SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3l7o'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BDW_B_DVAB6_0
(GRAMICIDIN A)		 3l7o RIBOSE-5-PHOSPHATE
ISOMERASE A
(Streptococcus
mutans) 		3 / 3 TRP A 116
ALA A  30
VAL A 118
 None
 0.93A 1bdwA-3l7oA:
undetectable
1bdwB-3l7oA:
undetectable		 1bdwA-3l7oA:
6.43
1bdwB-3l7oA:
6.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NT6_A_DVAA6_0
(GRAMICIDIN C)		 3l7o RIBOSE-5-PHOSPHATE
ISOMERASE A
(Streptococcus
mutans) 		3 / 3 ALA A 223
VAL A 210
TRP A 116
 None
 0.84A 1nt6A-3l7oA:
undetectable		 1nt6A-3l7oA:
6.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NT6_B_DVAB6_0
(GRAMICIDIN C)		 3l7o RIBOSE-5-PHOSPHATE
ISOMERASE A
(Streptococcus
mutans) 		3 / 3 ALA A 223
VAL A 210
TRP A 116
 None
 0.84A 1nt6B-3l7oA:
undetectable		 1nt6B-3l7oA:
6.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TKQ_B_DVAB8_0
(GRAMICIDIN A)		 3l7o RIBOSE-5-PHOSPHATE
ISOMERASE A
(Streptococcus
mutans) 		4 / 5 VAL A  22
GLY A  23
VAL A  79
TRP A 116
 None
 1.25A 1tkqB-3l7oA:
undetectable		 1tkqB-3l7oA:
6.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQ7_C_DX2C270_1
(PTERIDINE REDUCTASE
1)		 3l7o RIBOSE-5-PHOSPHATE
ISOMERASE A
(Streptococcus
mutans) 		4 / 8 PHE A 157
VAL A 134
LEU A 176
PRO A 155
 None
 1.03A 3jq7C-3l7oA:
2.4		 3jq7C-3l7oA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K13_A_THHA642_0
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		 3l7o RIBOSE-5-PHOSPHATE
ISOMERASE A
(Streptococcus
mutans) 		5 / 12 GLU A 104
GLY A  98
VAL A 197
GLY A 201
PHE A 130
 None
 1.17A 3k13A-3l7oA:
undetectable		 3k13A-3l7oA:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7T_A_5FWA1000_1
(SUPEROXIDE DISMUTASE
[CU-ZN])		 3l7o RIBOSE-5-PHOSPHATE
ISOMERASE A
(Streptococcus
mutans) 		4 / 6 GLU A 147
PRO A 155
LYS A 150
GLU A 149
 None
 1.18A 4a7tA-3l7oA:
undetectable		 4a7tA-3l7oA:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7T_F_5FWF1001_1
(SUPEROXIDE DISMUTASE
[CU-ZN])		 3l7o RIBOSE-5-PHOSPHATE
ISOMERASE A
(Streptococcus
mutans) 		4 / 6 GLU A 147
PRO A 155
LYS A 150
GLU A 149
 None
 1.21A 4a7tF-3l7oA:
undetectable		 4a7tF-3l7oA:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7U_A_ALEA1001_1
(SUPEROXIDE DISMUTASE
[CU-ZN])		 3l7o RIBOSE-5-PHOSPHATE
ISOMERASE A
(Streptococcus
mutans) 		4 / 6 GLU A 147
PRO A 155
LYS A 150
GLU A 149
 None
 1.18A 4a7uA-3l7oA:
undetectable		 4a7uA-3l7oA:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EYR_B_RITB301_2
(HIV-1 PROTEASE)		 3l7o RIBOSE-5-PHOSPHATE
ISOMERASE A
(Streptococcus
mutans) 		4 / 8 ARG A 209
GLY A  83
ALA A  84
ASP A  85
 None
 0.69A 4eyrB-3l7oA:
undetectable		 4eyrB-3l7oA:
15.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DBY_A_ACTA610_0
(SERUM ALBUMIN)		 3l7o RIBOSE-5-PHOSPHATE
ISOMERASE A
(Streptococcus
mutans) 		3 / 3 TYR A  32
LYS A   2
LYS A   5
 None
 0.95A 5dbyA-3l7oA:
undetectable		 5dbyA-3l7oA:
16.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_B_SAMB301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 3l7o RIBOSE-5-PHOSPHATE
ISOMERASE A
(Streptococcus
mutans) 		5 / 12 PRO A 133
PHE A 130
GLY A 128
SER A 180
THR A 126
 None
 1.24A 5hfjB-3l7oA:
undetectable		 5hfjB-3l7oA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_B_CVIB301_1
(REGULATORY PROTEIN
TETR)		 3l7o RIBOSE-5-PHOSPHATE
ISOMERASE A
(Streptococcus
mutans) 		4 / 8 GLY A 201
ARG A 158
ASP A 175
ASP A  85
 None
 0.93A 5vlmB-3l7oA:
undetectable		 5vlmB-3l7oA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X24_A_LSNA502_1
(CYTOCHROME P450 2C9)		 3l7o RIBOSE-5-PHOSPHATE
ISOMERASE A
(Streptococcus
mutans) 		5 / 12 ALA A 223
VAL A 210
VAL A  87
ASP A  88
GLY A  93
 None
 0.98A 5x24A-3l7oA:
undetectable		 5x24A-3l7oA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AK3_A_P2EA1201_0
(PROSTAGLANDIN E2
RECEPTOR EP3
SUBTYPE,SOLUBLE
CYTOCHROME B562)		 3l7o RIBOSE-5-PHOSPHATE
ISOMERASE A
(Streptococcus
mutans) 		5 / 12 THR A  52
THR A  53
VAL A 107
THR A 111
GLN A  60
 None
 1.45A 6ak3A-3l7oA:
undetectable		 6ak3A-3l7oA:
17.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6S_B_CXQB705_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		 3l7o RIBOSE-5-PHOSPHATE
ISOMERASE A
(Streptococcus
mutans) 		4 / 6 VAL A 134
LEU A 176
LEU A 178
MET A 190
 None
 0.97A 6f6sA-3l7oA:
undetectable
6f6sB-3l7oA:
undetectable		 6f6sA-3l7oA:
16.11
6f6sB-3l7oA:
16.23