SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3l8r'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1AM6_A_HAEA555_1 (CARBONIC ANHYDRASE)	3l8r	PUTATIVE PTS SYSTEM, CELLOBIOSE-SPECIFIC IIA COMPONENT (Streptococcus mutans)	4 / 7	HIS A 82 LEU A 89 THR A 86 THR A 85	None	0.85A	1am6A-3l8rA: undetectable	1am6A-3l8rA: 19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3U52_A_CUA515_0 (PHENOL HYDROXYLASE COMPONENT PHL PHENOL HYDROXYLASE COMPONENT PHN)	3l8r	PUTATIVE PTS SYSTEM, CELLOBIOSE-SPECIFIC IIA COMPONENT (Streptococcus mutans)	3 / 3	HIS A 82 HIS A 78 ILE A 14	None	0.62A	3u52A-3l8rA: undetectable 3u52C-3l8rA: 3.1	3u52A-3l8rA: 13.04 3u52C-3l8rA: 17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3VW7_A_VPXA2001_1 (PROTEINASE-ACTIVATED RECEPTOR 1, LYSOZYME)	3l8r	PUTATIVE PTS SYSTEM, CELLOBIOSE-SPECIFIC IIA COMPONENT (Streptococcus mutans)	5 / 12	HIS A 54 LEU A 60 LEU A 61 ALA A 10 ALA A 9	None	1.16A	3vw7A-3l8rA: undetectable	3vw7A-3l8rA: 13.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3ZNC_A_BZ1A500_1 (CARBONIC ANHYDRASE IV)	3l8r	PUTATIVE PTS SYSTEM, CELLOBIOSE-SPECIFIC IIA COMPONENT (Streptococcus mutans)	5 / 10	HIS A 82 PHE A 28 LEU A 89 THR A 86 THR A 85	None	1.46A	3zncA-3l8rA: undetectable	3zncA-3l8rA: 18.29

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1AM6_A_HAEA555_1","CARBONIC ANHYDRASE","3l8r","PUTATIVE PTS SYSTEM, CELLOBIOSE-SPECIFIC IIA COMPONENT","Streptococcus mutans",4,"HIS A  82;LEU A  89;THR A  86;THR A  85","None","0.85A","1am6A-3l8rA:undetectable","1am6A-3l8rA:19.47"],["3U52_A_CUA515_0","PHENOL HYDROXYLASE COMPONENT PHL;PHENOL HYDROXYLASE COMPONENT PHN","3l8r","PUTATIVE PTS SYSTEM, CELLOBIOSE-SPECIFIC IIA COMPONENT","Streptococcus mutans",3,"HIS A  82;HIS A  78;ILE A  14","None","0.62A","3u52A-3l8rA:undetectable;3u52C-3l8rA:3.1","3u52A-3l8rA:13.04;3u52C-3l8rA:17.99"],["3VW7_A_VPXA2001_1","PROTEINASE-ACTIVATED RECEPTOR 1, LYSOZYME","3l8r","PUTATIVE PTS SYSTEM, CELLOBIOSE-SPECIFIC IIA COMPONENT","Streptococcus mutans",5,"HIS A  54;LEU A  60;LEU A  61;ALA A  10;ALA A   9","None","1.16A","3vw7A-3l8rA:undetectable","3vw7A-3l8rA:13.80"],["3ZNC_A_BZ1A500_1","CARBONIC ANHYDRASE IV","3l8r","PUTATIVE PTS SYSTEM, CELLOBIOSE-SPECIFIC IIA COMPONENT","Streptococcus mutans",5,"HIS A  82;PHE A  28;LEU A  89;THR A  86;THR A  85","None","1.46A","3zncA-3l8rA:undetectable","3zncA-3l8rA:18.29"]]