SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3l60'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F7F_A_NIOA601_1
(NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE, PUTATIVE)		 3l60 BRANCHED-CHAIN
ALPHA-KETO ACID
DEHYDROGENASE
(Mycobacterium
tuberculosis) 		4 / 6 PHE A 314
SER A 312
GLY A 335
THR A 359
 UNL  A   1 ( 4.5A)
UNL  A   1 ( 3.6A)
None
None
 0.97A 2f7fA-3l60A:
undetectable		 2f7fA-3l60A:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RIW_A_T44A1395_1
(THYROXINE-BINDING
GLOBULIN)		 3l60 BRANCHED-CHAIN
ALPHA-KETO ACID
DEHYDROGENASE
(Mycobacterium
tuberculosis) 		5 / 10 LEU A 202
LEU A 205
LEU A 393
LEU A 221
ARG A 224
 None
 1.17A 2riwA-3l60A:
undetectable
2riwB-3l60A:
undetectable		 2riwA-3l60A:
20.41
2riwB-3l60A:
12.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZB8_A_IMNA800_1
(PROSTAGLANDIN
REDUCTASE 2)		 3l60 BRANCHED-CHAIN
ALPHA-KETO ACID
DEHYDROGENASE
(Mycobacterium
tuberculosis) 		5 / 9 CYH A 199
THR A 355
PHE A 375
VAL A 311
LEU A 334
 None
 1.47A 2zb8A-3l60A:
0.0		 2zb8A-3l60A:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_D_DVAD10_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 3l60 BRANCHED-CHAIN
ALPHA-KETO ACID
DEHYDROGENASE
(Mycobacterium
tuberculosis) 		3 / 3 GLY A 337
GLY A 318
GLY A 315
 None
 0.41A 3bogD-3l60A:
undetectable		 3bogD-3l60A:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N4T_A_BEZA507_0
(BETA-LACTAMASE VIM-2)		 3l60 BRANCHED-CHAIN
ALPHA-KETO ACID
DEHYDROGENASE
(Mycobacterium
tuberculosis) 		3 / 3 THR A 239
HIS A 252
ASN A 237
 None
 0.89A 5n4tA-3l60A:
undetectable		 5n4tA-3l60A:
25.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6J21_A_GBQA1201_0
(SUBSTANCE-P
RECEPTOR,ENDOLYSIN)		 3l60 BRANCHED-CHAIN
ALPHA-KETO ACID
DEHYDROGENASE
(Mycobacterium
tuberculosis) 		5 / 12 ASN A 233
ILE A 235
VAL A 366
VAL A 251
PHE A 309
 None
 1.27A 6j21A-3l60A:
undetectable		 6j21A-3l60A:
19.42