SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3l7g'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FKF_A_FK5A108_1
(FK506 BINDING
PROTEIN)		 3l7g XAA-PRO DIPEPTIDASE
(Alteromonas
sp.) 		5 / 11 PHE A  56
VAL A  62
TYR A   8
HIS A  11
PHE A 104
 None
 1.23A 1fkfA-3l7gA:
undetectable		 1fkfA-3l7gA:
13.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FKJ_A_FK5A108_1
(FK506 BINDING
PROTEIN)		 3l7g XAA-PRO DIPEPTIDASE
(Alteromonas
sp.) 		5 / 11 PHE A  56
VAL A  62
TYR A   8
HIS A  11
PHE A 104
 None
 1.26A 1fkjA-3l7gA:
undetectable		 1fkjA-3l7gA:
13.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TCO_C_FK5C509_2
(FK506-BINDING
PROTEIN)		 3l7g XAA-PRO DIPEPTIDASE
(Alteromonas
sp.) 		5 / 11 PHE A  56
VAL A  62
TYR A   8
HIS A  11
PHE A 104
 None
 1.37A 1tcoC-3l7gA:
undetectable		 1tcoC-3l7gA:
13.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWH_A_BAXA1723_2
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 3l7g XAA-PRO DIPEPTIDASE
(Alteromonas
sp.) 		4 / 6 ILE A  63
VAL A  52
VAL A 149
ILE A  22
 None
 0.70A 1uwhA-3l7gA:
undetectable		 1uwhA-3l7gA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F80_B_017B301_1
(POL POLYPROTEIN)		 3l7g XAA-PRO DIPEPTIDASE
(Alteromonas
sp.) 		5 / 12 LEU A 391
GLY A 415
ALA A 223
GLY A 383
ILE A 387
 None
 0.96A 2f80A-3l7gA:
undetectable		 2f80A-3l7gA:
10.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8G_B_017B401_1
(POL POLYPROTEIN)		 3l7g XAA-PRO DIPEPTIDASE
(Alteromonas
sp.) 		5 / 12 LEU A 391
GLY A 415
ALA A 223
GLY A 383
ILE A 387
 None
 0.99A 2f8gA-3l7gA:
undetectable		 2f8gA-3l7gA:
10.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FKE_A_FK5A108_1
(FK506 BINDING
PROTEIN)		 3l7g XAA-PRO DIPEPTIDASE
(Alteromonas
sp.) 		5 / 11 PHE A  56
VAL A  62
TYR A   8
HIS A  11
PHE A 104
 None
 1.27A 2fkeA-3l7gA:
undetectable		 2fkeA-3l7gA:
13.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HS2_A_017A201_2
(PROTEASE)		 3l7g XAA-PRO DIPEPTIDASE
(Alteromonas
sp.) 		5 / 12 LEU A 391
GLY A 415
ALA A 223
GLY A 383
ILE A 387
 None
 0.99A 2hs2B-3l7gA:
undetectable		 2hs2B-3l7gA:
10.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGZ_D_COCD401_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 3l7g XAA-PRO DIPEPTIDASE
(Alteromonas
sp.) 		4 / 6 TYR A  99
TYR A 103
GLN A  16
ILE A  12
 None
 1.31A 2pgzD-3l7gA:
undetectable
2pgzE-3l7gA:
undetectable		 2pgzD-3l7gA:
18.38
2pgzE-3l7gA:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZD1_A_T27A557_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 3l7g XAA-PRO DIPEPTIDASE
(Alteromonas
sp.) 		5 / 12 PRO A  54
LEU A 340
LYS A 160
TYR A 153
TYR A 252
 None
 1.19A 2zd1A-3l7gA:
0.0		 2zd1A-3l7gA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOY_A_HISA1001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 3l7g XAA-PRO DIPEPTIDASE
(Alteromonas
sp.) 		5 / 10 ILE A 256
ALA A 247
HIS A 179
TYR A 199
TYR A 212
 None
None
None
None
M44  A 518 (-3.6A)
 1.47A 3boyA-3l7gA:
1.9
3boyC-3l7gA:
undetectable		 3boyA-3l7gA:
17.48
3boyC-3l7gA:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOY_A_HISA2001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 3l7g XAA-PRO DIPEPTIDASE
(Alteromonas
sp.) 		5 / 10 TYR A 199
TYR A 212
ILE A 256
ALA A 247
HIS A 179
 None
M44  A 518 (-3.6A)
None
None
None
 1.47A 3boyA-3l7gA:
1.9
3boyB-3l7gA:
undetectable		 3boyA-3l7gA:
17.48
3boyB-3l7gA:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOY_A_HISA3001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 3l7g XAA-PRO DIPEPTIDASE
(Alteromonas
sp.) 		5 / 10 TYR A 199
TYR A 212
ILE A 256
ALA A 247
HIS A 179
 None
M44  A 518 (-3.6A)
None
None
None
 1.45A 3boyB-3l7gA:
undetectable
3boyC-3l7gA:
undetectable		 3boyB-3l7gA:
17.48
3boyC-3l7gA:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BRF_A_SORA2_0
(LIN-12 AND GLP-1
PHENOTYPE PROTEIN 1,
ISOFORM A)		 3l7g XAA-PRO DIPEPTIDASE
(Alteromonas
sp.) 		3 / 3 LYS A  57
LYS A  51
VAL A  52
 None
 1.11A 3brfA-3l7gA:
undetectable		 3brfA-3l7gA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CR5_X_PNTX94_0
(PROTEIN S100-B)		 3l7g XAA-PRO DIPEPTIDASE
(Alteromonas
sp.) 		3 / 3 PHE A  82
CYH A  68
PHE A  56
 None
 1.03A 3cr5X-3l7gA:
undetectable		 3cr5X-3l7gA:
11.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D1Z_B_017B201_2
(HIV-1 PROTEASE)		 3l7g XAA-PRO DIPEPTIDASE
(Alteromonas
sp.) 		5 / 12 LEU A 391
GLY A 415
ALA A 223
GLY A 383
ILE A 387
 None
 1.06A 3d1zB-3l7gA:
undetectable		 3d1zB-3l7gA:
9.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D20_A_017A201_1
(HIV-1 PROTEASE)		 3l7g XAA-PRO DIPEPTIDASE
(Alteromonas
sp.) 		5 / 12 LEU A 391
GLY A 415
ALA A 223
GLY A 383
ILE A 387
 None
 1.01A 3d20A-3l7gA:
undetectable		 3d20A-3l7gA:
10.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKT_D_017D200_2
(PROTEASE)		 3l7g XAA-PRO DIPEPTIDASE
(Alteromonas
sp.) 		5 / 11 LEU A 391
GLY A 415
ALA A 223
GLY A 383
ILE A 387
 None
 1.06A 3ektD-3l7gA:
undetectable		 3ektD-3l7gA:
11.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL1_A_DR7A100_1
(PROTEASE)		 3l7g XAA-PRO DIPEPTIDASE
(Alteromonas
sp.) 		5 / 11 LEU A 391
GLY A 415
ALA A 223
GLY A 383
ILE A 387
 None
 1.01A 3el1A-3l7gA:
undetectable		 3el1A-3l7gA:
10.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JVY_B_017B401_1
(GAG-POL POLYPROTEIN)		 3l7g XAA-PRO DIPEPTIDASE
(Alteromonas
sp.) 		5 / 12 LEU A 391
GLY A 415
ALA A 223
GLY A 383
ILE A 387
 None
 0.93A 3jvyA-3l7gA:
undetectable		 3jvyA-3l7gA:
9.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_B_TFPB202_1
(PROTEIN S100-A4)		 3l7g XAA-PRO DIPEPTIDASE
(Alteromonas
sp.) 		3 / 3 GLU A 294
LEU A 297
ASP A 298
 None
 0.36A 3ko0A-3l7gA:
undetectable		 3ko0A-3l7gA:
11.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_S_TFPS202_2
(PROTEIN S100-A4)		 3l7g XAA-PRO DIPEPTIDASE
(Alteromonas
sp.) 		3 / 3 GLU A 294
LEU A 297
ASP A 298
 None
 0.33A 3ko0T-3l7gA:
undetectable		 3ko0T-3l7gA:
11.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_B_SALB3004_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 3l7g XAA-PRO DIPEPTIDASE
(Alteromonas
sp.) 		4 / 5 ILE A  70
PHE A 104
ASP A 105
GLU A 107
 None
None
MN  A 522 (-2.5A)
MN  A 522 (-2.6A)
 1.18A 3kp6A-3l7gA:
undetectable
3kp6B-3l7gA:
undetectable		 3kp6A-3l7gA:
14.89
3kp6B-3l7gA:
14.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_B_SALB3007_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 3l7g XAA-PRO DIPEPTIDASE
(Alteromonas
sp.) 		5 / 9 THR A 203
ALA A 202
LEU A 200
ALA A 198
ASN A 214
 None
 1.29A 3kp6B-3l7gA:
0.6		 3kp6B-3l7gA:
14.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MWS_B_017B201_1
(HIV-1 PROTEASE)		 3l7g XAA-PRO DIPEPTIDASE
(Alteromonas
sp.) 		5 / 12 LEU A 391
GLY A 415
ALA A 223
GLY A 383
ILE A 387
 None
 0.98A 3mwsA-3l7gA:
undetectable		 3mwsA-3l7gA:
11.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NU3_B_478B401_1
(PROTEASE)		 3l7g XAA-PRO DIPEPTIDASE
(Alteromonas
sp.) 		5 / 12 LEU A 391
GLY A 415
ALA A 223
GLY A 383
ILE A 387
 None
 0.90A 3nu3A-3l7gA:
undetectable		 3nu3A-3l7gA:
10.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXX_A_DR7A100_1
(HIV-1 PROTEASE)		 3l7g XAA-PRO DIPEPTIDASE
(Alteromonas
sp.) 		5 / 12 LEU A 391
GLY A 415
ALA A 223
GLY A 383
ILE A 387
 None
 1.01A 3oxxA-3l7gA:
undetectable		 3oxxA-3l7gA:
10.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXX_C_DR7C100_1
(HIV-1 PROTEASE)		 3l7g XAA-PRO DIPEPTIDASE
(Alteromonas
sp.) 		5 / 12 LEU A 391
GLY A 415
ALA A 223
GLY A 383
ILE A 387
 None
 0.91A 3oxxC-3l7gA:
undetectable		 3oxxC-3l7gA:
10.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PWM_B_017B402_1
(PROTEASE)		 3l7g XAA-PRO DIPEPTIDASE
(Alteromonas
sp.) 		5 / 12 LEU A 391
GLY A 415
ALA A 223
GLY A 383
ILE A 387
 None
 0.93A 3pwmA-3l7gA:
undetectable		 3pwmA-3l7gA:
11.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QF1_A_PZEA6951_1
(LACTOPEROXIDASE)		 3l7g XAA-PRO DIPEPTIDASE
(Alteromonas
sp.) 		3 / 3 HIS A 156
ARG A  18
GLU A  21
 None
 1.00A 3qf1A-3l7gA:
undetectable		 3qf1A-3l7gA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RLB_A_VIBA191_1
(THIT)		 3l7g XAA-PRO DIPEPTIDASE
(Alteromonas
sp.) 		5 / 10 GLU A 381
TYR A 212
HIS A 336
GLY A 339
VAL A 377
 MN  A 519 ( 2.7A)
M44  A 518 (-3.6A)
MN  A 519 (-3.3A)
None
None
 1.30A 3rlbA-3l7gA:
0.0		 3rlbA-3l7gA:
14.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RLB_B_VIBB187_1
(THIT)		 3l7g XAA-PRO DIPEPTIDASE
(Alteromonas
sp.) 		5 / 12 GLU A 381
TYR A 212
HIS A 336
GLY A 339
VAL A 377
 MN  A 519 ( 2.7A)
M44  A 518 (-3.6A)
MN  A 519 (-3.3A)
None
None
 1.30A 3rlbB-3l7gA:
undetectable		 3rlbB-3l7gA:
14.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_D_RTZD2_1
(CYTOCHROME P450 2D6)		 3l7g XAA-PRO DIPEPTIDASE
(Alteromonas
sp.) 		5 / 9 PHE A 386
LEU A 271
THR A 274
GLU A 270
ILE A 312
 None
 1.12A 3tbgD-3l7gA:
undetectable		 3tbgD-3l7gA:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CEV_A_GAIA407_0
(PROTEIN (ARGINASE))		 3l7g XAA-PRO DIPEPTIDASE
(Alteromonas
sp.) 		4 / 6 ARG A 302
HIS A 300
LEU A 334
ASP A 298
 None
 1.32A 4cevA-3l7gA:
undetectable
4cevB-3l7gA:
undetectable		 4cevA-3l7gA:
21.99
4cevB-3l7gA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CEV_C_GAIC409_0
(PROTEIN (ARGINASE))		 3l7g XAA-PRO DIPEPTIDASE
(Alteromonas
sp.) 		4 / 6 ASP A 298
ARG A 302
HIS A 300
LEU A 334
 None
 1.33A 4cevA-3l7gA:
undetectable
4cevC-3l7gA:
undetectable		 4cevA-3l7gA:
21.99
4cevC-3l7gA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G1Q_A_T27A601_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 3l7g XAA-PRO DIPEPTIDASE
(Alteromonas
sp.) 		5 / 12 PRO A  54
LEU A 340
LYS A 160
TYR A 153
TYR A 252
 None
 1.19A 4g1qA-3l7gA:
0.6		 4g1qA-3l7gA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HLA_A_017A200_2
(PROTEASE)		 3l7g XAA-PRO DIPEPTIDASE
(Alteromonas
sp.) 		5 / 11 LEU A 391
GLY A 415
ALA A 223
GLY A 383
ILE A 387
 None
 1.00A 4hlaB-3l7gA:
undetectable		 4hlaB-3l7gA:
10.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ICL_A_T27A601_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 3l7g XAA-PRO DIPEPTIDASE
(Alteromonas
sp.) 		5 / 12 PRO A  54
LEU A 340
LYS A 160
TYR A 153
TYR A 252
 None
 1.19A 4iclA-3l7gA:
0.1		 4iclA-3l7gA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ID5_A_T27A601_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 3l7g XAA-PRO DIPEPTIDASE
(Alteromonas
sp.) 		5 / 12 PRO A  54
LEU A 340
LYS A 160
TYR A 153
TYR A 252
 None
 1.18A 4id5A-3l7gA:
undetectable		 4id5A-3l7gA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IDK_A_T27A601_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 3l7g XAA-PRO DIPEPTIDASE
(Alteromonas
sp.) 		5 / 12 PRO A  54
LEU A 340
LYS A 160
TYR A 153
TYR A 252
 None
 1.20A 4idkA-3l7gA:
0.4		 4idkA-3l7gA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IFV_A_T27A601_1
(EXORIBONUCLEASE H,
P66 RT)		 3l7g XAA-PRO DIPEPTIDASE
(Alteromonas
sp.) 		5 / 12 PRO A  54
LEU A 340
LYS A 160
TYR A 153
TYR A 252
 None
 1.20A 4ifvA-3l7gA:
undetectable		 4ifvA-3l7gA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IFY_A_T27A601_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 3l7g XAA-PRO DIPEPTIDASE
(Alteromonas
sp.) 		5 / 12 PRO A  54
LEU A 340
LYS A 160
TYR A 153
TYR A 252
 None
 1.19A 4ifyA-3l7gA:
undetectable		 4ifyA-3l7gA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IG3_A_T27A601_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 3l7g XAA-PRO DIPEPTIDASE
(Alteromonas
sp.) 		5 / 12 PRO A  54
LEU A 340
LYS A 160
TYR A 153
TYR A 252
 None
 1.18A 4ig3A-3l7gA:
undetectable		 4ig3A-3l7gA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JEC_B_478B401_2
(HIV-1 PROTEASE)		 3l7g XAA-PRO DIPEPTIDASE
(Alteromonas
sp.) 		5 / 12 LEU A 391
GLY A 415
ALA A 223
GLY A 383
ILE A 387
 None
 0.93A 4jecB-3l7gA:
undetectable		 4jecB-3l7gA:
10.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KFB_A_T27A607_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H,
EXORIBONUCLEA P66 RT)		 3l7g XAA-PRO DIPEPTIDASE
(Alteromonas
sp.) 		5 / 12 PRO A  54
LEU A 340
LYS A 160
TYR A 153
TYR A 252
 None
 1.20A 4kfbA-3l7gA:
1.6		 4kfbA-3l7gA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M11_C_MXMC606_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3l7g XAA-PRO DIPEPTIDASE
(Alteromonas
sp.) 		3 / 3 LEU A 242
ARG A 258
MET A 433
 None
 0.71A 4m11C-3l7gA:
undetectable		 4m11C-3l7gA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4S0V_A_SUVA2001_2
(HUMAN OREXIN
RECEPTOR TYPE 2
FUSION PROTEIN TO P.
ABYSII GLYCOGEN
SYNTHASE)		 3l7g XAA-PRO DIPEPTIDASE
(Alteromonas
sp.) 		4 / 5 ILE A 423
HIS A 332
TYR A 212
VAL A 342
 None
M44  A 518 (-3.7A)
M44  A 518 (-3.6A)
None
 1.36A 4s0vA-3l7gA:
undetectable		 4s0vA-3l7gA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XT8_A_TMQA302_1
(RV2671)		 3l7g XAA-PRO DIPEPTIDASE
(Alteromonas
sp.) 		5 / 12 ILE A 256
GLY A 246
ALA A 254
GLU A 381
THR A 434
 None
None
None
MN  A 519 ( 2.7A)
None
 1.30A 4xt8A-3l7gA:
undetectable		 4xt8A-3l7gA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BYJ_A_OQRA302_0
(SULFOTRANSFERASE)		 3l7g XAA-PRO DIPEPTIDASE
(Alteromonas
sp.) 		5 / 12 PHE A 386
VAL A 272
THR A 259
LEU A 307
THR A 306
 None
 1.20A 5byjA-3l7gA:
undetectable		 5byjA-3l7gA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CYM_A_T27A601_1
(HIV-1 REVERSE
TRANSCRIPTASE, P66
SUBUNIT)		 3l7g XAA-PRO DIPEPTIDASE
(Alteromonas
sp.) 		5 / 12 PRO A  54
LEU A 340
LYS A 160
TYR A 153
TYR A 252
 None
 1.21A 5cymA-3l7gA:
undetectable		 5cymA-3l7gA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CYQ_A_T27A601_1
(HIV-1 REVERSE
TRANSCRIPTASE, P66
SUBUNIT)		 3l7g XAA-PRO DIPEPTIDASE
(Alteromonas
sp.) 		5 / 12 PRO A  54
LEU A 340
LYS A 160
TYR A 153
TYR A 252
 None
 1.24A 5cyqA-3l7gA:
undetectable		 5cyqA-3l7gA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EYP_B_LOCB502_2
(TUBULIN BETA CHAIN)		 3l7g XAA-PRO DIPEPTIDASE
(Alteromonas
sp.) 		5 / 12 LEU A 200
ALA A 202
ILE A 195
ALA A 185
ILE A 243
 None
 1.05A 5eypB-3l7gA:
undetectable		 5eypB-3l7gA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HJI_A_ADNA401_1
(TRNA
(GUANINE(37)-N1)-MET
HYLTRANSFERASE TRM5A)		 3l7g XAA-PRO DIPEPTIDASE
(Alteromonas
sp.) 		5 / 11 TYR A  83
ARG A  84
ASP A  64
VAL A  62
PRO A  96
 None
 1.23A 5hjiA-3l7gA:
undetectable		 5hjiA-3l7gA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCY_A_DB8A401_2
(MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE)		 3l7g XAA-PRO DIPEPTIDASE
(Alteromonas
sp.) 		4 / 4 VAL A  52
LEU A 340
ASN A  65
ASP A  64
 None
 1.25A 5vcyA-3l7gA:
undetectable		 5vcyA-3l7gA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WM2_A_ACTA605_0
(SALICYLATE-AMP
LIGASE)		 3l7g XAA-PRO DIPEPTIDASE
(Alteromonas
sp.) 		3 / 3 THR A 161
THR A  14
ARG A  18
 None
 0.92A 5wm2A-3l7gA:
undetectable		 5wm2A-3l7gA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z6J_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 3l7g XAA-PRO DIPEPTIDASE
(Alteromonas
sp.) 		3 / 3 MET A 168
ASP A 344
ARG A  18
 None
 1.21A 5z6jA-3l7gA:
undetectable		 5z6jA-3l7gA:
15.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z6K_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 3l7g XAA-PRO DIPEPTIDASE
(Alteromonas
sp.) 		3 / 3 MET A 168
ASP A 344
ARG A  18
 None
 1.00A 5z6kA-3l7gA:
undetectable		 5z6kA-3l7gA:
15.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DH3_A_017A101_1
(PROTEASE)		 3l7g XAA-PRO DIPEPTIDASE
(Alteromonas
sp.) 		5 / 12 LEU A 391
GLY A 415
ALA A 223
GLY A 383
ILE A 387
 None
 0.97A 6dh3B-3l7gA:
undetectable		 6dh3B-3l7gA:
9.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DH6_A_017A104_1
(PROTEASE)		 3l7g XAA-PRO DIPEPTIDASE
(Alteromonas
sp.) 		5 / 12 LEU A 391
GLY A 415
ALA A 223
GLY A 383
ILE A 387
 None
 1.00A 6dh6B-3l7gA:
undetectable		 6dh6B-3l7gA:
10.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ELI_A_T27A701_1
(REVERSE
TRANSCRIPTASE)		 3l7g XAA-PRO DIPEPTIDASE
(Alteromonas
sp.) 		5 / 12 PRO A  54
LEU A 340
LYS A 160
TYR A 153
TYR A 252
 None
 1.19A 6eliA-3l7gA:
undetectable		 6eliA-3l7gA:
9.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G1P_B_ACTB403_0
(ADP-RIBOSYLHYDROLASE
LIKE 2)		 3l7g XAA-PRO DIPEPTIDASE
(Alteromonas
sp.) 		3 / 3 PHE A 230
ARG A 232
GLN A 197
 None
 0.93A 6g1pB-3l7gA:
undetectable		 6g1pB-3l7gA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G2P_A_TRPA502_0
(FLAVIN-DEPENDENT
L-TRYPTOPHAN OXIDASE
VIOA)		 3l7g XAA-PRO DIPEPTIDASE
(Alteromonas
sp.) 		4 / 7 TYR A 128
HIS A  34
LEU A 119
VAL A 115
 None
 1.18A 6g2pA-3l7gA:
undetectable		 6g2pA-3l7gA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMP_C_CHDC307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3l7g XAA-PRO DIPEPTIDASE
(Alteromonas
sp.) 		4 / 6 LYS A 190
GLN A 188
PHE A 187
LEU A 218
 None
 1.28A 6nmpC-3l7gA:
undetectable
6nmpJ-3l7gA:
undetectable		 6nmpC-3l7gA:
17.41
6nmpJ-3l7gA:
7.92