SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3l7y'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KVL_A_CLSA371_1
(BETA-LACTAMASE)		 3l7y PUTATIVE
UNCHARACTERIZED
PROTEIN SMU.1108C
(Streptococcus
mutans) 		5 / 10 LEU A  51
GLN A  50
ASN A  46
THR A  13
GLY A  12
 None
None
None
None
MG  A 271 ( 4.5A)
 1.21A 1kvlA-3l7yA:
undetectable		 1kvlA-3l7yA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOH_C_FRDC305_1
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 3l7y PUTATIVE
UNCHARACTERIZED
PROTEIN SMU.1108C
(Streptococcus
mutans) 		4 / 5 ASP A   9
GLY A 182
PRO A 239
ALA A 238
 MG  A 271 (-2.9A)
None
None
None
 0.95A 2aohA-3l7yA:
undetectable		 2aohA-3l7yA:
15.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEI_A_CXXA802_1
(TRANSPORTER)		 3l7y PUTATIVE
UNCHARACTERIZED
PROTEIN SMU.1108C
(Streptococcus
mutans) 		4 / 6 ARG A  25
PHE A  26
ILE A  29
PHE A  40
 None
 1.23A 2qeiA-3l7yA:
undetectable		 2qeiA-3l7yA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z71_A_PNVA903_1
(PENICILLIN ACYLASE)		 3l7y PUTATIVE
UNCHARACTERIZED
PROTEIN SMU.1108C
(Streptococcus
mutans) 		5 / 10 THR A 179
ASN A  46
GLU A 224
ASP A 187
GLY A  66
 None
 1.33A 2z71A-3l7yA:
0.0
2z71C-3l7yA:
0.0		 2z71A-3l7yA:
21.25
2z71C-3l7yA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADX_B_IMNB3_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3l7y PUTATIVE
UNCHARACTERIZED
PROTEIN SMU.1108C
(Streptococcus
mutans) 		5 / 12 LEU A 176
ALA A 166
ILE A 163
LEU A 153
ILE A  93
 None
 1.01A 3adxB-3l7yA:
undetectable		 3adxB-3l7yA:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CFQ_A_DIFA1_1
(TRANSTHYRETIN)		 3l7y PUTATIVE
UNCHARACTERIZED
PROTEIN SMU.1108C
(Streptococcus
mutans) 		4 / 6 LEU A 134
ALA A 106
SER A 108
THR A 152
 None
 1.00A 3cfqA-3l7yA:
undetectable		 3cfqA-3l7yA:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CFQ_B_DIFB1_1
(TRANSTHYRETIN)		 3l7y PUTATIVE
UNCHARACTERIZED
PROTEIN SMU.1108C
(Streptococcus
mutans) 		4 / 7 LEU A 134
ALA A 106
SER A 108
THR A 152
 None
 0.95A 3cfqA-3l7yA:
undetectable
3cfqB-3l7yA:
undetectable		 3cfqA-3l7yA:
17.99
3cfqB-3l7yA:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FSU_A_C2FA995_0
(5,10-METHYLENETETRAH
YDROFOLATE REDUCTASE)		 3l7y PUTATIVE
UNCHARACTERIZED
PROTEIN SMU.1108C
(Streptococcus
mutans) 		5 / 12 THR A   8
GLN A  32
LEU A  30
TYR A  21
LEU A 259
 None
 1.36A 3fsuA-3l7yA:
undetectable		 3fsuA-3l7yA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_D_SAMD6735_1
(16S RRNA METHYLASE)		 3l7y PUTATIVE
UNCHARACTERIZED
PROTEIN SMU.1108C
(Streptococcus
mutans) 		4 / 4 ASN A 237
ASP A   9
GLU A 224
THR A 179
 None
MG  A 271 (-2.9A)
None
None
 1.43A 3p2kD-3l7yA:
0.3		 3p2kD-3l7yA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_B_TCWB1126_1
(TRANSTHYRETIN)		 3l7y PUTATIVE
UNCHARACTERIZED
PROTEIN SMU.1108C
(Streptococcus
mutans) 		4 / 7 LEU A 134
ALA A 106
SER A 108
THR A 152
 None
 0.98A 4d7bA-3l7yA:
undetectable		 4d7bA-3l7yA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FO4_A_MOAA502_1
(INOSINE
5'-MONOPHOSPHATE
DEHYDROGENASE)		 3l7y PUTATIVE
UNCHARACTERIZED
PROTEIN SMU.1108C
(Streptococcus
mutans) 		4 / 8 SER A  44
SER A  45
THR A 152
GLY A 182
 None
 0.99A 4fo4A-3l7yA:
undetectable		 4fo4A-3l7yA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKI_B_IMNB201_1
(TRANSTHYRETIN)		 3l7y PUTATIVE
UNCHARACTERIZED
PROTEIN SMU.1108C
(Streptococcus
mutans) 		4 / 6 LEU A 134
ALA A 106
SER A 108
THR A 152
 None
 1.00A 4ikiB-3l7yA:
undetectable		 4ikiB-3l7yA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKJ_A_SUZA201_1
(TRANSTHYRETIN)		 3l7y PUTATIVE
UNCHARACTERIZED
PROTEIN SMU.1108C
(Streptococcus
mutans) 		4 / 7 LEU A 134
ALA A 106
SER A 108
THR A 152
 None
 1.06A 4ikjA-3l7yA:
undetectable
4ikjB-3l7yA:
undetectable		 4ikjA-3l7yA:
19.44
4ikjB-3l7yA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKK_B_SUZB201_1
(TRANSTHYRETIN)		 3l7y PUTATIVE
UNCHARACTERIZED
PROTEIN SMU.1108C
(Streptococcus
mutans) 		4 / 7 LEU A 134
ALA A 106
SER A 108
THR A 152
 None
 1.00A 4ikkA-3l7yA:
undetectable
4ikkB-3l7yA:
undetectable		 4ikkA-3l7yA:
19.44
4ikkB-3l7yA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_F_377F401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 3l7y PUTATIVE
UNCHARACTERIZED
PROTEIN SMU.1108C
(Streptococcus
mutans) 		4 / 7 GLU A 146
TYR A 114
PHE A 148
ARG A  86
 None
 1.20A 4twdF-3l7yA:
undetectable
4twdJ-3l7yA:
undetectable		 4twdF-3l7yA:
25.00
4twdJ-3l7yA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_G_377G401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 3l7y PUTATIVE
UNCHARACTERIZED
PROTEIN SMU.1108C
(Streptococcus
mutans) 		4 / 6 ARG A  86
GLU A 146
TYR A 114
PHE A 148
 None
 1.19A 4twdF-3l7yA:
undetectable
4twdG-3l7yA:
undetectable		 4twdF-3l7yA:
25.00
4twdG-3l7yA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XT7_A_TOPA302_1
(RV2671)		 3l7y PUTATIVE
UNCHARACTERIZED
PROTEIN SMU.1108C
(Streptococcus
mutans) 		5 / 11 ASN A  46
SER A 181
GLY A 182
ASP A  11
PHE A 130
 None
 1.47A 4xt7A-3l7yA:
2.0		 4xt7A-3l7yA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L1F_A_6ZPA902_1
(GLUTAMATE RECEPTOR 2)		 3l7y PUTATIVE
UNCHARACTERIZED
PROTEIN SMU.1108C
(Streptococcus
mutans) 		4 / 8 ASP A   9
SER A  17
ASN A 253
SER A  45
 MG  A 271 (-2.9A)
None
None
None
 0.88A 5l1fA-3l7yA:
undetectable
5l1fB-3l7yA:
undetectable		 5l1fA-3l7yA:
17.12
5l1fB-3l7yA:
17.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_A_PCFA1808_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 3l7y PUTATIVE
UNCHARACTERIZED
PROTEIN SMU.1108C
(Streptococcus
mutans) 		4 / 5 LEU A 153
ALA A 106
LEU A 107
LEU A 127
 None
 0.79A 5vkqA-3l7yA:
undetectable
5vkqD-3l7yA:
undetectable		 5vkqA-3l7yA:
10.57
5vkqD-3l7yA:
10.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_B_PCFB1805_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 3l7y PUTATIVE
UNCHARACTERIZED
PROTEIN SMU.1108C
(Streptococcus
mutans) 		4 / 5 LEU A 127
LEU A 153
ALA A 106
LEU A 107
 None
 0.78A 5vkqA-3l7yA:
undetectable
5vkqB-3l7yA:
undetectable		 5vkqA-3l7yA:
10.57
5vkqB-3l7yA:
10.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_C_PCFC1806_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 3l7y PUTATIVE
UNCHARACTERIZED
PROTEIN SMU.1108C
(Streptococcus
mutans) 		4 / 5 LEU A 127
LEU A 153
ALA A 106
LEU A 107
 None
 0.76A 5vkqB-3l7yA:
undetectable
5vkqC-3l7yA:
undetectable		 5vkqB-3l7yA:
10.57
5vkqC-3l7yA:
10.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_D_PCFD1806_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 3l7y PUTATIVE
UNCHARACTERIZED
PROTEIN SMU.1108C
(Streptococcus
mutans) 		4 / 5 LEU A 127
LEU A 153
ALA A 106
LEU A 107
 None
 0.82A 5vkqC-3l7yA:
undetectable
5vkqD-3l7yA:
undetectable		 5vkqC-3l7yA:
10.57
5vkqD-3l7yA:
10.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MB5_A_NMYA301_0
(AAC(3)-IIIB PROTEIN)		 3l7y PUTATIVE
UNCHARACTERIZED
PROTEIN SMU.1108C
(Streptococcus
mutans) 		5 / 11 ASP A 254
ASN A 237
ASP A   9
THR A  13
GLY A  19
 None
None
MG  A 271 (-2.9A)
None
None
 1.47A 6mb5A-3l7yA:
undetectable		 6mb5A-3l7yA:
14.24