SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3l6u'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DL9_A_V2HA602_1
(CYTOCHROME P450 2R1)		 3l6u ABC-TYPE SUGAR
TRANSPORT SYSTEM
PERIPLASMIC
COMPONENT
(Exiguobacterium
sibiricum) 		4 / 5 ALA A 244
LEU A 234
GLY A 229
THR A 276
 None
 0.84A 3dl9A-3l6uA:
undetectable		 3dl9A-3l6uA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UGR_A_IMNA2001_2
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 3l6u ABC-TYPE SUGAR
TRANSPORT SYSTEM
PERIPLASMIC
COMPONENT
(Exiguobacterium
sibiricum) 		4 / 7 TYR A 200
GLU A 152
TYR A 148
TYR A 275
 None
 1.16A 3ugrA-3l6uA:
undetectable		 3ugrA-3l6uA:
25.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZT_A_SAMA1472_0
(METHYLTRANSFERASE
WBDD)		 3l6u ABC-TYPE SUGAR
TRANSPORT SYSTEM
PERIPLASMIC
COMPONENT
(Exiguobacterium
sibiricum) 		5 / 12 GLY A  12
ALA A  41
ILE A  68
VAL A  65
ILE A  90
 None
 1.11A 4aztA-3l6uA:
2.6		 4aztA-3l6uA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YHA_B_MZMB303_1
(ALPHA-CARBONIC
ANHYDRASE)		 3l6u ABC-TYPE SUGAR
TRANSPORT SYSTEM
PERIPLASMIC
COMPONENT
(Exiguobacterium
sibiricum) 		5 / 10 ASP A 171
VAL A 139
VAL A 199
LEU A 214
ALA A 213
 None
 1.12A 4yhaB-3l6uA:
undetectable		 4yhaB-3l6uA:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_A_P06A801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 3l6u ABC-TYPE SUGAR
TRANSPORT SYSTEM
PERIPLASMIC
COMPONENT
(Exiguobacterium
sibiricum) 		4 / 7 GLY A  89
PHE A 258
PHE A  13
ASP A  66
 None
 0.78A 5hieA-3l6uA:
undetectable		 5hieA-3l6uA:
22.77