SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3l7n'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UPF_B_URFB999_1
(URACIL
PHOSPHORIBOSYLTRANSF
ERASE)		 3l7n PUTATIVE
UNCHARACTERIZED
PROTEIN
(Streptococcus
mutans) 		5 / 7 ALA A 153
TYR A 174
ILE A 167
ILE A 166
ASP A 127
 None
 1.49A 1upfB-3l7nA:
undetectable		 1upfB-3l7nA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOH_C_FRDC305_2
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 3l7n PUTATIVE
UNCHARACTERIZED
PROTEIN
(Streptococcus
mutans) 		4 / 5 LEU A  49
GLY A  98
ALA A  80
ILE A  87
 None
 0.74A 2aohB-3l7nA:
undetectable		 2aohB-3l7nA:
16.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NMZ_B_ROCB401_1
(PROTEASE)		 3l7n PUTATIVE
UNCHARACTERIZED
PROTEIN
(Streptococcus
mutans) 		5 / 12 LEU A  49
GLY A  89
GLY A  98
ALA A  80
ILE A  87
 None
 0.81A 2nmzA-3l7nA:
undetectable		 2nmzA-3l7nA:
16.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD5_B_CHDB1104_0
(FERROCHELATASE)		 3l7n PUTATIVE
UNCHARACTERIZED
PROTEIN
(Streptococcus
mutans) 		3 / 3 LEU A  39
PRO A  40
LEU A  76
 None
 0.36A 2qd5B-3l7nA:
undetectable		 2qd5B-3l7nA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B9L_A_AZZA1009_1
(SERUM ALBUMIN)		 3l7n PUTATIVE
UNCHARACTERIZED
PROTEIN
(Streptococcus
mutans) 		4 / 8 GLU A 112
SER A 159
GLN A 165
CYH A  91
 None
 1.13A 3b9lA-3l7nA:
undetectable		 3b9lA-3l7nA:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3l7n PUTATIVE
UNCHARACTERIZED
PROTEIN
(Streptococcus
mutans) 		3 / 3 LEU A  39
PRO A  40
LEU A  76
 None
 0.38A 3w1wB-3l7nA:
undetectable		 3w1wB-3l7nA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L8F_B_MTXB301_1
(GAMMA-GLUTAMYL
HYDROLASE)		 3l7n PUTATIVE
UNCHARACTERIZED
PROTEIN
(Streptococcus
mutans) 		6 / 11 PHE A  65
GLY A  53
GLY A  54
LEU A  92
HIS A 143
HIS A 179
 None
 1.00A 4l8fB-3l7nA:
15.9		 4l8fB-3l7nA:
23.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L8F_D_MTXD301_1
(GAMMA-GLUTAMYL
HYDROLASE)		 3l7n PUTATIVE
UNCHARACTERIZED
PROTEIN
(Streptococcus
mutans) 		6 / 11 PHE A  65
GLY A  53
GLY A  54
LEU A  92
HIS A 143
HIS A 179
 None
 0.97A 4l8fD-3l7nA:
15.9		 4l8fD-3l7nA:
23.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HGC_A_HCYA501_1
(SERPIN)		 3l7n PUTATIVE
UNCHARACTERIZED
PROTEIN
(Streptococcus
mutans) 		5 / 12 VAL A  90
ALA A 175
PHE A 133
ILE A 166
GLN A 165
 None
 1.30A 5hgcA-3l7nA:
undetectable		 5hgcA-3l7nA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J4N_B_AG2B501_1
(ARGININE/AGMATINE
ANTIPORTER)		 3l7n PUTATIVE
UNCHARACTERIZED
PROTEIN
(Streptococcus
mutans) 		4 / 6 ILE A  86
GLY A  93
MET A  97
ILE A  50
 None
 0.91A 5j4nB-3l7nA:
undetectable		 5j4nB-3l7nA:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U63_B_ACTB405_0
(THIOREDOXIN
REDUCTASE)		 3l7n PUTATIVE
UNCHARACTERIZED
PROTEIN
(Streptococcus
mutans) 		3 / 3 GLY A  54
LEU A  92
HIS A   8
 None
 0.68A 5u63B-3l7nA:
undetectable		 5u63B-3l7nA:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ECT_A_SAMA1300_0
(STIE PROTEIN)		 3l7n PUTATIVE
UNCHARACTERIZED
PROTEIN
(Streptococcus
mutans) 		5 / 12 GLY A 140
ILE A 113
VAL A 187
LEU A 190
ILE A 191
 None
 0.65A 6ectA-3l7nA:
undetectable		 6ectA-3l7nA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ECX_A_SAMA1301_0
(STIE PROTEIN)		 3l7n PUTATIVE
UNCHARACTERIZED
PROTEIN
(Streptococcus
mutans) 		5 / 12 GLY A 140
ILE A 113
VAL A 187
LEU A 190
ILE A 191
 None
 0.62A 6ecxA-3l7nA:
2.3		 6ecxA-3l7nA:
21.18