SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3l7f'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7W_A_MTXA301_1
(PTERIDINE REDUCTASE)		 3l7f H2L6 HEAVY CHAIN
(Homo
sapiens) 		5 / 12 ARG H  68
PRO H  43
LEU H  20
LEU H  18
ASP H  91
 None
 1.44A 1e7wA-3l7fH:
undetectable		 1e7wA-3l7fH:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HUO_A_PNNA302_0
(CTX-M-9
EXTENDED-SPECTRUM
BETA-LACTAMASE)		 3l7f H2L6 HEAVY CHAIN
(Homo
sapiens) 		4 / 6 LEU H 197
GLY H 198
ALA H 133
PRO H 134
 None
 0.50A 3huoA-3l7fH:
undetectable		 3huoA-3l7fH:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BXN_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 3l7f H2L6 HEAVY CHAIN
(Homo
sapiens) 		5 / 11 SER H 196
GLY H 142
THR H 143
ALA H 144
THR H 139
 None
 0.88A 5bxnH-3l7fH:
undetectable
5bxnI-3l7fH:
undetectable		 5bxnH-3l7fH:
20.16
5bxnI-3l7fH:
22.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5MTH_A_ACTA302_0
(ANTIBODY FAB HEAVY
CHAIN)		 3l7f H2L6 HEAVY CHAIN
(Homo
sapiens) 		4 / 5 SER H 120
ALA H 122
PHE H 154
LEU H 178
 None
 0.30A 5mthA-3l7fH:
27.2		 5mthA-3l7fH:
49.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HWD_H_BO2H301_0
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 3l7f H2L6 HEAVY CHAIN
(Homo
sapiens) 		5 / 12 SER H 196
GLY H 142
THR H 143
ALA H 144
THR H 139
 None
 0.97A 6hwdH-3l7fH:
undetectable
6hwdI-3l7fH:
undetectable		 6hwdH-3l7fH:
19.29
6hwdI-3l7fH:
17.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HWD_V_BO2V301_0
(PROTEASOME SUBUNIT
BETA TYPE-2)		 3l7f H2L6 HEAVY CHAIN
(Homo
sapiens) 		5 / 11 SER H 196
GLY H 142
THR H 143
ALA H 144
THR H 139
 None
 0.97A 6hwdV-3l7fH:
undetectable		 6hwdV-3l7fH:
19.29