SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3l6n'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IA0_B_TXLB502_1
(TUBULIN BETA CHAIN)		 3l6n METALLO-BETA-LACTAMA
SE
(Chryseobacterium
indologenes) 		5 / 12 VAL A 165
ASP A 175
LEU A 236
PRO A 218
GLY A 219
 None
 1.36A 1ia0B-3l6nA:
undetectable		 1ia0B-3l6nA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IBG_H_OBNH1_2
(IGG2B-KAPPA 40-50
FAB (HEAVY CHAIN)
IGG2B-KAPPA 40-50
FAB (LIGHT CHAIN))		 3l6n METALLO-BETA-LACTAMA
SE
(Chryseobacterium
indologenes) 		4 / 7 HIS A  85
ARG A  84
TYR A  38
LEU A  77
 None
 1.16A 1ibgL-3l6nA:
undetectable		 1ibgL-3l6nA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TUB_B_TXLB501_1
(TUBULIN)		 3l6n METALLO-BETA-LACTAMA
SE
(Chryseobacterium
indologenes) 		5 / 12 VAL A 165
ASP A 175
LEU A 236
PRO A 218
GLY A 219
 None
 1.36A 1tubB-3l6nA:
undetectable		 1tubB-3l6nA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_F_SAMF301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 3l6n METALLO-BETA-LACTAMA
SE
(Chryseobacterium
indologenes) 		3 / 3 LYS A 130
ASP A  66
CYH A 178
 None
None
ZN  A 302 (-2.0A)
 1.14A 2br4F-3l6nA:
undetectable		 2br4F-3l6nA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_H_CLMH221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3l6n METALLO-BETA-LACTAMA
SE
(Chryseobacterium
indologenes) 		5 / 12 LEU A  64
VAL A  67
PHE A 108
VAL A  89
PHE A  25
 None
 1.23A 3u9fH-3l6nA:
undetectable
3u9fI-3l6nA:
undetectable		 3u9fH-3l6nA:
20.43
3u9fI-3l6nA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_S_CLMS221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3l6n METALLO-BETA-LACTAMA
SE
(Chryseobacterium
indologenes) 		5 / 12 PHE A  25
LEU A  64
VAL A  67
PHE A 108
VAL A  89
 None
 1.12A 3u9fP-3l6nA:
undetectable
3u9fS-3l6nA:
undetectable		 3u9fP-3l6nA:
20.43
3u9fS-3l6nA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UQ6_A_ADNA401_1
(ADENOSINE KINASE,
PUTATIVE)		 3l6n METALLO-BETA-LACTAMA
SE
(Chryseobacterium
indologenes) 		5 / 12 ILE A 203
LEU A 236
GLY A 219
THR A 232
LEU A 188
 None
 1.03A 3uq6A-3l6nA:
undetectable		 3uq6A-3l6nA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VAQ_A_ADNA401_1
(PUTATIVE ADENOSINE
KINASE)		 3l6n METALLO-BETA-LACTAMA
SE
(Chryseobacterium
indologenes) 		5 / 12 ILE A 203
LEU A 236
GLY A 219
THR A 232
LEU A 188
 None
 1.00A 3vaqA-3l6nA:
undetectable		 3vaqA-3l6nA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_A_CHDA1504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3l6n METALLO-BETA-LACTAMA
SE
(Chryseobacterium
indologenes) 		4 / 4 PRO A  68
LEU A  77
ILE A  81
ARG A  84
 None
 1.36A 3w1wA-3l6nA:
undetectable		 3w1wA-3l6nA:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C1D_A_X8ZA350_1
(BETA-LACTAMASE CLASS
B VIM-2)		 3l6n METALLO-BETA-LACTAMA
SE
(Chryseobacterium
indologenes) 		7 / 9 TYR A  49
TRP A  69
HIS A  98
ASP A 100
HIS A 159
CYH A 178
HIS A 220
 None
None
ZN  A 301 (-3.1A)
ZN  A 302 (-2.5A)
ZN  A 301 (-3.2A)
ZN  A 302 (-2.0A)
ZN  A 302 (-3.6A)
 0.57A 4c1dA-3l6nA:
30.3		 4c1dA-3l6nA:
28.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C1D_B_X8ZB350_1
(BETA-LACTAMASE CLASS
B VIM-2)		 3l6n METALLO-BETA-LACTAMA
SE
(Chryseobacterium
indologenes) 		8 / 10 TYR A  49
TRP A  69
HIS A  96
HIS A  98
ASP A 100
HIS A 159
CYH A 178
HIS A 220
 None
None
ZN  A 301 (-3.3A)
ZN  A 301 (-3.1A)
ZN  A 302 (-2.5A)
ZN  A 301 (-3.2A)
ZN  A 302 (-2.0A)
ZN  A 302 (-3.6A)
 0.62A 4c1dB-3l6nA:
30.4		 4c1dB-3l6nA:
28.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4C1F_A_X8ZA300_1
(BETA-LACTAMASE IMP-1)		 3l6n METALLO-BETA-LACTAMA
SE
(Chryseobacterium
indologenes) 		6 / 11 HIS A  96
HIS A  98
ASP A 100
HIS A 159
CYH A 178
HIS A 220
 ZN  A 301 (-3.3A)
ZN  A 301 (-3.1A)
ZN  A 302 (-2.5A)
ZN  A 301 (-3.2A)
ZN  A 302 (-2.0A)
ZN  A 302 (-3.6A)
 0.60A 4c1fA-3l6nA:
29.4
4c1fB-3l6nA:
29.1		 4c1fA-3l6nA:
35.83
4c1fB-3l6nA:
35.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4C1H_A_X8ZA305_1
(BETA-LACTAMASE 2)		 3l6n METALLO-BETA-LACTAMA
SE
(Chryseobacterium
indologenes) 		6 / 9 HIS A  96
HIS A  98
ASP A 100
HIS A 159
CYH A 178
HIS A 220
 ZN  A 301 (-3.3A)
ZN  A 301 (-3.1A)
ZN  A 302 (-2.5A)
ZN  A 301 (-3.2A)
ZN  A 302 (-2.0A)
ZN  A 302 (-3.6A)
 0.43A 4c1hA-3l6nA:
32.8		 4c1hA-3l6nA:
36.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4C1H_A_X8ZA305_1
(BETA-LACTAMASE 2)		 3l6n METALLO-BETA-LACTAMA
SE
(Chryseobacterium
indologenes) 		6 / 9 HIS A  96
HIS A  98
ASP A 100
HIS A 159
GLY A 189
HIS A 220
 ZN  A 301 (-3.3A)
ZN  A 301 (-3.1A)
ZN  A 302 (-2.5A)
ZN  A 301 (-3.2A)
None
ZN  A 302 (-3.6A)
 0.55A 4c1hA-3l6nA:
32.8		 4c1hA-3l6nA:
36.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4C1H_A_X8ZA305_1
(BETA-LACTAMASE 2)		 3l6n METALLO-BETA-LACTAMA
SE
(Chryseobacterium
indologenes) 		5 / 9 TRP A  69
HIS A  96
ASP A 100
CYH A 178
HIS A 220
 None
ZN  A 301 (-3.3A)
ZN  A 302 (-2.5A)
ZN  A 302 (-2.0A)
ZN  A 302 (-3.6A)
 1.07A 4c1hA-3l6nA:
32.8		 4c1hA-3l6nA:
36.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C8B_B_0LIB1000_2
(RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2)		 3l6n METALLO-BETA-LACTAMA
SE
(Chryseobacterium
indologenes) 		3 / 3 TYR A  38
MET A  54
ILE A 216
 None
None
SO4  A 402 (-3.0A)
 0.68A 4c8bB-3l6nA:
undetectable		 4c8bB-3l6nA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EXS_A_X8ZA301_1
(BETA-LACTAMASE NDM-1)		 3l6n METALLO-BETA-LACTAMA
SE
(Chryseobacterium
indologenes) 		5 / 9 HIS A  98
ASP A 100
HIS A 159
CYH A 178
HIS A 220
 ZN  A 301 (-3.1A)
ZN  A 302 (-2.5A)
ZN  A 301 (-3.2A)
ZN  A 302 (-2.0A)
ZN  A 302 (-3.6A)
 0.40A 4exsA-3l6nA:
28.1		 4exsA-3l6nA:
24.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EXS_B_X8ZB301_1
(BETA-LACTAMASE NDM-1)		 3l6n METALLO-BETA-LACTAMA
SE
(Chryseobacterium
indologenes) 		5 / 8 HIS A  98
ASP A 100
HIS A 159
CYH A 178
HIS A 220
 ZN  A 301 (-3.1A)
ZN  A 302 (-2.5A)
ZN  A 301 (-3.2A)
ZN  A 302 (-2.0A)
ZN  A 302 (-3.6A)
 0.46A 4exsB-3l6nA:
28.0		 4exsB-3l6nA:
24.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YHA_B_MZMB303_1
(ALPHA-CARBONIC
ANHYDRASE)		 3l6n METALLO-BETA-LACTAMA
SE
(Chryseobacterium
indologenes) 		5 / 10 HIS A 228
VAL A 229
VAL A 180
LEU A 174
ALA A 213
 SO4  A 402 (-3.7A)
SO4  A 402 (-3.9A)
None
None
None
 1.45A 4yhaB-3l6nA:
undetectable		 4yhaB-3l6nA:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A5Z_A_WJZA304_0
(BETA-LACTAMASE NDM-1)		 3l6n METALLO-BETA-LACTAMA
SE
(Chryseobacterium
indologenes) 		5 / 8 HIS A  98
ASP A 100
HIS A 159
CYH A 178
HIS A 220
 ZN  A 301 (-3.1A)
ZN  A 302 (-2.5A)
ZN  A 301 (-3.2A)
ZN  A 302 (-2.0A)
ZN  A 302 (-3.6A)
 0.40A 5a5zA-3l6nA:
28.1		 5a5zA-3l6nA:
26.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A5Z_C_WJZC304_0
(BETA-LACTAMASE NDM-1)		 3l6n METALLO-BETA-LACTAMA
SE
(Chryseobacterium
indologenes) 		5 / 7 HIS A 159
CYH A 178
LYS A 181
GLY A 189
HIS A 220
 ZN  A 301 (-3.2A)
ZN  A 302 (-2.0A)
None
None
ZN  A 302 (-3.6A)
 0.88A 5a5zC-3l6nA:
28.1		 5a5zC-3l6nA:
26.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AYA_A_X8ZA307_1
(METALLO-BETA-LACTAMA
SE)		 3l6n METALLO-BETA-LACTAMA
SE
(Chryseobacterium
indologenes) 		5 / 11 HIS A  96
HIS A  98
ASP A 100
HIS A 159
HIS A 220
 ZN  A 301 (-3.3A)
ZN  A 301 (-3.1A)
ZN  A 302 (-2.5A)
ZN  A 301 (-3.2A)
ZN  A 302 (-3.6A)
 0.87A 5ayaA-3l6nA:
16.7		 5ayaA-3l6nA:
25.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FPD_A_PZAA1385_0
(HEAT SHOCK-RELATED
70KDA PROTEIN 2)		 3l6n METALLO-BETA-LACTAMA
SE
(Chryseobacterium
indologenes) 		4 / 7 VAL A  92
ALA A  94
GLY A 103
VAL A  67
 None
 0.89A 5fpdA-3l6nA:
undetectable		 5fpdA-3l6nA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FPD_B_PZAB1385_0
(HEAT SHOCK-RELATED
70KDA PROTEIN 2)		 3l6n METALLO-BETA-LACTAMA
SE
(Chryseobacterium
indologenes) 		4 / 7 VAL A  92
ALA A  94
GLY A 103
VAL A  67
 None
 0.89A 5fpdB-3l6nA:
undetectable		 5fpdB-3l6nA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZJ8_A_9DCA303_0
(METALLO-BETA-LACTAMA
SE TYPE 2)		 3l6n METALLO-BETA-LACTAMA
SE
(Chryseobacterium
indologenes) 		5 / 8 HIS A  98
ASP A 100
HIS A 159
CYH A 178
HIS A 220
 ZN  A 301 (-3.1A)
ZN  A 302 (-2.5A)
ZN  A 301 (-3.2A)
ZN  A 302 (-2.0A)
ZN  A 302 (-3.6A)
 0.47A 5zj8A-3l6nA:
28.4		 5zj8A-3l6nA:
26.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZJ8_A_9DCA303_0
(METALLO-BETA-LACTAMA
SE TYPE 2)		 3l6n METALLO-BETA-LACTAMA
SE
(Chryseobacterium
indologenes) 		5 / 8 TRP A  69
ASP A 100
HIS A 159
CYH A 178
HIS A 220
 None
ZN  A 302 (-2.5A)
ZN  A 301 (-3.2A)
ZN  A 302 (-2.0A)
ZN  A 302 (-3.6A)
 1.16A 5zj8A-3l6nA:
28.4		 5zj8A-3l6nA:
26.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DH0_A_017A101_2
(PROTEASE)		 3l6n METALLO-BETA-LACTAMA
SE
(Chryseobacterium
indologenes) 		3 / 3 LEU A 233
ASP A 187
ILE A 191
 None
 0.64A 6dh0B-3l6nA:
undetectable		 6dh0B-3l6nA:
17.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_E_AM2E301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 3l6n METALLO-BETA-LACTAMA
SE
(Chryseobacterium
indologenes) 		4 / 7 THR A 115
ARG A 101
HIS A 159
ASP A  66
 None
ZN  A 302 (-4.4A)
ZN  A 301 (-3.2A)
None
 1.10A 6mn4E-3l6nA:
undetectable		 6mn4E-3l6nA:
19.56