SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3l8h'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AV2_A_DVAA6_0
(GRAMICIDIN A)		 3l8h PUTATIVE HALOACID
DEHALOGENASE-LIKE
HYDROLASE
(Bordetella
bronchiseptica) 		3 / 3 ALA A 134
VAL A 124
TRP A 142
 None
 0.94A 1av2A-3l8hA:
undetectable
1av2B-3l8hA:
undetectable		 1av2A-3l8hA:
9.68
1av2B-3l8hA:
9.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AV2_D_DVAD6_0
(GRAMICIDIN A)		 3l8h PUTATIVE HALOACID
DEHALOGENASE-LIKE
HYDROLASE
(Bordetella
bronchiseptica) 		3 / 3 TRP A 142
ALA A 134
VAL A 124
 None
 1.00A 1av2C-3l8hA:
undetectable
1av2D-3l8hA:
undetectable		 1av2C-3l8hA:
9.68
1av2D-3l8hA:
9.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W5U_A_DVAA6_0
(GRAMICIDIN D)		 3l8h PUTATIVE HALOACID
DEHALOGENASE-LIKE
HYDROLASE
(Bordetella
bronchiseptica) 		3 / 3 ALA A 134
VAL A 124
TRP A 142
 None
 0.96A 1w5uA-3l8hA:
undetectable
1w5uB-3l8hA:
undetectable		 1w5uA-3l8hA:
9.68
1w5uB-3l8hA:
9.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IZQ_D_DVAD6_0
(GRAMICIDIN D)		 3l8h PUTATIVE HALOACID
DEHALOGENASE-LIKE
HYDROLASE
(Bordetella
bronchiseptica) 		3 / 3 TRP A 142
ALA A 134
VAL A 124
 None
 0.90A 2izqC-3l8hA:
undetectable
2izqD-3l8hA:
undetectable		 2izqC-3l8hA:
9.68
2izqD-3l8hA:
9.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DTU_B_CUB1022_0
(CYTOCHROME C OXIDASE
SUBUNIT 2)		 3l8h PUTATIVE HALOACID
DEHALOGENASE-LIKE
HYDROLASE
(Bordetella
bronchiseptica) 		3 / 3 CYH A  89
CYH A  97
HIS A  91
 ZN  A 901 (-2.3A)
ZN  A 901 (-2.2A)
ZN  A 901 (-3.1A)
 0.85A 3dtuB-3l8hA:
undetectable		 3dtuB-3l8hA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DTU_D_CUD3_0
(CYTOCHROME C OXIDASE
SUBUNIT 2)		 3l8h PUTATIVE HALOACID
DEHALOGENASE-LIKE
HYDROLASE
(Bordetella
bronchiseptica) 		3 / 3 CYH A  89
CYH A  97
HIS A  91
 ZN  A 901 (-2.3A)
ZN  A 901 (-2.2A)
ZN  A 901 (-3.1A)
 0.83A 3dtuD-3l8hA:
undetectable		 3dtuD-3l8hA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K5V_B_STIB2_2
(TYROSINE-PROTEIN
KINASE ABL1)		 3l8h PUTATIVE HALOACID
DEHALOGENASE-LIKE
HYDROLASE
(Bordetella
bronchiseptica) 		4 / 6 LEU A 131
VAL A  83
VAL A  11
ILE A   4
 None
 1.24A 3k5vB-3l8hA:
undetectable		 3k5vB-3l8hA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KU1_G_SAMG226_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 3l8h PUTATIVE HALOACID
DEHALOGENASE-LIKE
HYDROLASE
(Bordetella
bronchiseptica) 		5 / 12 GLY A 138
ALA A 140
GLY A 120
LEU A   3
ILE A   5
 None
 1.08A 3ku1G-3l8hA:
2.2		 3ku1G-3l8hA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L8L_B_DVAB6_0
(GRAMICIDIN D)		 3l8h PUTATIVE HALOACID
DEHALOGENASE-LIKE
HYDROLASE
(Bordetella
bronchiseptica) 		3 / 3 TRP A 142
ALA A 134
VAL A 124
 None
 0.91A 3l8lA-3l8hA:
undetectable
3l8lB-3l8hA:
undetectable		 3l8lA-3l8hA:
9.68
3l8lB-3l8hA:
8.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L8L_D_DVAD6_0
(GRAMICIDIN D)		 3l8h PUTATIVE HALOACID
DEHALOGENASE-LIKE
HYDROLASE
(Bordetella
bronchiseptica) 		3 / 3 TRP A 142
ALA A 134
VAL A 124
 None
 0.95A 3l8lC-3l8hA:
undetectable
3l8lD-3l8hA:
undetectable		 3l8lC-3l8hA:
9.68
3l8lD-3l8hA:
8.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR1_B_017B101_1
(PROTEASE PR5-DRV)		 3l8h PUTATIVE HALOACID
DEHALOGENASE-LIKE
HYDROLASE
(Bordetella
bronchiseptica) 		5 / 10 LEU A   3
ALA A  49
ASP A   7
VAL A 121
ILE A   5
 None
None
PO4  A2001 ( 2.8A)
None
None
 0.92A 5kr1A-3l8hA:
undetectable		 5kr1A-3l8hA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUN_A_MTLA805_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3l8h PUTATIVE HALOACID
DEHALOGENASE-LIKE
HYDROLASE
(Bordetella
bronchiseptica) 		4 / 8 SER A  16
GLN A  52
PHE A  19
ASP A   9
 None
PO4  A2001 ( 4.8A)
None
PO4  A2001 ( 4.3A)
 1.31A 5vunA-3l8hA:
undetectable		 5vunA-3l8hA:
16.98