SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3l8k'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_A_TRPA81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 3l8k DIHYDROLIPOYL
DEHYDROGENASE
(Sulfolobus
solfataricus) 		5 / 9 GLY A  14
HIS A  16
ALA A 325
THR A 304
ILE A 135
 None
 1.26A 1c9sA-3l8kA:
undetectable
1c9sK-3l8kA:
undetectable		 1c9sA-3l8kA:
11.76
1c9sK-3l8kA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_B_TRPB81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 3l8k DIHYDROLIPOYL
DEHYDROGENASE
(Sulfolobus
solfataricus) 		5 / 9 ARG A 319
GLY A  14
ALA A 325
THR A 304
ILE A 135
 None
 1.38A 1c9sA-3l8kA:
undetectable
1c9sB-3l8kA:
undetectable		 1c9sA-3l8kA:
11.76
1c9sB-3l8kA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_C_TRPC81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 3l8k DIHYDROLIPOYL
DEHYDROGENASE
(Sulfolobus
solfataricus) 		5 / 10 ARG A 319
GLY A  14
ALA A 325
THR A 304
ILE A 135
 None
 1.38A 1c9sB-3l8kA:
undetectable
1c9sC-3l8kA:
undetectable		 1c9sB-3l8kA:
11.76
1c9sC-3l8kA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_C_TRPC81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 3l8k DIHYDROLIPOYL
DEHYDROGENASE
(Sulfolobus
solfataricus) 		5 / 10 GLY A  14
HIS A  16
ALA A 325
THR A 304
ILE A 135
 None
 1.28A 1c9sB-3l8kA:
undetectable
1c9sC-3l8kA:
undetectable		 1c9sB-3l8kA:
11.76
1c9sC-3l8kA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_D_TRPD81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 3l8k DIHYDROLIPOYL
DEHYDROGENASE
(Sulfolobus
solfataricus) 		5 / 9 GLY A  14
HIS A  16
ALA A 325
THR A 304
ILE A 135
 None
 1.25A 1c9sC-3l8kA:
undetectable
1c9sD-3l8kA:
undetectable		 1c9sC-3l8kA:
11.76
1c9sD-3l8kA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_E_TRPE81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 3l8k DIHYDROLIPOYL
DEHYDROGENASE
(Sulfolobus
solfataricus) 		5 / 9 GLY A  14
HIS A  16
ALA A 325
THR A 304
ILE A 135
 None
 1.26A 1c9sD-3l8kA:
undetectable
1c9sE-3l8kA:
undetectable		 1c9sD-3l8kA:
11.76
1c9sE-3l8kA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_F_TRPF81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 3l8k DIHYDROLIPOYL
DEHYDROGENASE
(Sulfolobus
solfataricus) 		5 / 9 GLY A  14
HIS A  16
ALA A 325
THR A 304
ILE A 135
 None
 1.27A 1c9sE-3l8kA:
undetectable
1c9sF-3l8kA:
undetectable		 1c9sE-3l8kA:
11.76
1c9sF-3l8kA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_G_TRPG81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 3l8k DIHYDROLIPOYL
DEHYDROGENASE
(Sulfolobus
solfataricus) 		5 / 9 GLY A  14
HIS A  16
ALA A 325
THR A 304
ILE A 135
 None
 1.25A 1c9sF-3l8kA:
undetectable
1c9sG-3l8kA:
undetectable		 1c9sF-3l8kA:
11.76
1c9sG-3l8kA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_H_TRPH81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 3l8k DIHYDROLIPOYL
DEHYDROGENASE
(Sulfolobus
solfataricus) 		5 / 10 ARG A 319
GLY A  14
ALA A 325
THR A 304
ILE A 135
 None
 1.38A 1c9sG-3l8kA:
undetectable
1c9sH-3l8kA:
undetectable		 1c9sG-3l8kA:
11.76
1c9sH-3l8kA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_H_TRPH81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 3l8k DIHYDROLIPOYL
DEHYDROGENASE
(Sulfolobus
solfataricus) 		5 / 10 GLY A  14
HIS A  16
ALA A 325
THR A 304
ILE A 135
 None
 1.26A 1c9sG-3l8kA:
undetectable
1c9sH-3l8kA:
undetectable		 1c9sG-3l8kA:
11.76
1c9sH-3l8kA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_I_TRPI81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 3l8k DIHYDROLIPOYL
DEHYDROGENASE
(Sulfolobus
solfataricus) 		5 / 9 GLY A  14
HIS A  16
ALA A 325
THR A 304
ILE A 135
 None
 1.25A 1c9sH-3l8kA:
undetectable
1c9sI-3l8kA:
undetectable		 1c9sH-3l8kA:
11.76
1c9sI-3l8kA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_K_TRPK81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 3l8k DIHYDROLIPOYL
DEHYDROGENASE
(Sulfolobus
solfataricus) 		5 / 9 GLY A  14
HIS A  16
ALA A 325
THR A 304
ILE A 135
 None
 1.27A 1c9sJ-3l8kA:
undetectable
1c9sK-3l8kA:
undetectable		 1c9sJ-3l8kA:
11.76
1c9sK-3l8kA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_O_TRPO81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 3l8k DIHYDROLIPOYL
DEHYDROGENASE
(Sulfolobus
solfataricus) 		5 / 9 GLY A  14
HIS A  16
ALA A 325
THR A 304
ILE A 135
 None
 1.29A 1c9sO-3l8kA:
undetectable
1c9sP-3l8kA:
undetectable		 1c9sO-3l8kA:
11.76
1c9sP-3l8kA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DDR_B_MTXB200_1
(DIHYDROFOLATE
REDUCTASE)		 3l8k DIHYDROLIPOYL
DEHYDROGENASE
(Sulfolobus
solfataricus) 		5 / 12 ILE A 198
LEU A 222
ILE A 347
LEU A 206
THR A 196
 None
 1.16A 1ddrB-3l8kA:
undetectable		 1ddrB-3l8kA:
17.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DDS_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 3l8k DIHYDROLIPOYL
DEHYDROGENASE
(Sulfolobus
solfataricus) 		5 / 12 ILE A 198
LEU A 222
ILE A 347
LEU A 206
THR A 196
 None
 1.12A 1ddsA-3l8kA:
undetectable		 1ddsA-3l8kA:
17.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DDS_B_MTXB201_1
(DIHYDROFOLATE
REDUCTASE)		 3l8k DIHYDROLIPOYL
DEHYDROGENASE
(Sulfolobus
solfataricus) 		5 / 12 ILE A 198
LEU A 222
ILE A 347
LEU A 206
THR A 196
 None
 1.05A 1ddsB-3l8kA:
undetectable		 1ddsB-3l8kA:
17.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DYI_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 3l8k DIHYDROLIPOYL
DEHYDROGENASE
(Sulfolobus
solfataricus) 		5 / 12 ILE A 198
LEU A 222
ILE A 347
LEU A 206
THR A 196
 None
 1.15A 1dyiA-3l8kA:
undetectable		 1dyiA-3l8kA:
17.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_A_TRPA81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 3l8k DIHYDROLIPOYL
DEHYDROGENASE
(Sulfolobus
solfataricus) 		5 / 9 GLY A  14
HIS A  16
ALA A 325
THR A 304
ILE A 135
 None
 1.27A 1gtfA-3l8kA:
undetectable
1gtfK-3l8kA:
undetectable		 1gtfA-3l8kA:
11.76
1gtfK-3l8kA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_C_TRPC81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 3l8k DIHYDROLIPOYL
DEHYDROGENASE
(Sulfolobus
solfataricus) 		5 / 9 GLY A  14
HIS A  16
ALA A 325
THR A 304
ILE A 135
 None
 1.25A 1gtfB-3l8kA:
undetectable
1gtfC-3l8kA:
undetectable		 1gtfB-3l8kA:
11.76
1gtfC-3l8kA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_D_TRPD81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 3l8k DIHYDROLIPOYL
DEHYDROGENASE
(Sulfolobus
solfataricus) 		5 / 10 ARG A 319
GLY A  14
ALA A 325
THR A 304
ILE A 135
 None
 1.40A 1gtfC-3l8kA:
undetectable
1gtfD-3l8kA:
undetectable		 1gtfC-3l8kA:
11.76
1gtfD-3l8kA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_D_TRPD81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 3l8k DIHYDROLIPOYL
DEHYDROGENASE
(Sulfolobus
solfataricus) 		5 / 10 GLY A  14
HIS A  16
ALA A 325
THR A 304
ILE A 135
 None
 1.28A 1gtfC-3l8kA:
undetectable
1gtfD-3l8kA:
undetectable		 1gtfC-3l8kA:
11.76
1gtfD-3l8kA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_F_TRPF81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 3l8k DIHYDROLIPOYL
DEHYDROGENASE
(Sulfolobus
solfataricus) 		5 / 9 GLY A  14
HIS A  16
ALA A 325
THR A 304
ILE A 135
 None
 1.28A 1gtfE-3l8kA:
undetectable
1gtfF-3l8kA:
undetectable		 1gtfE-3l8kA:
11.76
1gtfF-3l8kA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_G_TRPG81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 3l8k DIHYDROLIPOYL
DEHYDROGENASE
(Sulfolobus
solfataricus) 		5 / 9 ARG A 319
GLY A  14
ALA A 325
THR A 304
ILE A 135
 None
 1.38A 1gtfF-3l8kA:
undetectable
1gtfG-3l8kA:
undetectable		 1gtfF-3l8kA:
11.76
1gtfG-3l8kA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_H_TRPH81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 3l8k DIHYDROLIPOYL
DEHYDROGENASE
(Sulfolobus
solfataricus) 		5 / 10 ARG A 319
GLY A  14
ALA A 325
THR A 304
ILE A 135
 None
 1.41A 1gtfG-3l8kA:
undetectable
1gtfH-3l8kA:
undetectable		 1gtfG-3l8kA:
11.76
1gtfH-3l8kA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_H_TRPH81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 3l8k DIHYDROLIPOYL
DEHYDROGENASE
(Sulfolobus
solfataricus) 		5 / 10 GLY A  14
HIS A  16
ALA A 325
THR A 304
ILE A 135
 None
 1.26A 1gtfG-3l8kA:
undetectable
1gtfH-3l8kA:
undetectable		 1gtfG-3l8kA:
11.76
1gtfH-3l8kA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_I_TRPI81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 3l8k DIHYDROLIPOYL
DEHYDROGENASE
(Sulfolobus
solfataricus) 		5 / 10 ARG A 319
GLY A  14
ALA A 325
THR A 304
ILE A 135
 None
 1.41A 1gtfH-3l8kA:
undetectable
1gtfI-3l8kA:
undetectable		 1gtfH-3l8kA:
11.76
1gtfI-3l8kA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_I_TRPI81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 3l8k DIHYDROLIPOYL
DEHYDROGENASE
(Sulfolobus
solfataricus) 		5 / 10 GLY A  14
HIS A  16
ALA A 325
THR A 304
ILE A 135
 None
 1.28A 1gtfH-3l8kA:
undetectable
1gtfI-3l8kA:
undetectable		 1gtfH-3l8kA:
11.76
1gtfI-3l8kA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_J_TRPJ81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 3l8k DIHYDROLIPOYL
DEHYDROGENASE
(Sulfolobus
solfataricus) 		5 / 9 GLY A  14
HIS A  16
ALA A 325
THR A 304
ILE A 135
 None
 1.27A 1gtfI-3l8kA:
undetectable
1gtfJ-3l8kA:
undetectable		 1gtfI-3l8kA:
11.76
1gtfJ-3l8kA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_P_TRPP81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 3l8k DIHYDROLIPOYL
DEHYDROGENASE
(Sulfolobus
solfataricus) 		5 / 10 GLY A  14
HIS A  16
ALA A 325
THR A 304
ILE A 135
 None
 1.28A 1gtfP-3l8kA:
undetectable
1gtfQ-3l8kA:
undetectable		 1gtfP-3l8kA:
11.76
1gtfQ-3l8kA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_T_TRPT81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 3l8k DIHYDROLIPOYL
DEHYDROGENASE
(Sulfolobus
solfataricus) 		5 / 10 GLY A  14
HIS A  16
ALA A 325
THR A 304
ILE A 135
 None
 1.29A 1gtfT-3l8kA:
undetectable
1gtfU-3l8kA:
undetectable		 1gtfT-3l8kA:
11.76
1gtfU-3l8kA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_U_TRPU81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 3l8k DIHYDROLIPOYL
DEHYDROGENASE
(Sulfolobus
solfataricus) 		5 / 11 GLY A  14
ALA A 325
THR A 304
ILE A 135
ARG A 319
 None
 1.34A 1gtfU-3l8kA:
undetectable
1gtfV-3l8kA:
undetectable		 1gtfU-3l8kA:
11.76
1gtfV-3l8kA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_U_TRPU81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 3l8k DIHYDROLIPOYL
DEHYDROGENASE
(Sulfolobus
solfataricus) 		5 / 11 GLY A  14
HIS A  16
ALA A 325
THR A 304
ILE A 135
 None
 1.26A 1gtfU-3l8kA:
undetectable
1gtfV-3l8kA:
undetectable		 1gtfU-3l8kA:
11.76
1gtfV-3l8kA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_V_TRPV81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 3l8k DIHYDROLIPOYL
DEHYDROGENASE
(Sulfolobus
solfataricus) 		5 / 10 GLY A  14
HIS A  16
ALA A 325
THR A 304
ILE A 135
 None
 1.28A 1gtfL-3l8kA:
undetectable
1gtfV-3l8kA:
undetectable		 1gtfL-3l8kA:
11.76
1gtfV-3l8kA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_H_TRPH81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 3l8k DIHYDROLIPOYL
DEHYDROGENASE
(Sulfolobus
solfataricus) 		5 / 9 GLY A  14
HIS A  16
ALA A 325
THR A 304
ILE A 135
 None
 1.29A 1gtnG-3l8kA:
undetectable
1gtnH-3l8kA:
undetectable		 1gtnG-3l8kA:
11.76
1gtnH-3l8kA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_N_TRPN81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 3l8k DIHYDROLIPOYL
DEHYDROGENASE
(Sulfolobus
solfataricus) 		5 / 10 GLY A  14
HIS A  16
ALA A 325
THR A 304
ILE A 135
 None
 1.29A 1gtnN-3l8kA:
undetectable
1gtnO-3l8kA:
undetectable		 1gtnN-3l8kA:
11.76
1gtnO-3l8kA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_P_TRPP81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 3l8k DIHYDROLIPOYL
DEHYDROGENASE
(Sulfolobus
solfataricus) 		5 / 8 GLY A  14
HIS A  16
ALA A 325
THR A 304
ILE A 135
 None
 1.24A 1gtnP-3l8kA:
undetectable
1gtnQ-3l8kA:
undetectable		 1gtnP-3l8kA:
11.76
1gtnQ-3l8kA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_S_TRPS81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 3l8k DIHYDROLIPOYL
DEHYDROGENASE
(Sulfolobus
solfataricus) 		5 / 9 GLY A  14
HIS A  16
ALA A 325
THR A 304
ILE A 135
 None
 1.32A 1gtnS-3l8kA:
undetectable
1gtnT-3l8kA:
undetectable		 1gtnS-3l8kA:
11.76
1gtnT-3l8kA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JOL_A_FFOA161_0
(DIHYDROFOLATE
REDUCTASE)		 3l8k DIHYDROLIPOYL
DEHYDROGENASE
(Sulfolobus
solfataricus) 		5 / 12 ILE A 198
LEU A 222
ILE A 347
LEU A 206
THR A 196
 None
 1.19A 1jolA-3l8kA:
undetectable		 1jolA-3l8kA:
17.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P91_A_SAMA1401_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE A)		 3l8k DIHYDROLIPOYL
DEHYDROGENASE
(Sulfolobus
solfataricus) 		5 / 11 GLY A 182
GLY A 179
ILE A 347
TYR A 348
HIS A 315
 None
 1.22A 1p91A-3l8kA:
undetectable		 1p91A-3l8kA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_A_TRPA81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3l8k DIHYDROLIPOYL
DEHYDROGENASE
(Sulfolobus
solfataricus) 		5 / 9 GLY A  14
HIS A  16
ALA A 325
THR A 304
ILE A 135
 None
 1.27A 1utdA-3l8kA:
undetectable
1utdB-3l8kA:
undetectable		 1utdA-3l8kA:
11.76
1utdB-3l8kA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_C_TRPC81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3l8k DIHYDROLIPOYL
DEHYDROGENASE
(Sulfolobus
solfataricus) 		5 / 9 GLY A  14
HIS A  16
ALA A 325
THR A 304
ILE A 135
 None
 1.29A 1utdC-3l8kA:
undetectable
1utdD-3l8kA:
undetectable		 1utdC-3l8kA:
11.76
1utdD-3l8kA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_D_TRPD81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3l8k DIHYDROLIPOYL
DEHYDROGENASE
(Sulfolobus
solfataricus) 		5 / 9 GLY A  14
HIS A  16
ALA A 325
THR A 304
ILE A 135
 None
 1.25A 1utdD-3l8kA:
undetectable
1utdE-3l8kA:
undetectable		 1utdD-3l8kA:
11.76
1utdE-3l8kA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_G_TRPG81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3l8k DIHYDROLIPOYL
DEHYDROGENASE
(Sulfolobus
solfataricus) 		5 / 9 GLY A  14
HIS A  16
ALA A 325
THR A 304
ILE A 135
 None
 1.29A 1utdG-3l8kA:
undetectable
1utdH-3l8kA:
undetectable		 1utdG-3l8kA:
11.76
1utdH-3l8kA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_K_TRPK81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3l8k DIHYDROLIPOYL
DEHYDROGENASE
(Sulfolobus
solfataricus) 		5 / 9 GLY A  14
HIS A  16
ALA A 325
THR A 304
ILE A 135
 None
 1.26A 1utdA-3l8kA:
undetectable
1utdK-3l8kA:
undetectable		 1utdA-3l8kA:
11.76
1utdK-3l8kA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_M_TRPM81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3l8k DIHYDROLIPOYL
DEHYDROGENASE
(Sulfolobus
solfataricus) 		5 / 11 GLY A  14
ALA A 325
THR A 304
ILE A 135
ARG A 319
 None
 1.32A 1utdM-3l8kA:
undetectable
1utdN-3l8kA:
undetectable		 1utdM-3l8kA:
11.76
1utdN-3l8kA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_M_TRPM81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3l8k DIHYDROLIPOYL
DEHYDROGENASE
(Sulfolobus
solfataricus) 		5 / 11 GLY A  14
HIS A  16
ALA A 325
THR A 304
ILE A 135
 None
 1.26A 1utdM-3l8kA:
undetectable
1utdN-3l8kA:
undetectable		 1utdM-3l8kA:
11.76
1utdN-3l8kA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_N_TRPN81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3l8k DIHYDROLIPOYL
DEHYDROGENASE
(Sulfolobus
solfataricus) 		5 / 10 GLY A  14
HIS A  16
ALA A 325
THR A 304
ILE A 135
 None
 1.29A 1utdN-3l8kA:
undetectable
1utdO-3l8kA:
undetectable		 1utdN-3l8kA:
11.76
1utdO-3l8kA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_Q_TRPQ81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3l8k DIHYDROLIPOYL
DEHYDROGENASE
(Sulfolobus
solfataricus) 		5 / 10 GLY A  14
HIS A  16
ALA A 325
THR A 304
ILE A 135
 None
 1.29A 1utdQ-3l8kA:
undetectable
1utdR-3l8kA:
undetectable		 1utdQ-3l8kA:
11.76
1utdR-3l8kA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_R_TRPR81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3l8k DIHYDROLIPOYL
DEHYDROGENASE
(Sulfolobus
solfataricus) 		5 / 10 GLY A  14
HIS A  16
ALA A 325
THR A 304
ILE A 135
 None
 1.30A 1utdR-3l8kA:
undetectable
1utdS-3l8kA:
undetectable		 1utdR-3l8kA:
11.76
1utdS-3l8kA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDK_E_9CRE1500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3l8k DIHYDROLIPOYL
DEHYDROGENASE
(Sulfolobus
solfataricus) 		5 / 12 ILE A 176
ALA A 266
ALA A 265
ALA A 143
VAL A 245
 None
 1.05A 1xdkE-3l8kA:
undetectable		 1xdkE-3l8kA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z11_A_8MOA501_0
(CYTOCHROME P450,
FAMILY 2, SUBFAMILY
A, POLYPEPTIDE 6)		 3l8k DIHYDROLIPOYL
DEHYDROGENASE
(Sulfolobus
solfataricus) 		5 / 11 VAL A 215
ILE A 207
ILE A 226
LEU A 219
PHE A 228
 None
 1.04A 1z11A-3l8kA:
undetectable		 1z11A-3l8kA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z11_C_8MOC501_0
(CYTOCHROME P450,
FAMILY 2, SUBFAMILY
A, POLYPEPTIDE 6)		 3l8k DIHYDROLIPOYL
DEHYDROGENASE
(Sulfolobus
solfataricus) 		5 / 10 VAL A 215
GLY A 179
ILE A 226
LEU A 219
PHE A 228
 None
 1.11A 1z11C-3l8kA:
undetectable		 1z11C-3l8kA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z11_C_8MOC501_0
(CYTOCHROME P450,
FAMILY 2, SUBFAMILY
A, POLYPEPTIDE 6)		 3l8k DIHYDROLIPOYL
DEHYDROGENASE
(Sulfolobus
solfataricus) 		5 / 10 VAL A 215
ILE A 207
ILE A 226
LEU A 219
PHE A 228
 None
 1.09A 1z11C-3l8kA:
undetectable		 1z11C-3l8kA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JAP_A_J01A1249_1
(CLAVALDEHYDE
DEHYDROGENASE)		 3l8k DIHYDROLIPOYL
DEHYDROGENASE
(Sulfolobus
solfataricus) 		5 / 12 MET A  96
LEU A 102
ALA A  10
VAL A   7
ALA A  18
 None
 1.26A 2japA-3l8kA:
3.5		 2japA-3l8kA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JAP_B_J01B1249_1
(CLAVALDEHYDE
DEHYDROGENASE)		 3l8k DIHYDROLIPOYL
DEHYDROGENASE
(Sulfolobus
solfataricus) 		5 / 12 MET A  96
LEU A 102
ALA A  10
VAL A   7
ALA A  18
 None
 1.25A 2japB-3l8kA:
3.5		 2japB-3l8kA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JAP_C_J01C1249_1
(CLAVALDEHYDE
DEHYDROGENASE)		 3l8k DIHYDROLIPOYL
DEHYDROGENASE
(Sulfolobus
solfataricus) 		5 / 12 MET A  96
LEU A 102
ALA A  10
VAL A   7
ALA A  18
 None
 1.26A 2japC-3l8kA:
3.8		 2japC-3l8kA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JAP_D_J01D1249_1
(CLAVALDEHYDE
DEHYDROGENASE)		 3l8k DIHYDROLIPOYL
DEHYDROGENASE
(Sulfolobus
solfataricus) 		5 / 12 MET A  96
LEU A 102
ALA A  10
VAL A   7
ALA A  18
 None
 1.26A 2japD-3l8kA:
3.2		 2japD-3l8kA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JJ8_B_AZZB1211_1
(DEOXYNUCLEOSIDE
KINASE)		 3l8k DIHYDROLIPOYL
DEHYDROGENASE
(Sulfolobus
solfataricus) 		5 / 12 LEU A 169
PHE A  74
GLN A  78
VAL A  77
PHE A 160
 None
 1.40A 2jj8B-3l8kA:
undetectable		 2jj8B-3l8kA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JJ8_C_AZZC1211_1
(DEOXYNUCLEOSIDE
KINASE)		 3l8k DIHYDROLIPOYL
DEHYDROGENASE
(Sulfolobus
solfataricus) 		5 / 12 ILE A 185
LEU A 169
PHE A  74
GLN A  78
PHE A 160
 None
 1.30A 2jj8C-3l8kA:
undetectable		 2jj8C-3l8kA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JJ8_D_AZZD1211_1
(DEOXYNUCLEOSIDE
KINASE)		 3l8k DIHYDROLIPOYL
DEHYDROGENASE
(Sulfolobus
solfataricus) 		5 / 10 ILE A 185
PHE A  74
GLN A  78
VAL A  77
PHE A 160
 None
 1.27A 2jj8D-3l8kA:
0.0		 2jj8D-3l8kA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VN1_A_FK5A501_2
(70 KDA
PEPTIDYLPROLYL
ISOMERASE)		 3l8k DIHYDROLIPOYL
DEHYDROGENASE
(Sulfolobus
solfataricus) 		4 / 6 SER A 156
PHE A 160
ASP A 157
GLU A 184
 None
 1.14A 2vn1B-3l8kA:
undetectable		 2vn1B-3l8kA:
13.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3B_B_FOLB401_1
(DIHYDROFOLATE
REDUCTASE)		 3l8k DIHYDROLIPOYL
DEHYDROGENASE
(Sulfolobus
solfataricus) 		3 / 3 GLU A  36
GLN A  91
ARG A  94
 None
 0.67A 2w3bB-3l8kA:
undetectable		 2w3bB-3l8kA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZZA_A_FOLA164_0
(DIHYDROFOLATE
REDUCTASE)		 3l8k DIHYDROLIPOYL
DEHYDROGENASE
(Sulfolobus
solfataricus) 		5 / 12 ILE A 198
LEU A 222
ILE A 347
LEU A 206
THR A 196
 None
 1.31A 2zzaA-3l8kA:
undetectable		 2zzaA-3l8kA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZZA_B_FOLB164_0
(DIHYDROFOLATE
REDUCTASE)		 3l8k DIHYDROLIPOYL
DEHYDROGENASE
(Sulfolobus
solfataricus) 		5 / 11 ILE A 198
LEU A 222
ILE A 347
LEU A 206
THR A 196
 None
 1.30A 2zzaB-3l8kA:
undetectable		 2zzaB-3l8kA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E00_A_9CRA7223_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3l8k DIHYDROLIPOYL
DEHYDROGENASE
(Sulfolobus
solfataricus) 		5 / 12 ILE A 176
ALA A 266
ALA A 265
ALA A 143
VAL A 245
 None
 1.06A 3e00A-3l8kA:
undetectable		 3e00A-3l8kA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_C_TOPC200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 3l8k DIHYDROLIPOYL
DEHYDROGENASE
(Sulfolobus
solfataricus) 		5 / 11 ALA A 186
LEU A 222
ILE A 347
LEU A 206
THR A 196
 None
 1.15A 3fl9C-3l8kA:
undetectable		 3fl9C-3l8kA:
14.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_H_TOPH200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 3l8k DIHYDROLIPOYL
DEHYDROGENASE
(Sulfolobus
solfataricus) 		5 / 9 ALA A 186
LEU A 222
ILE A 347
LEU A 206
THR A 196
 None
 1.22A 3fl9H-3l8kA:
undetectable		 3fl9H-3l8kA:
14.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JAY_A_SAMA1102_0
(STRUCTURAL PROTEIN
VP3)		 3l8k DIHYDROLIPOYL
DEHYDROGENASE
(Sulfolobus
solfataricus) 		5 / 12 GLY A 309
ALA A 316
PRO A 270
ALA A 140
TYR A 180
 None
 1.11A 3jayA-3l8kA:
undetectable		 3jayA-3l8kA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB1_A_SAMA1101_0
(STRUCTURAL PROTEIN
VP3)		 3l8k DIHYDROLIPOYL
DEHYDROGENASE
(Sulfolobus
solfataricus) 		5 / 12 ILE A   8
GLY A   9
ASP A  32
PRO A  33
ALA A  13
 ADP  A 465 (-4.3A)
ADP  A 465 (-3.4A)
ADP  A 465 (-2.8A)
ADP  A 465 (-4.3A)
ADP  A 465 (-3.2A)
 1.07A 3jb1A-3l8kA:
2.4		 3jb1A-3l8kA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_G_PZIG801_0
(GLUTAMATE RECEPTOR 2)		 3l8k DIHYDROLIPOYL
DEHYDROGENASE
(Sulfolobus
solfataricus) 		3 / 3 PRO A 442
SER A 382
ASN A 445
 None
 0.94A 3lslG-3l8kA:
undetectable		 3lslG-3l8kA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O7W_A_SAMA801_0
(LEUCINE CARBOXYL
METHYLTRANSFERASE 1)		 3l8k DIHYDROLIPOYL
DEHYDROGENASE
(Sulfolobus
solfataricus) 		5 / 12 ALA A 266
GLY A 182
ILE A 198
ASP A 172
VAL A 263
 None
 1.12A 3o7wA-3l8kA:
undetectable		 3o7wA-3l8kA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OWX_A_XRAA233_2
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 3l8k DIHYDROLIPOYL
DEHYDROGENASE
(Sulfolobus
solfataricus) 		4 / 5 VAL A 262
PHE A 166
ILE A 159
PHE A  74
 None
 1.08A 3owxB-3l8kA:
undetectable		 3owxB-3l8kA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QL0_A_FOLA160_0
(DIHYDROFOLATE
REDUCTASE)		 3l8k DIHYDROLIPOYL
DEHYDROGENASE
(Sulfolobus
solfataricus) 		5 / 12 ILE A 198
LEU A 222
ILE A 347
LEU A 206
THR A 196
 None
 1.18A 3ql0A-3l8kA:
undetectable		 3ql0A-3l8kA:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LV9_A_20JA602_1
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)		 3l8k DIHYDROLIPOYL
DEHYDROGENASE
(Sulfolobus
solfataricus) 		4 / 7 VAL A  28
ARG A  20
ILE A 328
ALA A 324
 None
 0.89A 4lv9A-3l8kA:
undetectable		 4lv9A-3l8kA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LV9_B_20JB602_1
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)		 3l8k DIHYDROLIPOYL
DEHYDROGENASE
(Sulfolobus
solfataricus) 		4 / 7 VAL A  28
ARG A  20
ILE A 328
ALA A 324
 None
 0.89A 4lv9B-3l8kA:
undetectable		 4lv9B-3l8kA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_A_SAMA602_0
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)		 3l8k DIHYDROLIPOYL
DEHYDROGENASE
(Sulfolobus
solfataricus) 		5 / 12 ALA A  13
GLY A 305
ILE A 135
MET A 294
GLY A   9
 ADP  A 465 (-3.2A)
ADP  A 465 (-3.3A)
None
None
ADP  A 465 (-3.4A)
 1.26A 4obwA-3l8kA:
2.6		 4obwA-3l8kA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_D_SAMD601_0
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)		 3l8k DIHYDROLIPOYL
DEHYDROGENASE
(Sulfolobus
solfataricus) 		5 / 12 ALA A  13
GLY A 305
ILE A 135
MET A 294
GLY A   9
 ADP  A 465 (-3.2A)
ADP  A 465 (-3.3A)
None
None
ADP  A 465 (-3.4A)
 1.22A 4obwD-3l8kA:
undetectable		 4obwD-3l8kA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QLF_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3l8k DIHYDROLIPOYL
DEHYDROGENASE
(Sulfolobus
solfataricus) 		5 / 11 ILE A 198
LEU A 222
ILE A 347
LEU A 206
THR A 196
 None
 1.17A 4qlfA-3l8kA:
undetectable		 4qlfA-3l8kA:
17.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QLG_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3l8k DIHYDROLIPOYL
DEHYDROGENASE
(Sulfolobus
solfataricus) 		5 / 12 ILE A 198
LEU A 222
ILE A 347
LEU A 206
THR A 196
 None
 1.19A 4qlgA-3l8kA:
undetectable		 4qlgA-3l8kA:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QTU_B_SAMB301_0
(PUTATIVE
METHYLTRANSFERASE
BUD23)		 3l8k DIHYDROLIPOYL
DEHYDROGENASE
(Sulfolobus
solfataricus) 		5 / 12 GLY A 179
LEU A 264
ILE A 207
ILE A 175
ALA A 178
 None
 1.04A 4qtuB-3l8kA:
2.5		 4qtuB-3l8kA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RGC_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3l8k DIHYDROLIPOYL
DEHYDROGENASE
(Sulfolobus
solfataricus) 		5 / 12 ILE A 198
LEU A 222
ILE A 347
LEU A 206
THR A 196
 None
 1.14A 4rgcA-3l8kA:
undetectable		 4rgcA-3l8kA:
17.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5G_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3l8k DIHYDROLIPOYL
DEHYDROGENASE
(Sulfolobus
solfataricus) 		5 / 12 ILE A 198
LEU A 222
ILE A 347
LEU A 206
THR A 196
 None
 1.15A 4x5gA-3l8kA:
undetectable		 4x5gA-3l8kA:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XDT_A_ACTA409_0
(FAD:PROTEIN FMN
TRANSFERASE)		 3l8k DIHYDROLIPOYL
DEHYDROGENASE
(Sulfolobus
solfataricus) 		4 / 5 ILE A 257
VAL A 174
ILE A 176
VAL A 245
 None
 0.72A 4xdtA-3l8kA:
undetectable		 4xdtA-3l8kA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZDZ_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3l8k DIHYDROLIPOYL
DEHYDROGENASE
(Sulfolobus
solfataricus) 		4 / 7 PHE A 189
ILE A 185
PHE A  74
THR A 164
 None
 0.94A 4zdzA-3l8kA:
2.9		 4zdzA-3l8kA:
23.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE3_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3l8k DIHYDROLIPOYL
DEHYDROGENASE
(Sulfolobus
solfataricus) 		4 / 7 PHE A 189
ILE A 185
PHE A  74
THR A 164
 None
 0.88A 4ze3A-3l8kA:
undetectable		 4ze3A-3l8kA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_A_TRPA101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3l8k DIHYDROLIPOYL
DEHYDROGENASE
(Sulfolobus
solfataricus) 		5 / 9 GLY A  14
HIS A  16
ALA A 325
THR A 304
ILE A 135
 None
 1.27A 5eeuA-3l8kA:
undetectable
5eeuB-3l8kA:
undetectable		 5eeuA-3l8kA:
11.76
5eeuB-3l8kA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_B_TRPB101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3l8k DIHYDROLIPOYL
DEHYDROGENASE
(Sulfolobus
solfataricus) 		5 / 9 GLY A  14
HIS A  16
ALA A 325
THR A 304
ILE A 135
 None
 1.26A 5eeuB-3l8kA:
undetectable
5eeuC-3l8kA:
undetectable		 5eeuB-3l8kA:
11.76
5eeuC-3l8kA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_D_TRPD101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3l8k DIHYDROLIPOYL
DEHYDROGENASE
(Sulfolobus
solfataricus) 		5 / 10 ARG A 319
GLY A  14
ALA A 325
THR A 304
ILE A 135
 None
 1.41A 5eeuD-3l8kA:
undetectable
5eeuE-3l8kA:
undetectable		 5eeuD-3l8kA:
11.76
5eeuE-3l8kA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_E_TRPE101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3l8k DIHYDROLIPOYL
DEHYDROGENASE
(Sulfolobus
solfataricus) 		5 / 9 GLY A  14
HIS A  16
ALA A 325
THR A 304
ILE A 135
 None
 1.26A 5eeuE-3l8kA:
undetectable
5eeuF-3l8kA:
undetectable		 5eeuE-3l8kA:
11.76
5eeuF-3l8kA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_G_TRPG101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3l8k DIHYDROLIPOYL
DEHYDROGENASE
(Sulfolobus
solfataricus) 		5 / 10 GLY A  14
HIS A  16
ALA A 325
THR A 304
ILE A 135
 None
 1.26A 5eeuG-3l8kA:
undetectable
5eeuH-3l8kA:
undetectable		 5eeuG-3l8kA:
11.76
5eeuH-3l8kA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_H_TRPH101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3l8k DIHYDROLIPOYL
DEHYDROGENASE
(Sulfolobus
solfataricus) 		5 / 10 ARG A 319
GLY A  14
ALA A 325
THR A 304
ILE A 135
 None
 1.40A 5eeuH-3l8kA:
undetectable
5eeuI-3l8kA:
undetectable		 5eeuH-3l8kA:
11.76
5eeuI-3l8kA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_H_TRPH101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3l8k DIHYDROLIPOYL
DEHYDROGENASE
(Sulfolobus
solfataricus) 		5 / 10 GLY A  14
HIS A  16
ALA A 325
THR A 304
ILE A 135
 None
 1.27A 5eeuH-3l8kA:
undetectable
5eeuI-3l8kA:
undetectable		 5eeuH-3l8kA:
11.76
5eeuI-3l8kA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_J_TRPJ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3l8k DIHYDROLIPOYL
DEHYDROGENASE
(Sulfolobus
solfataricus) 		5 / 10 ARG A 319
GLY A  14
ALA A 325
THR A 304
ILE A 135
 None
 1.40A 5eeuJ-3l8kA:
undetectable
5eeuK-3l8kA:
undetectable		 5eeuJ-3l8kA:
11.76
5eeuK-3l8kA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_J_TRPJ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3l8k DIHYDROLIPOYL
DEHYDROGENASE
(Sulfolobus
solfataricus) 		5 / 10 GLY A  14
HIS A  16
ALA A 325
THR A 304
ILE A 135
 None
 1.26A 5eeuJ-3l8kA:
undetectable
5eeuK-3l8kA:
undetectable		 5eeuJ-3l8kA:
11.76
5eeuK-3l8kA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_K_TRPK101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3l8k DIHYDROLIPOYL
DEHYDROGENASE
(Sulfolobus
solfataricus) 		5 / 9 GLY A  14
HIS A  16
ALA A 325
THR A 304
ILE A 135
 None
 1.27A 5eeuA-3l8kA:
undetectable
5eeuK-3l8kA:
undetectable		 5eeuA-3l8kA:
11.76
5eeuK-3l8kA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_O_TRPO101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3l8k DIHYDROLIPOYL
DEHYDROGENASE
(Sulfolobus
solfataricus) 		5 / 10 GLY A  14
HIS A  16
ALA A 325
THR A 304
ILE A 135
 None
 1.26A 5eeuN-3l8kA:
undetectable
5eeuO-3l8kA:
undetectable		 5eeuN-3l8kA:
11.76
5eeuO-3l8kA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_Q_TRPQ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3l8k DIHYDROLIPOYL
DEHYDROGENASE
(Sulfolobus
solfataricus) 		5 / 10 GLY A  14
HIS A  16
ALA A 325
THR A 304
ILE A 135
 None
 1.28A 5eeuP-3l8kA:
undetectable
5eeuQ-3l8kA:
undetectable		 5eeuP-3l8kA:
11.76
5eeuQ-3l8kA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_S_TRPS101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3l8k DIHYDROLIPOYL
DEHYDROGENASE
(Sulfolobus
solfataricus) 		5 / 10 GLY A  14
HIS A  16
ALA A 325
THR A 304
ILE A 135
 None
 1.29A 5eeuR-3l8kA:
undetectable
5eeuS-3l8kA:
undetectable		 5eeuR-3l8kA:
11.76
5eeuS-3l8kA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_T_TRPT101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3l8k DIHYDROLIPOYL
DEHYDROGENASE
(Sulfolobus
solfataricus) 		5 / 10 GLY A  14
HIS A  16
ALA A 325
THR A 304
ILE A 135
 None
 1.25A 5eeuS-3l8kA:
undetectable
5eeuT-3l8kA:
undetectable		 5eeuS-3l8kA:
11.76
5eeuT-3l8kA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_U_TRPU101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3l8k DIHYDROLIPOYL
DEHYDROGENASE
(Sulfolobus
solfataricus) 		5 / 10 GLY A  14
HIS A  16
ALA A 325
THR A 304
ILE A 135
 None
 1.31A 5eeuT-3l8kA:
undetectable
5eeuU-3l8kA:
undetectable		 5eeuT-3l8kA:
11.76
5eeuU-3l8kA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_V_TRPV101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3l8k DIHYDROLIPOYL
DEHYDROGENASE
(Sulfolobus
solfataricus) 		5 / 10 GLY A  14
HIS A  16
ALA A 325
THR A 304
ILE A 135
 None
 1.27A 5eeuU-3l8kA:
undetectable
5eeuV-3l8kA:
undetectable		 5eeuU-3l8kA:
11.76
5eeuV-3l8kA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_B_TRPB101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3l8k DIHYDROLIPOYL
DEHYDROGENASE
(Sulfolobus
solfataricus) 		5 / 9 GLY A  14
HIS A  16
ALA A 325
THR A 304
ILE A 135
 None
 1.26A 5eevB-3l8kA:
undetectable
5eevC-3l8kA:
undetectable		 5eevB-3l8kA:
11.76
5eevC-3l8kA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_D_TRPD101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3l8k DIHYDROLIPOYL
DEHYDROGENASE
(Sulfolobus
solfataricus) 		5 / 10 ARG A 319
GLY A  14
ALA A 325
THR A 304
ILE A 135
 None
 1.40A 5eevD-3l8kA:
undetectable
5eevE-3l8kA:
undetectable		 5eevD-3l8kA:
11.76
5eevE-3l8kA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_E_TRPE101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3l8k DIHYDROLIPOYL
DEHYDROGENASE
(Sulfolobus
solfataricus) 		5 / 9 GLY A  14
HIS A  16
ALA A 325
THR A 304
ILE A 135
 None
 1.26A 5eevE-3l8kA:
undetectable
5eevF-3l8kA:
undetectable		 5eevE-3l8kA:
11.76
5eevF-3l8kA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_G_TRPG101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3l8k DIHYDROLIPOYL
DEHYDROGENASE
(Sulfolobus
solfataricus) 		5 / 10 GLY A  14
HIS A  16
ALA A 325
THR A 304
ILE A 135
 None
 1.26A 5eevG-3l8kA:
undetectable
5eevH-3l8kA:
undetectable		 5eevG-3l8kA:
11.76
5eevH-3l8kA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_H_TRPH101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3l8k DIHYDROLIPOYL
DEHYDROGENASE
(Sulfolobus
solfataricus) 		5 / 9 GLY A  14
HIS A  16
ALA A 325
THR A 304
ILE A 135
 None
 1.27A 5eevH-3l8kA:
undetectable
5eevI-3l8kA:
undetectable		 5eevH-3l8kA:
11.76
5eevI-3l8kA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_J_TRPJ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3l8k DIHYDROLIPOYL
DEHYDROGENASE
(Sulfolobus
solfataricus) 		5 / 10 ARG A 319
GLY A  14
ALA A 325
THR A 304
ILE A 135
 None
 1.40A 5eevJ-3l8kA:
undetectable
5eevK-3l8kA:
undetectable		 5eevJ-3l8kA:
11.76
5eevK-3l8kA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_J_TRPJ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3l8k DIHYDROLIPOYL
DEHYDROGENASE
(Sulfolobus
solfataricus) 		5 / 10 GLY A  14
HIS A  16
ALA A 325
THR A 304
ILE A 135
 None
 1.25A 5eevJ-3l8kA:
undetectable
5eevK-3l8kA:
undetectable		 5eevJ-3l8kA:
11.76
5eevK-3l8kA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_K_TRPK101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3l8k DIHYDROLIPOYL
DEHYDROGENASE
(Sulfolobus
solfataricus) 		5 / 9 GLY A  14
HIS A  16
ALA A 325
THR A 304
ILE A 135
 None
 1.27A 5eevA-3l8kA:
undetectable
5eevK-3l8kA:
undetectable		 5eevA-3l8kA:
11.76
5eevK-3l8kA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_O_TRPO101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3l8k DIHYDROLIPOYL
DEHYDROGENASE
(Sulfolobus
solfataricus) 		5 / 10 GLY A  14
HIS A  16
ALA A 325
THR A 304
ILE A 135
 None
 1.26A 5eevN-3l8kA:
undetectable
5eevO-3l8kA:
undetectable		 5eevN-3l8kA:
11.76
5eevO-3l8kA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_Q_TRPQ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3l8k DIHYDROLIPOYL
DEHYDROGENASE
(Sulfolobus
solfataricus) 		5 / 10 GLY A  14
HIS A  16
ALA A 325
THR A 304
ILE A 135
 None
 1.28A 5eevP-3l8kA:
undetectable
5eevQ-3l8kA:
undetectable		 5eevP-3l8kA:
11.76
5eevQ-3l8kA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_S_TRPS101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3l8k DIHYDROLIPOYL
DEHYDROGENASE
(Sulfolobus
solfataricus) 		5 / 10 GLY A  14
HIS A  16
ALA A 325
THR A 304
ILE A 135
 None
 1.29A 5eevR-3l8kA:
undetectable
5eevS-3l8kA:
undetectable		 5eevR-3l8kA:
11.76
5eevS-3l8kA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_T_TRPT101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3l8k DIHYDROLIPOYL
DEHYDROGENASE
(Sulfolobus
solfataricus) 		5 / 10 GLY A  14
HIS A  16
ALA A 325
THR A 304
ILE A 135
 None
 1.25A 5eevS-3l8kA:
undetectable
5eevT-3l8kA:
undetectable		 5eevS-3l8kA:
11.76
5eevT-3l8kA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_U_TRPU101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3l8k DIHYDROLIPOYL
DEHYDROGENASE
(Sulfolobus
solfataricus) 		5 / 10 GLY A  14
HIS A  16
ALA A 325
THR A 304
ILE A 135
 None
 1.30A 5eevT-3l8kA:
undetectable
5eevU-3l8kA:
undetectable		 5eevT-3l8kA:
11.76
5eevU-3l8kA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_V_TRPV101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3l8k DIHYDROLIPOYL
DEHYDROGENASE
(Sulfolobus
solfataricus) 		5 / 10 GLY A  14
HIS A  16
ALA A 325
THR A 304
ILE A 135
 None
 1.27A 5eevU-3l8kA:
undetectable
5eevV-3l8kA:
undetectable		 5eevU-3l8kA:
11.76
5eevV-3l8kA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_B_TRPB101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3l8k DIHYDROLIPOYL
DEHYDROGENASE
(Sulfolobus
solfataricus) 		5 / 9 GLY A  14
HIS A  16
ALA A 325
THR A 304
ILE A 135
 None
 1.26A 5eewB-3l8kA:
undetectable
5eewC-3l8kA:
undetectable		 5eewB-3l8kA:
11.76
5eewC-3l8kA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_D_TRPD101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3l8k DIHYDROLIPOYL
DEHYDROGENASE
(Sulfolobus
solfataricus) 		5 / 10 ARG A 319
GLY A  14
ALA A 325
THR A 304
ILE A 135
 None
 1.40A 5eewD-3l8kA:
undetectable
5eewE-3l8kA:
undetectable		 5eewD-3l8kA:
11.76
5eewE-3l8kA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_E_TRPE101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3l8k DIHYDROLIPOYL
DEHYDROGENASE
(Sulfolobus
solfataricus) 		5 / 9 GLY A  14
HIS A  16
ALA A 325
THR A 304
ILE A 135
 None
 1.26A 5eewE-3l8kA:
undetectable
5eewF-3l8kA:
undetectable		 5eewE-3l8kA:
11.76
5eewF-3l8kA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_G_TRPG101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3l8k DIHYDROLIPOYL
DEHYDROGENASE
(Sulfolobus
solfataricus) 		5 / 10 GLY A  14
HIS A  16
ALA A 325
THR A 304
ILE A 135
 None
 1.26A 5eewG-3l8kA:
undetectable
5eewH-3l8kA:
undetectable		 5eewG-3l8kA:
11.76
5eewH-3l8kA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_H_TRPH101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3l8k DIHYDROLIPOYL
DEHYDROGENASE
(Sulfolobus
solfataricus) 		5 / 10 ARG A 319
GLY A  14
ALA A 325
THR A 304
ILE A 135
 None
 1.40A 5eewH-3l8kA:
undetectable
5eewI-3l8kA:
undetectable		 5eewH-3l8kA:
11.76
5eewI-3l8kA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_H_TRPH101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3l8k DIHYDROLIPOYL
DEHYDROGENASE
(Sulfolobus
solfataricus) 		5 / 10 GLY A  14
HIS A  16
ALA A 325
THR A 304
ILE A 135
 None
 1.27A 5eewH-3l8kA:
undetectable
5eewI-3l8kA:
undetectable		 5eewH-3l8kA:
11.76
5eewI-3l8kA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_J_TRPJ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3l8k DIHYDROLIPOYL
DEHYDROGENASE
(Sulfolobus
solfataricus) 		5 / 10 ARG A 319
GLY A  14
ALA A 325
THR A 304
ILE A 135
 None
 1.40A 5eewJ-3l8kA:
undetectable
5eewK-3l8kA:
undetectable		 5eewJ-3l8kA:
11.76
5eewK-3l8kA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_J_TRPJ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3l8k DIHYDROLIPOYL
DEHYDROGENASE
(Sulfolobus
solfataricus) 		5 / 10 GLY A  14
HIS A  16
ALA A 325
THR A 304
ILE A 135
 None
 1.25A 5eewJ-3l8kA:
undetectable
5eewK-3l8kA:
undetectable		 5eewJ-3l8kA:
11.76
5eewK-3l8kA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_K_TRPK101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3l8k DIHYDROLIPOYL
DEHYDROGENASE
(Sulfolobus
solfataricus) 		5 / 9 GLY A  14
HIS A  16
ALA A 325
THR A 304
ILE A 135
 None
 1.27A 5eewA-3l8kA:
undetectable
5eewK-3l8kA:
undetectable		 5eewA-3l8kA:
11.76
5eewK-3l8kA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_O_TRPO101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3l8k DIHYDROLIPOYL
DEHYDROGENASE
(Sulfolobus
solfataricus) 		5 / 10 GLY A  14
HIS A  16
ALA A 325
THR A 304
ILE A 135
 None
 1.26A 5eewN-3l8kA:
undetectable
5eewO-3l8kA:
undetectable		 5eewN-3l8kA:
11.76
5eewO-3l8kA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_Q_TRPQ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3l8k DIHYDROLIPOYL
DEHYDROGENASE
(Sulfolobus
solfataricus) 		5 / 10 GLY A  14
HIS A  16
ALA A 325
THR A 304
ILE A 135
 None
 1.28A 5eewP-3l8kA:
undetectable
5eewQ-3l8kA:
undetectable		 5eewP-3l8kA:
11.76
5eewQ-3l8kA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_S_TRPS101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3l8k DIHYDROLIPOYL
DEHYDROGENASE
(Sulfolobus
solfataricus) 		5 / 10 GLY A  14
HIS A  16
ALA A 325
THR A 304
ILE A 135
 None
 1.29A 5eewR-3l8kA:
undetectable
5eewS-3l8kA:
undetectable		 5eewR-3l8kA:
11.76
5eewS-3l8kA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_T_TRPT101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3l8k DIHYDROLIPOYL
DEHYDROGENASE
(Sulfolobus
solfataricus) 		5 / 10 GLY A  14
HIS A  16
ALA A 325
THR A 304
ILE A 135
 None
 1.26A 5eewS-3l8kA:
undetectable
5eewT-3l8kA:
undetectable		 5eewS-3l8kA:
11.76
5eewT-3l8kA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_U_TRPU101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3l8k DIHYDROLIPOYL
DEHYDROGENASE
(Sulfolobus
solfataricus) 		5 / 10 GLY A  14
HIS A  16
ALA A 325
THR A 304
ILE A 135
 None
 1.31A 5eewT-3l8kA:
undetectable
5eewU-3l8kA:
undetectable		 5eewT-3l8kA:
11.76
5eewU-3l8kA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_V_TRPV101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3l8k DIHYDROLIPOYL
DEHYDROGENASE
(Sulfolobus
solfataricus) 		5 / 10 GLY A  14
HIS A  16
ALA A 325
THR A 304
ILE A 135
 None
 1.27A 5eewU-3l8kA:
undetectable
5eewV-3l8kA:
undetectable		 5eewU-3l8kA:
11.76
5eewV-3l8kA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_B_TRPB101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3l8k DIHYDROLIPOYL
DEHYDROGENASE
(Sulfolobus
solfataricus) 		5 / 9 GLY A  14
HIS A  16
ALA A 325
THR A 304
ILE A 135
 None
 1.26A 5eexB-3l8kA:
undetectable
5eexC-3l8kA:
undetectable		 5eexB-3l8kA:
11.76
5eexC-3l8kA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_D_TRPD101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3l8k DIHYDROLIPOYL
DEHYDROGENASE
(Sulfolobus
solfataricus) 		5 / 10 ARG A 319
GLY A  14
ALA A 325
THR A 304
ILE A 135
 None
 1.40A 5eexD-3l8kA:
undetectable
5eexE-3l8kA:
undetectable		 5eexD-3l8kA:
11.76
5eexE-3l8kA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_E_TRPE101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3l8k DIHYDROLIPOYL
DEHYDROGENASE
(Sulfolobus
solfataricus) 		5 / 9 GLY A  14
HIS A  16
ALA A 325
THR A 304
ILE A 135
 None
 1.26A 5eexE-3l8kA:
undetectable
5eexF-3l8kA:
undetectable		 5eexE-3l8kA:
11.76
5eexF-3l8kA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_G_TRPG101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3l8k DIHYDROLIPOYL
DEHYDROGENASE
(Sulfolobus
solfataricus) 		5 / 10 GLY A  14
HIS A  16
ALA A 325
THR A 304
ILE A 135
 None
 1.26A 5eexG-3l8kA:
undetectable
5eexH-3l8kA:
undetectable		 5eexG-3l8kA:
11.76
5eexH-3l8kA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_H_TRPH101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3l8k DIHYDROLIPOYL
DEHYDROGENASE
(Sulfolobus
solfataricus) 		5 / 10 ARG A 319
GLY A  14
ALA A 325
THR A 304
ILE A 135
 None
 1.40A 5eexH-3l8kA:
undetectable
5eexI-3l8kA:
undetectable		 5eexH-3l8kA:
11.76
5eexI-3l8kA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_H_TRPH101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3l8k DIHYDROLIPOYL
DEHYDROGENASE
(Sulfolobus
solfataricus) 		5 / 10 GLY A  14
HIS A  16
ALA A 325
THR A 304
ILE A 135
 None
 1.27A 5eexH-3l8kA:
undetectable
5eexI-3l8kA:
undetectable		 5eexH-3l8kA:
11.76
5eexI-3l8kA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_I_TRPI101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3l8k DIHYDROLIPOYL
DEHYDROGENASE
(Sulfolobus
solfataricus) 		5 / 11 GLY A  14
HIS A  16
ALA A 325
THR A 304
ILE A 135
 None
 1.28A 5eexI-3l8kA:
undetectable
5eexJ-3l8kA:
undetectable		 5eexI-3l8kA:
11.76
5eexJ-3l8kA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_J_TRPJ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3l8k DIHYDROLIPOYL
DEHYDROGENASE
(Sulfolobus
solfataricus) 		5 / 10 ARG A 319
GLY A  14
ALA A 325
THR A 304
ILE A 135
 None
 1.40A 5eexJ-3l8kA:
undetectable
5eexK-3l8kA:
undetectable		 5eexJ-3l8kA:
11.76
5eexK-3l8kA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_J_TRPJ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3l8k DIHYDROLIPOYL
DEHYDROGENASE
(Sulfolobus
solfataricus) 		5 / 10 GLY A  14
HIS A  16
ALA A 325
THR A 304
ILE A 135
 None
 1.25A 5eexJ-3l8kA:
undetectable
5eexK-3l8kA:
undetectable		 5eexJ-3l8kA:
11.76
5eexK-3l8kA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_K_TRPK101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3l8k DIHYDROLIPOYL
DEHYDROGENASE
(Sulfolobus
solfataricus) 		5 / 10 GLY A  14
HIS A  16
ALA A 325
THR A 304
ILE A 135
 None
 1.27A 5eexA-3l8kA:
undetectable
5eexK-3l8kA:
undetectable		 5eexA-3l8kA:
11.76
5eexK-3l8kA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_O_TRPO101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3l8k DIHYDROLIPOYL
DEHYDROGENASE
(Sulfolobus
solfataricus) 		5 / 10 GLY A  14
HIS A  16
ALA A 325
THR A 304
ILE A 135
 None
 1.26A 5eexN-3l8kA:
undetectable
5eexO-3l8kA:
undetectable		 5eexN-3l8kA:
11.76
5eexO-3l8kA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_Q_TRPQ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3l8k DIHYDROLIPOYL
DEHYDROGENASE
(Sulfolobus
solfataricus) 		5 / 10 GLY A  14
HIS A  16
ALA A 325
THR A 304
ILE A 135
 None
 1.28A 5eexP-3l8kA:
undetectable
5eexQ-3l8kA:
undetectable		 5eexP-3l8kA:
11.76
5eexQ-3l8kA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_R_TRPR101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3l8k DIHYDROLIPOYL
DEHYDROGENASE
(Sulfolobus
solfataricus) 		5 / 9 GLY A  14
HIS A  16
ALA A 325
THR A 304
ILE A 135
 None
 1.27A 5eexQ-3l8kA:
undetectable
5eexR-3l8kA:
undetectable		 5eexQ-3l8kA:
11.76
5eexR-3l8kA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_S_TRPS101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3l8k DIHYDROLIPOYL
DEHYDROGENASE
(Sulfolobus
solfataricus) 		5 / 10 GLY A  14
HIS A  16
ALA A 325
THR A 304
ILE A 135
 None
 1.29A 5eexR-3l8kA:
undetectable
5eexS-3l8kA:
undetectable		 5eexR-3l8kA:
11.76
5eexS-3l8kA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_T_TRPT101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3l8k DIHYDROLIPOYL
DEHYDROGENASE
(Sulfolobus
solfataricus) 		5 / 10 GLY A  14
HIS A  16
ALA A 325
THR A 304
ILE A 135
 None
 1.25A 5eexS-3l8kA:
undetectable
5eexT-3l8kA:
undetectable		 5eexS-3l8kA:
11.76
5eexT-3l8kA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_U_TRPU101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3l8k DIHYDROLIPOYL
DEHYDROGENASE
(Sulfolobus
solfataricus) 		5 / 10 GLY A  14
HIS A  16
ALA A 325
THR A 304
ILE A 135
 None
 1.30A 5eexT-3l8kA:
undetectable
5eexU-3l8kA:
undetectable		 5eexT-3l8kA:
11.76
5eexU-3l8kA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_V_TRPV101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3l8k DIHYDROLIPOYL
DEHYDROGENASE
(Sulfolobus
solfataricus) 		5 / 10 GLY A  14
HIS A  16
ALA A 325
THR A 304
ILE A 135
 None
 1.27A 5eexU-3l8kA:
undetectable
5eexV-3l8kA:
undetectable		 5eexU-3l8kA:
11.76
5eexV-3l8kA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_B_TRPB101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3l8k DIHYDROLIPOYL
DEHYDROGENASE
(Sulfolobus
solfataricus) 		5 / 9 GLY A  14
HIS A  16
ALA A 325
THR A 304
ILE A 135
 None
 1.26A 5eeyB-3l8kA:
undetectable
5eeyC-3l8kA:
undetectable		 5eeyB-3l8kA:
11.76
5eeyC-3l8kA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_D_TRPD101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3l8k DIHYDROLIPOYL
DEHYDROGENASE
(Sulfolobus
solfataricus) 		5 / 10 ARG A 319
GLY A  14
ALA A 325
THR A 304
ILE A 135
 None
 1.40A 5eeyD-3l8kA:
undetectable
5eeyE-3l8kA:
undetectable		 5eeyD-3l8kA:
11.76
5eeyE-3l8kA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_E_TRPE101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3l8k DIHYDROLIPOYL
DEHYDROGENASE
(Sulfolobus
solfataricus) 		5 / 9 GLY A  14
HIS A  16
ALA A 325
THR A 304
ILE A 135
 None
 1.26A 5eeyE-3l8kA:
undetectable
5eeyF-3l8kA:
undetectable		 5eeyE-3l8kA:
11.76
5eeyF-3l8kA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_G_TRPG101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3l8k DIHYDROLIPOYL
DEHYDROGENASE
(Sulfolobus
solfataricus) 		5 / 10 GLY A  14
HIS A  16
ALA A 325
THR A 304
ILE A 135
 None
 1.26A 5eeyG-3l8kA:
undetectable
5eeyH-3l8kA:
undetectable		 5eeyG-3l8kA:
11.76
5eeyH-3l8kA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_H_TRPH101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3l8k DIHYDROLIPOYL
DEHYDROGENASE
(Sulfolobus
solfataricus) 		5 / 9 GLY A  14
HIS A  16
ALA A 325
THR A 304
ILE A 135
 None
 1.27A 5eeyH-3l8kA:
undetectable
5eeyI-3l8kA:
undetectable		 5eeyH-3l8kA:
11.76
5eeyI-3l8kA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_I_TRPI101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3l8k DIHYDROLIPOYL
DEHYDROGENASE
(Sulfolobus
solfataricus) 		5 / 11 GLY A  14
HIS A  16
ALA A 325
THR A 304
ILE A 135
 None
 1.28A 5eeyI-3l8kA:
undetectable
5eeyJ-3l8kA:
undetectable		 5eeyI-3l8kA:
11.76
5eeyJ-3l8kA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_J_TRPJ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3l8k DIHYDROLIPOYL
DEHYDROGENASE
(Sulfolobus
solfataricus) 		5 / 10 ARG A 319
GLY A  14
ALA A 325
THR A 304
ILE A 135
 None
 1.40A 5eeyJ-3l8kA:
undetectable
5eeyK-3l8kA:
undetectable		 5eeyJ-3l8kA:
11.76
5eeyK-3l8kA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_J_TRPJ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3l8k DIHYDROLIPOYL
DEHYDROGENASE
(Sulfolobus
solfataricus) 		5 / 10 GLY A  14
HIS A  16
ALA A 325
THR A 304
ILE A 135
 None
 1.25A 5eeyJ-3l8kA:
undetectable
5eeyK-3l8kA:
undetectable		 5eeyJ-3l8kA:
11.76
5eeyK-3l8kA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_K_TRPK101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3l8k DIHYDROLIPOYL
DEHYDROGENASE
(Sulfolobus
solfataricus) 		5 / 9 GLY A  14
HIS A  16
ALA A 325
THR A 304
ILE A 135
 None
 1.27A 5eeyA-3l8kA:
undetectable
5eeyK-3l8kA:
undetectable		 5eeyA-3l8kA:
11.76
5eeyK-3l8kA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_O_TRPO101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3l8k DIHYDROLIPOYL
DEHYDROGENASE
(Sulfolobus
solfataricus) 		5 / 10 GLY A  14
HIS A  16
ALA A 325
THR A 304
ILE A 135
 None
 1.26A 5eeyN-3l8kA:
undetectable
5eeyO-3l8kA:
undetectable		 5eeyN-3l8kA:
11.76
5eeyO-3l8kA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_Q_TRPQ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3l8k DIHYDROLIPOYL
DEHYDROGENASE
(Sulfolobus
solfataricus) 		5 / 10 GLY A  14
HIS A  16
ALA A 325
THR A 304
ILE A 135
 None
 1.28A 5eeyP-3l8kA:
undetectable
5eeyQ-3l8kA:
undetectable		 5eeyP-3l8kA:
11.76
5eeyQ-3l8kA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_R_TRPR101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3l8k DIHYDROLIPOYL
DEHYDROGENASE
(Sulfolobus
solfataricus) 		5 / 9 GLY A  14
HIS A  16
ALA A 325
THR A 304
ILE A 135
 None
 1.27A 5eeyQ-3l8kA:
undetectable
5eeyR-3l8kA:
undetectable		 5eeyQ-3l8kA:
11.76
5eeyR-3l8kA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_S_TRPS101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3l8k DIHYDROLIPOYL
DEHYDROGENASE
(Sulfolobus
solfataricus) 		5 / 10 GLY A  14
HIS A  16
ALA A 325
THR A 304
ILE A 135
 None
 1.29A 5eeyR-3l8kA:
undetectable
5eeyS-3l8kA:
undetectable		 5eeyR-3l8kA:
11.76
5eeyS-3l8kA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_T_TRPT101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3l8k DIHYDROLIPOYL
DEHYDROGENASE
(Sulfolobus
solfataricus) 		5 / 10 GLY A  14
HIS A  16
ALA A 325
THR A 304
ILE A 135
 None
 1.25A 5eeyS-3l8kA:
undetectable
5eeyT-3l8kA:
undetectable		 5eeyS-3l8kA:
11.76
5eeyT-3l8kA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_U_TRPU101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3l8k DIHYDROLIPOYL
DEHYDROGENASE
(Sulfolobus
solfataricus) 		5 / 10 GLY A  14
HIS A  16
ALA A 325
THR A 304
ILE A 135
 None
 1.30A 5eeyT-3l8kA:
undetectable
5eeyU-3l8kA:
undetectable		 5eeyT-3l8kA:
11.76
5eeyU-3l8kA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_V_TRPV101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3l8k DIHYDROLIPOYL
DEHYDROGENASE
(Sulfolobus
solfataricus) 		5 / 10 GLY A  14
HIS A  16
ALA A 325
THR A 304
ILE A 135
 None
 1.27A 5eeyU-3l8kA:
undetectable
5eeyV-3l8kA:
undetectable		 5eeyU-3l8kA:
11.76
5eeyV-3l8kA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_B_TRPB101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3l8k DIHYDROLIPOYL
DEHYDROGENASE
(Sulfolobus
solfataricus) 		5 / 9 GLY A  14
HIS A  16
ALA A 325
THR A 304
ILE A 135
 None
 1.26A 5eezB-3l8kA:
undetectable
5eezC-3l8kA:
undetectable		 5eezB-3l8kA:
11.76
5eezC-3l8kA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_D_TRPD101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3l8k DIHYDROLIPOYL
DEHYDROGENASE
(Sulfolobus
solfataricus) 		5 / 10 ARG A 319
GLY A  14
ALA A 325
THR A 304
ILE A 135
 None
 1.40A 5eezD-3l8kA:
undetectable
5eezE-3l8kA:
undetectable		 5eezD-3l8kA:
11.76
5eezE-3l8kA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_E_TRPE101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3l8k DIHYDROLIPOYL
DEHYDROGENASE
(Sulfolobus
solfataricus) 		5 / 9 GLY A  14
HIS A  16
ALA A 325
THR A 304
ILE A 135
 None
 1.26A 5eezE-3l8kA:
undetectable
5eezF-3l8kA:
undetectable		 5eezE-3l8kA:
11.76
5eezF-3l8kA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_G_TRPG101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3l8k DIHYDROLIPOYL
DEHYDROGENASE
(Sulfolobus
solfataricus) 		5 / 10 GLY A  14
HIS A  16
ALA A 325
THR A 304
ILE A 135
 None
 1.26A 5eezG-3l8kA:
undetectable
5eezH-3l8kA:
undetectable		 5eezG-3l8kA:
11.76
5eezH-3l8kA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_H_TRPH101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3l8k DIHYDROLIPOYL
DEHYDROGENASE
(Sulfolobus
solfataricus) 		5 / 9 GLY A  14
HIS A  16
ALA A 325
THR A 304
ILE A 135
 None
 1.27A 5eezH-3l8kA:
undetectable
5eezI-3l8kA:
undetectable		 5eezH-3l8kA:
11.76
5eezI-3l8kA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_I_TRPI101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3l8k DIHYDROLIPOYL
DEHYDROGENASE
(Sulfolobus
solfataricus) 		5 / 11 GLY A  14
HIS A  16
ALA A 325
THR A 304
ILE A 135
 None
 1.28A 5eezI-3l8kA:
undetectable
5eezJ-3l8kA:
undetectable		 5eezI-3l8kA:
11.76
5eezJ-3l8kA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_J_TRPJ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3l8k DIHYDROLIPOYL
DEHYDROGENASE
(Sulfolobus
solfataricus) 		5 / 9 GLY A  14
HIS A  16
ALA A 325
THR A 304
ILE A 135
 None
 1.25A 5eezJ-3l8kA:
undetectable
5eezK-3l8kA:
undetectable		 5eezJ-3l8kA:
11.76
5eezK-3l8kA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_K_TRPK101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3l8k DIHYDROLIPOYL
DEHYDROGENASE
(Sulfolobus
solfataricus) 		5 / 9 GLY A  14
HIS A  16
ALA A 325
THR A 304
ILE A 135
 None
 1.27A 5eezA-3l8kA:
undetectable
5eezK-3l8kA:
undetectable		 5eezA-3l8kA:
11.76
5eezK-3l8kA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_O_TRPO101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3l8k DIHYDROLIPOYL
DEHYDROGENASE
(Sulfolobus
solfataricus) 		5 / 10 GLY A  14
HIS A  16
ALA A 325
THR A 304
ILE A 135
 None
 1.26A 5eezN-3l8kA:
undetectable
5eezO-3l8kA:
undetectable		 5eezN-3l8kA:
11.76
5eezO-3l8kA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_Q_TRPQ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3l8k DIHYDROLIPOYL
DEHYDROGENASE
(Sulfolobus
solfataricus) 		5 / 10 GLY A  14
HIS A  16
ALA A 325
THR A 304
ILE A 135
 None
 1.28A 5eezP-3l8kA:
undetectable
5eezQ-3l8kA:
undetectable		 5eezP-3l8kA:
11.76
5eezQ-3l8kA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_R_TRPR101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3l8k DIHYDROLIPOYL
DEHYDROGENASE
(Sulfolobus
solfataricus) 		5 / 9 GLY A  14
HIS A  16
ALA A 325
THR A 304
ILE A 135
 None
 1.27A 5eezQ-3l8kA:
undetectable
5eezR-3l8kA:
undetectable		 5eezQ-3l8kA:
11.76
5eezR-3l8kA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_S_TRPS101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3l8k DIHYDROLIPOYL
DEHYDROGENASE
(Sulfolobus
solfataricus) 		5 / 10 GLY A  14
HIS A  16
ALA A 325
THR A 304
ILE A 135
 None
 1.29A 5eezR-3l8kA:
undetectable
5eezS-3l8kA:
undetectable		 5eezR-3l8kA:
11.76
5eezS-3l8kA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_T_TRPT101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3l8k DIHYDROLIPOYL
DEHYDROGENASE
(Sulfolobus
solfataricus) 		5 / 10 GLY A  14
HIS A  16
ALA A 325
THR A 304
ILE A 135
 None
 1.25A 5eezS-3l8kA:
undetectable
5eezT-3l8kA:
undetectable		 5eezS-3l8kA:
11.76
5eezT-3l8kA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_U_TRPU101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3l8k DIHYDROLIPOYL
DEHYDROGENASE
(Sulfolobus
solfataricus) 		5 / 10 GLY A  14
HIS A  16
ALA A 325
THR A 304
ILE A 135
 None
 1.31A 5eezT-3l8kA:
undetectable
5eezU-3l8kA:
undetectable		 5eezT-3l8kA:
11.76
5eezU-3l8kA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_V_TRPV101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3l8k DIHYDROLIPOYL
DEHYDROGENASE
(Sulfolobus
solfataricus) 		5 / 10 GLY A  14
HIS A  16
ALA A 325
THR A 304
ILE A 135
 None
 1.27A 5eezU-3l8kA:
undetectable
5eezV-3l8kA:
undetectable		 5eezU-3l8kA:
11.76
5eezV-3l8kA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_B_TRPB101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3l8k DIHYDROLIPOYL
DEHYDROGENASE
(Sulfolobus
solfataricus) 		5 / 9 GLY A  14
HIS A  16
ALA A 325
THR A 304
ILE A 135
 None
 1.26A 5ef0B-3l8kA:
undetectable
5ef0C-3l8kA:
undetectable		 5ef0B-3l8kA:
11.76
5ef0C-3l8kA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_D_TRPD101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3l8k DIHYDROLIPOYL
DEHYDROGENASE
(Sulfolobus
solfataricus) 		5 / 10 ARG A 319
GLY A  14
ALA A 325
THR A 304
ILE A 135
 None
 1.40A 5ef0D-3l8kA:
undetectable
5ef0E-3l8kA:
undetectable		 5ef0D-3l8kA:
11.76
5ef0E-3l8kA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_E_TRPE101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3l8k DIHYDROLIPOYL
DEHYDROGENASE
(Sulfolobus
solfataricus) 		5 / 9 GLY A  14
HIS A  16
ALA A 325
THR A 304
ILE A 135
 None
 1.26A 5ef0E-3l8kA:
undetectable
5ef0F-3l8kA:
undetectable		 5ef0E-3l8kA:
11.76
5ef0F-3l8kA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_G_TRPG101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3l8k DIHYDROLIPOYL
DEHYDROGENASE
(Sulfolobus
solfataricus) 		5 / 10 GLY A  14
HIS A  16
ALA A 325
THR A 304
ILE A 135
 None
 1.26A 5ef0G-3l8kA:
undetectable
5ef0H-3l8kA:
undetectable		 5ef0G-3l8kA:
11.76
5ef0H-3l8kA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_H_TRPH101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3l8k DIHYDROLIPOYL
DEHYDROGENASE
(Sulfolobus
solfataricus) 		5 / 9 GLY A  14
HIS A  16
ALA A 325
THR A 304
ILE A 135
 None
 1.27A 5ef0H-3l8kA:
undetectable
5ef0I-3l8kA:
undetectable		 5ef0H-3l8kA:
11.76
5ef0I-3l8kA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_I_TRPI101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3l8k DIHYDROLIPOYL
DEHYDROGENASE
(Sulfolobus
solfataricus) 		5 / 11 GLY A  14
HIS A  16
ALA A 325
THR A 304
ILE A 135
 None
 1.28A 5ef0I-3l8kA:
undetectable
5ef0J-3l8kA:
undetectable		 5ef0I-3l8kA:
11.76
5ef0J-3l8kA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_J_TRPJ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3l8k DIHYDROLIPOYL
DEHYDROGENASE
(Sulfolobus
solfataricus) 		5 / 9 GLY A  14
HIS A  16
ALA A 325
THR A 304
ILE A 135
 None
 1.25A 5ef0J-3l8kA:
undetectable
5ef0K-3l8kA:
undetectable		 5ef0J-3l8kA:
11.76
5ef0K-3l8kA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_K_TRPK101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3l8k DIHYDROLIPOYL
DEHYDROGENASE
(Sulfolobus
solfataricus) 		5 / 10 GLY A  14
HIS A  16
ALA A 325
THR A 304
ILE A 135
 None
 1.27A 5ef0A-3l8kA:
undetectable
5ef0K-3l8kA:
undetectable		 5ef0A-3l8kA:
11.76
5ef0K-3l8kA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_O_TRPO101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3l8k DIHYDROLIPOYL
DEHYDROGENASE
(Sulfolobus
solfataricus) 		5 / 10 GLY A  14
HIS A  16
ALA A 325
THR A 304
ILE A 135
 None
 1.26A 5ef0N-3l8kA:
undetectable
5ef0O-3l8kA:
undetectable		 5ef0N-3l8kA:
11.76
5ef0O-3l8kA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_Q_TRPQ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3l8k DIHYDROLIPOYL
DEHYDROGENASE
(Sulfolobus
solfataricus) 		5 / 10 GLY A  14
HIS A  16
ALA A 325
THR A 304
ILE A 135
 None
 1.28A 5ef0P-3l8kA:
undetectable
5ef0Q-3l8kA:
undetectable		 5ef0P-3l8kA:
11.76
5ef0Q-3l8kA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_R_TRPR101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3l8k DIHYDROLIPOYL
DEHYDROGENASE
(Sulfolobus
solfataricus) 		5 / 9 GLY A  14
HIS A  16
ALA A 325
THR A 304
ILE A 135
 None
 1.27A 5ef0Q-3l8kA:
undetectable
5ef0R-3l8kA:
undetectable		 5ef0Q-3l8kA:
11.76
5ef0R-3l8kA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_S_TRPS101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3l8k DIHYDROLIPOYL
DEHYDROGENASE
(Sulfolobus
solfataricus) 		5 / 10 GLY A  14
HIS A  16
ALA A 325
THR A 304
ILE A 135
 None
 1.29A 5ef0R-3l8kA:
undetectable
5ef0S-3l8kA:
undetectable		 5ef0R-3l8kA:
11.76
5ef0S-3l8kA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_T_TRPT101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3l8k DIHYDROLIPOYL
DEHYDROGENASE
(Sulfolobus
solfataricus) 		5 / 10 GLY A  14
HIS A  16
ALA A 325
THR A 304
ILE A 135
 None
 1.25A 5ef0S-3l8kA:
undetectable
5ef0T-3l8kA:
undetectable		 5ef0S-3l8kA:
11.76
5ef0T-3l8kA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_U_TRPU101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3l8k DIHYDROLIPOYL
DEHYDROGENASE
(Sulfolobus
solfataricus) 		5 / 10 GLY A  14
HIS A  16
ALA A 325
THR A 304
ILE A 135
 None
 1.31A 5ef0T-3l8kA:
undetectable
5ef0U-3l8kA:
undetectable		 5ef0T-3l8kA:
11.76
5ef0U-3l8kA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_V_TRPV101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3l8k DIHYDROLIPOYL
DEHYDROGENASE
(Sulfolobus
solfataricus) 		5 / 10 GLY A  14
HIS A  16
ALA A 325
THR A 304
ILE A 135
 None
 1.27A 5ef0U-3l8kA:
undetectable
5ef0V-3l8kA:
undetectable		 5ef0U-3l8kA:
11.76
5ef0V-3l8kA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_B_TRPB101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3l8k DIHYDROLIPOYL
DEHYDROGENASE
(Sulfolobus
solfataricus) 		5 / 9 GLY A  14
HIS A  16
ALA A 325
THR A 304
ILE A 135
 None
 1.26A 5ef1B-3l8kA:
undetectable
5ef1C-3l8kA:
undetectable		 5ef1B-3l8kA:
11.76
5ef1C-3l8kA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_D_TRPD101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3l8k DIHYDROLIPOYL
DEHYDROGENASE
(Sulfolobus
solfataricus) 		5 / 10 ARG A 319
GLY A  14
ALA A 325
THR A 304
ILE A 135
 None
 1.40A 5ef1D-3l8kA:
undetectable
5ef1E-3l8kA:
undetectable		 5ef1D-3l8kA:
11.76
5ef1E-3l8kA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_E_TRPE101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3l8k DIHYDROLIPOYL
DEHYDROGENASE
(Sulfolobus
solfataricus) 		5 / 9 GLY A  14
HIS A  16
ALA A 325
THR A 304
ILE A 135
 None
 1.26A 5ef1E-3l8kA:
undetectable
5ef1F-3l8kA:
undetectable		 5ef1E-3l8kA:
11.76
5ef1F-3l8kA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_G_TRPG101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3l8k DIHYDROLIPOYL
DEHYDROGENASE
(Sulfolobus
solfataricus) 		5 / 10 GLY A  14
HIS A  16
ALA A 325
THR A 304
ILE A 135
 None
 1.26A 5ef1G-3l8kA:
undetectable
5ef1H-3l8kA:
undetectable		 5ef1G-3l8kA:
11.76
5ef1H-3l8kA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_H_TRPH101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3l8k DIHYDROLIPOYL
DEHYDROGENASE
(Sulfolobus
solfataricus) 		5 / 9 GLY A  14
HIS A  16
ALA A 325
THR A 304
ILE A 135
 None
 1.27A 5ef1H-3l8kA:
undetectable
5ef1I-3l8kA:
undetectable		 5ef1H-3l8kA:
11.76
5ef1I-3l8kA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_I_TRPI101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3l8k DIHYDROLIPOYL
DEHYDROGENASE
(Sulfolobus
solfataricus) 		5 / 11 GLY A  14
HIS A  16
ALA A 325
THR A 304
ILE A 135
 None
 1.28A 5ef1I-3l8kA:
undetectable
5ef1J-3l8kA:
undetectable		 5ef1I-3l8kA:
11.76
5ef1J-3l8kA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_J_TRPJ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3l8k DIHYDROLIPOYL
DEHYDROGENASE
(Sulfolobus
solfataricus) 		5 / 9 GLY A  14
HIS A  16
ALA A 325
THR A 304
ILE A 135
 None
 1.25A 5ef1J-3l8kA:
undetectable
5ef1K-3l8kA:
undetectable		 5ef1J-3l8kA:
11.76
5ef1K-3l8kA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_K_TRPK101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3l8k DIHYDROLIPOYL
DEHYDROGENASE
(Sulfolobus
solfataricus) 		5 / 9 GLY A  14
HIS A  16
ALA A 325
THR A 304
ILE A 135
 None
 1.27A 5ef1A-3l8kA:
undetectable
5ef1K-3l8kA:
undetectable		 5ef1A-3l8kA:
11.76
5ef1K-3l8kA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_O_TRPO101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3l8k DIHYDROLIPOYL
DEHYDROGENASE
(Sulfolobus
solfataricus) 		5 / 10 GLY A  14
HIS A  16
ALA A 325
THR A 304
ILE A 135
 None
 1.26A 5ef1N-3l8kA:
undetectable
5ef1O-3l8kA:
undetectable		 5ef1N-3l8kA:
11.76
5ef1O-3l8kA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_Q_TRPQ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3l8k DIHYDROLIPOYL
DEHYDROGENASE
(Sulfolobus
solfataricus) 		5 / 10 GLY A  14
HIS A  16
ALA A 325
THR A 304
ILE A 135
 None
 1.28A 5ef1P-3l8kA:
undetectable
5ef1Q-3l8kA:
undetectable		 5ef1P-3l8kA:
11.76
5ef1Q-3l8kA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_R_TRPR101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3l8k DIHYDROLIPOYL
DEHYDROGENASE
(Sulfolobus
solfataricus) 		5 / 9 GLY A  14
HIS A  16
ALA A 325
THR A 304
ILE A 135
 None
 1.27A 5ef1Q-3l8kA:
undetectable
5ef1R-3l8kA:
undetectable		 5ef1Q-3l8kA:
11.76
5ef1R-3l8kA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_S_TRPS101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3l8k DIHYDROLIPOYL
DEHYDROGENASE
(Sulfolobus
solfataricus) 		5 / 10 GLY A  14
HIS A  16
ALA A 325
THR A 304
ILE A 135
 None
 1.30A 5ef1R-3l8kA:
undetectable
5ef1S-3l8kA:
undetectable		 5ef1R-3l8kA:
11.76
5ef1S-3l8kA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_T_TRPT101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3l8k DIHYDROLIPOYL
DEHYDROGENASE
(Sulfolobus
solfataricus) 		5 / 10 GLY A  14
HIS A  16
ALA A 325
THR A 304
ILE A 135
 None
 1.25A 5ef1S-3l8kA:
undetectable
5ef1T-3l8kA:
undetectable		 5ef1S-3l8kA:
11.76
5ef1T-3l8kA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_U_TRPU101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3l8k DIHYDROLIPOYL
DEHYDROGENASE
(Sulfolobus
solfataricus) 		5 / 10 GLY A  14
HIS A  16
ALA A 325
THR A 304
ILE A 135
 None
 1.31A 5ef1T-3l8kA:
undetectable
5ef1U-3l8kA:
undetectable		 5ef1T-3l8kA:
11.76
5ef1U-3l8kA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_V_TRPV101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3l8k DIHYDROLIPOYL
DEHYDROGENASE
(Sulfolobus
solfataricus) 		5 / 10 GLY A  14
HIS A  16
ALA A 325
THR A 304
ILE A 135
 None
 1.27A 5ef1U-3l8kA:
undetectable
5ef1V-3l8kA:
undetectable		 5ef1U-3l8kA:
11.76
5ef1V-3l8kA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_B_TRPB101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3l8k DIHYDROLIPOYL
DEHYDROGENASE
(Sulfolobus
solfataricus) 		5 / 9 GLY A  14
HIS A  16
ALA A 325
THR A 304
ILE A 135
 None
 1.26A 5ef2B-3l8kA:
undetectable
5ef2C-3l8kA:
undetectable		 5ef2B-3l8kA:
11.76
5ef2C-3l8kA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_D_TRPD101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3l8k DIHYDROLIPOYL
DEHYDROGENASE
(Sulfolobus
solfataricus) 		5 / 10 ARG A 319
GLY A  14
ALA A 325
THR A 304
ILE A 135
 None
 1.40A 5ef2D-3l8kA:
undetectable
5ef2E-3l8kA:
undetectable		 5ef2D-3l8kA:
11.76
5ef2E-3l8kA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_E_TRPE101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3l8k DIHYDROLIPOYL
DEHYDROGENASE
(Sulfolobus
solfataricus) 		5 / 9 GLY A  14
HIS A  16
ALA A 325
THR A 304
ILE A 135
 None
 1.26A 5ef2E-3l8kA:
undetectable
5ef2F-3l8kA:
undetectable		 5ef2E-3l8kA:
11.76
5ef2F-3l8kA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_G_TRPG101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3l8k DIHYDROLIPOYL
DEHYDROGENASE
(Sulfolobus
solfataricus) 		5 / 10 GLY A  14
HIS A  16
ALA A 325
THR A 304
ILE A 135
 None
 1.26A 5ef2G-3l8kA:
undetectable
5ef2H-3l8kA:
undetectable		 5ef2G-3l8kA:
11.76
5ef2H-3l8kA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_H_TRPH101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3l8k DIHYDROLIPOYL
DEHYDROGENASE
(Sulfolobus
solfataricus) 		5 / 9 GLY A  14
HIS A  16
ALA A 325
THR A 304
ILE A 135
 None
 1.27A 5ef2H-3l8kA:
undetectable
5ef2I-3l8kA:
undetectable		 5ef2H-3l8kA:
11.76
5ef2I-3l8kA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_I_TRPI101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3l8k DIHYDROLIPOYL
DEHYDROGENASE
(Sulfolobus
solfataricus) 		5 / 11 GLY A  14
HIS A  16
ALA A 325
THR A 304
ILE A 135
 None
 1.28A 5ef2I-3l8kA:
undetectable
5ef2J-3l8kA:
undetectable		 5ef2I-3l8kA:
11.76
5ef2J-3l8kA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_J_TRPJ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3l8k DIHYDROLIPOYL
DEHYDROGENASE
(Sulfolobus
solfataricus) 		5 / 9 GLY A  14
HIS A  16
ALA A 325
THR A 304
ILE A 135
 None
 1.25A 5ef2J-3l8kA:
undetectable
5ef2K-3l8kA:
undetectable		 5ef2J-3l8kA:
11.76
5ef2K-3l8kA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_K_TRPK101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3l8k DIHYDROLIPOYL
DEHYDROGENASE
(Sulfolobus
solfataricus) 		5 / 9 GLY A  14
HIS A  16
ALA A 325
THR A 304
ILE A 135
 None
 1.27A 5ef2A-3l8kA:
undetectable
5ef2K-3l8kA:
undetectable		 5ef2A-3l8kA:
11.76
5ef2K-3l8kA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_O_TRPO101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3l8k DIHYDROLIPOYL
DEHYDROGENASE
(Sulfolobus
solfataricus) 		5 / 10 GLY A  14
HIS A  16
ALA A 325
THR A 304
ILE A 135
 None
 1.26A 5ef2N-3l8kA:
undetectable
5ef2O-3l8kA:
undetectable		 5ef2N-3l8kA:
11.76
5ef2O-3l8kA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_Q_TRPQ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3l8k DIHYDROLIPOYL
DEHYDROGENASE
(Sulfolobus
solfataricus) 		5 / 10 GLY A  14
HIS A  16
ALA A 325
THR A 304
ILE A 135
 None
 1.28A 5ef2P-3l8kA:
undetectable
5ef2Q-3l8kA:
undetectable		 5ef2P-3l8kA:
11.76
5ef2Q-3l8kA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_R_TRPR101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3l8k DIHYDROLIPOYL
DEHYDROGENASE
(Sulfolobus
solfataricus) 		5 / 9 GLY A  14
HIS A  16
ALA A 325
THR A 304
ILE A 135
 None
 1.27A 5ef2Q-3l8kA:
undetectable
5ef2R-3l8kA:
undetectable		 5ef2Q-3l8kA:
11.76
5ef2R-3l8kA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_S_TRPS101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3l8k DIHYDROLIPOYL
DEHYDROGENASE
(Sulfolobus
solfataricus) 		5 / 10 GLY A  14
HIS A  16
ALA A 325
THR A 304
ILE A 135
 None
 1.29A 5ef2R-3l8kA:
undetectable
5ef2S-3l8kA:
undetectable		 5ef2R-3l8kA:
11.76
5ef2S-3l8kA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_T_TRPT101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3l8k DIHYDROLIPOYL
DEHYDROGENASE
(Sulfolobus
solfataricus) 		5 / 10 GLY A  14
HIS A  16
ALA A 325
THR A 304
ILE A 135
 None
 1.26A 5ef2S-3l8kA:
undetectable
5ef2T-3l8kA:
undetectable		 5ef2S-3l8kA:
11.76
5ef2T-3l8kA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_U_TRPU101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3l8k DIHYDROLIPOYL
DEHYDROGENASE
(Sulfolobus
solfataricus) 		5 / 10 GLY A  14
HIS A  16
ALA A 325
THR A 304
ILE A 135
 None
 1.30A 5ef2T-3l8kA:
undetectable
5ef2U-3l8kA:
undetectable		 5ef2T-3l8kA:
11.76
5ef2U-3l8kA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_V_TRPV101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3l8k DIHYDROLIPOYL
DEHYDROGENASE
(Sulfolobus
solfataricus) 		5 / 10 GLY A  14
HIS A  16
ALA A 325
THR A 304
ILE A 135
 None
 1.27A 5ef2U-3l8kA:
undetectable
5ef2V-3l8kA:
undetectable		 5ef2U-3l8kA:
11.76
5ef2V-3l8kA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_B_TRPB101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3l8k DIHYDROLIPOYL
DEHYDROGENASE
(Sulfolobus
solfataricus) 		5 / 9 GLY A  14
HIS A  16
ALA A 325
THR A 304
ILE A 135
 None
 1.26A 5ef3B-3l8kA:
undetectable
5ef3C-3l8kA:
undetectable		 5ef3B-3l8kA:
11.76
5ef3C-3l8kA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_D_TRPD101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3l8k DIHYDROLIPOYL
DEHYDROGENASE
(Sulfolobus
solfataricus) 		5 / 10 ARG A 319
GLY A  14
ALA A 325
THR A 304
ILE A 135
 None
 1.40A 5ef3D-3l8kA:
undetectable
5ef3E-3l8kA:
undetectable		 5ef3D-3l8kA:
11.76
5ef3E-3l8kA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_E_TRPE101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3l8k DIHYDROLIPOYL
DEHYDROGENASE
(Sulfolobus
solfataricus) 		5 / 9 GLY A  14
HIS A  16
ALA A 325
THR A 304
ILE A 135
 None
 1.26A 5ef3E-3l8kA:
undetectable
5ef3F-3l8kA:
undetectable		 5ef3E-3l8kA:
11.76
5ef3F-3l8kA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_G_TRPG101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3l8k DIHYDROLIPOYL
DEHYDROGENASE
(Sulfolobus
solfataricus) 		5 / 10 GLY A  14
HIS A  16
ALA A 325
THR A 304
ILE A 135
 None
 1.26A 5ef3G-3l8kA:
undetectable
5ef3H-3l8kA:
undetectable		 5ef3G-3l8kA:
11.76
5ef3H-3l8kA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_H_TRPH101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3l8k DIHYDROLIPOYL
DEHYDROGENASE
(Sulfolobus
solfataricus) 		5 / 9 GLY A  14
HIS A  16
ALA A 325
THR A 304
ILE A 135
 None
 1.27A 5ef3H-3l8kA:
undetectable
5ef3I-3l8kA:
undetectable		 5ef3H-3l8kA:
11.76
5ef3I-3l8kA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_I_TRPI101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3l8k DIHYDROLIPOYL
DEHYDROGENASE
(Sulfolobus
solfataricus) 		5 / 11 GLY A  14
HIS A  16
ALA A 325
THR A 304
ILE A 135
 None
 1.28A 5ef3I-3l8kA:
undetectable
5ef3J-3l8kA:
undetectable		 5ef3I-3l8kA:
11.76
5ef3J-3l8kA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_J_TRPJ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3l8k DIHYDROLIPOYL
DEHYDROGENASE
(Sulfolobus
solfataricus) 		5 / 9 GLY A  14
HIS A  16
ALA A 325
THR A 304
ILE A 135
 None
 1.25A 5ef3J-3l8kA:
undetectable
5ef3K-3l8kA:
undetectable		 5ef3J-3l8kA:
11.76
5ef3K-3l8kA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_K_TRPK101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3l8k DIHYDROLIPOYL
DEHYDROGENASE
(Sulfolobus
solfataricus) 		5 / 10 GLY A  14
HIS A  16
ALA A 325
THR A 304
ILE A 135
 None
 1.27A 5ef3A-3l8kA:
undetectable
5ef3K-3l8kA:
undetectable		 5ef3A-3l8kA:
11.76
5ef3K-3l8kA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_O_TRPO101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3l8k DIHYDROLIPOYL
DEHYDROGENASE
(Sulfolobus
solfataricus) 		5 / 10 GLY A  14
HIS A  16
ALA A 325
THR A 304
ILE A 135
 None
 1.26A 5ef3N-3l8kA:
undetectable
5ef3O-3l8kA:
undetectable		 5ef3N-3l8kA:
11.76
5ef3O-3l8kA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_Q_TRPQ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3l8k DIHYDROLIPOYL
DEHYDROGENASE
(Sulfolobus
solfataricus) 		5 / 10 GLY A  14
HIS A  16
ALA A 325
THR A 304
ILE A 135
 None
 1.28A 5ef3P-3l8kA:
undetectable
5ef3Q-3l8kA:
undetectable		 5ef3P-3l8kA:
11.76
5ef3Q-3l8kA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_R_TRPR101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3l8k DIHYDROLIPOYL
DEHYDROGENASE
(Sulfolobus
solfataricus) 		5 / 9 GLY A  14
HIS A  16
ALA A 325
THR A 304
ILE A 135
 None
 1.27A 5ef3Q-3l8kA:
undetectable
5ef3R-3l8kA:
undetectable		 5ef3Q-3l8kA:
11.76
5ef3R-3l8kA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_S_TRPS101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3l8k DIHYDROLIPOYL
DEHYDROGENASE
(Sulfolobus
solfataricus) 		5 / 10 GLY A  14
HIS A  16
ALA A 325
THR A 304
ILE A 135
 None
 1.29A 5ef3R-3l8kA:
undetectable
5ef3S-3l8kA:
undetectable		 5ef3R-3l8kA:
11.76
5ef3S-3l8kA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_T_TRPT101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3l8k DIHYDROLIPOYL
DEHYDROGENASE
(Sulfolobus
solfataricus) 		5 / 10 GLY A  14
HIS A  16
ALA A 325
THR A 304
ILE A 135
 None
 1.25A 5ef3S-3l8kA:
undetectable
5ef3T-3l8kA:
undetectable		 5ef3S-3l8kA:
11.76
5ef3T-3l8kA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_U_TRPU101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3l8k DIHYDROLIPOYL
DEHYDROGENASE
(Sulfolobus
solfataricus) 		5 / 10 GLY A  14
HIS A  16
ALA A 325
THR A 304
ILE A 135
 None
 1.31A 5ef3T-3l8kA:
undetectable
5ef3U-3l8kA:
undetectable		 5ef3T-3l8kA:
11.76
5ef3U-3l8kA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_V_TRPV101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3l8k DIHYDROLIPOYL
DEHYDROGENASE
(Sulfolobus
solfataricus) 		5 / 10 GLY A  14
HIS A  16
ALA A 325
THR A 304
ILE A 135
 None
 1.27A 5ef3U-3l8kA:
undetectable
5ef3V-3l8kA:
undetectable		 5ef3U-3l8kA:
11.76
5ef3V-3l8kA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESF_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3l8k DIHYDROLIPOYL
DEHYDROGENASE
(Sulfolobus
solfataricus) 		4 / 8 PHE A 189
ILE A 185
PHE A  74
THR A 164
 None
 0.92A 5esfA-3l8kA:
undetectable		 5esfA-3l8kA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESM_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3l8k DIHYDROLIPOYL
DEHYDROGENASE
(Sulfolobus
solfataricus) 		4 / 7 PHE A 189
ILE A 185
PHE A  74
THR A 164
 None
 0.94A 5esmA-3l8kA:
undetectable		 5esmA-3l8kA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HI6_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 3l8k DIHYDROLIPOYL
DEHYDROGENASE
(Sulfolobus
solfataricus) 		5 / 12 ILE A 198
LEU A 222
ILE A 347
LEU A 206
THR A 196
 None
 1.15A 5hi6A-3l8kA:
undetectable		 5hi6A-3l8kA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HS6_A_J3ZA302_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE 14)		 3l8k DIHYDROLIPOYL
DEHYDROGENASE
(Sulfolobus
solfataricus) 		4 / 8 LEU A 395
TRP A 408
LEU A 393
MET A 377
 None
 1.09A 5hs6A-3l8kA:
5.9		 5hs6A-3l8kA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HV1_A_RFPA902_1
(PHOSPHOENOLPYRUVATE
SYNTHASE)		 3l8k DIHYDROLIPOYL
DEHYDROGENASE
(Sulfolobus
solfataricus) 		5 / 12 VAL A 338
PRO A 312
ALA A 311
VAL A 340
ILE A 136
 None
 1.24A 5hv1A-3l8kA:
undetectable		 5hv1A-3l8kA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V0V_A_8QPA613_1
(SERUM ALBUMIN)		 3l8k DIHYDROLIPOYL
DEHYDROGENASE
(Sulfolobus
solfataricus) 		4 / 8 ALA A 407
VAL A 356
THR A 346
GLY A 422
 None
 0.93A 5v0vA-3l8kA:
4.7		 5v0vA-3l8kA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		 3l8k DIHYDROLIPOYL
DEHYDROGENASE
(Sulfolobus
solfataricus) 		3 / 3 LYS A 394
LEU A 209
ASP A 213
 None
 0.93A 5zv2A-3l8kA:
undetectable		 5zv2A-3l8kA:
11.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F7L_B_ACTB505_0
(AMINE OXIDASE LKCE)		 3l8k DIHYDROLIPOYL
DEHYDROGENASE
(Sulfolobus
solfataricus) 		3 / 3 HIS A 197
ASN A 225
LEU A 224
 None
 0.75A 6f7lB-3l8kA:
10.6		 6f7lB-3l8kA:
22.39