SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3l8j'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX6_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3l8j PROGRAMMED CELL
DEATH PROTEIN 10
(Homo
sapiens) 		4 / 7 ARG A  95
VAL A 145
PHE A 208
GLU A 161
 None
 1.19A 3jx6A-3l8jA:
undetectable
3jx6B-3l8jA:
undetectable		 3jx6A-3l8jA:
18.72
3jx6B-3l8jA:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KKZ_A_SAMA301_0
(UNCHARACTERIZED
PROTEIN Q5LES9)		 3l8j PROGRAMMED CELL
DEATH PROTEIN 10
(Homo
sapiens) 		5 / 12 GLN A 112
LEU A 103
LEU A 110
GLU A  89
ASN A 202
 None
 0.90A 3kkzA-3l8jA:
undetectable		 3kkzA-3l8jA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N5V_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE)		 3l8j PROGRAMMED CELL
DEATH PROTEIN 10
(Homo
sapiens) 		4 / 7 PHE A 208
GLU A 161
ARG A  95
VAL A 145
 None
 1.11A 3n5vA-3l8jA:
undetectable
3n5vB-3l8jA:
undetectable		 3n5vA-3l8jA:
18.96
3n5vB-3l8jA:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UFO_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3l8j PROGRAMMED CELL
DEATH PROTEIN 10
(Homo
sapiens) 		4 / 7 ARG A  95
VAL A 145
PHE A 208
GLU A 161
 None
 1.18A 3ufoA-3l8jA:
3.6
3ufoB-3l8jA:
undetectable		 3ufoA-3l8jA:
18.96
3ufoB-3l8jA:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FIA_A_0U9A601_1
(CHOLESTEROL
24-HYDROXYLASE)		 3l8j PROGRAMMED CELL
DEATH PROTEIN 10
(Homo
sapiens) 		5 / 12 TYR A 181
LEU A 178
PHE A 174
VAL A 190
THR A 130
 None
 1.25A 4fiaA-3l8jA:
undetectable		 4fiaA-3l8jA:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FIA_A_198A602_1
(CHOLESTEROL
24-HYDROXYLASE)		 3l8j PROGRAMMED CELL
DEATH PROTEIN 10
(Homo
sapiens) 		5 / 12 TYR A 181
LEU A 178
PHE A 174
VAL A 190
THR A 130
 None
 1.25A 4fiaA-3l8jA:
undetectable		 4fiaA-3l8jA:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RJD_B_TFPB204_1
(CALMODULIN)		 3l8j PROGRAMMED CELL
DEATH PROTEIN 10
(Homo
sapiens) 		4 / 8 LEU A  58
GLY A  57
MET A  26
ALA A  24
 None
 0.89A 4rjdA-3l8jA:
undetectable
4rjdB-3l8jA:
undetectable		 4rjdA-3l8jA:
16.57
4rjdB-3l8jA:
16.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MUR_E_PFLE406_1
(PROTON-GATED ION
CHANNEL)		 3l8j PROGRAMMED CELL
DEATH PROTEIN 10
(Homo
sapiens) 		5 / 10 TYR A  27
THR A  59
ILE A  62
ILE A  63
ILE A  66
 None
 1.11A 5murE-3l8jA:
5.9		 5murE-3l8jA:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_A_ACTA307_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 3l8j PROGRAMMED CELL
DEATH PROTEIN 10
(Homo
sapiens) 		4 / 4 LEU A 110
LEU A 114
SER A 171
ALA A 194
 None
 0.99A 5uunA-3l8jA:
3.0		 5uunA-3l8jA:
19.53