SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3l6g'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BDW_B_DVAB6_0
(GRAMICIDIN A)		 3l6g BETAINE ABC
TRANSPORTER PERMEASE
AND SUBSTRATE
BINDING PROTEIN
(Lactococcus
lactis) 		3 / 3 TRP A 484
ALA A 403
VAL A 405
 None
 0.65A 1bdwA-3l6gA:
undetectable
1bdwB-3l6gA:
undetectable		 1bdwA-3l6gA:
7.98
1bdwB-3l6gA:
7.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OQ5_A_CELA701_1
(CARBONIC ANHYDRASE
II)		 3l6g BETAINE ABC
TRANSPORTER PERMEASE
AND SUBSTRATE
BINDING PROTEIN
(Lactococcus
lactis) 		5 / 12 VAL A 568
PHE A 572
VAL A 529
LEU A 340
TRP A 535
 None
 0.94A 1oq5A-3l6gA:
undetectable		 1oq5A-3l6gA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PKV_B_RBFB101_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 3l6g BETAINE ABC
TRANSPORTER PERMEASE
AND SUBSTRATE
BINDING PROTEIN
(Lactococcus
lactis) 		5 / 11 VAL A 515
LEU A 340
THR A 341
ILE A 514
THR A 513
 None
 1.23A 1pkvA-3l6gA:
undetectable
1pkvB-3l6gA:
undetectable		 1pkvA-3l6gA:
19.20
1pkvB-3l6gA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DTJ_A_THRA401_0
(ASPARTOKINASE)		 3l6g BETAINE ABC
TRANSPORTER PERMEASE
AND SUBSTRATE
BINDING PROTEIN
(Lactococcus
lactis) 		4 / 8 GLY A 470
GLU A 471
ALA A 472
ILE A 479
 None
 0.84A 2dtjA-3l6gA:
undetectable
2dtjB-3l6gA:
undetectable		 2dtjA-3l6gA:
23.90
2dtjB-3l6gA:
23.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DXR_A_SORA1002_0
(LACTOTRANSFERRIN)		 3l6g BETAINE ABC
TRANSPORTER PERMEASE
AND SUBSTRATE
BINDING PROTEIN
(Lactococcus
lactis) 		3 / 3 THR A 504
PRO A 501
TYR A 449
 None
 0.92A 2dxrA-3l6gA:
5.7		 2dxrA-3l6gA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J9C_A_ACTA1121_0
(HYPOTHETICAL
NITROGEN REGULATORY
PII-LIKE PROTEIN
MJ0059)		 3l6g BETAINE ABC
TRANSPORTER PERMEASE
AND SUBSTRATE
BINDING PROTEIN
(Lactococcus
lactis) 		4 / 5 SER A 336
VAL A 374
SER A 332
SER A 375
 None
 1.27A 2j9cA-3l6gA:
undetectable
2j9cB-3l6gA:
undetectable
2j9cC-3l6gA:
undetectable		 2j9cA-3l6gA:
19.76
2j9cB-3l6gA:
19.76
2j9cC-3l6gA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J9C_A_ACTA1121_0
(HYPOTHETICAL
NITROGEN REGULATORY
PII-LIKE PROTEIN
MJ0059)		 3l6g BETAINE ABC
TRANSPORTER PERMEASE
AND SUBSTRATE
BINDING PROTEIN
(Lactococcus
lactis) 		4 / 5 SER A 375
SER A 336
VAL A 374
SER A 332
 None
 1.28A 2j9cA-3l6gA:
undetectable
2j9cB-3l6gA:
undetectable
2j9cC-3l6gA:
undetectable		 2j9cA-3l6gA:
19.76
2j9cB-3l6gA:
19.76
2j9cC-3l6gA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J9C_A_ACTA1122_0
(HYPOTHETICAL
NITROGEN REGULATORY
PII-LIKE PROTEIN
MJ0059)		 3l6g BETAINE ABC
TRANSPORTER PERMEASE
AND SUBSTRATE
BINDING PROTEIN
(Lactococcus
lactis) 		4 / 7 SER A 375
SER A 336
VAL A 374
SER A 332
 None
 1.28A 2j9cA-3l6gA:
undetectable
2j9cB-3l6gA:
undetectable
2j9cC-3l6gA:
undetectable		 2j9cA-3l6gA:
19.76
2j9cB-3l6gA:
19.76
2j9cC-3l6gA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DTU_C_DXCC576_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2)		 3l6g BETAINE ABC
TRANSPORTER PERMEASE
AND SUBSTRATE
BINDING PROTEIN
(Lactococcus
lactis) 		4 / 8 ALA A 472
ILE A 479
HIS A 487
THR A 430
 None
 0.75A 3dtuC-3l6gA:
undetectable
3dtuD-3l6gA:
undetectable		 3dtuC-3l6gA:
17.81
3dtuD-3l6gA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L8L_B_DVAB6_0
(GRAMICIDIN D)		 3l6g BETAINE ABC
TRANSPORTER PERMEASE
AND SUBSTRATE
BINDING PROTEIN
(Lactococcus
lactis) 		3 / 3 TRP A 484
ALA A 403
VAL A 405
 None
 1.02A 3l8lA-3l6gA:
undetectable
3l8lB-3l6gA:
undetectable		 3l8lA-3l6gA:
7.98
3l8lB-3l6gA:
5.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L8L_D_DVAD6_0
(GRAMICIDIN D)		 3l6g BETAINE ABC
TRANSPORTER PERMEASE
AND SUBSTRATE
BINDING PROTEIN
(Lactococcus
lactis) 		3 / 3 TRP A 484
ALA A 403
VAL A 405
 None
 0.99A 3l8lC-3l6gA:
undetectable
3l8lD-3l6gA:
undetectable		 3l8lC-3l6gA:
7.98
3l8lD-3l6gA:
5.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TI1_A_B49A299_1
(CYCLIN-DEPENDENT
KINASE 2)		 3l6g BETAINE ABC
TRANSPORTER PERMEASE
AND SUBSTRATE
BINDING PROTEIN
(Lactococcus
lactis) 		5 / 9 ILE A 429
VAL A 415
PHE A 407
LEU A 421
ASP A 478
 None
 1.28A 3ti1A-3l6gA:
undetectable		 3ti1A-3l6gA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BCC_A_EZLA302_1
(CARBONIC ANHYDRASE 2)		 3l6g BETAINE ABC
TRANSPORTER PERMEASE
AND SUBSTRATE
BINDING PROTEIN
(Lactococcus
lactis) 		5 / 12 VAL A 568
PHE A 572
VAL A 529
LEU A 340
TRP A 535
 None
 0.94A 6bccA-3l6gA:
undetectable		 6bccA-3l6gA:
19.74