SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3l87'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HMY_B_SAMB328_0
(PROTEIN
(CYTOSINE-SPECIFIC
METHYLTRANSFERASE
HHAI))		 3l87 PEPTIDE DEFORMYLASE
(Streptococcus
mutans) 		5 / 12 GLY A  70
ASP A  15
ILE A  14
TYR A 167
VAL A 171
 None
 0.99A 2hmyB-3l87A:
undetectable		 2hmyB-3l87A:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_A_ACHA1211_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 3l87 PEPTIDE DEFORMYLASE
(Streptococcus
mutans) 		4 / 7 SER A 169
GLN A 121
ILE A 203
SER A 119
 None
 1.19A 2xz5A-3l87A:
undetectable
2xz5B-3l87A:
undetectable		 2xz5A-3l87A:
23.11
2xz5B-3l87A:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7B_B_HAEB1270_1
(COLLAGENASE 3)		 3l87 PEPTIDE DEFORMYLASE
(Streptococcus
mutans) 		4 / 5 LEU A  53
HIS A 174
GLU A 175
HIS A 178
 None
FE  A 205 (-3.5A)
FE  A 205 ( 4.1A)
FE  A 205 (-3.8A)
 0.91A 4a7bB-3l87A:
undetectable		 4a7bB-3l87A:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZS_A_SAMA1475_0
(METHYLTRANSFERASE
WBDD)		 3l87 PEPTIDE DEFORMYLASE
(Streptococcus
mutans) 		5 / 12 GLY A  72
ALA A  86
ARG A 144
GLU A 129
HIS A 178
 None
None
None
None
FE  A 205 (-3.8A)
 1.11A 4azsA-3l87A:
undetectable		 4azsA-3l87A:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B58_A_ACTA609_0
(FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT)		 3l87 PEPTIDE DEFORMYLASE
(Streptococcus
mutans) 		3 / 3 HIS A 178
HIS A 174
ARG A 144
 FE  A 205 (-3.8A)
FE  A 205 (-3.5A)
None
 1.09A 6b58A-3l87A:
undetectable		 6b58A-3l87A:
17.18