SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3l84'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EII_A_RTLA135_0
(CELLULAR
RETINOL-BINDING
PROTEIN II)		 3l84 TRANSKETOLASE
(Campylobacter
jejuni) 		5 / 12 THR A 240
ALA A 238
ILE A 146
LEU A  61
LEU A 224
 None
 1.15A 1eiiA-3l84A:
undetectable		 1eiiA-3l84A:
12.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EII_A_RTLA135_0
(CELLULAR
RETINOL-BINDING
PROTEIN II)		 3l84 TRANSKETOLASE
(Campylobacter
jejuni) 		5 / 12 THR A 240
ILE A 146
LEU A  61
LEU A  35
LEU A 224
 None
 1.06A 1eiiA-3l84A:
undetectable		 1eiiA-3l84A:
12.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1G5Y_C_9CRC502_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3l84 TRANSKETOLASE
(Campylobacter
jejuni) 		5 / 10 LEU A 459
SER A 589
ALA A 586
PHE A 415
PHE A 414
 None
 1.28A 1g5yC-3l84A:
undetectable		 1g5yC-3l84A:
16.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HA2_A_SWFA3001_1
(SERUM ALBUMIN)		 3l84 TRANSKETOLASE
(Campylobacter
jejuni) 		5 / 11 PHE A  75
LEU A 149
LEU A  42
LEU A 224
ILE A 176
 None
 0.93A 1ha2A-3l84A:
undetectable		 1ha2A-3l84A:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1M4D_A_TOYA500_1
(AMINOGLYCOSIDE
2'-N-ACETYLTRANSFERA
SE)		 3l84 TRANSKETOLASE
(Campylobacter
jejuni) 		5 / 10 PHE A 615
ASP A 611
SER A 498
ALA A 474
THR A 340
 None
 1.30A 1m4dA-3l84A:
0.0		 1m4dA-3l84A:
14.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1M4D_A_TOYA500_1
(AMINOGLYCOSIDE
2'-N-ACETYLTRANSFERA
SE)		 3l84 TRANSKETOLASE
(Campylobacter
jejuni) 		5 / 10 PHE A 615
ASP A 611
SER A 498
SER A 535
ALA A 474
 None
 1.19A 1m4dA-3l84A:
0.0		 1m4dA-3l84A:
14.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_B_SAMB200_0
(METHIONINE REPRESSOR)		 3l84 TRANSKETOLASE
(Campylobacter
jejuni) 		5 / 11 GLU A 291
PHE A  75
GLY A  80
LEU A  71
HIS A  77
 GOL  A2002 (-2.6A)
None
GOL  A2002 ( 4.1A)
None
GOL  A2002 (-4.4A)
 1.32A 1mjqA-3l84A:
undetectable
1mjqB-3l84A:
undetectable		 1mjqA-3l84A:
10.19
1mjqB-3l84A:
10.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C12_F_SPMF1433_1
(NITROALKANE OXIDASE)		 3l84 TRANSKETOLASE
(Campylobacter
jejuni) 		5 / 11 LEU A  61
ALA A  68
SER A  64
LEU A 149
ASP A 154
 None
 1.32A 2c12F-3l84A:
undetectable		 2c12F-3l84A:
24.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNJ_A_225A501_1
(CYTOCHROME P450 2C8)		 3l84 TRANSKETOLASE
(Campylobacter
jejuni) 		5 / 10 ILE A 397
LEU A 172
ALA A 121
VAL A  62
ILE A 146
 None
 0.98A 2nnjA-3l84A:
undetectable		 2nnjA-3l84A:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X1L_B_ADNB601_1
(METHIONYL-TRNA
SYNTHETASE)		 3l84 TRANSKETOLASE
(Campylobacter
jejuni) 		5 / 12 ALA A 129
GLY A 357
GLY A 360
ILE A 385
LEU A 355
 None
 1.00A 2x1lB-3l84A:
undetectable		 2x1lB-3l84A:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7K_A_SALA1302_1
(LYSR-TYPE REGULATORY
PROTEIN)		 3l84 TRANSKETOLASE
(Campylobacter
jejuni) 		5 / 11 GLY A 125
PHE A 401
PHE A 379
HIS A 170
ILE A 385
 None
 1.46A 2y7kA-3l84A:
undetectable		 2y7kA-3l84A:
14.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7K_B_SALB1304_1
(LYSR-TYPE REGULATORY
PROTEIN)		 3l84 TRANSKETOLASE
(Campylobacter
jejuni) 		5 / 10 GLY A 125
PHE A 401
PHE A 379
HIS A 170
ILE A 385
 None
 1.49A 2y7kB-3l84A:
undetectable		 2y7kB-3l84A:
14.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3I5U_A_SAMA401_0
(O-METHYLTRANSFERASE)		 3l84 TRANSKETOLASE
(Campylobacter
jejuni) 		5 / 12 PHE A 439
HIS A 435
GLY A 361
LEU A 365
ALA A 395
 None
 1.16A 3i5uA-3l84A:
undetectable		 3i5uA-3l84A:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ITA_D_AICD501_1
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACC)		 3l84 TRANSKETOLASE
(Campylobacter
jejuni) 		3 / 3 PRO A 492
PHE A 462
ALA A 425
 None
 0.71A 3itaD-3l84A:
undetectable		 3itaD-3l84A:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJV_D_RITD500_2
(PROTEASE)		 3l84 TRANSKETOLASE
(Campylobacter
jejuni) 		5 / 12 GLY A 125
ALA A 400
ILE A 433
THR A 113
ILE A 111
 None
 0.97A 4njvD-3l84A:
undetectable		 4njvD-3l84A:
8.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOG_B_ML1B302_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 3l84 TRANSKETOLASE
(Campylobacter
jejuni) 		4 / 6 GLY A 366
PHE A 410
ILE A 438
PHE A 358
 None
 1.09A 4qogA-3l84A:
4.2
4qogB-3l84A:
4.1		 4qogA-3l84A:
17.74
4qogB-3l84A:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RET_A_DGXA1107_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 3l84 TRANSKETOLASE
(Campylobacter
jejuni) 		5 / 12 LEU A  61
GLU A 110
PHE A 126
ALA A 163
ARG A 403
 None
 1.16A 4retA-3l84A:
3.0		 4retA-3l84A:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZO1_X_T3X500_1
(THYROID HORMONE
RECEPTOR BETA)		 3l84 TRANSKETOLASE
(Campylobacter
jejuni) 		5 / 12 ILE A 397
ALA A 396
ALA A 428
ASN A 122
PHE A 387
 None
 1.48A 4zo1X-3l84A:
undetectable		 4zo1X-3l84A:
16.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C8T_B_SAMB605_0
(GUANINE-N7
METHYLTRANSFERASE)		 3l84 TRANSKETOLASE
(Campylobacter
jejuni) 		5 / 11 GLY A 476
ASP A 475
ALA A 504
TRP A 483
ASN A 344
 None
 1.47A 5c8tB-3l84A:
1.5		 5c8tB-3l84A:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GSN_C_MMZC503_1
(FLAVIN-CONTAINING
MONOOXYGENASE)		 3l84 TRANSKETOLASE
(Campylobacter
jejuni) 		4 / 4 TYR A 600
ASN A 627
SER A 623
SER A 621
 None
 1.14A 5gsnC-3l84A:
2.7		 5gsnC-3l84A:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TJY_A_BEZA304_0
(4-HYDROXY-TETRAHYDRO
DIPICOLINATE
REDUCTASE)		 3l84 TRANSKETOLASE
(Campylobacter
jejuni) 		3 / 3 MET A 431
GLU A 110
ARG A 403
 None
 1.01A 5tjyA-3l84A:
4.1		 5tjyA-3l84A:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TJZ_A_BEZA302_0
(4-HYDROXY-TETRAHYDRO
DIPICOLINATE
REDUCTASE)		 3l84 TRANSKETOLASE
(Campylobacter
jejuni) 		3 / 3 MET A 431
GLU A 110
ARG A 403
 None
 0.93A 5tjzA-3l84A:
3.1		 5tjzA-3l84A:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUD_A_ERMA2001_2
(5-HYDROXYTRYPTAMINE
RECEPTOR 2B,SOLUBLE
CYTOCHROME B562
CHIMERA)		 3l84 TRANSKETOLASE
(Campylobacter
jejuni) 		4 / 7 LYS A 244
ASN A  11
GLN A 271
GLU A 270
 None
 1.09A 5tudA-3l84A:
undetectable		 5tudA-3l84A:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A93_A_8NUA3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		 3l84 TRANSKETOLASE
(Campylobacter
jejuni) 		5 / 12 SER A  79
SER A  17
LEU A  42
PHE A  91
PHE A  63
 None
 1.37A 6a93A-3l84A:
undetectable		 6a93A-3l84A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B58_A_ACTA609_0
(FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT)		 3l84 TRANSKETOLASE
(Campylobacter
jejuni) 		3 / 3 HIS A  67
HIS A 101
ARG A  92
 None
 1.04A 6b58A-3l84A:
2.3		 6b58A-3l84A:
22.71