SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3l8q'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_C_DCFC1353_2
(ADENOSINE DEAMINASE)		 3l8q CELLULOSOMAL
SCAFFOLDIN ADAPTOR
PROTEIN B
(Acetivibrio
cellulolyticus) 		4 / 5 LEU A 283
LEU A 239
LEU A 268
GLY A 204
 None
 0.82A 1a4lC-3l8qA:
undetectable		 1a4lC-3l8qA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BX4_A_ADNA350_2
(PROTEIN (ADENOSINE
KINASE))		 3l8q CELLULOSOMAL
SCAFFOLDIN ADAPTOR
PROTEIN B
(Acetivibrio
cellulolyticus) 		3 / 3 LEU A 261
SER A 231
ASN A 229
 None
 0.70A 1bx4A-3l8qA:
undetectable		 1bx4A-3l8qA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9Q_A_CHDA459_0
(ESTROGEN-RELATED
RECEPTOR GAMMA)		 3l8q CELLULOSOMAL
SCAFFOLDIN ADAPTOR
PROTEIN B
(Acetivibrio
cellulolyticus) 		4 / 6 ASP A  12
LEU A  11
VAL A  10
ILE A   9
 None
 0.95A 1s9qA-3l8qA:
undetectable		 1s9qA-3l8qA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVV_A_MK1A901_2
(POL POLYPROTEIN)		 3l8q CELLULOSOMAL
SCAFFOLDIN ADAPTOR
PROTEIN B
(Acetivibrio
cellulolyticus) 		3 / 3 ASP A 151
VAL A 144
PRO A 137
 None
 0.64A 2avvA-3l8qA:
undetectable		 2avvA-3l8qA:
17.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FT9_A_CHDA131_0
(FATTY ACID-BINDING
PROTEIN 2, LIVER)		 3l8q CELLULOSOMAL
SCAFFOLDIN ADAPTOR
PROTEIN B
(Acetivibrio
cellulolyticus) 		5 / 11 TYR A  95
LEU A  76
ILE A  69
ASN A  27
LEU A  98
 None
 1.34A 2ft9A-3l8qA:
undetectable		 2ft9A-3l8qA:
16.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6F_C_010C6_0
(INFECTIOUS
BRONCHITIS VIRUS
(IBV) MAIN PROTEASE
N-[(5-METHYLISOXAZOL
-3-YL)CARBONYL]ALANY
L-L-VALYL-N~1~-((1R,
2Z)-4-(BENZYLOXY)-4-
OXO-1-{[(3R)-2-OXOPY
RROLIDIN-3-YL]METHYL
}BUT-2-ENYL)-L-LEUCI
NAMIDE)		 3l8q CELLULOSOMAL
SCAFFOLDIN ADAPTOR
PROTEIN B
(Acetivibrio
cellulolyticus) 		3 / 3 ASN A 208
LEU A 261
HIS A 252
 None
 0.83A 2q6fB-3l8qA:
undetectable		 2q6fB-3l8qA:
23.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A51_B_VDYB6178_1
(VITAMIN D
HYDROXYLASE)		 3l8q CELLULOSOMAL
SCAFFOLDIN ADAPTOR
PROTEIN B
(Acetivibrio
cellulolyticus) 		5 / 12 THR A 143
LEU A  39
ILE A  28
THR A  68
LEU A  70
 None
 1.41A 3a51B-3l8qA:
undetectable		 3a51B-3l8qA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABK_C_CHDC271_0
(CYTOCHROME C OXIDASE
SUBUNIT 3)		 3l8q CELLULOSOMAL
SCAFFOLDIN ADAPTOR
PROTEIN B
(Acetivibrio
cellulolyticus) 		4 / 4 ARG A 102
GLN A 109
PHE A  34
LEU A  98
 None
 1.11A 3abkC-3l8qA:
undetectable		 3abkC-3l8qA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_A_CHDA150_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 3l8q CELLULOSOMAL
SCAFFOLDIN ADAPTOR
PROTEIN B
(Acetivibrio
cellulolyticus) 		5 / 12 MET A  41
THR A 143
VAL A 144
PHE A 130
VAL A 116
 None
 1.24A 3em0A-3l8qA:
undetectable		 3em0A-3l8qA:
17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FPJ_A_SAMA301_1
(PUTATIVE
UNCHARACTERIZED
PROTEIN)		 3l8q CELLULOSOMAL
SCAFFOLDIN ADAPTOR
PROTEIN B
(Acetivibrio
cellulolyticus) 		4 / 6 TYR A 174
GLY A 281
THR A 176
GLU A 237
 None
 0.88A 3fpjA-3l8qA:
undetectable		 3fpjA-3l8qA:
24.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SOA_A_DB8A445_1
(CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE II
SUBUNIT ALPHA WITH A
BETA 7 LINKER)		 3l8q CELLULOSOMAL
SCAFFOLDIN ADAPTOR
PROTEIN B
(Acetivibrio
cellulolyticus) 		4 / 6 LEU A 283
VAL A 194
MET A 177
PHE A 300
 None
 1.06A 3soaA-3l8qA:
undetectable		 3soaA-3l8qA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G19_A_ACTA304_0
(GLUTATHIONE
TRANSFERASE GTE1)		 3l8q CELLULOSOMAL
SCAFFOLDIN ADAPTOR
PROTEIN B
(Acetivibrio
cellulolyticus) 		4 / 5 ALA A  16
LEU A  11
LYS A  13
ASN A 166
 None
 1.18A 4g19A-3l8qA:
undetectable		 4g19A-3l8qA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMA_A_CXXA603_1
(TRANSPORTER)		 3l8q CELLULOSOMAL
SCAFFOLDIN ADAPTOR
PROTEIN B
(Acetivibrio
cellulolyticus) 		5 / 11 ASP A  12
PRO A  64
ALA A  66
SER A  25
THR A  52
 None
 1.25A 4mmaA-3l8qA:
undetectable		 4mmaA-3l8qA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MUE_A_VIVA302_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 3l8q CELLULOSOMAL
SCAFFOLDIN ADAPTOR
PROTEIN B
(Acetivibrio
cellulolyticus) 		5 / 12 ILE A 190
ILE A 258
PHE A 288
VAL A 207
LEU A 261
 None
 0.96A 5mueA-3l8qA:
undetectable		 5mueA-3l8qA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z84_P_CHDP305_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3l8q CELLULOSOMAL
SCAFFOLDIN ADAPTOR
PROTEIN B
(Acetivibrio
cellulolyticus) 		4 / 6 ARG A 102
GLN A 109
PHE A  34
LEU A  98
 None
 1.09A 5z84P-3l8qA:
undetectable
5z84W-3l8qA:
undetectable		 5z84P-3l8qA:
20.00
5z84W-3l8qA:
13.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z85_P_CHDP307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3l8q CELLULOSOMAL
SCAFFOLDIN ADAPTOR
PROTEIN B
(Acetivibrio
cellulolyticus) 		4 / 6 ARG A 102
GLN A 109
PHE A  34
LEU A  98
 None
 1.08A 5z85P-3l8qA:
undetectable
5z85W-3l8qA:
undetectable		 5z85P-3l8qA:
20.00
5z85W-3l8qA:
13.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z86_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3l8q CELLULOSOMAL
SCAFFOLDIN ADAPTOR
PROTEIN B
(Acetivibrio
cellulolyticus) 		4 / 6 ARG A 102
GLN A 109
PHE A  34
LEU A  98
 None
 1.09A 5z86C-3l8qA:
undetectable
5z86J-3l8qA:
undetectable		 5z86C-3l8qA:
20.00
5z86J-3l8qA:
13.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z86_P_CHDP307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3l8q CELLULOSOMAL
SCAFFOLDIN ADAPTOR
PROTEIN B
(Acetivibrio
cellulolyticus) 		4 / 6 ARG A 102
GLN A 109
PHE A  34
LEU A  98
 None
 1.08A 5z86P-3l8qA:
undetectable
5z86W-3l8qA:
undetectable		 5z86P-3l8qA:
20.00
5z86W-3l8qA:
13.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCO_P_CHDP305_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3l8q CELLULOSOMAL
SCAFFOLDIN ADAPTOR
PROTEIN B
(Acetivibrio
cellulolyticus) 		4 / 6 ARG A 102
GLN A 109
PHE A  34
LEU A  98
 None
 1.09A 5zcoP-3l8qA:
undetectable
5zcoW-3l8qA:
undetectable		 5zcoP-3l8qA:
20.00
5zcoW-3l8qA:
13.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCP_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3l8q CELLULOSOMAL
SCAFFOLDIN ADAPTOR
PROTEIN B
(Acetivibrio
cellulolyticus) 		4 / 6 ARG A 102
GLN A 109
PHE A  34
LEU A  98
 None
 1.10A 5zcpC-3l8qA:
undetectable
5zcpJ-3l8qA:
undetectable		 5zcpC-3l8qA:
20.00
5zcpJ-3l8qA:
13.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCP_P_CHDP306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3l8q CELLULOSOMAL
SCAFFOLDIN ADAPTOR
PROTEIN B
(Acetivibrio
cellulolyticus) 		4 / 6 ARG A 102
GLN A 109
PHE A  34
LEU A  98
 None
 1.08A 5zcpP-3l8qA:
undetectable
5zcpW-3l8qA:
undetectable		 5zcpP-3l8qA:
20.00
5zcpW-3l8qA:
13.72