SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3l91'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NH8_A_HISA289_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 3l91 ACYL-HOMOSERINE
LACTONE ACYLASE PVDQ
SUBUNIT BETA
(Pseudomonas
aeruginosa) 		4 / 5 ASP B 386
LEU B 476
ALA B 407
LEU B 280
 None
 1.13A 1nh8A-3l91B:
undetectable		 1nh8A-3l91B:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NRU_A_DVAA6_0
(GRAMICIDIN A)		 3l91 ACYL-HOMOSERINE
LACTONE ACYLASE PVDQ
SUBUNIT BETA
(Pseudomonas
aeruginosa) 		3 / 3 ALA B 363
VAL B 349
TRP B 356
 None
 0.94A 1nruA-3l91B:
undetectable		 1nruA-3l91B:
3.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NRU_B_DVAB6_0
(GRAMICIDIN A)		 3l91 ACYL-HOMOSERINE
LACTONE ACYLASE PVDQ
SUBUNIT BETA
(Pseudomonas
aeruginosa) 		3 / 3 ALA B 363
VAL B 349
TRP B 356
 None
 0.93A 1nruB-3l91B:
undetectable		 1nruB-3l91B:
3.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J7X_A_ESTA1454_1
(ESTROGEN RECEPTOR
BETA)		 3l91 ACYL-HOMOSERINE
LACTONE ACYLASE PVDQ
SUBUNIT BETA
(Pseudomonas
aeruginosa) 		5 / 12 MET B 593
LEU B 634
LEU B 554
LEU B 552
GLY B 618
 None
 1.10A 2j7xA-3l91B:
undetectable		 2j7xA-3l91B:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEU_B_ACTB141_0
(PUTATIVE
CARBOXYMUCONOLACTONE
DECARBOXYLASE)		 3l91 ACYL-HOMOSERINE
LACTONE ACYLASE PVDQ
SUBUNIT BETA
(Pseudomonas
aeruginosa) 		3 / 3 PRO B 401
ASN B 371
ARG B 373
 OCA  B   1 ( 4.7A)
None
EDO  B 911 (-4.1A)
 0.94A 2qeuB-3l91B:
undetectable		 2qeuB-3l91B:
13.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QL8_B_BEZB143_0
(PUTATIVE REDOX
PROTEIN)		 3l91 ACYL-HOMOSERINE
LACTONE ACYLASE PVDQ
SUBUNIT BETA
(Pseudomonas
aeruginosa) 		4 / 6 TYR B 697
THR B 283
ALA B 281
PRO B 238
 None
None
None
OCA  B   1 (-4.0A)
 1.41A 2ql8A-3l91B:
undetectable
2ql8B-3l91B:
undetectable		 2ql8A-3l91B:
13.77
2ql8B-3l91B:
13.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R2V_D_ACTD36_0
(GCN4 LEUCINE ZIPPER)		 3l91 ACYL-HOMOSERINE
LACTONE ACYLASE PVDQ
SUBUNIT BETA
(Pseudomonas
aeruginosa) 		3 / 3 SER B 719
TYR B 727
HIS B 726
 None
 0.70A 2r2vD-3l91B:
undetectable		 2r2vD-3l91B:
6.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RCT_A_RTLA140_1
(RETINOL-BINDING
PROTEIN II, CELLULAR)		 3l91 ACYL-HOMOSERINE
LACTONE ACYLASE PVDQ
SUBUNIT BETA
(Pseudomonas
aeruginosa) 		3 / 3 GLN B 250
THR B 695
TRP B 739
 EDO  B 900 (-2.9A)
None
None
 0.81A 2rctA-3l91B:
undetectable		 2rctA-3l91B:
11.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RCT_A_RTLA140_1
(RETINOL-BINDING
PROTEIN II, CELLULAR)		 3l91 ACYL-HOMOSERINE
LACTONE ACYLASE PVDQ
SUBUNIT BETA
(Pseudomonas
aeruginosa) 		3 / 3 GLN B 699
THR B 405
TRP B 378
 None
None
EDO  B 915 ( 3.5A)
 0.88A 2rctA-3l91B:
undetectable		 2rctA-3l91B:
11.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_B_ASDB1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 3l91 ACYL-HOMOSERINE
LACTONE ACYLASE PVDQ
SUBUNIT BETA
(Pseudomonas
aeruginosa) 		4 / 6 PHE B 592
LEU B 621
ALA B 602
ALA B 633
 None
None
EDO  B 913 (-3.6A)
None
 0.81A 2vcvB-3l91B:
undetectable		 2vcvB-3l91B:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_K_ASDK1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 3l91 ACYL-HOMOSERINE
LACTONE ACYLASE PVDQ
SUBUNIT BETA
(Pseudomonas
aeruginosa) 		4 / 6 PHE B 592
LEU B 621
ALA B 602
ALA B 633
 None
None
EDO  B 913 (-3.6A)
None
 0.78A 2vcvK-3l91B:
undetectable		 2vcvK-3l91B:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y01_A_Y00A601_1
(BETA-1 ADRENERGIC
RECEPTOR)		 3l91 ACYL-HOMOSERINE
LACTONE ACYLASE PVDQ
SUBUNIT BETA
(Pseudomonas
aeruginosa) 		5 / 12 SER B 217
PHE B 248
PHE B 240
VAL B 272
ASN B 273
 OCA  B   1 (-2.6A)
None
OCA  B   1 (-4.7A)
None
OCA  B   1 ( 3.1A)
 1.47A 2y01A-3l91B:
undetectable		 2y01A-3l91B:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y05_A_RALA801_1
(PROSTAGLANDIN
REDUCTASE 1)		 3l91 ACYL-HOMOSERINE
LACTONE ACYLASE PVDQ
SUBUNIT BETA
(Pseudomonas
aeruginosa) 		4 / 8 SER B 289
TYR B 677
VAL B 481
TYR B 416
 None
 1.32A 2y05A-3l91B:
undetectable
2y05B-3l91B:
undetectable		 2y05A-3l91B:
23.21
2y05B-3l91B:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_E_SVRE503_1
(PHOSPHOLIPASE A2)		 3l91 ACYL-HOMOSERINE
LACTONE ACYLASE PVDQ
SUBUNIT BETA
(Pseudomonas
aeruginosa) 		5 / 11 LEU B 714
ILE B 274
PRO B 238
SER B 217
THR B 695
 None
None
OCA  B   1 (-4.0A)
OCA  B   1 (-2.6A)
None
 1.36A 3bjwE-3l91B:
2.6		 3bjwE-3l91B:
11.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FRQ_A_ERYA195_1
(REPRESSOR PROTEIN
MPHR(A))		 3l91 ACYL-HOMOSERINE
LACTONE ACYLASE PVDQ
SUBUNIT BETA
(Pseudomonas
aeruginosa) 		4 / 5 ASN B 539
ASN B 218
HIS B 239
ALA B 679
 None
 1.15A 3frqA-3l91B:
undetectable		 3frqA-3l91B:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FRQ_A_ERYA195_1
(REPRESSOR PROTEIN
MPHR(A))		 3l91 ACYL-HOMOSERINE
LACTONE ACYLASE PVDQ
SUBUNIT BETA
(Pseudomonas
aeruginosa) 		4 / 5 ASN B 539
ASN B 237
HIS B 239
ALA B 679
 None
 1.30A 3frqA-3l91B:
undetectable		 3frqA-3l91B:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HKU_A_TORA300_2
(CARBONIC ANHYDRASE 2)		 3l91 ACYL-HOMOSERINE
LACTONE ACYLASE PVDQ
SUBUNIT BETA
(Pseudomonas
aeruginosa) 		3 / 3 GLU B 690
HIS B 688
THR B 659
 None
 0.71A 3hkuA-3l91B:
undetectable		 3hkuA-3l91B:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OGP_B_017B200_1
(FIV PROTEASE)		 3l91 ACYL-HOMOSERINE
LACTONE ACYLASE PVDQ
SUBUNIT BETA
(Pseudomonas
aeruginosa) 		6 / 10 ALA B 469
GLY B 399
ILE B 400
SER B 289
VAL B 504
LEU B 472
 None
 1.38A 3ogpA-3l91B:
undetectable		 3ogpA-3l91B:
11.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_B_SAMB300_1
(SAM-DEPENDENT
METHYLTRANSFERASE)		 3l91 ACYL-HOMOSERINE
LACTONE ACYLASE PVDQ
SUBUNIT BETA
(Pseudomonas
aeruginosa) 		3 / 3 TYR B 516
ASP B 545
ASP B 614
 None
 0.89A 3ou7B-3l91B:
undetectable		 3ou7B-3l91B:
17.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T7S_C_SAMC300_0
(PUTATIVE
METHYLTRANSFERASE)		 3l91 ACYL-HOMOSERINE
LACTONE ACYLASE PVDQ
SUBUNIT BETA
(Pseudomonas
aeruginosa) 		5 / 12 GLN B 656
GLY B 694
GLN B 681
ALA B 679
ASN B 678
 None
 1.45A 3t7sC-3l91B:
undetectable		 3t7sC-3l91B:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TEG_A_DAHA416_1
(PHENYLALANYL-TRNA
SYNTHETASE,
MITOCHONDRIAL)		 3l91 ACYL-HOMOSERINE
LACTONE ACYLASE PVDQ
SUBUNIT BETA
(Pseudomonas
aeruginosa) 		5 / 12 ARG B 591
GLN B 590
GLY B 694
ALA B 679
GLY B 670
 EDO  B 917 (-3.9A)
None
None
None
None
 1.08A 3tegA-3l91B:
undetectable		 3tegA-3l91B:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TJ7_A_ACTA604_0
(GBAA_1210 PROTEIN)		 3l91 ACYL-HOMOSERINE
LACTONE ACYLASE PVDQ
SUBUNIT BETA
(Pseudomonas
aeruginosa) 		4 / 6 VAL B 422
HIS B 291
SER B 420
THR B 467
 None
 1.10A 3tj7A-3l91B:
undetectable
3tj7B-3l91B:
undetectable		 3tj7A-3l91B:
16.05
3tj7B-3l91B:
16.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TJ7_C_ACTC606_0
(GBAA_1210 PROTEIN)		 3l91 ACYL-HOMOSERINE
LACTONE ACYLASE PVDQ
SUBUNIT BETA
(Pseudomonas
aeruginosa) 		4 / 6 VAL B 422
HIS B 291
SER B 420
THR B 467
 None
 1.06A 3tj7C-3l91B:
undetectable
3tj7D-3l91B:
undetectable		 3tj7C-3l91B:
16.05
3tj7D-3l91B:
16.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TJ7_D_ACTD605_0
(GBAA_1210 PROTEIN)		 3l91 ACYL-HOMOSERINE
LACTONE ACYLASE PVDQ
SUBUNIT BETA
(Pseudomonas
aeruginosa) 		4 / 6 VAL B 422
HIS B 291
SER B 420
THR B 467
 None
 1.09A 3tj7C-3l91B:
undetectable
3tj7D-3l91B:
undetectable		 3tj7C-3l91B:
16.05
3tj7D-3l91B:
16.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UCB_B_017B202_1
(PROTEASE)		 3l91 ACYL-HOMOSERINE
LACTONE ACYLASE PVDQ
SUBUNIT BETA
(Pseudomonas
aeruginosa) 		4 / 7 TRP B 455
ARG B 365
GLY B 345
PRO B 346
 None
EDO  B 912 (-2.8A)
None
None
 1.26A 3ucbB-3l91B:
undetectable		 3ucbB-3l91B:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGK_A_0TXA304_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 3l91 ACYL-HOMOSERINE
LACTONE ACYLASE PVDQ
SUBUNIT BETA
(Pseudomonas
aeruginosa) 		5 / 10 GLY B 694
GLY B 693
ASN B 485
VAL B 286
PHE B 248
 None
None
None
OCA  B   1 (-4.0A)
None
 1.16A 4fgkA-3l91B:
undetectable
4fgkB-3l91B:
undetectable		 4fgkA-3l91B:
19.82
4fgkB-3l91B:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LG1_B_SAMB301_0
(PROTEIN-LYSINE
METHYLTRANSFERASE
METTL21D)		 3l91 ACYL-HOMOSERINE
LACTONE ACYLASE PVDQ
SUBUNIT BETA
(Pseudomonas
aeruginosa) 		5 / 12 ALA B 407
GLY B 223
GLY B 412
ALA B 221
GLU B 528
 None
 1.13A 4lg1B-3l91B:
undetectable		 4lg1B-3l91B:
16.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O4D_A_ACTA406_0
(INOSITOL
HEXAKISPHOSPHATE
KINASE)		 3l91 ACYL-HOMOSERINE
LACTONE ACYLASE PVDQ
SUBUNIT BETA
(Pseudomonas
aeruginosa) 		4 / 7 ASP B 671
ARG B 513
PHE B 674
HIS B 673
 None
 1.15A 4o4dA-3l91B:
undetectable		 4o4dA-3l91B:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_B_GCSB305_1
(CHITOSANASE)		 3l91 ACYL-HOMOSERINE
LACTONE ACYLASE PVDQ
SUBUNIT BETA
(Pseudomonas
aeruginosa) 		3 / 3 GLY B 707
PRO B 708
GLN B 748
 EDO  B 908 ( 3.4A)
EDO  B 908 ( 4.0A)
EDO  B 909 ( 3.9A)
 0.55A 4qwpB-3l91B:
undetectable		 4qwpB-3l91B:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R29_D_SAMD301_1
(UNCHARACTERIZED
PROTEIN)		 3l91 ACYL-HOMOSERINE
LACTONE ACYLASE PVDQ
SUBUNIT BETA
(Pseudomonas
aeruginosa) 		3 / 3 ARG B 296
GLU B 441
TYR B 362
 None
 0.88A 4r29D-3l91B:
undetectable		 4r29D-3l91B:
16.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4YFB_C_PACC601_0
(PROTEIN RELATED TO
PENICILLIN ACYLASE)		 3l91 ACYL-HOMOSERINE
LACTONE ACYLASE PVDQ
SUBUNIT BETA
(Pseudomonas
aeruginosa) 		9 / 12 SER B 217
PRO B 238
PHE B 248
ILE B 274
HIS B 284
VAL B 286
TRP B 378
TRP B 402
VAL B 403
 OCA  B   1 (-2.6A)
OCA  B   1 (-4.0A)
None
None
OCA  B   1 (-4.6A)
OCA  B   1 (-4.0A)
EDO  B 915 ( 3.5A)
OCA  B   1 (-4.6A)
OCA  B   1 (-4.8A)
 0.62A 4yfbC-3l91B:
49.2		 4yfbC-3l91B:
36.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4YFB_F_PACF601_0
(PROTEIN RELATED TO
PENICILLIN ACYLASE)		 3l91 ACYL-HOMOSERINE
LACTONE ACYLASE PVDQ
SUBUNIT BETA
(Pseudomonas
aeruginosa) 		9 / 12 SER B 217
PRO B 238
PHE B 248
ILE B 274
HIS B 284
VAL B 286
TRP B 378
TRP B 402
VAL B 403
 OCA  B   1 (-2.6A)
OCA  B   1 (-4.0A)
None
None
OCA  B   1 (-4.6A)
OCA  B   1 (-4.0A)
EDO  B 915 ( 3.5A)
OCA  B   1 (-4.6A)
OCA  B   1 (-4.8A)
 0.62A 4yfbF-3l91B:
49.3		 4yfbF-3l91B:
36.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4YFB_I_PACI601_0
(PROTEIN RELATED TO
PENICILLIN ACYLASE)		 3l91 ACYL-HOMOSERINE
LACTONE ACYLASE PVDQ
SUBUNIT BETA
(Pseudomonas
aeruginosa) 		9 / 12 SER B 217
PRO B 238
PHE B 248
ILE B 274
HIS B 284
VAL B 286
TRP B 378
TRP B 402
VAL B 403
 OCA  B   1 (-2.6A)
OCA  B   1 (-4.0A)
None
None
OCA  B   1 (-4.6A)
OCA  B   1 (-4.0A)
EDO  B 915 ( 3.5A)
OCA  B   1 (-4.6A)
OCA  B   1 (-4.8A)
 0.57A 4yfbI-3l91B:
48.2		 4yfbI-3l91B:
36.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4YFB_L_PACL601_0
(PROTEIN RELATED TO
PENICILLIN ACYLASE)		 3l91 ACYL-HOMOSERINE
LACTONE ACYLASE PVDQ
SUBUNIT BETA
(Pseudomonas
aeruginosa) 		9 / 12 SER B 217
PRO B 238
PHE B 248
ILE B 274
HIS B 284
VAL B 286
TRP B 378
TRP B 402
VAL B 403
 OCA  B   1 (-2.6A)
OCA  B   1 (-4.0A)
None
None
OCA  B   1 (-4.6A)
OCA  B   1 (-4.0A)
EDO  B 915 ( 3.5A)
OCA  B   1 (-4.6A)
OCA  B   1 (-4.8A)
 0.61A 4yfbL-3l91B:
48.9		 4yfbL-3l91B:
36.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEI_A_SHHA2004_1
(HDAC6 PROTEIN)		 3l91 ACYL-HOMOSERINE
LACTONE ACYLASE PVDQ
SUBUNIT BETA
(Pseudomonas
aeruginosa) 		5 / 12 PRO B 708
GLY B 263
PHE B 276
HIS B 252
ASP B 260
 EDO  B 908 ( 4.0A)
None
None
None
EDO  B 906 (-4.6A)
 1.36A 5eeiA-3l91B:
undetectable		 5eeiA-3l91B:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEI_B_SHHB801_1
(HDAC6 PROTEIN)		 3l91 ACYL-HOMOSERINE
LACTONE ACYLASE PVDQ
SUBUNIT BETA
(Pseudomonas
aeruginosa) 		5 / 12 PRO B 708
GLY B 263
PHE B 276
HIS B 252
ASP B 260
 EDO  B 908 ( 4.0A)
None
None
None
EDO  B 906 (-4.6A)
 1.35A 5eeiB-3l91B:
undetectable		 5eeiB-3l91B:
22.14