SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3l8d'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RI4_A_SAMA299_0
(MRNA CAPPING ENZYME)		 3l8d METHYLTRANSFERASE
(Bacillus
thuringiensis) 		5 / 12 GLY A  61
GLY A  63
ILE A  83
ASP A 106
SER A 125
 None
 0.70A 1ri4A-3l8dA:
15.0		 1ri4A-3l8dA:
25.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SG9_A_SAMA301_0
(HEMK PROTEIN)		 3l8d METHYLTRANSFERASE
(Bacillus
thuringiensis) 		5 / 12 GLY A  67
ILE A 123
SER A  72
GLU A  56
PHE A 117
 None
 1.18A 1sg9A-3l8dA:
10.9		 1sg9A-3l8dA:
22.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1VE3_B_SAMB301_0
(HYPOTHETICAL PROTEIN
PH0226)		 3l8d METHYLTRANSFERASE
(Bacillus
thuringiensis) 		5 / 12 GLY A  63
ILE A  83
SER A  84
ILE A 123
SER A 125
 None
 1.00A 1ve3B-3l8dA:
18.6		 1ve3B-3l8dA:
30.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_F_BEZF5023_0
(CES1 PROTEIN)		 3l8d METHYLTRANSFERASE
(Bacillus
thuringiensis) 		4 / 6 GLY A  61
SER A 125
LEU A  58
ILE A 139
 None
 0.84A 1yajF-3l8dA:
undetectable		 1yajF-3l8dA:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_A_SAMA300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 3l8d METHYLTRANSFERASE
(Bacillus
thuringiensis) 		5 / 12 GLY A  63
SER A  84
MET A  87
ASP A 106
LEU A 107
 None
 1.05A 3ou6A-3l8dA:
14.4		 3ou6A-3l8dA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_A_SAMA300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 3l8d METHYLTRANSFERASE
(Bacillus
thuringiensis) 		5 / 12 GLY A  63
SER A  84
MET A  87
ASP A 106
LEU A 107
 None
 1.06A 3ou7A-3l8dA:
14.2		 3ou7A-3l8dA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_C_SAMC300_1
(SAM-DEPENDENT
METHYLTRANSFERASE)		 3l8d METHYLTRANSFERASE
(Bacillus
thuringiensis) 		3 / 3 GLY A  63
ASP A  82
ASP A 106
 None
 0.33A 3ou7C-3l8dA:
14.2		 3ou7C-3l8dA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_D_SAMD300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 3l8d METHYLTRANSFERASE
(Bacillus
thuringiensis) 		5 / 12 GLY A  63
SER A  84
MET A  87
ASP A 106
LEU A 107
 None
 1.02A 3ou7D-3l8dA:
14.3		 3ou7D-3l8dA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U5K_A_08JA1_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 3l8d METHYLTRANSFERASE
(Bacillus
thuringiensis) 		4 / 8 VAL A 200
ASN A 124
ILE A 123
MET A 121
 None
 0.79A 3u5kA-3l8dA:
undetectable		 3u5kA-3l8dA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U5K_C_08JC3_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 3l8d METHYLTRANSFERASE
(Bacillus
thuringiensis) 		4 / 8 VAL A 200
ASN A 124
ILE A 123
MET A 121
 None
 0.82A 3u5kC-3l8dA:
undetectable		 3u5kC-3l8dA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U5K_D_08JD4_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 3l8d METHYLTRANSFERASE
(Bacillus
thuringiensis) 		4 / 8 VAL A 200
ASN A 124
ILE A 123
MET A 121
 None
 0.80A 3u5kD-3l8dA:
undetectable		 3u5kD-3l8dA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GC9_A_ACTA402_0
(DIMETHYLADENOSINE
TRANSFERASE 1,
MITOCHONDRIAL)		 3l8d METHYLTRANSFERASE
(Bacillus
thuringiensis) 		3 / 3 LYS A  70
TYR A  69
ARG A  73
 None
 1.46A 4gc9A-3l8dA:
8.9		 4gc9A-3l8dA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HDL_A_DXCA75_0
(PPCA)		 3l8d METHYLTRANSFERASE
(Bacillus
thuringiensis) 		4 / 8 LYS A 104
ILE A  83
LYS A  92
GLY A  91
 None
 0.95A 4hdlA-3l8dA:
undetectable		 4hdlA-3l8dA:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IV8_A_SAMA301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 3l8d METHYLTRANSFERASE
(Bacillus
thuringiensis) 		5 / 12 GLY A  61
GLY A  63
ASP A  82
ILE A  83
ASP A 106
 None
 0.44A 4iv8A-3l8dA:
15.8		 4iv8A-3l8dA:
27.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IV8_A_SAMA301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 3l8d METHYLTRANSFERASE
(Bacillus
thuringiensis) 		5 / 12 GLY A  61
GLY A  63
ASP A  82
ILE A  83
MET A  87
 None
 0.67A 4iv8A-3l8dA:
15.8		 4iv8A-3l8dA:
27.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IV8_B_SAMB301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 3l8d METHYLTRANSFERASE
(Bacillus
thuringiensis) 		5 / 12 GLY A  61
GLY A  63
ASP A  82
ILE A  83
ASP A 106
 None
 0.44A 4iv8B-3l8dA:
16.1		 4iv8B-3l8dA:
27.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IV8_B_SAMB301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 3l8d METHYLTRANSFERASE
(Bacillus
thuringiensis) 		5 / 12 GLY A  61
GLY A  63
ASP A  82
ILE A  83
MET A  87
 None
 0.69A 4iv8B-3l8dA:
16.1		 4iv8B-3l8dA:
27.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWX_A_ZMRA513_2
(NEURAMINIDASE)		 3l8d METHYLTRANSFERASE
(Bacillus
thuringiensis) 		3 / 3 ARG A  40
TRP A  35
ILE A 123
 None
 1.05A 4mwxA-3l8dA:
undetectable		 4mwxA-3l8dA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QDJ_A_SAMA301_0
(MAGNESIUM-PROTOPORPH
YRIN
O-METHYLTRANSFERASE)		 3l8d METHYLTRANSFERASE
(Bacillus
thuringiensis) 		5 / 12 GLY A  61
GLY A  63
ILE A  83
SER A  84
MET A  87
 None
 0.39A 4qdjA-3l8dA:
16.0		 4qdjA-3l8dA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QTU_B_SAMB301_0
(PUTATIVE
METHYLTRANSFERASE
BUD23)		 3l8d METHYLTRANSFERASE
(Bacillus
thuringiensis) 		6 / 12 GLY A  61
GLY A  63
ILE A  83
SER A  84
MET A  87
ILE A 123
 None
 0.61A 4qtuB-3l8dA:
15.3		 4qtuB-3l8dA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QTU_D_SAMD301_0
(PUTATIVE
METHYLTRANSFERASE
BUD23)		 3l8d METHYLTRANSFERASE
(Bacillus
thuringiensis) 		6 / 12 GLY A  61
GLY A  63
ILE A  83
SER A  84
MET A  87
ILE A 123
 None
 0.62A 4qtuD-3l8dA:
16.0		 4qtuD-3l8dA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UAC_A_ACRA501_2
(CARBOHYDRATE ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN, CUT1 FAMILY
(TC 3.A.1.1.-))		 3l8d METHYLTRANSFERASE
(Bacillus
thuringiensis) 		4 / 7 PRO A 132
SER A 125
ASP A  64
THR A  68
 None
 1.32A 4uacA-3l8dA:
undetectable		 4uacA-3l8dA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_A_NOVA2000_1
(DNA GYRASE SUBUNIT B)		 3l8d METHYLTRANSFERASE
(Bacillus
thuringiensis) 		5 / 12 SER A 108
GLU A 138
ARG A 141
ILE A 139
ILE A 120
 None
 1.28A 4uroA-3l8dA:
undetectable		 4uroA-3l8dA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_A_NOVA2000_1
(DNA GYRASE SUBUNIT B)		 3l8d METHYLTRANSFERASE
(Bacillus
thuringiensis) 		5 / 12 SER A 108
GLU A 138
ARG A 141
ILE A 139
SER A 125
 None
 1.11A 4uroA-3l8dA:
undetectable		 4uroA-3l8dA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_B_NOVB2000_1
(DNA GYRASE SUBUNIT B)		 3l8d METHYLTRANSFERASE
(Bacillus
thuringiensis) 		5 / 12 SER A 108
GLU A 138
ARG A 141
ILE A 139
ILE A 120
 None
 1.19A 4uroB-3l8dA:
undetectable		 4uroB-3l8dA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_B_NOVB2000_1
(DNA GYRASE SUBUNIT B)		 3l8d METHYLTRANSFERASE
(Bacillus
thuringiensis) 		5 / 12 SER A 108
GLU A 138
ARG A 141
ILE A 139
SER A 125
 None
 1.03A 4uroB-3l8dA:
undetectable		 4uroB-3l8dA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_D_NOVD2000_1
(DNA GYRASE SUBUNIT B)		 3l8d METHYLTRANSFERASE
(Bacillus
thuringiensis) 		5 / 12 SER A 108
GLU A 138
ARG A 141
ILE A 139
ILE A 120
 None
 1.28A 4uroD-3l8dA:
undetectable		 4uroD-3l8dA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_D_NOVD2000_1
(DNA GYRASE SUBUNIT B)		 3l8d METHYLTRANSFERASE
(Bacillus
thuringiensis) 		5 / 12 SER A 108
GLU A 138
ARG A 141
ILE A 139
SER A 125
 None
 1.02A 4uroD-3l8dA:
undetectable		 4uroD-3l8dA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OSP_A_ACTA403_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 3l8d METHYLTRANSFERASE
(Bacillus
thuringiensis) 		5 / 7 TYR A  76
VAL A  57
ILE A 120
VAL A  51
ALA A 119
 None
 1.36A 5ospA-3l8dA:
undetectable		 5ospA-3l8dA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WY0_A_SAMA800_0
(SMALL RNA
2'-O-METHYLTRANSFERA
SE)		 3l8d METHYLTRANSFERASE
(Bacillus
thuringiensis) 		5 / 12 GLY A  61
GLY A  63
ASP A  82
ILE A  83
ILE A 123
 None
 0.40A 5wy0A-3l8dA:
13.7		 5wy0A-3l8dA:
20.64