SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3l9c'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BDW_A_DVAA6_0
(GRAMICIDIN A)		 3l9c 3-DEHYDROQUINATE
DEHYDRATASE
(Streptococcus
mutans) 		3 / 3 ALA A  15
VAL A   7
TRP A  31
 None
 0.92A 1bdwA-3l9cA:
undetectable
1bdwB-3l9cA:
undetectable		 1bdwA-3l9cA:
4.44
1bdwB-3l9cA:
4.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z2B_C_VLBC800_1
(TUBULIN BETA CHAIN
TUBULIN ALPHA CHAIN)		 3l9c 3-DEHYDROQUINATE
DEHYDRATASE
(Streptococcus
mutans) 		4 / 8 VAL A 146
TYR A 117
PRO A 124
LEU A 127
 None
 1.03A 1z2bB-3l9cA:
undetectable		 1z2bB-3l9cA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BYO_A_LNLA1217_1
(LIPOPROTEIN LPPX)		 3l9c 3-DEHYDROQUINATE
DEHYDRATASE
(Streptococcus
mutans) 		4 / 4 VAL A  44
LEU A 201
ILE A  23
LEU A  20
 None
 0.94A 2byoA-3l9cA:
undetectable		 2byoA-3l9cA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XRZ_A_ACTA1467_0
(DEOXYRIBODIPYRIMIDIN
E PHOTOLYASE)		 3l9c 3-DEHYDROQUINATE
DEHYDRATASE
(Streptococcus
mutans) 		4 / 5 ARG A  62
ASP A  94
ILE A  58
LYS A 143
 None
 1.45A 2xrzA-3l9cA:
undetectable
2xrzB-3l9cA:
undetectable		 2xrzA-3l9cA:
24.69
2xrzB-3l9cA:
24.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WAR_A_NIOA401_1
(CASEIN KINASE II
SUBUNIT ALPHA)		 3l9c 3-DEHYDROQUINATE
DEHYDRATASE
(Streptococcus
mutans) 		4 / 8 VAL A 174
VAL A 141
LYS A 143
ILE A  58
 None
 0.59A 3warA-3l9cA:
undetectable		 3warA-3l9cA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YV5_A_SVRA205_2
(BASIC PHOSPHOLIPASE
A2 HOMOLOG 2)		 3l9c 3-DEHYDROQUINATE
DEHYDRATASE
(Streptococcus
mutans) 		4 / 6 LEU A 127
ASN A 126
PRO A 124
ARG A  62
 None
 1.45A 4yv5B-3l9cA:
undetectable		 4yv5B-3l9cA:
14.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YV5_B_SVRB207_1
(BASIC PHOSPHOLIPASE
A2 HOMOLOG 2)		 3l9c 3-DEHYDROQUINATE
DEHYDRATASE
(Streptococcus
mutans) 		4 / 6 LEU A 127
ASN A 126
PRO A 124
ARG A  62
 None
 1.45A 4yv5A-3l9cA:
undetectable		 4yv5A-3l9cA:
14.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y9M_A_NIOA401_1
(CASEIN KINASE II
SUBUNIT ALPHA')		 3l9c 3-DEHYDROQUINATE
DEHYDRATASE
(Streptococcus
mutans) 		4 / 8 VAL A 174
VAL A 141
LYS A 143
ILE A  58
 None
 0.68A 5y9mA-3l9cA:
undetectable		 5y9mA-3l9cA:
16.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y9M_X_NIOX401_1
(CASEIN KINASE II
SUBUNIT ALPHA')		 3l9c 3-DEHYDROQUINATE
DEHYDRATASE
(Streptococcus
mutans) 		4 / 8 VAL A 174
VAL A 141
LYS A 143
ILE A  58
 None
 0.65A 5y9mX-3l9cA:
undetectable		 5y9mX-3l9cA:
16.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YF9_B_NIOB401_1
(CASEIN KINASE II
SUBUNIT ALPHA')		 3l9c 3-DEHYDROQUINATE
DEHYDRATASE
(Streptococcus
mutans) 		4 / 7 VAL A 174
VAL A 141
LYS A 143
ILE A  58
 None
 0.62A 5yf9B-3l9cA:
undetectable		 5yf9B-3l9cA:
16.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YWM_X_NIOX403_0
(CASEIN KINASE II
SUBUNIT ALPHA')		 3l9c 3-DEHYDROQUINATE
DEHYDRATASE
(Streptococcus
mutans) 		4 / 7 VAL A 174
VAL A 141
LYS A 143
ILE A  58
 None
 0.72A 5ywmX-3l9cA:
undetectable		 5ywmX-3l9cA:
16.41