SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3l8m'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HYY_B_STIB600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3l8m PROBABLE THIAMINE
PYROPHOSPHOKINASE
(Staphylococcus
saprophyticus) 		4 / 6 LEU A 127
VAL A 163
VAL A 158
ILE A 137
 None
 1.11A 2hyyB-3l8mA:
undetectable		 2hyyB-3l8mA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K5V_A_STIA2_2
(TYROSINE-PROTEIN
KINASE ABL1)		 3l8m PROBABLE THIAMINE
PYROPHOSPHOKINASE
(Staphylococcus
saprophyticus) 		4 / 6 LEU A 127
VAL A 163
VAL A 158
ILE A 137
 None
 1.07A 3k5vA-3l8mA:
undetectable		 3k5vA-3l8mA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K5V_B_STIB2_2
(TYROSINE-PROTEIN
KINASE ABL1)		 3l8m PROBABLE THIAMINE
PYROPHOSPHOKINASE
(Staphylococcus
saprophyticus) 		4 / 6 LEU A 127
VAL A 163
VAL A 158
ILE A 137
 None
 1.09A 3k5vB-3l8mA:
undetectable		 3k5vB-3l8mA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EMA_A_BRLA601_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3l8m PROBABLE THIAMINE
PYROPHOSPHOKINASE
(Staphylococcus
saprophyticus) 		3 / 3 PHE A 136
VAL A  86
ILE A  82
 None
 0.62A 4emaA-3l8mA:
undetectable		 4emaA-3l8mA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B3S_P_CHDP306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3)		 3l8m PROBABLE THIAMINE
PYROPHOSPHOKINASE
(Staphylococcus
saprophyticus) 		4 / 7 LYS A 126
LEU A 127
PHE A 106
LEU A 110
 NA  A8001 (-4.8A)
None
None
None
 0.82A 5b3sP-3l8mA:
undetectable		 5b3sP-3l8mA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I1P_G_DVAG9_0
(D-VILLIN HEADPIECE
SUBDOMAIN
VILLIN-1)		 3l8m PROBABLE THIAMINE
PYROPHOSPHOKINASE
(Staphylococcus
saprophyticus) 		3 / 3 ALA A   3
ASN A   4
LEU A   5
 None
 0.47A 5i1pD-3l8mA:
undetectable		 5i1pD-3l8mA:
15.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_G_TA1G501_2
(TUBULIN BETA CHAIN)		 3l8m PROBABLE THIAMINE
PYROPHOSPHOKINASE
(Staphylococcus
saprophyticus) 		4 / 6 LEU A  78
LEU A 113
THR A  99
ARG A 208
 None
 0.95A 6ew0G-3l8mA:
undetectable		 6ew0G-3l8mA:
15.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H7U_A_FVTA501_0
(PEPTIDE ABC
TRANSPORTER PERMEASE)		 3l8m PROBABLE THIAMINE
PYROPHOSPHOKINASE
(Staphylococcus
saprophyticus) 		4 / 6 ASN A  67
PRO A  68
ILE A  66
GLU A  65
 None
 1.10A 6h7uA-3l8mA:
undetectable		 6h7uA-3l8mA:
17.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_Q_PCFQ202_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 5A,
MITOCHONDRIAL
CYTOCHROME C OXIDASE
SUBUNIT 1)		 3l8m PROBABLE THIAMINE
PYROPHOSPHOKINASE
(Staphylococcus
saprophyticus) 		4 / 6 TYR A 118
ILE A 123
ALA A  85
ASP A  75
 None
 1.09A 6hu9m-3l8mA:
undetectable
6hu9q-3l8mA:
undetectable		 6hu9m-3l8mA:
17.07
6hu9q-3l8mA:
21.05