SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3l7z'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_G_SAMG199_0
(METHIONINE REPRESSOR)		 3l7z PROBABLE EXOSOME
COMPLEX EXONUCLEASE
1
(Sulfolobus
solfataricus) 		5 / 10 GLU B 229
ALA B 146
LEU B  32
ALA B  42
PHE B  44
 None
 1.31A 1mjqG-3l7zB:
undetectable
1mjqH-3l7zB:
undetectable		 1mjqG-3l7zB:
19.11
1mjqH-3l7zB:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PXX_A_DIFA701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3l7z PROBABLE EXOSOME
COMPLEX EXONUCLEASE
2
(Sulfolobus
solfataricus) 		5 / 10 LEU A 189
LEU A 142
VAL A 162
ALA A 163
LEU A  44
 None
 1.05A 1pxxA-3l7zA:
undetectable		 1pxxA-3l7zA:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PXX_C_DIFC2701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3l7z PROBABLE EXOSOME
COMPLEX EXONUCLEASE
2
(Sulfolobus
solfataricus) 		5 / 12 LEU A 189
LEU A 142
VAL A 162
ALA A 163
LEU A  44
 None
 1.07A 1pxxC-3l7zA:
undetectable		 1pxxC-3l7zA:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RK3_A_VDXA500_1
(VITAMIN D3 RECEPTOR)		 3l7z PROBABLE EXOSOME
COMPLEX EXONUCLEASE
2
(Sulfolobus
solfataricus) 		5 / 12 VAL A 113
SER A 117
SER A 161
VAL A 153
LEU A  90
 None
 1.49A 1rk3A-3l7zA:
undetectable		 1rk3A-3l7zA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X8V_A_ESLA471_1
(CYTOCHROME P450 51)		 3l7z PROBABLE EXOSOME
COMPLEX EXONUCLEASE
2
(Sulfolobus
solfataricus) 		4 / 8 TYR A 149
ARG A  38
ALA A 156
LEU A 110
 None
 1.16A 1x8vA-3l7zA:
undetectable		 1x8vA-3l7zA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNI_A_MTKA501_1
(CYTOCHROME P450 2C8)		 3l7z PROBABLE EXOSOME
COMPLEX EXONUCLEASE
2
(Sulfolobus
solfataricus) 		5 / 12 SER A 197
SER A 224
ASN A 152
VAL A 162
VAL A 144
 None
 1.19A 2nniA-3l7zA:
undetectable		 2nniA-3l7zA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_C_ZMRC1776_2
(NEURAMINIDASE A)		 3l7z PROBABLE EXOSOME
COMPLEX EXONUCLEASE
1
PROBABLE EXOSOME
COMPLEX RNA-BINDING
PROTEIN 1
(Sulfolobus
solfataricus) 		4 / 6 ARG B  64
ASP C 138
ILE C 137
TYR C  69
 None
 1.21A 2ya7C-3l7zB:
undetectable		 2ya7C-3l7zB:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZB7_A_NCAA901_0
(PROSTAGLANDIN
REDUCTASE 2)		 3l7z PROBABLE EXOSOME
COMPLEX EXONUCLEASE
1
(Sulfolobus
solfataricus) 		4 / 5 ILE B 222
MET B  46
LEU B 172
LEU B  25
 None
 1.05A 2zb7A-3l7zB:
undetectable		 2zb7A-3l7zB:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZW9_A_SAMA801_0
(LEUCINE CARBOXYL
METHYLTRANSFERASE 2)		 3l7z PROBABLE EXOSOME
COMPLEX EXONUCLEASE
2
(Sulfolobus
solfataricus) 		5 / 12 ILE A 196
GLY A 233
ASP A 120
LEU A 154
ASN A 152
 None
 1.23A 2zw9A-3l7zA:
undetectable		 2zw9A-3l7zA:
17.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B9L_A_AZZA1009_1
(SERUM ALBUMIN)		 3l7z PROBABLE EXOSOME
COMPLEX EXONUCLEASE
2
(Sulfolobus
solfataricus) 		4 / 8 GLU A 109
SER A 237
VAL A 146
CYH A 157
 None
 1.14A 3b9lA-3l7zA:
undetectable		 3b9lA-3l7zA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_B_SVRB512_2
(PHOSPHOLIPASE A2)		 3l7z PROBABLE EXOSOME
COMPLEX RNA-BINDING
PROTEIN 1
(Sulfolobus
solfataricus) 		4 / 7 VAL C 188
ILE C 127
GLY C 149
LEU C 120
 None
 0.85A 3bjwB-3l7zC:
undetectable		 3bjwB-3l7zC:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_F_SVRF509_3
(PHOSPHOLIPASE A2)		 3l7z PROBABLE EXOSOME
COMPLEX RNA-BINDING
PROTEIN 1
(Sulfolobus
solfataricus) 		4 / 7 VAL C 188
ILE C 127
GLY C 149
LEU C 120
 None
 0.90A 3bjwF-3l7zC:
undetectable		 3bjwF-3l7zC:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_H_SVRH511_3
(PHOSPHOLIPASE A2)		 3l7z PROBABLE EXOSOME
COMPLEX RNA-BINDING
PROTEIN 1
(Sulfolobus
solfataricus) 		4 / 7 VAL C 188
ILE C 127
GLY C 149
LEU C 120
 None
 0.88A 3bjwH-3l7zC:
undetectable		 3bjwH-3l7zC:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUF_B_SUEB1201_3
(NS3 PROTEASE, NS4A
PROTEIN)		 3l7z PROBABLE EXOSOME
COMPLEX RNA-BINDING
PROTEIN 1
(Sulfolobus
solfataricus) 		4 / 5 SER C 136
PRO C 139
TYR C  96
VAL C 140
 None
 1.36A 3sufC-3l7zC:
undetectable		 3sufC-3l7zC:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VT3_A_VDXA500_1
(VITAMIN D3 RECEPTOR)		 3l7z PROBABLE EXOSOME
COMPLEX EXONUCLEASE
2
(Sulfolobus
solfataricus) 		5 / 12 VAL A 113
SER A 117
SER A 161
VAL A 153
LEU A  90
 None
 1.49A 3vt3A-3l7zA:
undetectable		 3vt3A-3l7zA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_C_DXCC1477_0
(MJ0495-LIKE PROTEIN)		 3l7z PROBABLE EXOSOME
COMPLEX EXONUCLEASE
1
(Sulfolobus
solfataricus) 		4 / 6 GLY B 160
ARG B  20
ILE B 225
LEU B 140
 None
 1.19A 4ac9C-3l7zB:
undetectable		 4ac9C-3l7zB:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IK7_A_IMNA201_1
(TRANSTHYRETIN)		 3l7z PROBABLE EXOSOME
COMPLEX EXONUCLEASE
1
PROBABLE EXOSOME
COMPLEX EXONUCLEASE
2
(Sulfolobus
solfataricus) 		4 / 7 LEU B 202
THR A 226
THR A 195
VAL A 193
 None
 0.92A 4ik7A-3l7zB:
undetectable		 4ik7A-3l7zB:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_STRA301_2
(ANCESTRAL STEROID
RECEPTOR 2)		 3l7z PROBABLE EXOSOME
COMPLEX EXONUCLEASE
2
(Sulfolobus
solfataricus) 		4 / 8 ALA A 199
MET A 217
THR A  61
VAL A 146
 None
 0.96A 4ltwA-3l7zA:
undetectable		 4ltwA-3l7zA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MX0_A_BCZA513_1
(NEURAMINIDASE)		 3l7z PROBABLE EXOSOME
COMPLEX EXONUCLEASE
1
(Sulfolobus
solfataricus) 		3 / 3 ARG B 136
ASP B 185
ARG B  96
 SO4  B 246 (-3.9A)
None
SO4  B 246 ( 4.8A)
 0.81A 4mx0A-3l7zB:
undetectable		 4mx0A-3l7zB:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_B_STRB601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 3l7z PROBABLE EXOSOME
COMPLEX EXONUCLEASE
2
(Sulfolobus
solfataricus) 		5 / 12 LEU A 110
ASN A 152
ALA A  54
VAL A  63
VAL A  56
 None
 0.86A 4nkxB-3l7zA:
undetectable		 4nkxB-3l7zA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OTY_A_LURA705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3l7z PROBABLE EXOSOME
COMPLEX EXONUCLEASE
2
(Sulfolobus
solfataricus) 		5 / 12 LEU A 189
LEU A 142
VAL A 162
ALA A 163
LEU A  44
 None
 1.05A 4otyA-3l7zA:
undetectable		 4otyA-3l7zA:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OTY_B_LURB705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3l7z PROBABLE EXOSOME
COMPLEX EXONUCLEASE
2
(Sulfolobus
solfataricus) 		5 / 12 LEU A 189
LEU A 142
VAL A 162
ALA A 163
LEU A  44
 None
 1.07A 4otyB-3l7zA:
undetectable		 4otyB-3l7zA:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRX_A_LURA706_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3l7z PROBABLE EXOSOME
COMPLEX EXONUCLEASE
2
(Sulfolobus
solfataricus) 		5 / 12 LEU A 189
LEU A 142
VAL A 162
ALA A 163
LEU A  44
 None
 1.01A 4rrxA-3l7zA:
undetectable		 4rrxA-3l7zA:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRX_B_LURB706_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3l7z PROBABLE EXOSOME
COMPLEX EXONUCLEASE
2
(Sulfolobus
solfataricus) 		5 / 12 LEU A 189
LEU A 142
VAL A 162
ALA A 163
LEU A  44
 None
 1.01A 4rrxB-3l7zA:
undetectable		 4rrxB-3l7zA:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBS_A_DIFA502_1
(PENTALENIC ACID
SYNTHASE)		 3l7z PROBABLE EXOSOME
COMPLEX EXONUCLEASE
1
PROBABLE EXOSOME
COMPLEX EXONUCLEASE
2
(Sulfolobus
solfataricus) 		5 / 9 VAL B 114
LEU B 194
SER A 241
THR B 198
ILE B 158
 None
 1.29A 4ubsA-3l7zB:
undetectable		 4ubsA-3l7zB:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WAN_C_ACTC303_0
(BRANCHPOINT-BRIDGING
PROTEIN)		 3l7z PROBABLE EXOSOME
COMPLEX EXONUCLEASE
2
PROBABLE EXOSOME
COMPLEX EXONUCLEASE
1
(Sulfolobus
solfataricus;
Sulfolobus
solfataricus) 		3 / 3 ASP A 104
ARG B 105
PRO A   5
 None
 0.97A 4wanC-3l7zA:
undetectable		 4wanC-3l7zA:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XMF_A_HSMA202_1
(NITROPHORIN-7)		 3l7z PROBABLE EXOSOME
COMPLEX EXONUCLEASE
1
(Sulfolobus
solfataricus) 		3 / 3 ASP B 185
LEU B 137
GLY B 134
 None
None
SO4  B 246 (-3.7A)
 0.57A 4xmfA-3l7zB:
undetectable		 4xmfA-3l7zB:
24.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z7F_B_FOLB201_0
(FOLATE ECF
TRANSPORTER)		 3l7z PROBABLE EXOSOME
COMPLEX EXONUCLEASE
2
(Sulfolobus
solfataricus) 		5 / 12 ASP A 155
ALA A 199
PHE A 223
THR A 195
THR A 257
 None
 1.40A 4z7fB-3l7zA:
0.0		 4z7fB-3l7zA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HBS_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 1)		 3l7z PROBABLE EXOSOME
COMPLEX RNA-BINDING
PROTEIN 1
(Sulfolobus
solfataricus) 		5 / 12 TYR C 125
VAL C  90
LEU C 141
ALA C 128
ILE C 159
 None
 1.15A 5hbsA-3l7zC:
undetectable		 5hbsA-3l7zC:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HQA_A_ACRA705_1
(ALPHA-GLUCOSIDASE)		 3l7z PROBABLE EXOSOME
COMPLEX EXONUCLEASE
1
PROBABLE EXOSOME
COMPLEX EXONUCLEASE
2
(Sulfolobus
solfataricus) 		5 / 12 ARG B 105
GLU A 214
LYS A 220
GLU B 106
GLU A 109
 None
 1.36A 5hqaA-3l7zB:
0.0		 5hqaA-3l7zB:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKQ_A_JMSA602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3l7z PROBABLE EXOSOME
COMPLEX EXONUCLEASE
2
(Sulfolobus
solfataricus) 		5 / 12 LEU A 189
LEU A 142
VAL A 162
ALA A 163
LEU A  44
 None
 1.00A 5ikqA-3l7zA:
undetectable		 5ikqA-3l7zA:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKQ_B_JMSB602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3l7z PROBABLE EXOSOME
COMPLEX EXONUCLEASE
2
(Sulfolobus
solfataricus) 		5 / 12 LEU A 189
LEU A 142
VAL A 162
ALA A 163
LEU A  44
 None
 1.01A 5ikqB-3l7zA:
undetectable		 5ikqB-3l7zA:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JCN_B_ASCB502_0
(OS09G0567300 PROTEIN)		 3l7z PROBABLE EXOSOME
COMPLEX EXONUCLEASE
2
PROBABLE EXOSOME
COMPLEX EXONUCLEASE
1
(Sulfolobus
solfataricus;
Sulfolobus
solfataricus) 		4 / 6 GLU B 106
PRO A   5
GLY A 238
ARG B  71
 None
 1.45A 5jcnB-3l7zB:
undetectable		 5jcnB-3l7zB:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A7P_A_9SCA601_1
(SERUM ALBUMIN)		 3l7z PROBABLE EXOSOME
COMPLEX EXONUCLEASE
2
(Sulfolobus
solfataricus) 		4 / 5 TYR A 225
VAL A 194
LEU A 262
SER A 256
 None
 1.21A 6a7pA-3l7zA:
undetectable		 6a7pA-3l7zA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DH0_A_017A101_2
(PROTEASE)		 3l7z PROBABLE EXOSOME
COMPLEX EXONUCLEASE
2
(Sulfolobus
solfataricus) 		3 / 3 LEU A 261
ASP A 228
ILE A 231
 None
 0.59A 6dh0B-3l7zA:
undetectable		 6dh0B-3l7zA:
15.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBP_B_DAHB123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 3l7z PROBABLE EXOSOME
COMPLEX EXONUCLEASE
2
(Sulfolobus
solfataricus) 		5 / 10 PHE A 223
THR A 195
ASP A 155
GLY A 233
ILE A 234
 None
 1.26A 6ebpB-3l7zA:
undetectable		 6ebpB-3l7zA:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBP_C_DAHC123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 3l7z PROBABLE EXOSOME
COMPLEX EXONUCLEASE
2
(Sulfolobus
solfataricus) 		5 / 10 PHE A 223
THR A 195
ASP A 155
GLY A 233
ILE A 234
 None
 1.25A 6ebpC-3l7zA:
undetectable		 6ebpC-3l7zA:
16.46