SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3l76'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DY4_A_SNPA437_1
(EXOGLUCANASE 1)		 3l76 ASPARTOKINASE
(Synechocystis
sp.
PCC
6803) 		5 / 12 ALA A 405
TYR A 266
ASP A 267
GLN A 270
THR A 317
 None
 1.30A 1dy4A-3l76A:
undetectable		 1dy4A-3l76A:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U70_A_MTXA187_2
(DIHYDROFOLATE
REDUCTASE)		 3l76 ASPARTOKINASE
(Synechocystis
sp.
PCC
6803) 		4 / 4 SER A 569
ILE A 568
VAL A 435
THR A 198
 None
LYS  A 603 (-4.5A)
None
None
 1.21A 1u70A-3l76A:
undetectable		 1u70A-3l76A:
16.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOX_A_THAA400_1
(HISTAMINE
N-METHYLTRANSFERASE)		 3l76 ASPARTOKINASE
(Synechocystis
sp.
PCC
6803) 		4 / 8 PHE A 376
PHE A 463
GLN A 478
TRP A 516
 None
None
THR  A 602 (-2.5A)
None
 1.46A 2aoxA-3l76A:
3.1		 2aoxA-3l76A:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOX_B_THAB401_1
(HISTAMINE
N-METHYLTRANSFERASE)		 3l76 ASPARTOKINASE
(Synechocystis
sp.
PCC
6803) 		4 / 7 PHE A 376
PHE A 463
GLN A 478
TRP A 516
 None
None
THR  A 602 (-2.5A)
None
 1.46A 2aoxB-3l76A:
3.6		 2aoxB-3l76A:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DTJ_A_THRA401_0
(ASPARTOKINASE)		 3l76 ASPARTOKINASE
(Synechocystis
sp.
PCC
6803) 		6 / 8 ASP A 280
GLY A 283
ALA A 285
GLN A 304
ASN A 557
ILE A 558
 THR  A 601 (-4.0A)
THR  A 601 (-4.1A)
THR  A 601 (-3.6A)
THR  A 601 (-2.6A)
THR  A 601 (-3.1A)
THR  A 601 (-3.7A)
 0.32A 2dtjA-3l76A:
21.4
2dtjB-3l76A:
21.3		 2dtjA-3l76A:
14.33
2dtjB-3l76A:
14.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DTJ_A_THRA401_0
(ASPARTOKINASE)		 3l76 ASPARTOKINASE
(Synechocystis
sp.
PCC
6803) 		6 / 8 ASP A 454
GLY A 457
ALA A 459
GLN A 478
ASN A 385
ILE A 386
 THR  A 602 (-3.7A)
THR  A 602 (-4.0A)
THR  A 602 (-3.8A)
THR  A 602 (-2.5A)
THR  A 602 (-3.0A)
THR  A 602 (-3.7A)
 0.24A 2dtjA-3l76A:
21.4
2dtjB-3l76A:
21.3		 2dtjA-3l76A:
14.33
2dtjB-3l76A:
14.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DTJ_B_THRB402_0
(ASPARTOKINASE)		 3l76 ASPARTOKINASE
(Synechocystis
sp.
PCC
6803) 		6 / 9 ASN A 385
ILE A 386
ASP A 454
GLY A 457
ALA A 459
GLN A 478
 THR  A 602 (-3.0A)
THR  A 602 (-3.7A)
THR  A 602 (-3.7A)
THR  A 602 (-4.0A)
THR  A 602 (-3.8A)
THR  A 602 (-2.5A)
 0.23A 2dtjA-3l76A:
21.4
2dtjB-3l76A:
21.3		 2dtjA-3l76A:
14.33
2dtjB-3l76A:
14.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DTJ_B_THRB402_0
(ASPARTOKINASE)		 3l76 ASPARTOKINASE
(Synechocystis
sp.
PCC
6803) 		6 / 9 ASN A 557
ILE A 558
ASP A 280
GLY A 283
ALA A 285
GLN A 304
 THR  A 601 (-3.1A)
THR  A 601 (-3.7A)
THR  A 601 (-4.0A)
THR  A 601 (-4.1A)
THR  A 601 (-3.6A)
THR  A 601 (-2.6A)
 0.28A 2dtjA-3l76A:
21.4
2dtjB-3l76A:
21.3		 2dtjA-3l76A:
14.33
2dtjB-3l76A:
14.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DTJ_B_THRB402_0
(ASPARTOKINASE)		 3l76 ASPARTOKINASE
(Synechocystis
sp.
PCC
6803) 		6 / 9 ASN A 557
ILE A 558
ILE A 314
GLY A 283
ALA A 285
GLN A 304
 THR  A 601 (-3.1A)
THR  A 601 (-3.7A)
None
THR  A 601 (-4.1A)
THR  A 601 (-3.6A)
THR  A 601 (-2.6A)
 1.46A 2dtjA-3l76A:
21.4
2dtjB-3l76A:
21.3		 2dtjA-3l76A:
14.33
2dtjB-3l76A:
14.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EGV_A_SAMA1300_0
(UPF0088 PROTEIN
AQ_165)		 3l76 ASPARTOKINASE
(Synechocystis
sp.
PCC
6803) 		5 / 12 LEU A 379
VAL A 384
GLY A 383
LEU A 412
ALA A 408
 None
 0.87A 2egvA-3l76A:
2.9		 2egvA-3l76A:
15.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EGV_B_SAMB1400_0
(UPF0088 PROTEIN
AQ_165)		 3l76 ASPARTOKINASE
(Synechocystis
sp.
PCC
6803) 		5 / 12 LEU A 379
VAL A 384
GLY A 383
LEU A 412
ALA A 408
 None
 0.91A 2egvB-3l76A:
3.2		 2egvB-3l76A:
15.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G72_B_SAMB2002_0
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 3l76 ASPARTOKINASE
(Synechocystis
sp.
PCC
6803) 		5 / 12 LEU A 193
ILE A 197
VAL A 242
ALA A 210
VAL A 230
 None
 1.04A 2g72B-3l76A:
undetectable		 2g72B-3l76A:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_A_SNLA1001_2
(MINERALOCORTICOID
RECEPTOR)		 3l76 ASPARTOKINASE
(Synechocystis
sp.
PCC
6803) 		4 / 5 LEU A 590
ALA A 191
LEU A 181
MET A 202
 None
 0.93A 2oaxA-3l76A:
undetectable		 2oaxA-3l76A:
17.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V3K_A_SAMA1254_0
(ESSENTIAL FOR
MITOTIC GROWTH 1)		 3l76 ASPARTOKINASE
(Synechocystis
sp.
PCC
6803) 		5 / 10 LEU A 379
VAL A 384
GLY A 383
LEU A 412
ALA A 408
 None
 0.96A 2v3kA-3l76A:
undetectable		 2v3kA-3l76A:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_L_ASDL1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 3l76 ASPARTOKINASE
(Synechocystis
sp.
PCC
6803) 		4 / 7 PHE A 547
LEU A 581
ALA A 584
PHE A 588
 None
 0.44A 2vcvL-3l76A:
undetectable		 2vcvL-3l76A:
17.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WX2_B_TPFB1460_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 3l76 ASPARTOKINASE
(Synechocystis
sp.
PCC
6803) 		4 / 8 ALA A 165
ALA A 161
THR A 157
LEU A 150
 None
 1.02A 2wx2B-3l76A:
undetectable		 2wx2B-3l76A:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A2Q_A_ACAA601_1
(6-AMINOHEXANOATE-CYC
LIC-DIMER HYDROLASE)		 3l76 ASPARTOKINASE
(Synechocystis
sp.
PCC
6803) 		4 / 7 ALA A 584
ALA A 587
VAL A 530
ILE A 558
 None
None
None
THR  A 601 (-3.7A)
 0.68A 3a2qA-3l76A:
undetectable		 3a2qA-3l76A:
24.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CFL_A_5CHA693_1
(LACTOTRANSFERRIN)		 3l76 ASPARTOKINASE
(Synechocystis
sp.
PCC
6803) 		4 / 4 THR A 149
VAL A  39
GLY A  10
THR A  11
 None
 0.93A 3cflA-3l76A:
undetectable		 3cflA-3l76A:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HRD_B_NIOB5661_1
(NICOTINATE
DEHYDROGENASE LARGE
MOLYBDOPTERIN
SUBUNIT
NICOTINATE
DEHYDROGENASE MEDIUM
MOLYBDOPTERIN
SUBUNIT)		 3l76 ASPARTOKINASE
(Synechocystis
sp.
PCC
6803) 		4 / 8 ILE A 493
ALA A 459
PHE A 376
ALA A 372
 None
THR  A 602 (-3.8A)
None
LYS  A 604 (-3.8A)
 0.86A 3hrdA-3l76A:
undetectable
3hrdB-3l76A:
undetectable		 3hrdA-3l76A:
23.20
3hrdB-3l76A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KHM_A_TPFA501_1
(STEROL 14
ALPHA-DEMETHYLASE)		 3l76 ASPARTOKINASE
(Synechocystis
sp.
PCC
6803) 		4 / 8 ALA A 165
ALA A 161
THR A 157
LEU A 150
 None
 0.95A 3khmA-3l76A:
undetectable		 3khmA-3l76A:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L4D_D_TPFD490_1
(STEROL 14-ALPHA
DEMETHYLASE)		 3l76 ASPARTOKINASE
(Synechocystis
sp.
PCC
6803) 		4 / 8 ALA A 165
ALA A 161
THR A 157
LEU A 150
 None
 1.02A 3l4dD-3l76A:
undetectable		 3l4dD-3l76A:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NU9_A_478A401_2
(PROTEASE)		 3l76 ASPARTOKINASE
(Synechocystis
sp.
PCC
6803) 		5 / 10 LEU A  95
GLY A 101
VAL A  39
VAL A 131
VAL A 133
 None
 0.85A 3nu9B-3l76A:
undetectable		 3nu9B-3l76A:
10.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O02_B_JN3B1_1
(CELL INVASION
PROTEIN SIPD)		 3l76 ASPARTOKINASE
(Synechocystis
sp.
PCC
6803) 		5 / 10 ILE A 349
PHE A 289
ALA A 326
LEU A 323
VAL A 318
 None
 1.16A 3o02A-3l76A:
undetectable
3o02B-3l76A:
undetectable		 3o02A-3l76A:
20.27
3o02B-3l76A:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3S_D_9PLD1_1
(CYTOCHROME P450 2A13)		 3l76 ASPARTOKINASE
(Synechocystis
sp.
PCC
6803) 		4 / 8 ALA A 587
PHE A 588
PHE A 548
ALA A 549
 None
 0.80A 3t3sD-3l76A:
undetectable		 3t3sD-3l76A:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UR0_B_SVRB516_1
(RNA-DEPENDENT RNA
POLYMERASE)		 3l76 ASPARTOKINASE
(Synechocystis
sp.
PCC
6803) 		4 / 7 PRO A 369
GLY A 367
ALA A 498
ASP A 501
 LYS  A 604 ( 4.7A)
LYS  A 604 ( 4.5A)
None
None
 0.87A 3ur0B-3l76A:
2.1		 3ur0B-3l76A:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FE1_B_PQNB840_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 3l76 ASPARTOKINASE
(Synechocystis
sp.
PCC
6803) 		5 / 9 SER A  94
ILE A  19
ALA A  84
LEU A  85
ALA A  92
 None
 1.41A 4fe1B-3l76A:
0.0		 4fe1B-3l76A:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKL_B_SUZB201_1
(TRANSTHYRETIN)		 3l76 ASPARTOKINASE
(Synechocystis
sp.
PCC
6803) 		4 / 8 SER A 392
SER A 390
ALA A 361
SER A 397
 None
 0.84A 4iklA-3l76A:
undetectable
4iklB-3l76A:
undetectable		 4iklA-3l76A:
12.84
4iklB-3l76A:
12.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L1W_B_STRB402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 3l76 ASPARTOKINASE
(Synechocystis
sp.
PCC
6803) 		4 / 6 VAL A  40
VAL A  13
ILE A  19
LEU A  85
 None
 0.93A 4l1wB-3l76A:
undetectable		 4l1wB-3l76A:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PEV_C_ADNC501_1
(MEMBRANE LIPOPROTEIN
FAMILY PROTEIN)		 3l76 ASPARTOKINASE
(Synechocystis
sp.
PCC
6803) 		5 / 12 VAL A 103
ASP A 119
LEU A 162
PHE A 136
GLY A 135
 None
 1.04A 4pevC-3l76A:
3.9		 4pevC-3l76A:
24.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z2E_H_TR6H101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
SYMMETRIZED E-SITE
DNA)		 3l76 ASPARTOKINASE
(Synechocystis
sp.
PCC
6803) 		3 / 5 GLY A 362
GLY A 263
GLU A 265
 None
 0.31A 4z2eA-3l76A:
4.0
4z2eD-3l76A:
2.2		 4z2eA-3l76A:
21.97
4z2eD-3l76A:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ENT_C_MIYC901_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT
ACRB,MULTIDRUG
EFFLUX PUMP SUBUNIT
ACRB)		 3l76 ASPARTOKINASE
(Synechocystis
sp.
PCC
6803) 		5 / 9 SER A 207
SER A 564
GLU A 204
ILE A 532
ALA A 544
 None
None
None
None
LYS  A 603 (-3.9A)
 1.41A 5entC-3l76A:
5.8		 5entC-3l76A:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_A_P06A801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 3l76 ASPARTOKINASE
(Synechocystis
sp.
PCC
6803) 		4 / 7 ILE A 366
GLY A 364
PHE A 376
PHE A 495
 None
 0.90A 5hieA-3l76A:
undetectable		 5hieA-3l76A:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KOC_A_SAMA401_0
(PAVINE
N-METHYLTRANSFERASE)		 3l76 ASPARTOKINASE
(Synechocystis
sp.
PCC
6803) 		5 / 12 GLY A 154
VAL A 133
VAL A 160
ALA A 161
LEU A 162
 None
 1.00A 5kocA-3l76A:
2.9		 5kocA-3l76A:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N5D_B_SAMB303_1
(METHYLTRANSFERASE)		 3l76 ASPARTOKINASE
(Synechocystis
sp.
PCC
6803) 		4 / 7 GLY A 153
SER A  41
ARG A 368
ASP A 156
 None
 1.05A 5n5dB-3l76A:
undetectable		 5n5dB-3l76A:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UMW_F_RBFF201_1
(GLYOXALASE/BLEOMYCIN
RESISANCE
PROTEIN/DIOXYGENASE)		 3l76 ASPARTOKINASE
(Synechocystis
sp.
PCC
6803) 		4 / 7 LEU A 203
ARG A 222
GLU A 265
SER A 421
 None
 1.28A 5umwA-3l76A:
undetectable
5umwF-3l76A:
undetectable		 5umwA-3l76A:
8.65
5umwF-3l76A:
8.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DH0_A_017A101_0
(PROTEASE)		 3l76 ASPARTOKINASE
(Synechocystis
sp.
PCC
6803) 		5 / 12 LEU A  95
GLY A 101
VAL A  39
VAL A 131
VAL A 133
 None
 0.93A 6dh0A-3l76A:
undetectable		 6dh0A-3l76A:
9.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA826_0
(GEPHYRIN)		 3l76 ASPARTOKINASE
(Synechocystis
sp.
PCC
6803) 		3 / 3 HIS A 307
ARG A 450
ILE A 306
 None
 0.74A 6fgdA-3l76A:
undetectable		 6fgdA-3l76A:
22.98