SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3l8e'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IWK_A_CUA1599_0
(NITROUS OXIDE
REDUCTASE)		 3l8e D,D-HEPTOSE
1,7-BISPHOSPHATE
PHOSPHATASE
(Escherichia
coli) 		3 / 3 CYH A  92
CYH A 107
HIS A  94
 ZN  A 801 (-2.2A)
ZN  A 801 (-2.3A)
ZN  A 801 (-3.2A)
 0.88A 2iwkA-3l8eA:
undetectable		 2iwkA-3l8eA:
14.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IWK_B_CUB1599_0
(NITROUS OXIDE
REDUCTASE)		 3l8e D,D-HEPTOSE
1,7-BISPHOSPHATE
PHOSPHATASE
(Escherichia
coli) 		3 / 3 CYH A  92
CYH A 107
HIS A  94
 ZN  A 801 (-2.2A)
ZN  A 801 (-2.3A)
ZN  A 801 (-3.2A)
 0.87A 2iwkB-3l8eA:
undetectable		 2iwkB-3l8eA:
14.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QMZ_A_LDPA501_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE)		 3l8e D,D-HEPTOSE
1,7-BISPHOSPHATE
PHOSPHATASE
(Escherichia
coli) 		4 / 7 TRP A  74
PHE A  31
ILE A  16
PHE A  29
 None
 0.89A 2qmzA-3l8eA:
3.0
2qmzB-3l8eA:
2.9		 2qmzA-3l8eA:
22.49
2qmzB-3l8eA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DTU_B_CUB1022_0
(CYTOCHROME C OXIDASE
SUBUNIT 2)		 3l8e D,D-HEPTOSE
1,7-BISPHOSPHATE
PHOSPHATASE
(Escherichia
coli) 		3 / 3 CYH A  92
CYH A 107
HIS A  94
 ZN  A 801 (-2.2A)
ZN  A 801 (-2.3A)
ZN  A 801 (-3.2A)
 0.73A 3dtuB-3l8eA:
undetectable		 3dtuB-3l8eA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DTU_D_CUD3_0
(CYTOCHROME C OXIDASE
SUBUNIT 2)		 3l8e D,D-HEPTOSE
1,7-BISPHOSPHATE
PHOSPHATASE
(Escherichia
coli) 		3 / 3 CYH A  92
CYH A 107
HIS A  94
 ZN  A 801 (-2.2A)
ZN  A 801 (-2.3A)
ZN  A 801 (-3.2A)
 0.70A 3dtuD-3l8eA:
undetectable		 3dtuD-3l8eA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ROD_D_NCAD302_0
(NICOTINAMIDE
N-METHYLTRANSFERASE)		 3l8e D,D-HEPTOSE
1,7-BISPHOSPHATE
PHOSPHATASE
(Escherichia
coli) 		4 / 7 LEU A 124
ALA A   7
ASP A  87
TYR A  90
 None
 1.09A 3rodD-3l8eA:
undetectable		 3rodD-3l8eA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOG_B_ML1B302_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 3l8e D,D-HEPTOSE
1,7-BISPHOSPHATE
PHOSPHATASE
(Escherichia
coli) 		4 / 6 TRP A  74
PHE A  31
ILE A  16
PHE A  29
 None
 1.10A 4qogA-3l8eA:
undetectable
4qogB-3l8eA:
undetectable		 4qogA-3l8eA:
23.20
4qogB-3l8eA:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MUG_A_VIVA301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 3l8e D,D-HEPTOSE
1,7-BISPHOSPHATE
PHOSPHATASE
(Escherichia
coli) 		5 / 12 LEU A 173
ILE A  32
ILE A   8
VAL A 134
LEU A  10
 None
 1.09A 5mugA-3l8eA:
undetectable		 5mugA-3l8eA:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSG_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)		 3l8e D,D-HEPTOSE
1,7-BISPHOSPHATE
PHOSPHATASE
(Escherichia
coli) 		5 / 10 LEU A 179
TYR A 132
GLY A 135
TRP A 171
LEU A 173
 None
 1.47A 6bsgA-3l8eA:
undetectable		 6bsgA-3l8eA:
16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSJ_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)		 3l8e D,D-HEPTOSE
1,7-BISPHOSPHATE
PHOSPHATASE
(Escherichia
coli) 		5 / 10 LEU A 179
TYR A 132
GLY A 135
TRP A 171
LEU A 173
 None
 1.45A 6bsjA-3l8eA:
undetectable		 6bsjA-3l8eA:
16.02