SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3l6a'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HRK_A_CHDA1501_0
(FERROCHELATASE)		 3l6a EUKARYOTIC
TRANSLATION
INITIATION FACTOR 4
GAMMA 2
(Homo
sapiens) 		5 / 12 LEU A  89
LEU A 128
ILE A  49
VAL A 162
VAL A 119
 None
None
None
MES  A 361 (-3.6A)
None
 1.15A 1hrkA-3l6aA:
undetectable		 1hrkA-3l6aA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HRK_B_CHDB2501_0
(FERROCHELATASE)		 3l6a EUKARYOTIC
TRANSLATION
INITIATION FACTOR 4
GAMMA 2
(Homo
sapiens) 		5 / 12 LEU A  89
LEU A 128
ILE A  49
VAL A 162
VAL A 119
 None
None
None
MES  A 361 (-3.6A)
None
 1.13A 1hrkB-3l6aA:
undetectable		 1hrkB-3l6aA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RK3_A_VDXA500_1
(VITAMIN D3 RECEPTOR)		 3l6a EUKARYOTIC
TRANSLATION
INITIATION FACTOR 4
GAMMA 2
(Homo
sapiens) 		5 / 12 LEU A  53
VAL A 102
SER A  64
HIS A 133
LEU A 128
 None
None
None
SO4  A 366 (-3.6A)
None
 1.47A 1rk3A-3l6aA:
undetectable		 1rk3A-3l6aA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UKB_A_BEZA1301_0
(2-HYDROXY-6-OXO-7-ME
THYLOCTA-2,4-DIENOAT
E HYDROLASE)		 3l6a EUKARYOTIC
TRANSLATION
INITIATION FACTOR 4
GAMMA 2
(Homo
sapiens) 		4 / 6 LEU A 106
PHE A 109
ALA A 110
LEU A  89
 None
 1.01A 1ukbA-3l6aA:
undetectable		 1ukbA-3l6aA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDK_A_9CRA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3l6a EUKARYOTIC
TRANSLATION
INITIATION FACTOR 4
GAMMA 2
(Homo
sapiens) 		5 / 12 ALA A 111
GLN A 143
LEU A 144
VAL A 162
LEU A 128
 None
None
None
MES  A 361 (-3.6A)
None
 1.03A 1xdkA-3l6aA:
undetectable		 1xdkA-3l6aA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDK_E_9CRE1500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3l6a EUKARYOTIC
TRANSLATION
INITIATION FACTOR 4
GAMMA 2
(Homo
sapiens) 		5 / 12 ALA A 111
GLN A 143
LEU A 144
VAL A 162
LEU A 128
 None
None
None
MES  A 361 (-3.6A)
None
 1.03A 1xdkE-3l6aA:
undetectable		 1xdkE-3l6aA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVV_A_MK1A901_2
(POL POLYPROTEIN)		 3l6a EUKARYOTIC
TRANSLATION
INITIATION FACTOR 4
GAMMA 2
(Homo
sapiens) 		3 / 3 ASP A 285
VAL A 227
PRO A 223
 None
 0.70A 2avvA-3l6aA:
undetectable		 2avvA-3l6aA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRC_A_CHDA701_0
(FERROCHELATASE)		 3l6a EUKARYOTIC
TRANSLATION
INITIATION FACTOR 4
GAMMA 2
(Homo
sapiens) 		5 / 12 LEU A  89
LEU A 128
ILE A  49
VAL A 162
VAL A 119
 None
None
None
MES  A 361 (-3.6A)
None
 1.19A 2hrcA-3l6aA:
undetectable		 2hrcA-3l6aA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PNJ_B_CHDB501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3l6a EUKARYOTIC
TRANSLATION
INITIATION FACTOR 4
GAMMA 2
(Homo
sapiens) 		5 / 12 LEU A  89
LEU A 128
ILE A  49
VAL A 162
VAL A 119
 None
None
None
MES  A 361 (-3.6A)
None
 1.16A 2pnjB-3l6aA:
undetectable		 2pnjB-3l6aA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO5_A_CHDA501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3l6a EUKARYOTIC
TRANSLATION
INITIATION FACTOR 4
GAMMA 2
(Homo
sapiens) 		5 / 12 LEU A  89
LEU A 128
ILE A  49
VAL A 162
VAL A 119
 None
None
None
MES  A 361 (-3.6A)
None
 1.03A 2po5A-3l6aA:
undetectable		 2po5A-3l6aA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO7_A_CHDA501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3l6a EUKARYOTIC
TRANSLATION
INITIATION FACTOR 4
GAMMA 2
(Homo
sapiens) 		5 / 12 LEU A  89
LEU A 128
ILE A  49
VAL A 162
VAL A 119
 None
None
None
MES  A 361 (-3.6A)
None
 1.14A 2po7A-3l6aA:
undetectable		 2po7A-3l6aA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_A_P1ZA1351_1
(PROSTAGLANDIN
REDUCTASE 2)		 3l6a EUKARYOTIC
TRANSLATION
INITIATION FACTOR 4
GAMMA 2
(Homo
sapiens) 		5 / 10 ILE A 114
PHE A 137
MET A 164
LEU A 153
LEU A 141
 None
 1.12A 2w98A-3l6aA:
undetectable		 2w98A-3l6aA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9S_B_TOPB1160_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 3l6a EUKARYOTIC
TRANSLATION
INITIATION FACTOR 4
GAMMA 2
(Homo
sapiens) 		5 / 11 ILE A 213
LEU A 201
ILE A 204
ILE A 243
PHE A 275
 None
 1.06A 2w9sB-3l6aA:
undetectable		 2w9sB-3l6aA:
16.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y05_A_RALA802_1
(PROSTAGLANDIN
REDUCTASE 1)		 3l6a EUKARYOTIC
TRANSLATION
INITIATION FACTOR 4
GAMMA 2
(Homo
sapiens) 		4 / 7 VAL A 291
TYR A 295
ASN A 233
GLY A 230
 None
 0.87A 2y05A-3l6aA:
undetectable
2y05B-3l6aA:
undetectable		 2y05A-3l6aA:
21.75
2y05B-3l6aA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGN_A_PCFA1179_0
(WNT INHIBITORY
FACTOR 1)		 3l6a EUKARYOTIC
TRANSLATION
INITIATION FACTOR 4
GAMMA 2
(Homo
sapiens) 		5 / 12 LEU A  69
LEU A 124
ILE A 114
PHE A  81
VAL A  48
 None
 1.04A 2ygnA-3l6aA:
undetectable		 2ygnA-3l6aA:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG1_W_CHDW1059_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 3l6a EUKARYOTIC
TRANSLATION
INITIATION FACTOR 4
GAMMA 2
(Homo
sapiens) 		4 / 6 ILE A 324
MET A 236
THR A 237
LEU A 240
 None
 0.95A 3ag1N-3l6aA:
undetectable
3ag1W-3l6aA:
undetectable		 3ag1N-3l6aA:
18.63
3ag1W-3l6aA:
9.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG2_C_CHDC271_0
(CYTOCHROME C OXIDASE
SUBUNIT 3)		 3l6a EUKARYOTIC
TRANSLATION
INITIATION FACTOR 4
GAMMA 2
(Homo
sapiens) 		4 / 7 LEU A 106
GLN A 108
PHE A  85
LEU A  89
 None
 0.95A 3ag2C-3l6aA:
undetectable		 3ag2C-3l6aA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG2_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3l6a EUKARYOTIC
TRANSLATION
INITIATION FACTOR 4
GAMMA 2
(Homo
sapiens) 		4 / 7 LEU A 106
GLN A 108
PHE A  85
LEU A  89
 None
 0.90A 3ag2P-3l6aA:
undetectable
3ag2W-3l6aA:
undetectable		 3ag2P-3l6aA:
20.70
3ag2W-3l6aA:
9.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AI9_X_SAMX501_0
(UPF0217 PROTEIN
MJ1640)		 3l6a EUKARYOTIC
TRANSLATION
INITIATION FACTOR 4
GAMMA 2
(Homo
sapiens) 		5 / 9 LEU A  70
ILE A  75
GLY A  74
LEU A  66
SER A  65
 None
 1.13A 3ai9X-3l6aA:
undetectable		 3ai9X-3l6aA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AQI_B_CHDB6_0
(FERROCHELATASE)		 3l6a EUKARYOTIC
TRANSLATION
INITIATION FACTOR 4
GAMMA 2
(Homo
sapiens) 		5 / 12 LEU A  89
LEU A 128
ILE A  49
VAL A 162
VAL A 119
 None
None
None
MES  A 361 (-3.6A)
None
 1.16A 3aqiB-3l6aA:
undetectable		 3aqiB-3l6aA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H0A_A_9RAA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3l6a EUKARYOTIC
TRANSLATION
INITIATION FACTOR 4
GAMMA 2
(Homo
sapiens) 		5 / 12 ALA A 111
GLN A 143
LEU A 144
VAL A 162
LEU A 128
 None
None
None
MES  A 361 (-3.6A)
None
 0.94A 3h0aA-3l6aA:
undetectable		 3h0aA-3l6aA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3I45_A_NIOA500_1
(TWIN-ARGININE
TRANSLOCATION
PATHWAY SIGNAL
PROTEIN)		 3l6a EUKARYOTIC
TRANSLATION
INITIATION FACTOR 4
GAMMA 2
(Homo
sapiens) 		4 / 8 PHE A 137
LEU A 187
PHE A 157
LEU A 153
 None
None
MES  A 362 (-4.8A)
None
 1.03A 3i45A-3l6aA:
undetectable		 3i45A-3l6aA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IAZ_A_AINA1202_1
(LACTOTRANSFERRIN)		 3l6a EUKARYOTIC
TRANSLATION
INITIATION FACTOR 4
GAMMA 2
(Homo
sapiens) 		3 / 3 GLU A 129
GLY A 131
THR A 132
 MES  A 361 (-3.4A)
None
PG4  A 364 (-4.5A)
 0.55A 3iazA-3l6aA:
undetectable		 3iazA-3l6aA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SXJ_B_SAMB258_0
(PUTATIVE
METHYLTRANSFERASE)		 3l6a EUKARYOTIC
TRANSLATION
INITIATION FACTOR 4
GAMMA 2
(Homo
sapiens) 		5 / 12 ARG A  32
SER A  46
GLU A  73
ALA A  76
ASN A  80
 None
 1.08A 3sxjB-3l6aA:
undetectable		 3sxjB-3l6aA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_A_CHDA1502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3l6a EUKARYOTIC
TRANSLATION
INITIATION FACTOR 4
GAMMA 2
(Homo
sapiens) 		5 / 12 LEU A  89
LEU A 128
ILE A  49
VAL A 162
VAL A 119
 None
None
None
MES  A 361 (-3.6A)
None
 1.15A 3w1wA-3l6aA:
undetectable		 3w1wA-3l6aA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_B_CHDB504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3l6a EUKARYOTIC
TRANSLATION
INITIATION FACTOR 4
GAMMA 2
(Homo
sapiens) 		5 / 12 LEU A  89
LEU A 128
ILE A  49
VAL A 162
VAL A 119
 None
None
None
MES  A 361 (-3.6A)
None
 1.23A 3w1wB-3l6aA:
undetectable		 3w1wB-3l6aA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AN2_A_EUIA1382_2
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		 3l6a EUKARYOTIC
TRANSLATION
INITIATION FACTOR 4
GAMMA 2
(Homo
sapiens) 		4 / 4 ASN A 233
SER A 222
LEU A 225
THR A 237
 None
 1.16A 4an2A-3l6aA:
undetectable		 4an2A-3l6aA:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FN9_A_STRA301_1
(STEROID RECEPTOR 2)		 3l6a EUKARYOTIC
TRANSLATION
INITIATION FACTOR 4
GAMMA 2
(Homo
sapiens) 		5 / 12 LEU A 138
LEU A 141
LEU A 144
ALA A 145
MET A 164
 None
 0.95A 4fn9A-3l6aA:
undetectable		 4fn9A-3l6aA:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FN9_B_STRB301_1
(STEROID RECEPTOR 2)		 3l6a EUKARYOTIC
TRANSLATION
INITIATION FACTOR 4
GAMMA 2
(Homo
sapiens) 		5 / 12 LEU A 138
LEU A 141
LEU A 144
ALA A 145
MET A 164
 None
 0.99A 4fn9B-3l6aA:
undetectable		 4fn9B-3l6aA:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_STRA301_1
(ANCESTRAL STEROID
RECEPTOR 2)		 3l6a EUKARYOTIC
TRANSLATION
INITIATION FACTOR 4
GAMMA 2
(Homo
sapiens) 		5 / 12 LEU A 138
LEU A 141
LEU A 144
ALA A 145
MET A 164
 None
 1.01A 4ltwA-3l6aA:
undetectable		 4ltwA-3l6aA:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1A_C_CHDC304_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3l6a EUKARYOTIC
TRANSLATION
INITIATION FACTOR 4
GAMMA 2
(Homo
sapiens) 		4 / 7 LEU A 106
GLN A 108
PHE A  85
LEU A  89
 None
 0.89A 5b1aC-3l6aA:
undetectable
5b1aJ-3l6aA:
undetectable		 5b1aC-3l6aA:
20.70
5b1aJ-3l6aA:
9.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1A_P_CHDP305_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3l6a EUKARYOTIC
TRANSLATION
INITIATION FACTOR 4
GAMMA 2
(Homo
sapiens) 		4 / 7 LEU A 106
GLN A 108
PHE A  85
LEU A  89
 None
 0.86A 5b1aP-3l6aA:
undetectable
5b1aW-3l6aA:
undetectable		 5b1aP-3l6aA:
20.70
5b1aW-3l6aA:
9.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1B_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3l6a EUKARYOTIC
TRANSLATION
INITIATION FACTOR 4
GAMMA 2
(Homo
sapiens) 		4 / 6 GLN A 280
PHE A 239
LEU A 235
PHE A 231
 None
 1.16A 5b1bC-3l6aA:
undetectable
5b1bJ-3l6aA:
undetectable		 5b1bC-3l6aA:
20.70
5b1bJ-3l6aA:
9.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B3S_C_CHDC307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3l6a EUKARYOTIC
TRANSLATION
INITIATION FACTOR 4
GAMMA 2
(Homo
sapiens) 		4 / 7 LEU A 106
GLN A 108
PHE A  85
LEU A  89
 None
 0.86A 5b3sC-3l6aA:
undetectable
5b3sJ-3l6aA:
undetectable		 5b3sC-3l6aA:
20.70
5b3sJ-3l6aA:
9.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B3S_P_CHDP306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3)		 3l6a EUKARYOTIC
TRANSLATION
INITIATION FACTOR 4
GAMMA 2
(Homo
sapiens) 		4 / 7 LEU A 106
GLN A 108
PHE A  85
LEU A  89
 None
 0.87A 5b3sP-3l6aA:
undetectable		 5b3sP-3l6aA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FUK_A_SNPA1236_1
(MROUPO)		 3l6a EUKARYOTIC
TRANSLATION
INITIATION FACTOR 4
GAMMA 2
(Homo
sapiens) 		4 / 7 ILE A 221
ILE A 234
SER A 238
PHE A 239
 None
 0.67A 5fukA-3l6aA:
undetectable
5fukB-3l6aA:
undetectable		 5fukA-3l6aA:
19.52
5fukB-3l6aA:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IY5_C_CHDC307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3l6a EUKARYOTIC
TRANSLATION
INITIATION FACTOR 4
GAMMA 2
(Homo
sapiens) 		4 / 7 LEU A 106
GLN A 108
PHE A  85
LEU A  89
 None
 0.96A 5iy5C-3l6aA:
undetectable
5iy5J-3l6aA:
undetectable		 5iy5C-3l6aA:
20.70
5iy5J-3l6aA:
9.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JI0_A_9CRA501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3l6a EUKARYOTIC
TRANSLATION
INITIATION FACTOR 4
GAMMA 2
(Homo
sapiens) 		5 / 11 GLN A 143
LEU A 139
LEU A 144
VAL A 162
LEU A 128
 None
None
None
MES  A 361 (-3.6A)
None
 1.23A 5ji0A-3l6aA:
undetectable		 5ji0A-3l6aA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UAN_A_9CRA503_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3l6a EUKARYOTIC
TRANSLATION
INITIATION FACTOR 4
GAMMA 2
(Homo
sapiens) 		5 / 12 ALA A 111
GLN A 143
LEU A 144
VAL A 162
LEU A 128
 None
None
None
MES  A 361 (-3.6A)
None
 1.00A 5uanA-3l6aA:
undetectable		 5uanA-3l6aA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XXI_A_LSNA503_1
(CYTOCHROME P450 2C9)		 3l6a EUKARYOTIC
TRANSLATION
INITIATION FACTOR 4
GAMMA 2
(Homo
sapiens) 		5 / 12 LEU A 147
GLN A 143
LEU A 136
PRO A 135
LEU A 187
 None
 1.25A 5xxiA-3l6aA:
undetectable		 5xxiA-3l6aA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z84_C_CHDC307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3l6a EUKARYOTIC
TRANSLATION
INITIATION FACTOR 4
GAMMA 2
(Homo
sapiens) 		4 / 7 LEU A 106
GLN A 108
PHE A  85
LEU A  89
 None
 0.85A 5z84C-3l6aA:
undetectable
5z84J-3l6aA:
undetectable		 5z84C-3l6aA:
20.70
5z84J-3l6aA:
9.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B5V_A_ECLA1001_1
(TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 5)		 3l6a EUKARYOTIC
TRANSLATION
INITIATION FACTOR 4
GAMMA 2
(Homo
sapiens) 		4 / 7 PHE A 157
ILE A 121
PHE A  85
LEU A 124
 MES  A 362 (-4.8A)
None
None
None
 0.86A 6b5vA-3l6aA:
undetectable
6b5vC-3l6aA:
1.5		 6b5vA-3l6aA:
13.23
6b5vC-3l6aA:
13.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B5V_C_ECLC1001_1
(TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 5)		 3l6a EUKARYOTIC
TRANSLATION
INITIATION FACTOR 4
GAMMA 2
(Homo
sapiens) 		4 / 7 PHE A 157
ILE A 121
PHE A  85
LEU A 124
 MES  A 362 (-4.8A)
None
None
None
 0.85A 6b5vC-3l6aA:
1.5
6b5vD-3l6aA:
1.9		 6b5vC-3l6aA:
13.23
6b5vD-3l6aA:
13.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B5V_D_ECLD1001_1
(TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 5)		 3l6a EUKARYOTIC
TRANSLATION
INITIATION FACTOR 4
GAMMA 2
(Homo
sapiens) 		4 / 7 PHE A 157
ILE A 121
PHE A  85
LEU A 124
 MES  A 362 (-4.8A)
None
None
None
 0.86A 6b5vB-3l6aA:
2.9
6b5vD-3l6aA:
1.9		 6b5vB-3l6aA:
13.23
6b5vD-3l6aA:
13.23