SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3l7x'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XWF_A_ADNA433_1
(ADENOSYLHOMOCYSTEINA
SE)		 3l7x PUTATIVE HIT-LIKE
PROTEIN INVOLVED IN
CELL-CYCLE
REGULATION
(Streptococcus
mutans) 		5 / 12 LEU A  40
HIS A 101
ASP A  30
GLY A  92
PHE A   6
 None
NA  A 141 (-4.1A)
None
None
None
 1.21A 1xwfA-3l7xA:
undetectable		 1xwfA-3l7xA:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LXE_A_TORA262_1
(CARBONIC ANHYDRASE 1)		 3l7x PUTATIVE HIT-LIKE
PROTEIN INVOLVED IN
CELL-CYCLE
REGULATION
(Streptococcus
mutans) 		5 / 12 HIS A  99
PHE A  28
HIS A  97
HIS A  46
VAL A  10
 NA  A 141 (-3.7A)
None
ZN  A 140 (-3.1A)
ZN  A 140 (-3.2A)
None
 1.36A 3lxeA-3l7xA:
undetectable		 3lxeA-3l7xA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LXE_B_TORB262_1
(CARBONIC ANHYDRASE 1)		 3l7x PUTATIVE HIT-LIKE
PROTEIN INVOLVED IN
CELL-CYCLE
REGULATION
(Streptococcus
mutans) 		5 / 12 HIS A  99
PHE A  28
HIS A  97
HIS A  46
VAL A  10
 NA  A 141 (-3.7A)
None
ZN  A 140 (-3.1A)
ZN  A 140 (-3.2A)
None
 1.35A 3lxeB-3l7xA:
undetectable		 3lxeB-3l7xA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O1C_A_ADNA127_1
(HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 1)		 3l7x PUTATIVE HIT-LIKE
PROTEIN INVOLVED IN
CELL-CYCLE
REGULATION
(Streptococcus
mutans) 		7 / 10 PHE A   6
ILE A   9
ASP A  30
ILE A  31
LEU A  40
HIS A  99
HIS A 101
 None
None
None
None
None
NA  A 141 (-3.7A)
NA  A 141 (-4.1A)
 0.61A 3o1cA-3l7xA:
14.6		 3o1cA-3l7xA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O1C_A_ADNA127_1
(HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 1)		 3l7x PUTATIVE HIT-LIKE
PROTEIN INVOLVED IN
CELL-CYCLE
REGULATION
(Streptococcus
mutans) 		5 / 10 PHE A   6
ILE A   9
ILE A  31
SER A  32
HIS A  99
 None
None
None
None
NA  A 141 (-3.7A)
 0.87A 3o1cA-3l7xA:
14.6		 3o1cA-3l7xA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O1X_A_ADNA1450_1
(HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 1)		 3l7x PUTATIVE HIT-LIKE
PROTEIN INVOLVED IN
CELL-CYCLE
REGULATION
(Streptococcus
mutans) 		7 / 10 PHE A   6
ILE A   9
ASP A  30
ILE A  31
LEU A  40
HIS A  99
HIS A 101
 None
None
None
None
None
NA  A 141 (-3.7A)
NA  A 141 (-4.1A)
 0.62A 3o1xA-3l7xA:
14.5		 3o1xA-3l7xA:
25.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QGZ_A_ADNA127_1
(HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 1)		 3l7x PUTATIVE HIT-LIKE
PROTEIN INVOLVED IN
CELL-CYCLE
REGULATION
(Streptococcus
mutans) 		7 / 10 PHE A   6
ILE A   9
ASP A  30
ILE A  31
LEU A  40
HIS A  99
HIS A 101
 None
None
None
None
None
NA  A 141 (-3.7A)
NA  A 141 (-4.1A)
 0.52A 3qgzA-3l7xA:
14.6		 3qgzA-3l7xA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QGZ_A_ADNA127_1
(HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 1)		 3l7x PUTATIVE HIT-LIKE
PROTEIN INVOLVED IN
CELL-CYCLE
REGULATION
(Streptococcus
mutans) 		5 / 10 PHE A   6
ILE A   9
ILE A  31
SER A  32
HIS A  99
 None
None
None
None
NA  A 141 (-3.7A)
 0.95A 3qgzA-3l7xA:
14.6		 3qgzA-3l7xA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_A_ACTA505_0
(RNA POLYMERASE
3D-POL)		 3l7x PUTATIVE HIT-LIKE
PROTEIN INVOLVED IN
CELL-CYCLE
REGULATION
(Streptococcus
mutans) 		3 / 3 CYH A   7
ASN A   2
LYS A  -1
 ZN  A 140 (-2.3A)
None
None
 1.31A 4k50A-3l7xA:
undetectable		 4k50A-3l7xA:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KM8_B_L8PB201_1
(HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 2,
MITOCHONDRIAL)		 3l7x PUTATIVE HIT-LIKE
PROTEIN INVOLVED IN
CELL-CYCLE
REGULATION
(Streptococcus
mutans) 		5 / 8 ASN A  86
ALA A  91
GLN A  93
HIS A  99
HIS A 101
 NA  A 141 (-3.9A)
None
None
NA  A 141 (-3.7A)
NA  A 141 (-4.1A)
 1.19A 5km8A-3l7xA:
11.5
5km8B-3l7xA:
14.6		 5km8A-3l7xA:
29.48
5km8B-3l7xA:
29.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KM9_B_ADNB201_1
(HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 2,
MITOCHONDRIAL)		 3l7x PUTATIVE HIT-LIKE
PROTEIN INVOLVED IN
CELL-CYCLE
REGULATION
(Streptococcus
mutans) 		5 / 12 ILE A   9
PHE A   6
ILE A  42
LEU A  26
ASP A  30
 None
 0.90A 5km9B-3l7xA:
14.7		 5km9B-3l7xA:
29.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KM9_B_ADNB201_1
(HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 2,
MITOCHONDRIAL)		 3l7x PUTATIVE HIT-LIKE
PROTEIN INVOLVED IN
CELL-CYCLE
REGULATION
(Streptococcus
mutans) 		7 / 12 PHE A   6
ILE A   9
ASP A  30
LEU A  40
VAL A  95
HIS A  99
HIS A 101
 None
None
None
None
None
NA  A 141 (-3.7A)
NA  A 141 (-4.1A)
 0.44A 5km9B-3l7xA:
14.7		 5km9B-3l7xA:
29.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5UVM_B_ADNB207_1
(HISTIDINE TRIAD
(HIT) PROTEIN)		 3l7x PUTATIVE HIT-LIKE
PROTEIN INVOLVED IN
CELL-CYCLE
REGULATION
(Streptococcus
mutans) 		8 / 12 PHE A   6
ILE A   9
ASP A  30
ILE A  31
LEU A  40
VAL A  95
HIS A  99
HIS A 101
 None
None
None
None
None
None
NA  A 141 (-3.7A)
NA  A 141 (-4.1A)
 0.63A 5uvmB-3l7xA:
15.0		 5uvmB-3l7xA:
40.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5UVM_B_ADNB207_1
(HISTIDINE TRIAD
(HIT) PROTEIN)		 3l7x PUTATIVE HIT-LIKE
PROTEIN INVOLVED IN
CELL-CYCLE
REGULATION
(Streptococcus
mutans) 		8 / 12 PHE A   6
ILE A   9
ASP A  30
LEU A  40
THR A  94
VAL A  95
HIS A  99
HIS A 101
 None
None
None
None
None
None
NA  A 141 (-3.7A)
NA  A 141 (-4.1A)
 0.52A 5uvmB-3l7xA:
15.0		 5uvmB-3l7xA:
40.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GTQ_A_ACTA204_0
(N-ACETYLTRANSFERASE)		 3l7x PUTATIVE HIT-LIKE
PROTEIN INVOLVED IN
CELL-CYCLE
REGULATION
(Streptococcus
mutans) 		4 / 5 LEU A 102
THR A  39
THR A  35
GLY A  37
 None
 0.97A 6gtqA-3l7xA:
2.2		 6gtqA-3l7xA:
19.02