SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3l77'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E3V_A_DXCA801_0
(STEROID
DELTA-ISOMERASE)		 3l77 SHORT-CHAIN ALCOHOL
DEHYDROGENASE
(Thermococcus
sibiricus) 		5 / 12 PHE A  92
TYR A 150
GLY A 186
VAL A 181
ASP A 138
 PG4  A 241 (-3.6A)
GOL  A 246 ( 4.4A)
PG4  A 241 ( 3.9A)
NJP  A 501 (-3.9A)
GOL  A 246 ( 2.4A)
 1.49A 1e3vA-3l77A:
undetectable		 1e3vA-3l77A:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDU_D_ESTD352_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE)		 3l77 SHORT-CHAIN ALCOHOL
DEHYDROGENASE
(Thermococcus
sibiricus) 		4 / 6 SER A 152
GLY A 149
LEU A  98
GLU A 101
 None
 0.97A 1fduD-3l77A:
27.0		 1fduD-3l77A:
27.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1G5Y_B_9CRB501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3l77 SHORT-CHAIN ALCOHOL
DEHYDROGENASE
(Thermococcus
sibiricus) 		5 / 12 ALA A   9
LEU A  45
LEU A  21
ALA A  20
ILE A   6
 None
 1.27A 1g5yB-3l77A:
undetectable		 1g5yB-3l77A:
24.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PCG_B_ESTB2_1
(ESTROGEN RECEPTOR)		 3l77 SHORT-CHAIN ALCOHOL
DEHYDROGENASE
(Thermococcus
sibiricus) 		5 / 10 LEU A 212
ALA A 207
GLU A 206
ARG A  23
LEU A 176
 GOL  A 248 (-4.6A)
None
None
None
None
 1.39A 1pcgB-3l77A:
undetectable		 1pcgB-3l77A:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_E_SAME301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 3l77 SHORT-CHAIN ALCOHOL
DEHYDROGENASE
(Thermococcus
sibiricus) 		5 / 12 GLY A   8
ARG A  33
ASP A  59
ASN A  86
ALA A  87
 NJP  A 501 (-3.3A)
NJP  A 501 (-3.5A)
NJP  A 501 (-3.6A)
NJP  A 501 (-3.3A)
NJP  A 501 (-3.5A)
 0.99A 2bm9E-3l77A:
5.9		 2bm9E-3l77A:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_C_SAMC301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 3l77 SHORT-CHAIN ALCOHOL
DEHYDROGENASE
(Thermococcus
sibiricus) 		5 / 12 GLY A   8
ARG A  33
ASP A  59
SER A  61
ALA A  87
 NJP  A 501 (-3.3A)
NJP  A 501 (-3.5A)
NJP  A 501 (-3.6A)
PG4  A 245 ( 4.1A)
NJP  A 501 (-3.5A)
 0.85A 2br4C-3l77A:
6.0		 2br4C-3l77A:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OCF_A_ESTA596_1
(ESTROGEN RECEPTOR)		 3l77 SHORT-CHAIN ALCOHOL
DEHYDROGENASE
(Thermococcus
sibiricus) 		5 / 10 LEU A 212
ALA A 207
GLU A 206
ARG A  23
LEU A 176
 GOL  A 248 (-4.6A)
None
None
None
None
 1.42A 2ocfA-3l77A:
undetectable		 2ocfA-3l77A:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_A_D2VA602_1
(CYTOCHROME P450 2R1)		 3l77 SHORT-CHAIN ALCOHOL
DEHYDROGENASE
(Thermococcus
sibiricus) 		5 / 12 PHE A 173
VAL A 134
ALA A  85
VAL A 171
THR A 136
 None
 1.10A 3czhA-3l77A:
undetectable		 3czhA-3l77A:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DL9_A_V2HA602_0
(CYTOCHROME P450 2R1)		 3l77 SHORT-CHAIN ALCOHOL
DEHYDROGENASE
(Thermococcus
sibiricus) 		5 / 12 PHE A 173
VAL A 134
ALA A  85
VAL A 171
THR A 136
 None
 1.08A 3dl9A-3l77A:
undetectable		 3dl9A-3l77A:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DMF_A_SAMA388_0
(PROBABLE RIBOSOMAL
RNA SMALL SUBUNIT
METHYLTRANSFERASE)		 3l77 SHORT-CHAIN ALCOHOL
DEHYDROGENASE
(Thermococcus
sibiricus) 		5 / 12 GLY A   8
ALA A  16
ASP A  59
VAL A  60
VAL A 109
 NJP  A 501 (-3.3A)
None
NJP  A 501 (-3.6A)
NJP  A 501 (-3.6A)
NJP  A 501 (-4.6A)
 0.96A 3dmfA-3l77A:
6.3		 3dmfA-3l77A:
25.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H52_B_486B1_2
(GLUCOCORTICOID
RECEPTOR)		 3l77 SHORT-CHAIN ALCOHOL
DEHYDROGENASE
(Thermococcus
sibiricus) 		5 / 12 GLY A 149
GLY A 148
VAL A 151
LEU A  89
ILE A 144
 None
None
None
None
GOL  A 246 (-4.5A)
 1.25A 3h52B-3l77A:
undetectable		 3h52B-3l77A:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_A_SAMA300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 3l77 SHORT-CHAIN ALCOHOL
DEHYDROGENASE
(Thermococcus
sibiricus) 		5 / 12 LEU A  38
ALA A  18
GLY A  14
SER A  10
LEU A  45
 None
None
None
NJP  A 501 (-2.7A)
None
 1.22A 3ou7A-3l77A:
5.5		 3ou7A-3l77A:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_D_SAMD300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 3l77 SHORT-CHAIN ALCOHOL
DEHYDROGENASE
(Thermococcus
sibiricus) 		5 / 12 LEU A  38
ALA A  18
GLY A  14
SER A  10
LEU A  45
 None
None
None
NJP  A 501 (-2.7A)
None
 1.26A 3ou7D-3l77A:
5.4		 3ou7D-3l77A:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WSJ_A_MK1A201_1
(PROTEASE)		 3l77 SHORT-CHAIN ALCOHOL
DEHYDROGENASE
(Thermococcus
sibiricus) 		5 / 9 LEU A  30
ALA A   4
VAL A  84
LEU A 133
ILE A   6
 None
 1.27A 3wsjA-3l77A:
undetectable		 3wsjA-3l77A:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOS_B_0LIB1000_2
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 3l77 SHORT-CHAIN ALCOHOL
DEHYDROGENASE
(Thermococcus
sibiricus) 		5 / 9 LEU A  89
ILE A  41
LEU A  30
ILE A   6
ILE A  17
 None
 1.20A 3zosB-3l77A:
undetectable		 3zosB-3l77A:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGK_A_0TXA302_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 3l77 SHORT-CHAIN ALCOHOL
DEHYDROGENASE
(Thermococcus
sibiricus) 		4 / 7 GLY A 148
GLY A 149
MET A 106
ASN A 110
 None
None
None
NJP  A 501 ( 4.8A)
 1.06A 4fgkB-3l77A:
7.0		 4fgkB-3l77A:
25.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM4_B_8PRB603_1
(TRANSPORTER)		 3l77 SHORT-CHAIN ALCOHOL
DEHYDROGENASE
(Thermococcus
sibiricus) 		5 / 12 VAL A  83
ALA A 132
VAL A 134
PHE A  69
PHE A 121
 None
 1.07A 4mm4B-3l77A:
undetectable		 4mm4B-3l77A:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DXE_B_ESTB1000_1
(ESTROGEN RECEPTOR)		 3l77 SHORT-CHAIN ALCOHOL
DEHYDROGENASE
(Thermococcus
sibiricus) 		5 / 10 LEU A 212
ALA A 207
GLU A 206
ARG A  23
LEU A 176
 GOL  A 248 (-4.6A)
None
None
None
None
 1.43A 5dxeB-3l77A:
undetectable		 5dxeB-3l77A:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HYR_A_ESTA601_1
(ESTROGEN RECEPTOR)		 3l77 SHORT-CHAIN ALCOHOL
DEHYDROGENASE
(Thermococcus
sibiricus) 		5 / 10 LEU A 212
ALA A 207
GLU A 206
ARG A  23
LEU A 176
 GOL  A 248 (-4.6A)
None
None
None
None
 1.44A 5hyrA-3l77A:
undetectable		 5hyrA-3l77A:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJE_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 1)		 3l77 SHORT-CHAIN ALCOHOL
DEHYDROGENASE
(Thermococcus
sibiricus) 		5 / 12 LEU A  28
LEU A  45
ALA A  22
ARG A  19
LEU A 133
 None
 1.05A 5ljeA-3l77A:
undetectable		 5ljeA-3l77A:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_B_TA1B501_2
(TUBULIN BETA CHAIN)		 3l77 SHORT-CHAIN ALCOHOL
DEHYDROGENASE
(Thermococcus
sibiricus) 		4 / 5 LEU A  89
THR A   7
PRO A 178
ARG A 177
 None
None
NJP  A 501 (-4.7A)
PG4  A 251 (-3.3A)
 1.21A 6ew0B-3l77A:
undetectable		 6ew0B-3l77A:
15.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_D_TA1D501_2
(TUBULIN BETA CHAIN)		 3l77 SHORT-CHAIN ALCOHOL
DEHYDROGENASE
(Thermococcus
sibiricus) 		4 / 5 LEU A  89
THR A   7
PRO A 178
ARG A 177
 None
None
NJP  A 501 (-4.7A)
PG4  A 251 (-3.3A)
 1.21A 6ew0D-3l77A:
undetectable		 6ew0D-3l77A:
15.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_H_TA1H501_2
(TUBULIN BETA CHAIN)		 3l77 SHORT-CHAIN ALCOHOL
DEHYDROGENASE
(Thermococcus
sibiricus) 		4 / 5 LEU A  89
THR A   7
PRO A 178
ARG A 177
 None
None
NJP  A 501 (-4.7A)
PG4  A 251 (-3.3A)
 1.21A 6ew0H-3l77A:
undetectable		 6ew0H-3l77A:
15.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_I_TA1I501_2
(TUBULIN BETA CHAIN)		 3l77 SHORT-CHAIN ALCOHOL
DEHYDROGENASE
(Thermococcus
sibiricus) 		4 / 5 LEU A  89
THR A   7
PRO A 178
ARG A 177
 None
None
NJP  A 501 (-4.7A)
PG4  A 251 (-3.3A)
 1.20A 6ew0I-3l77A:
undetectable		 6ew0I-3l77A:
15.52