SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3l8a'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DF7_A_MTXA501_1
(DIHYDROFOLATE
REDUCTASE)		 3l8a PUTATIVE
AMINOTRANSFERASE,
PROBABLE
BETA-CYSTATHIONASE
(Streptococcus
mutans) 		5 / 12 ILE A 382
LEU A 365
VAL A 323
LEU A 325
ILE A 381
 None
 0.99A 1df7A-3l8aA:
undetectable		 1df7A-3l8aA:
17.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A5H_A_SAMA417_0
(L-LYSINE
2,3-AMINOMUTASE)		 3l8a PUTATIVE
AMINOTRANSFERASE,
PROBABLE
BETA-CYSTATHIONASE
(Streptococcus
mutans) 		5 / 11 HIS A 170
VAL A 118
TYR A 119
ASP A 199
LEU A 166
 None
None
PLP  A 388 (-3.5A)
PLP  A 388 (-2.8A)
None
 1.16A 2a5hA-3l8aA:
1.0		 2a5hA-3l8aA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A5H_B_SAMB417_0
(L-LYSINE
2,3-AMINOMUTASE)		 3l8a PUTATIVE
AMINOTRANSFERASE,
PROBABLE
BETA-CYSTATHIONASE
(Streptococcus
mutans) 		5 / 12 HIS A 170
VAL A 118
TYR A 119
ASP A 199
LEU A 166
 None
None
PLP  A 388 (-3.5A)
PLP  A 388 (-2.8A)
None
 1.16A 2a5hB-3l8aA:
1.4		 2a5hB-3l8aA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A5H_C_SAMC417_0
(L-LYSINE
2,3-AMINOMUTASE)		 3l8a PUTATIVE
AMINOTRANSFERASE,
PROBABLE
BETA-CYSTATHIONASE
(Streptococcus
mutans) 		5 / 12 HIS A 170
VAL A 118
TYR A 119
ASP A 199
LEU A 166
 None
None
PLP  A 388 (-3.5A)
PLP  A 388 (-2.8A)
None
 1.17A 2a5hC-3l8aA:
1.0		 2a5hC-3l8aA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A5H_D_SAMD417_0
(L-LYSINE
2,3-AMINOMUTASE)		 3l8a PUTATIVE
AMINOTRANSFERASE,
PROBABLE
BETA-CYSTATHIONASE
(Streptococcus
mutans) 		5 / 12 HIS A 170
VAL A 118
TYR A 119
ASP A 199
LEU A 166
 None
None
PLP  A 388 (-3.5A)
PLP  A 388 (-2.8A)
None
 1.16A 2a5hD-3l8aA:
1.1		 2a5hD-3l8aA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JFA_B_CCSB417_0
(ESTROGEN RECEPTOR)		 3l8a PUTATIVE
AMINOTRANSFERASE,
PROBABLE
BETA-CYSTATHIONASE
(Streptococcus
mutans) 		3 / 3 GLN A  69
LYS A  85
VAL A  83
 None
 0.88A 2jfaB-3l8aA:
undetectable		 2jfaB-3l8aA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NXE_B_SAMB303_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 3l8a PUTATIVE
AMINOTRANSFERASE,
PROBABLE
BETA-CYSTATHIONASE
(Streptococcus
mutans) 		6 / 12 LEU A 365
ILE A 312
ASP A 326
ASN A 350
LEU A 349
LEU A 341
 None
 1.20A 2nxeB-3l8aA:
undetectable		 2nxeB-3l8aA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QMJ_A_ACRA1001_1
(MALTASE-GLUCOAMYLASE
, INTESTINAL)		 3l8a PUTATIVE
AMINOTRANSFERASE,
PROBABLE
BETA-CYSTATHIONASE
(Streptococcus
mutans) 		5 / 12 ASN A 237
ILE A  88
ILE A 247
PHE A 281
ALA A 280
 None
 1.37A 2qmjA-3l8aA:
undetectable		 2qmjA-3l8aA:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XNR_A_ACTA1001_0
(NUCLEAR
POLYADENYLATED
RNA-BINDING PROTEIN
3)		 3l8a PUTATIVE
AMINOTRANSFERASE,
PROBABLE
BETA-CYSTATHIONASE
(Streptococcus
mutans) 		3 / 3 SER A  99
ARG A 260
GLN A 103
 None
 0.95A 2xnrA-3l8aA:
undetectable		 2xnrA-3l8aA:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CJT_C_SAMC302_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 3l8a PUTATIVE
AMINOTRANSFERASE,
PROBABLE
BETA-CYSTATHIONASE
(Streptococcus
mutans) 		5 / 12 LEU A 322
ILE A 312
ASP A 326
LEU A 349
LEU A 341
 None
 0.92A 3cjtC-3l8aA:
4.7		 3cjtC-3l8aA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CJT_C_SAMC302_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 3l8a PUTATIVE
AMINOTRANSFERASE,
PROBABLE
BETA-CYSTATHIONASE
(Streptococcus
mutans) 		5 / 12 LEU A 365
ILE A 312
ASP A 326
LEU A 349
LEU A 341
 None
 1.00A 3cjtC-3l8aA:
4.7		 3cjtC-3l8aA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CJT_G_SAMG302_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 3l8a PUTATIVE
AMINOTRANSFERASE,
PROBABLE
BETA-CYSTATHIONASE
(Streptococcus
mutans) 		5 / 12 ILE A 312
ASP A 326
ASN A 350
LEU A 349
LEU A 341
 None
 1.11A 3cjtG-3l8aA:
3.9		 3cjtG-3l8aA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CJT_G_SAMG302_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 3l8a PUTATIVE
AMINOTRANSFERASE,
PROBABLE
BETA-CYSTATHIONASE
(Streptococcus
mutans) 		5 / 12 LEU A 322
ILE A 312
ASN A 350
LEU A 349
LEU A 341
 None
 1.16A 3cjtG-3l8aA:
3.9		 3cjtG-3l8aA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CJT_G_SAMG302_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 3l8a PUTATIVE
AMINOTRANSFERASE,
PROBABLE
BETA-CYSTATHIONASE
(Streptococcus
mutans) 		5 / 12 LEU A 365
ILE A 312
ASP A 326
LEU A 349
LEU A 341
 None
 1.02A 3cjtG-3l8aA:
3.9		 3cjtG-3l8aA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CJT_K_SAMK302_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 3l8a PUTATIVE
AMINOTRANSFERASE,
PROBABLE
BETA-CYSTATHIONASE
(Streptococcus
mutans) 		5 / 12 ILE A 312
ASP A 326
ASN A 350
LEU A 349
LEU A 341
 None
 1.10A 3cjtK-3l8aA:
2.5		 3cjtK-3l8aA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CJT_O_SAMO302_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 3l8a PUTATIVE
AMINOTRANSFERASE,
PROBABLE
BETA-CYSTATHIONASE
(Streptococcus
mutans) 		6 / 12 LEU A 322
ILE A 312
ASP A 326
ASN A 350
LEU A 349
LEU A 341
 None
 1.15A 3cjtO-3l8aA:
3.5		 3cjtO-3l8aA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CJT_O_SAMO302_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 3l8a PUTATIVE
AMINOTRANSFERASE,
PROBABLE
BETA-CYSTATHIONASE
(Streptococcus
mutans) 		6 / 12 LEU A 365
ILE A 312
ASP A 326
ASN A 350
LEU A 349
LEU A 341
 None
 1.18A 3cjtO-3l8aA:
3.5		 3cjtO-3l8aA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELW_A_SAMA4633_0
(METHYLTRANSFERASE)		 3l8a PUTATIVE
AMINOTRANSFERASE,
PROBABLE
BETA-CYSTATHIONASE
(Streptococcus
mutans) 		6 / 12 GLY A 209
GLY A 319
LEU A 322
ASN A 366
VAL A 367
ILE A 295
 None
 1.27A 3elwA-3l8aA:
2.9		 3elwA-3l8aA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OZW_A_KKKA413_1
(FLAVOHEMOGLOBIN)		 3l8a PUTATIVE
AMINOTRANSFERASE,
PROBABLE
BETA-CYSTATHIONASE
(Streptococcus
mutans) 		4 / 8 ILE A 312
ALA A 363
LEU A 325
LEU A 378
 None
 0.83A 3ozwA-3l8aA:
2.3		 3ozwA-3l8aA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_B_2FAB401_2
(ADENOSINE KINASE)		 3l8a PUTATIVE
AMINOTRANSFERASE,
PROBABLE
BETA-CYSTATHIONASE
(Streptococcus
mutans) 		4 / 5 LEU A 102
ILE A 227
ALA A 104
PHE A 105
 None
 1.00A 4dc3B-3l8aA:
3.6		 4dc3B-3l8aA:
26.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8H_A_RKEA401_1
(PROTON-GATED ION
CHANNEL)		 3l8a PUTATIVE
AMINOTRANSFERASE,
PROBABLE
BETA-CYSTATHIONASE
(Streptococcus
mutans) 		4 / 8 TYR A  62
ASN A  64
ASP A  65
ASP A  66
 None
 0.83A 4f8hA-3l8aA:
undetectable
4f8hB-3l8aA:
undetectable		 4f8hA-3l8aA:
22.38
4f8hB-3l8aA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8H_B_RKEB401_1
(PROTON-GATED ION
CHANNEL)		 3l8a PUTATIVE
AMINOTRANSFERASE,
PROBABLE
BETA-CYSTATHIONASE
(Streptococcus
mutans) 		4 / 8 TYR A  62
ASN A  64
ASP A  65
ASP A  66
 None
 0.83A 4f8hB-3l8aA:
undetectable
4f8hC-3l8aA:
undetectable		 4f8hB-3l8aA:
22.38
4f8hC-3l8aA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8H_C_RKEC401_1
(PROTON-GATED ION
CHANNEL)		 3l8a PUTATIVE
AMINOTRANSFERASE,
PROBABLE
BETA-CYSTATHIONASE
(Streptococcus
mutans) 		4 / 8 TYR A  62
ASN A  64
ASP A  65
ASP A  66
 None
 0.83A 4f8hC-3l8aA:
undetectable
4f8hD-3l8aA:
undetectable		 4f8hC-3l8aA:
22.38
4f8hD-3l8aA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8H_D_RKED401_1
(PROTON-GATED ION
CHANNEL)		 3l8a PUTATIVE
AMINOTRANSFERASE,
PROBABLE
BETA-CYSTATHIONASE
(Streptococcus
mutans) 		4 / 8 TYR A  62
ASN A  64
ASP A  65
ASP A  66
 None
 0.84A 4f8hD-3l8aA:
undetectable
4f8hE-3l8aA:
undetectable		 4f8hD-3l8aA:
22.38
4f8hE-3l8aA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8H_E_RKEE401_1
(PROTON-GATED ION
CHANNEL)		 3l8a PUTATIVE
AMINOTRANSFERASE,
PROBABLE
BETA-CYSTATHIONASE
(Streptococcus
mutans) 		4 / 8 TYR A  62
ASN A  64
ASP A  65
ASP A  66
 None
 0.83A 4f8hA-3l8aA:
undetectable
4f8hE-3l8aA:
undetectable		 4f8hA-3l8aA:
22.38
4f8hE-3l8aA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IAQ_A_2GMA2001_2
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 1B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 3l8a PUTATIVE
AMINOTRANSFERASE,
PROBABLE
BETA-CYSTATHIONASE
(Streptococcus
mutans) 		4 / 6 ILE A 381
VAL A 348
SER A 383
ASP A  38
 None
 1.14A 4iaqA-3l8aA:
undetectable		 4iaqA-3l8aA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K4Y_A_ACTA502_0
(RNA-DEPENDENT RNA
POLYMERASE)		 3l8a PUTATIVE
AMINOTRANSFERASE,
PROBABLE
BETA-CYSTATHIONASE
(Streptococcus
mutans) 		4 / 5 LYS A 309
LEU A 306
GLU A 305
LEU A 378
 None
 1.36A 4k4yA-3l8aA:
undetectable		 4k4yA-3l8aA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K4Y_E_ACTE503_0
(RNA-DEPENDENT RNA
POLYMERASE)		 3l8a PUTATIVE
AMINOTRANSFERASE,
PROBABLE
BETA-CYSTATHIONASE
(Streptococcus
mutans) 		4 / 4 LYS A 309
LEU A 306
GLU A 305
LEU A 378
 None
 1.37A 4k4yE-3l8aA:
undetectable		 4k4yE-3l8aA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K4Y_I_ACTI503_0
(RNA-DEPENDENT RNA
POLYMERASE)		 3l8a PUTATIVE
AMINOTRANSFERASE,
PROBABLE
BETA-CYSTATHIONASE
(Streptococcus
mutans) 		4 / 5 LYS A 309
LEU A 306
GLU A 305
LEU A 378
 None
 1.36A 4k4yI-3l8aA:
undetectable		 4k4yI-3l8aA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UY8_7_TRP71002_0
(TRYPTOPHANASE)		 3l8a PUTATIVE
AMINOTRANSFERASE,
PROBABLE
BETA-CYSTATHIONASE
(Streptococcus
mutans) 		4 / 4 ILE A  50
ASN A  51
ILE A 275
VAL A 272
 None
 1.22A 4uy87-3l8aA:
undetectable		 4uy87-3l8aA:
5.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VC0_A_RITA602_2
(CYTOCHROME P450 3A4)		 3l8a PUTATIVE
AMINOTRANSFERASE,
PROBABLE
BETA-CYSTATHIONASE
(Streptococcus
mutans) 		4 / 7 ARG A 380
LEU A 301
THR A 310
THR A 369
 None
 0.98A 5vc0A-3l8aA:
undetectable		 5vc0A-3l8aA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_C_PCFC1807_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 3l8a PUTATIVE
AMINOTRANSFERASE,
PROBABLE
BETA-CYSTATHIONASE
(Streptococcus
mutans) 		4 / 6 ILE A 183
ILE A 156
LEU A 152
PHE A 149
 None
 1.04A 5vkqC-3l8aA:
undetectable
5vkqD-3l8aA:
undetectable		 5vkqC-3l8aA:
13.39
5vkqD-3l8aA:
13.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_H_CVIH301_0
(REGULATORY PROTEIN
TETR)		 3l8a PUTATIVE
AMINOTRANSFERASE,
PROBABLE
BETA-CYSTATHIONASE
(Streptococcus
mutans) 		5 / 12 ALA A 111
SER A 106
LEU A 102
VAL A 194
CYH A 189
 None
 1.28A 5vlmH-3l8aA:
undetectable		 5vlmH-3l8aA:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ2_C_SAMC601_0
(NS5 MTASE)		 3l8a PUTATIVE
AMINOTRANSFERASE,
PROBABLE
BETA-CYSTATHIONASE
(Streptococcus
mutans) 		6 / 12 GLY A 143
GLY A 174
THR A 320
GLU A 318
VAL A 367
ILE A 299
 None
 1.47A 5wz2C-3l8aA:
2.9		 5wz2C-3l8aA:
21.26