PHE A 134
 None
 0.88A 3ko0K-3l5kA:
undetectable
3ko0S-3l5kA:
undetectable		 3ko0K-3l5kA:
18.44
3ko0S-3l5kA:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGK_A_0TXA302_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 3l5k HALOACID
DEHALOGENASE-LIKE
HYDROLASE
DOMAIN-CONTAINING
PROTEIN 1A
(Homo
sapiens) 		4 / 6 ILE A 107
PRO A 108
PHE A 109
PHE A  13
 None
 0.84A 4fgkA-3l5kA:
2.4		 4fgkA-3l5kA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U8Y_B_MIYB1102_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 3l5k HALOACID
DEHALOGENASE-LIKE
HYDROLASE
DOMAIN-CONTAINING
PROTEIN 1A
(Homo
sapiens) 		5 / 12 GLY A 180
GLU A 182
ASP A 153
ILE A 154
ALA A 112
 None
 1.13A 4u8yB-3l5kA:
undetectable		 4u8yB-3l5kA:
12.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U95_B_MIYB1102_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 3l5k HALOACID
DEHALOGENASE-LIKE
HYDROLASE
DOMAIN-CONTAINING
PROTEIN 1A
(Homo
sapiens) 		5 / 12 GLY A 180
GLU A 182
ASP A 153
ILE A 154
ALA A 112
 None
 1.12A 4u95B-3l5kA:
undetectable		 4u95B-3l5kA:
12.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJ8_A_SUVA2001_1
(HUMAN OX1R FUSION
PROTEIN TO P.ABYSII
GLYCOGEN SYNTHASE)		 3l5k HALOACID
DEHALOGENASE-LIKE
HYDROLASE
DOMAIN-CONTAINING
PROTEIN 1A
(Homo
sapiens) 		5 / 12 ALA A 118
SER A 119
GLN A  79
VAL A  75
GLU A  84
 None
CL  A 232 (-3.4A)
None
None
None
 1.29A 4zj8A-3l5kA:
undetectable		 4zj8A-3l5kA:
17.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K9D_A_CE9A402_0
(DIHYDROOROTATE
DEHYDROGENASE
(QUINONE),
MITOCHONDRIAL)		 3l5k HALOACID
DEHALOGENASE-LIKE
HYDROLASE
DOMAIN-CONTAINING
PROTEIN 1A
(Homo
sapiens) 		5 / 12 ALA A 112
LEU A 111
ALA A 110
PHE A 134
PHE A 162
 None
 1.12A 5k9dA-3l5kA:
undetectable		 5k9dA-3l5kA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TWJ_C_SAMC201_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE H)		 3l5k HALOACID
DEHALOGENASE-LIKE
HYDROLASE
DOMAIN-CONTAINING
PROTEIN 1A
(Homo
sapiens) 		5 / 12 LEU A 102
ILE A 100
ILE A 107
GLY A 106
LEU A  98
 None
 1.10A 5twjC-3l5kA:
undetectable		 5twjC-3l5kA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AN0_A_HISA520_0
(HISTIDINOL
DEHYDROGENASE)		 3l5k HALOACID
DEHALOGENASE-LIKE
HYDROLASE
DOMAIN-CONTAINING
PROTEIN 1A
(Homo
sapiens) 		4 / 6 GLU A 175
GLU A 182
ALA A 183
LYS A 149
 K  A 229 (-3.3A)
None
None
K  A 229 ( 4.2A)
 1.02A 6an0A-3l5kA:
3.8		 6an0A-3l5kA:
20.56