SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3l8u'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V2X_A_SAMA400_0
(TRNA (GM18)
METHYLTRANSFERASE)
3l8u PUTATIVE RRNA
METHYLASE

(Streptococcus
mutans)
6 / 12 PHE A 116
GLY A 117
GLY A 122
ILE A 138
SER A 147
LEU A 148
None
0.76A 1v2xA-3l8uA:
16.0
1v2xA-3l8uA:
28.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ROX_B_T44B128_1
(TRANSTHYRETIN)
3l8u PUTATIVE RRNA
METHYLASE

(Streptococcus
mutans)
5 / 6 LYS A 134
GLU A 133
ALA A 135
LEU A 115
THR A  94
None
1.30A 2roxB-3l8uA:
undetectable
2roxB-3l8uA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UXP_B_CLMB1211_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR TTGR)
3l8u PUTATIVE RRNA
METHYLASE

(Streptococcus
mutans)
5 / 11 HIS A  19
HIS A 112
ALA A 161
GLY A 169
ILE A 168
None
1.26A 2uxpB-3l8uA:
undetectable
2uxpB-3l8uA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CFQ_A_DIFA1_1
(TRANSTHYRETIN)
3l8u PUTATIVE RRNA
METHYLASE

(Streptococcus
mutans)
4 / 6 LYS A 134
ALA A 135
LEU A 115
THR A  94
None
1.03A 3cfqA-3l8uA:
undetectable
3cfqA-3l8uA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NK7_A_SAMA770_0
(23S RRNA
METHYLTRANSFERASE)
3l8u PUTATIVE RRNA
METHYLASE

(Streptococcus
mutans)
6 / 12 ASN A  30
GLY A 117
GLY A 122
ILE A 138
SER A 147
ASN A 149
None
0.63A 3nk7A-3l8uA:
16.4
3nk7A-3l8uA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NK7_B_SAMB770_0
(23S RRNA
METHYLTRANSFERASE)
3l8u PUTATIVE RRNA
METHYLASE

(Streptococcus
mutans)
7 / 12 ASN A  30
PHE A 116
GLY A 117
GLY A 122
ILE A 138
SER A 147
LEU A 148
None
0.73A 3nk7B-3l8uA:
16.4
3nk7B-3l8uA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NK7_B_SAMB770_0
(23S RRNA
METHYLTRANSFERASE)
3l8u PUTATIVE RRNA
METHYLASE

(Streptococcus
mutans)
5 / 12 GLY A 117
GLU A 119
GLY A 122
SER A 147
LEU A 148
None
0.97A 3nk7B-3l8uA:
16.4
3nk7B-3l8uA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X3M_B_ADNB301_1
(RNA 2'-O RIBOSE
METHYLTRANSFERASE)
3l8u PUTATIVE RRNA
METHYLASE

(Streptococcus
mutans)
5 / 9 GLY A 117
ILE A 138
SER A 147
LEU A 148
THR A 153
None
0.59A 4x3mB-3l8uA:
17.2
4x3mB-3l8uA:
23.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L0Z_A_SAMA304_0
(PROBABLE RNA
METHYLTRANSFERASE,
TRMH FAMILY)
3l8u PUTATIVE RRNA
METHYLASE

(Streptococcus
mutans)
6 / 12 GLY A 117
GLY A 122
ILE A 138
SER A 147
LEU A 148
LEU A 150
None
0.69A 5l0zA-3l8uA:
18.6
5l0zA-3l8uA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L0Z_B_SAMB304_0
(PROBABLE RNA
METHYLTRANSFERASE,
TRMH FAMILY)
3l8u PUTATIVE RRNA
METHYLASE

(Streptococcus
mutans)
5 / 10 GLY A 117
GLY A 122
ILE A 138
LEU A 148
LEU A 150
None
0.57A 5l0zB-3l8uA:
8.0
5l0zB-3l8uA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L0Z_B_SAMB304_0
(PROBABLE RNA
METHYLTRANSFERASE,
TRMH FAMILY)
3l8u PUTATIVE RRNA
METHYLASE

(Streptococcus
mutans)
5 / 10 GLY A 117
ILE A 138
SER A 147
LEU A 148
LEU A 150
None
0.75A 5l0zB-3l8uA:
8.0
5l0zB-3l8uA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OCS_A_ACTA402_0
(PUTATIVE
NADH-DEPENTDENT
FLAVIN
OXIDOREDUCTASE)
3l8u PUTATIVE RRNA
METHYLASE

(Streptococcus
mutans)
4 / 5 ILE A  85
HIS A  46
HIS A  74
TYR A  76
None
1.43A 5ocsA-3l8uA:
undetectable
5ocsA-3l8uA:
16.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OCS_C_ACTC402_0
(PUTATIVE
NADH-DEPENTDENT
FLAVIN
OXIDOREDUCTASE)
3l8u PUTATIVE RRNA
METHYLASE

(Streptococcus
mutans)
4 / 5 ILE A  85
HIS A  46
HIS A  74
TYR A  76
None
1.41A 5ocsC-3l8uA:
2.1
5ocsC-3l8uA:
16.27