SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3l6y'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1B2I_A_AMHA84_1
(PROTEIN
(PLASMINOGEN))		 3l6y CATENIN DELTA-1
(Homo
sapiens) 		4 / 7 TYR A 650
GLU A 593
PHE A 654
ARG A 599
 None
 1.26A 1b2iA-3l6yA:
undetectable		 1b2iA-3l6yA:
8.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I18_B_RBFB99_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 3l6y CATENIN DELTA-1
(Homo
sapiens) 		5 / 10 THR A 498
LEU A 527
THR A 469
ILE A 472
THR A 473
 None
 1.24A 1i18A-3l6yA:
undetectable
1i18B-3l6yA:
undetectable		 1i18A-3l6yA:
11.93
1i18B-3l6yA:
11.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CC8_A_RBFA1067_1
(VNG1446H)		 3l6y CATENIN DELTA-1
(Homo
sapiens) 		3 / 3 PHE A 654
VAL A 590
TRP A 690
 None
 0.69A 2cc8A-3l6yA:
undetectable		 2cc8A-3l6yA:
8.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CCB_A_RBFA1067_1
(VNG1446H)		 3l6y CATENIN DELTA-1
(Homo
sapiens) 		3 / 3 PHE A 654
VAL A 590
TRP A 690
 None
 0.67A 2ccbA-3l6yA:
undetectable		 2ccbA-3l6yA:
8.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CD2_A_FOLA307_0
(DIHYDROFOLATE
REDUCTASE)		 3l6y CATENIN DELTA-1
(Homo
sapiens) 		5 / 12 ILE A 503
LEU A 494
THR A 530
LEU A 558
ILE A 502
 None
 1.01A 2cd2A-3l6yA:
undetectable		 2cd2A-3l6yA:
16.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DQY_A_CHDA1_0
(LIVER
CARBOXYLESTERASE 1)		 3l6y CATENIN DELTA-1
(Homo
sapiens) 		4 / 5 TRP A 477
GLY A 438
LYS A 444
LEU A 479
 None
 1.41A 2dqyA-3l6yA:
undetectable		 2dqyA-3l6yA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q63_A_1UNA1001_2
(PROTEASE RETROPEPSIN)		 3l6y CATENIN DELTA-1
(Homo
sapiens) 		3 / 3 ARG A 729
ASN A 715
THR A 768
 None
 0.87A 2q63A-3l6yA:
undetectable		 2q63A-3l6yA:
9.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VX9_A_RBFA1064_1
(DODECIN)		 3l6y CATENIN DELTA-1
(Homo
sapiens) 		3 / 3 PHE A 654
VAL A 590
TRP A 690
 None
 0.69A 2vx9A-3l6yA:
undetectable		 2vx9A-3l6yA:
8.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YFB_B_ACTB501_0
(METHYL-ACCEPTING
CHEMOTAXIS
TRANSDUCER)		 3l6y CATENIN DELTA-1
(Homo
sapiens) 		4 / 6 ASP A 440
VAL A 404
ARG A 405
ILE A 410
 None
 1.21A 2yfbB-3l6yA:
undetectable		 2yfbB-3l6yA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D9L_A_ACTA501_0
(CTD-PEPTIDE
RNA-BINDING PROTEIN
16)		 3l6y CATENIN DELTA-1
(Homo
sapiens) 		4 / 5 PRO A 656
ILE A 696
TYR A 692
TYR A 695
 None
 1.32A 3d9lA-3l6yA:
2.8
3d9lY-3l6yA:
undetectable		 3d9lA-3l6yA:
13.30
3d9lY-3l6yA:
1.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_C_SAMC6735_0
(16S RRNA METHYLASE)		 3l6y CATENIN DELTA-1
(Homo
sapiens) 		5 / 12 GLY A 474
ASN A 529
ALA A 463
LEU A 432
LEU A 468
 None
 1.04A 3p2kC-3l6yA:
undetectable		 3p2kC-3l6yA:
17.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SO9_A_017A100_2
(HIV-1 PROTEASE)		 3l6y CATENIN DELTA-1
(Homo
sapiens) 		5 / 12 LEU A 527
ASP A 465
ASP A 467
THR A 530
VAL A 526
 None
 0.96A 3so9B-3l6yA:
undetectable		 3so9B-3l6yA:
12.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GBO_B_CUB301_0
(E7)		 3l6y CATENIN DELTA-1
(Homo
sapiens) 		4 / 5 ALA A 687
HIS A 591
GLN A 589
TYR A 588
 None
 1.36A 4gboB-3l6yA:
undetectable		 4gboB-3l6yA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L1W_A_STRA402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 3l6y CATENIN DELTA-1
(Homo
sapiens) 		4 / 7 VAL A 562
ILE A 561
LEU A 548
LEU A 554
 None
 0.88A 4l1wA-3l6yA:
undetectable		 4l1wA-3l6yA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MK4_A_CHDA503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3l6y CATENIN DELTA-1
(Homo
sapiens) 		5 / 10 LEU A 479
LEU A 476
LEU A 460
ILE A 485
THR A 498
 None
 1.35A 4mk4A-3l6yA:
undetectable		 4mk4A-3l6yA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_D_AERD601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 3l6y CATENIN DELTA-1
(Homo
sapiens) 		4 / 5 GLY A 553
ASP A 556
GLU A 550
VAL A 590
 None
 1.15A 4nkvD-3l6yA:
undetectable		 4nkvD-3l6yA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1Z_A_MXMA807_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 3l6y CATENIN DELTA-1
(Homo
sapiens) 		5 / 12 LEU A 666
ILE A 682
GLY A 680
ALA A 681
LEU A 583
 None
 0.98A 4o1zA-3l6yA:
0.9		 4o1zA-3l6yA:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XO7_A_ASDA402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 3l6y CATENIN DELTA-1
(Homo
sapiens) 		4 / 7 VAL A 562
ILE A 561
LEU A 548
LEU A 554
 None
 1.00A 4xo7A-3l6yA:
undetectable		 4xo7A-3l6yA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I1N_F_DVAF9_0
(D-VILLIN HEADPIECE
SUBDOMAIN
VILLIN-1)		 3l6y CATENIN DELTA-1
(Homo
sapiens) 		3 / 3 ALA A 727
ASN A 730
LEU A 731
 None
 0.45A 5i1nC-3l6yA:
undetectable		 5i1nC-3l6yA:
4.99