SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3la4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1E9Y_B_HAEB800_1
(UREASE SUBUNIT BETA)		 3la4 UREASE
(Canavalia
ensiformis) 		5 / 5 HIS A 407
HIS A 492
HIS A 519
HIS A 545
ASP A 633
 NI  A 841 ( 3.3A)
PO4  A 843 (-4.0A)
NI  A 842 (-3.2A)
NI  A 842 ( 3.4A)
PO4  A 843 ( 2.5A)
 0.29A 1e9yB-3la4A:
58.2		 1e9yB-3la4A:
40.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1FWE_C_HAEC989_1
(UREASE)		 3la4 UREASE
(Canavalia
ensiformis) 		6 / 6 HIS A 407
HIS A 409
HIS A 492
HIS A 519
HIS A 545
ASP A 633
 NI  A 841 ( 3.3A)
NI  A 841 ( 3.3A)
PO4  A 843 (-4.0A)
NI  A 842 (-3.2A)
NI  A 842 ( 3.4A)
PO4  A 843 ( 2.5A)
 0.23A 1fweC-3la4A:
57.9		 1fweC-3la4A:
41.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HSH_A_MK1A401_1
(HIV-II PROTEASE)		 3la4 UREASE
(Canavalia
ensiformis) 		6 / 12 GLY A 723
ALA A 703
ASP A 704
ILE A 357
GLY A 700
ILE A 359
 None
 1.44A 1hshA-3la4A:
undetectable		 1hshA-3la4A:
8.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JG4_A_SAMA500_1
(PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE)		 3la4 UREASE
(Canavalia
ensiformis) 		4 / 8 GLY A 488
ILE A 508
LEU A 478
ASP A 513
 None
 0.94A 1jg4A-3la4A:
undetectable		 1jg4A-3la4A:
15.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_L_TRPL81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3la4 UREASE
(Canavalia
ensiformis) 		5 / 12 GLY A 326
HIS A 170
ALA A 370
ILE A 385
GLY A 310
 None
 0.87A 1utdL-3la4A:
undetectable
1utdM-3la4A:
undetectable		 1utdL-3la4A:
6.68
1utdM-3la4A:
6.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_V_TRPV81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3la4 UREASE
(Canavalia
ensiformis) 		5 / 11 GLY A 310
GLY A 326
HIS A 170
ALA A 370
ILE A 385
 None
 0.90A 1utdL-3la4A:
undetectable
1utdV-3la4A:
undetectable		 1utdL-3la4A:
6.68
1utdV-3la4A:
6.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W76_B_GNTB1538_1
(ACETYLCHOLINESTERASE)		 3la4 UREASE
(Canavalia
ensiformis) 		5 / 10 ASP A 521
GLY A 550
GLY A 551
PHE A 605
HIS A 593
 None
PO4  A 843 ( 4.5A)
None
None
PO4  A 844 (-3.3A)
 1.16A 1w76B-3la4A:
undetectable		 1w76B-3la4A:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X70_B_715B801_1
(DIPEPTIDYL PEPTIDASE
IV)		 3la4 UREASE
(Canavalia
ensiformis) 		5 / 12 GLU A 312
ARG A 276
SER A 169
VAL A 320
HIS A 170
 None
 1.45A 1x70B-3la4A:
undetectable		 1x70B-3la4A:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XWF_C_ADNC433_2
(ADENOSYLHOMOCYSTEINA
SE)		 3la4 UREASE
(Canavalia
ensiformis) 		3 / 3 THR A 158
GLU A 254
HIS A 251
 CME  A 207 ( 3.4A)
None
None
 0.91A 1xwfC-3la4A:
3.0		 1xwfC-3la4A:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z95_A_198A501_1
(ANDROGEN RECEPTOR)		 3la4 UREASE
(Canavalia
ensiformis) 		5 / 12 GLY A 429
MET A 487
VAL A 765
THR A 426
ILE A 404
 None
 1.31A 1z95A-3la4A:
undetectable		 1z95A-3la4A:
14.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVO_B_MK1B902_2
(POL POLYPROTEIN)		 3la4 UREASE
(Canavalia
ensiformis) 		5 / 12 ALA A 355
VAL A 399
ILE A 341
GLY A 358
ILE A 346
 None
 0.85A 2avoB-3la4A:
undetectable		 2avoB-3la4A:
8.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVO_B_MK1B902_2
(POL POLYPROTEIN)		 3la4 UREASE
(Canavalia
ensiformis) 		6 / 12 GLY A 368
ALA A 355
ASP A 356
VAL A 399
ILE A 341
ILE A 346
 None
 1.35A 2avoB-3la4A:
undetectable		 2avoB-3la4A:
8.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVS_B_MK1B902_1
(POL POLYPROTEIN)		 3la4 UREASE
(Canavalia
ensiformis) 		5 / 12 ARG A 245
ALA A 228
ASP A 229
GLY A 224
VAL A 176
 None
 0.89A 2avsA-3la4A:
undetectable		 2avsA-3la4A:
8.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_B_SAMB301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 3la4 UREASE
(Canavalia
ensiformis) 		5 / 12 GLU A  51
GLY A  50
ASP A  49
ALA A  47
ALA A  85
 None
 1.26A 2br4B-3la4A:
undetectable		 2br4B-3la4A:
14.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2D55_C_DVAC2_0
(ACTINOMYCIN D)		 3la4 UREASE
(Canavalia
ensiformis) 		3 / 3 THR A 574
PRO A 576
PRO A 573
 None
 0.90A 2d55C-3la4A:
undetectable		 2d55C-3la4A:
3.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JC9_A_ADNA1497_1
(CYTOSOLIC PURINE
5'-NUCLEOTIDASE)		 3la4 UREASE
(Canavalia
ensiformis) 		4 / 7 ASP A 556
ILE A 563
ASN A 565
PHE A 536
 None
 0.82A 2jc9A-3la4A:
undetectable		 2jc9A-3la4A:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q63_A_1UNA1001_4
(PROTEASE RETROPEPSIN)		 3la4 UREASE
(Canavalia
ensiformis) 		3 / 3 ASP A 374
ASN A 372
THR A 389
 None
 0.71A 2q63B-3la4A:
undetectable		 2q63B-3la4A:
8.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD4_A_CHDA801_0
(FERROCHELATASE)		 3la4 UREASE
(Canavalia
ensiformis) 		5 / 12 LEU A  24
LEU A  38
PRO A  99
VAL A  96
VAL A  74
 None
 1.39A 2qd4A-3la4A:
undetectable		 2qd4A-3la4A:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R5P_B_MK1B902_2
(PROTEASE)		 3la4 UREASE
(Canavalia
ensiformis) 		5 / 12 ALA A 355
VAL A 399
ILE A 341
GLY A 358
ILE A 346
 None
 0.89A 2r5pB-3la4A:
undetectable		 2r5pB-3la4A:
8.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RKF_A_AB1A501_2
(PROTEASE RETROPEPSIN)		 3la4 UREASE
(Canavalia
ensiformis) 		6 / 12 GLY A 723
ALA A 703
ASP A 704
ILE A 357
GLY A 700
ILE A 359
 None
 1.45A 2rkfB-3la4A:
undetectable		 2rkfB-3la4A:
8.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9G_A_TOPA1159_1
(DIHYDROFOLATE
REDUCTASE)		 3la4 UREASE
(Canavalia
ensiformis) 		5 / 10 ASP A 704
LEU A 702
VAL A 694
PHE A 764
THR A 425
 None
 1.05A 2w9gA-3la4A:
undetectable		 2w9gA-3la4A:
10.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9H_A_TOPA1160_1
(DIHYDROFOLATE
REDUCTASE)		 3la4 UREASE
(Canavalia
ensiformis) 		5 / 10 ASP A 704
LEU A 702
VAL A 694
PHE A 764
THR A 425
 None
 0.98A 2w9hA-3la4A:
undetectable		 2w9hA-3la4A:
10.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7H_B_SAMB530_0
(TYPE I RESTRICTION
ENZYME ECOKI M
PROTEIN)		 3la4 UREASE
(Canavalia
ensiformis) 		5 / 12 THR A 339
ILE A 341
GLY A 723
THR A 752
LEU A 753
 None
 1.06A 2y7hB-3la4A:
undetectable		 2y7hB-3la4A:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7H_C_SAMC530_0
(TYPE I RESTRICTION
ENZYME ECOKI M
PROTEIN)		 3la4 UREASE
(Canavalia
ensiformis) 		5 / 12 THR A 339
ILE A 341
GLY A 723
THR A 752
LEU A 753
 None
 1.06A 2y7hC-3la4A:
undetectable		 2y7hC-3la4A:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A27_A_SAMA250_1
(UNCHARACTERIZED
PROTEIN MJ1557)		 3la4 UREASE
(Canavalia
ensiformis) 		3 / 3 MET A 637
GLU A 493
ASN A 524
 PO4  A 843 ( 4.1A)
PO4  A 844 (-3.8A)
None
 0.89A 3a27A-3la4A:
undetectable		 3a27A-3la4A:
16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEO_A_SAMA328_0
(MODIFICATION
METHYLASE HHAI)		 3la4 UREASE
(Canavalia
ensiformis) 		5 / 12 LEU A 427
GLY A 429
ILE A 686
TYR A 410
ASN A 463
 None
 0.98A 3eeoA-3la4A:
undetectable		 3eeoA-3la4A:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_A_SAMA300_0
(PUTATIVE RRNA
METHYLASE)		 3la4 UREASE
(Canavalia
ensiformis) 		5 / 12 GLY A 757
ASN A 781
ASP A 458
ILE A 420
LEU A 760
 None
 1.07A 3eeyA-3la4A:
undetectable		 3eeyA-3la4A:
13.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_B_SAMB300_0
(PUTATIVE RRNA
METHYLASE)		 3la4 UREASE
(Canavalia
ensiformis) 		5 / 12 GLY A 757
ASN A 781
ASP A 458
ILE A 420
LEU A 760
 None
 1.06A 3eeyB-3la4A:
undetectable		 3eeyB-3la4A:
13.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_F_SAMF300_0
(PUTATIVE RRNA
METHYLASE)		 3la4 UREASE
(Canavalia
ensiformis) 		5 / 12 GLY A 757
ASN A 781
ASP A 458
ILE A 420
LEU A 760
 None
 1.19A 3eeyF-3la4A:
undetectable		 3eeyF-3la4A:
13.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_H_SAMH300_0
(PUTATIVE RRNA
METHYLASE)		 3la4 UREASE
(Canavalia
ensiformis) 		5 / 12 GLY A 757
ASN A 781
ASP A 458
ILE A 420
LEU A 760
 None
 1.14A 3eeyH-3la4A:
undetectable		 3eeyH-3la4A:
13.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_I_SAMI300_0
(PUTATIVE RRNA
METHYLASE)		 3la4 UREASE
(Canavalia
ensiformis) 		5 / 12 GLY A 757
ASN A 781
ASP A 458
ILE A 420
LEU A 760
 None
 1.09A 3eeyI-3la4A:
undetectable		 3eeyI-3la4A:
13.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FRB_X_TOPX300_1
(DIHYDROFOLATE
REDUCTASE)		 3la4 UREASE
(Canavalia
ensiformis) 		5 / 11 ASP A 704
LEU A 702
VAL A 694
PHE A 764
THR A 425
 None
 1.01A 3frbX-3la4A:
undetectable		 3frbX-3la4A:
10.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FRE_X_TOPX300_1
(DIHYDROFOLATE
REDUCTASE)		 3la4 UREASE
(Canavalia
ensiformis) 		5 / 9 ASP A 704
LEU A 702
VAL A 694
PHE A 764
THR A 425
 None
 0.97A 3freX-3la4A:
undetectable		 3freX-3la4A:
10.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCN_B_CHDB2_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3la4 UREASE
(Canavalia
ensiformis) 		3 / 3 LEU A 111
LEU A 116
ARG A  26
 None
 0.55A 3hcnB-3la4A:
undetectable		 3hcnB-3la4A:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JUS_B_ECNB602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3la4 UREASE
(Canavalia
ensiformis) 		5 / 9 LEU A 462
THR A 426
GLY A 695
ALA A 401
ILE A 644
 None
 1.36A 3jusB-3la4A:
undetectable		 3jusB-3la4A:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_B_30BB500_2
(GENOME POLYPROTEIN)		 3la4 UREASE
(Canavalia
ensiformis) 		3 / 3 PHE A 671
TYR A 349
LEU A 299
 None
 0.69A 3keeB-3la4A:
undetectable		 3keeB-3la4A:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NUJ_B_478B401_1
(PROTEASE)		 3la4 UREASE
(Canavalia
ensiformis) 		5 / 10 ALA A 355
VAL A 399
ILE A 341
GLY A 358
ILE A 346
 None
 0.96A 3nujA-3la4A:
undetectable		 3nujA-3la4A:
9.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OWX_B_XRAB233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 3la4 UREASE
(Canavalia
ensiformis) 		5 / 11 VAL A 784
PHE A 690
GLY A 488
ASN A 517
ILE A 482
 None
 1.27A 3owxA-3la4A:
undetectable
3owxB-3la4A:
undetectable		 3owxA-3la4A:
13.17
3owxB-3la4A:
13.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OZW_B_KKKB413_1
(FLAVOHEMOGLOBIN)		 3la4 UREASE
(Canavalia
ensiformis) 		5 / 12 GLN A  69
ALA A 110
HIS A  14
LEU A 115
ILE A 100
 None
 1.12A 3ozwB-3la4A:
undetectable		 3ozwB-3la4A:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SJ4_X_DXCX75_0
(CYTOCHROME C7)		 3la4 UREASE
(Canavalia
ensiformis) 		5 / 9 ILE A 364
LEU A 705
LYS A 354
ILE A 353
GLY A 394
 None
 0.81A 3sj4X-3la4A:
undetectable		 3sj4X-3la4A:
6.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_B_SUEB1201_2
(NS3 PROTEASE, NS4A
PROTEIN)		 3la4 UREASE
(Canavalia
ensiformis) 		3 / 3 PHE A 671
TYR A 349
LEU A 299
 None
 0.77A 3sueB-3la4A:
undetectable		 3sueB-3la4A:
14.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKD_A_CYZA266_2
(GLUTAMATE RECEPTOR 2)		 3la4 UREASE
(Canavalia
ensiformis) 		4 / 5 ILE A 481
SER A 471
LYS A 469
GLY A 468
 None
KCX  A 490 ( 4.2A)
None
None
 1.17A 3tkdB-3la4A:
undetectable		 3tkdB-3la4A:
17.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKD_B_CYZB267_1
(GLUTAMATE RECEPTOR 2)		 3la4 UREASE
(Canavalia
ensiformis) 		4 / 5 ILE A 481
SER A 471
LYS A 469
GLY A 468
 None
KCX  A 490 ( 4.2A)
None
None
 1.17A 3tkdA-3la4A:
undetectable		 3tkdA-3la4A:
17.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UM5_A_CP6A609_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3la4 UREASE
(Canavalia
ensiformis) 		5 / 10 ILE A 682
ASP A 348
THR A 647
ILE A 644
THR A 350
 None
 1.16A 3um5A-3la4A:
undetectable		 3um5A-3la4A:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UM5_B_CP6B709_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3la4 UREASE
(Canavalia
ensiformis) 		5 / 10 ILE A 682
ASP A 348
THR A 647
ILE A 644
THR A 350
 None
 1.24A 3um5B-3la4A:
undetectable		 3um5B-3la4A:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_A_W9TA1004_1
(HEMOLYTIC LECTIN
CEL-III)		 3la4 UREASE
(Canavalia
ensiformis) 		4 / 5 ASP A 348
GLY A 695
TYR A 349
GLU A 698
 None
 1.04A 3w9tA-3la4A:
undetectable		 3w9tA-3la4A:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_B_W9TB502_1
(HEMOLYTIC LECTIN
CEL-III)		 3la4 UREASE
(Canavalia
ensiformis) 		4 / 6 ASP A 348
GLY A 695
TYR A 349
GLU A 698
 None
 1.03A 3w9tB-3la4A:
undetectable		 3w9tB-3la4A:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_C_W9TC1002_1
(HEMOLYTIC LECTIN
CEL-III)		 3la4 UREASE
(Canavalia
ensiformis) 		4 / 5 ASP A 348
GLY A 695
TYR A 349
GLU A 698
 None
 1.03A 3w9tC-3la4A:
undetectable		 3w9tC-3la4A:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_C_W9TC1005_1
(HEMOLYTIC LECTIN
CEL-III)		 3la4 UREASE
(Canavalia
ensiformis) 		3 / 3 ASP A 348
GLY A 695
TYR A 349
 None
 0.80A 3w9tC-3la4A:
undetectable		 3w9tC-3la4A:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_D_W9TD512_1
(HEMOLYTIC LECTIN
CEL-III)		 3la4 UREASE
(Canavalia
ensiformis) 		4 / 5 ASP A 348
GLY A 695
TYR A 349
GLU A 698
 None
 1.04A 3w9tD-3la4A:
undetectable		 3w9tD-3la4A:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_E_W9TE502_1
(HEMOLYTIC LECTIN
CEL-III)		 3la4 UREASE
(Canavalia
ensiformis) 		4 / 6 ASP A 348
GLY A 695
TYR A 349
GLU A 698
 None
 1.04A 3w9tE-3la4A:
undetectable		 3w9tE-3la4A:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_F_W9TF503_1
(HEMOLYTIC LECTIN
CEL-III)		 3la4 UREASE
(Canavalia
ensiformis) 		4 / 6 ASP A 348
GLY A 695
TYR A 349
GLU A 698
 None
 1.04A 3w9tF-3la4A:
undetectable		 3w9tF-3la4A:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_G_W9TG502_1
(HEMOLYTIC LECTIN
CEL-III)		 3la4 UREASE
(Canavalia
ensiformis) 		4 / 5 ASP A 348
GLY A 695
TYR A 349
GLU A 698
 None
 1.04A 3w9tG-3la4A:
undetectable		 3w9tG-3la4A:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_G_W9TG503_1
(HEMOLYTIC LECTIN
CEL-III)		 3la4 UREASE
(Canavalia
ensiformis) 		3 / 3 ASP A 348
GLY A 695
TYR A 349
 None
 0.80A 3w9tG-3la4A:
undetectable		 3w9tG-3la4A:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WXO_A_NIZA804_1
(CATALASE-PEROXIDASE)		 3la4 UREASE
(Canavalia
ensiformis) 		3 / 3 ASN A 225
GLU A 175
ARG A 184
 None
 1.09A 3wxoA-3la4A:
undetectable		 3wxoA-3la4A:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DF2_A_4CHA506_0
(NADPH DEHYDROGENASE)		 3la4 UREASE
(Canavalia
ensiformis) 		4 / 6 THR A 467
HIS A 542
TYR A 544
TYR A 410
 KCX  A 490 ( 4.8A)
None
KCX  A 490 ( 4.5A)
None
 1.37A 4df2A-3la4A:
3.5		 4df2A-3la4A:
20.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4H9M_A_HAEA929_1
(UREASE)		 3la4 UREASE
(Canavalia
ensiformis) 		5 / 5 HIS A 407
HIS A 492
HIS A 519
HIS A 545
ASP A 633
 NI  A 841 ( 3.3A)
PO4  A 843 (-4.0A)
NI  A 842 (-3.2A)
NI  A 842 ( 3.4A)
PO4  A 843 ( 2.5A)
 0.19A 4h9mA-3la4A:
71.2		 4h9mA-3la4A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_I_ACTI507_0
(RNA POLYMERASE
3D-POL)		 3la4 UREASE
(Canavalia
ensiformis) 		3 / 3 LYS A 709
PRO A 710
SER A 711
 None
 0.29A 4k50I-3la4A:
undetectable		 4k50I-3la4A:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MK4_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3la4 UREASE
(Canavalia
ensiformis) 		5 / 11 LEU A  24
LEU A  38
ARG A  29
PRO A  99
VAL A  81
 None
 1.14A 4mk4B-3la4A:
3.9		 4mk4B-3la4A:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MK4_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3la4 UREASE
(Canavalia
ensiformis) 		5 / 11 LEU A  24
LEU A  38
ARG A  29
PRO A  99
VAL A  96
 None
 1.04A 4mk4B-3la4A:
3.9		 4mk4B-3la4A:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MK4_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3la4 UREASE
(Canavalia
ensiformis) 		5 / 11 LEU A  24
LEU A  38
PRO A  99
VAL A  96
VAL A  74
 None
 1.44A 4mk4B-3la4A:
3.9		 4mk4B-3la4A:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N48_A_SAMA601_1
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)		 3la4 UREASE
(Canavalia
ensiformis) 		4 / 5 ALA A 280
GLY A 284
ASP A 669
ASP A 289
 None
 0.91A 4n48A-3la4A:
undetectable		 4n48A-3la4A:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O4D_A_ACTA406_0
(INOSITOL
HEXAKISPHOSPHATE
KINASE)		 3la4 UREASE
(Canavalia
ensiformis) 		4 / 7 ASP A 494
THR A 441
SER A 497
HIS A 519
 PO4  A 844 (-3.2A)
None
None
NI  A 842 (-3.2A)
 1.36A 4o4dA-3la4A:
undetectable		 4o4dA-3la4A:
14.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKB_A_198A1002_1
(ANDROGEN RECEPTOR)		 3la4 UREASE
(Canavalia
ensiformis) 		5 / 12 GLY A 429
MET A 487
VAL A 765
THR A 426
ILE A 404
 None
 1.35A 4okbA-3la4A:
undetectable		 4okbA-3la4A:
15.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKW_A_198A1001_1
(ANDROGEN RECEPTOR)		 3la4 UREASE
(Canavalia
ensiformis) 		5 / 12 GLY A 429
MET A 487
VAL A 765
THR A 426
ILE A 404
 None
 1.31A 4okwA-3la4A:
undetectable		 4okwA-3la4A:
15.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKW_A_198A1001_1
(ANDROGEN RECEPTOR)		 3la4 UREASE
(Canavalia
ensiformis) 		5 / 12 MET A 487
VAL A 765
THR A 426
ILE A 404
VAL A 694
 None
 1.32A 4okwA-3la4A:
undetectable		 4okwA-3la4A:
15.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4POO_A_SAMA301_0
(PUTATIVE RNA
METHYLASE)		 3la4 UREASE
(Canavalia
ensiformis) 		5 / 12 THR A 442
GLY A 468
HIS A 409
ASN A 517
SER A 634
 KCX  A 490 ( 3.4A)
None
NI  A 841 ( 3.3A)
None
None
 1.31A 4pooA-3la4A:
2.3		 4pooA-3la4A:
15.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QTU_B_SAMB301_0
(PUTATIVE
METHYLTRANSFERASE
BUD23)		 3la4 UREASE
(Canavalia
ensiformis) 		5 / 12 GLY A 310
LEU A 308
ILE A 194
SER A 169
ILE A 148
 None
 1.09A 4qtuB-3la4A:
undetectable		 4qtuB-3la4A:
12.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVL_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 3la4 UREASE
(Canavalia
ensiformis) 		5 / 11 SER A 634
THR A 442
THR A 441
THR A 438
THR A 571
 None
KCX  A 490 ( 3.4A)
None
None
None
 1.45A 4qvlV-3la4A:
undetectable
4qvlb-3la4A:
undetectable		 4qvlV-3la4A:
15.16
4qvlb-3la4A:
14.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVL_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 3la4 UREASE
(Canavalia
ensiformis) 		5 / 11 SER A 634
THR A 442
THR A 441
THR A 438
THR A 571
 None
KCX  A 490 ( 3.4A)
None
None
None
 1.45A 4qvlH-3la4A:
undetectable
4qvlN-3la4A:
undetectable		 4qvlH-3la4A:
15.16
4qvlN-3la4A:
14.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVM_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 3la4 UREASE
(Canavalia
ensiformis) 		5 / 11 SER A 634
THR A 442
THR A 441
THR A 438
THR A 571
 None
KCX  A 490 ( 3.4A)
None
None
None
 1.45A 4qvmV-3la4A:
undetectable
4qvmb-3la4A:
undetectable		 4qvmV-3la4A:
15.16
4qvmb-3la4A:
14.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVM_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 3la4 UREASE
(Canavalia
ensiformis) 		5 / 11 SER A 634
THR A 442
THR A 441
THR A 438
THR A 571
 None
KCX  A 490 ( 3.4A)
None
None
None
 1.45A 4qvmH-3la4A:
undetectable
4qvmN-3la4A:
undetectable		 4qvmH-3la4A:
15.16
4qvmN-3la4A:
14.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVP_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 3la4 UREASE
(Canavalia
ensiformis) 		5 / 11 SER A 634
THR A 442
THR A 441
THR A 438
THR A 571
 None
KCX  A 490 ( 3.4A)
None
None
None
 1.45A 4qvpV-3la4A:
undetectable
4qvpb-3la4A:
undetectable		 4qvpV-3la4A:
15.16
4qvpb-3la4A:
14.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVP_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 3la4 UREASE
(Canavalia
ensiformis) 		5 / 11 SER A 634
THR A 442
THR A 441
THR A 438
THR A 571
 None
KCX  A 490 ( 3.4A)
None
None
None
 1.45A 4qvpH-3la4A:
undetectable
4qvpN-3la4A:
undetectable		 4qvpH-3la4A:
15.16
4qvpN-3la4A:
14.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVQ_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 3la4 UREASE
(Canavalia
ensiformis) 		5 / 11 SER A 634
THR A 442
THR A 441
THR A 438
THR A 571
 None
KCX  A 490 ( 3.4A)
None
None
None
 1.45A 4qvqV-3la4A:
undetectable
4qvqb-3la4A:
undetectable		 4qvqV-3la4A:
15.16
4qvqb-3la4A:
14.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVQ_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 3la4 UREASE
(Canavalia
ensiformis) 		5 / 11 SER A 634
THR A 442
THR A 441
THR A 438
THR A 571
 None
KCX  A 490 ( 3.4A)
None
None
None
 1.45A 4qvqH-3la4A:
undetectable
4qvqN-3la4A:
undetectable		 4qvqH-3la4A:
15.16
4qvqN-3la4A:
14.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVV_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 3la4 UREASE
(Canavalia
ensiformis) 		5 / 10 SER A 634
THR A 442
THR A 441
THR A 438
THR A 571
 None
KCX  A 490 ( 3.4A)
None
None
None
 1.46A 4qvvV-3la4A:
0.0
4qvvb-3la4A:
undetectable		 4qvvV-3la4A:
15.16
4qvvb-3la4A:
14.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVV_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 3la4 UREASE
(Canavalia
ensiformis) 		5 / 10 SER A 634
THR A 442
THR A 441
THR A 438
THR A 571
 None
KCX  A 490 ( 3.4A)
None
None
None
 1.44A 4qvvH-3la4A:
0.0
4qvvN-3la4A:
0.0		 4qvvH-3la4A:
15.16
4qvvN-3la4A:
14.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVV_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 3la4 UREASE
(Canavalia
ensiformis) 		5 / 8 THR A 438
GLY A 430
GLY A 429
VAL A 408
ASP A 405
 None
 1.33A 4qvvY-3la4A:
undetectable
4qvvZ-3la4A:
undetectable		 4qvvY-3la4A:
13.29
4qvvZ-3la4A:
15.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVW_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 3la4 UREASE
(Canavalia
ensiformis) 		5 / 11 SER A 634
THR A 442
THR A 441
THR A 438
THR A 571
 None
KCX  A 490 ( 3.4A)
None
None
None
 1.44A 4qvwV-3la4A:
undetectable
4qvwb-3la4A:
undetectable		 4qvwV-3la4A:
15.16
4qvwb-3la4A:
14.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVW_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 3la4 UREASE
(Canavalia
ensiformis) 		5 / 11 SER A 634
THR A 442
THR A 441
THR A 438
THR A 571
 None
KCX  A 490 ( 3.4A)
None
None
None
 1.44A 4qvwH-3la4A:
undetectable
4qvwN-3la4A:
undetectable		 4qvwH-3la4A:
15.16
4qvwN-3la4A:
14.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW0_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 3la4 UREASE
(Canavalia
ensiformis) 		5 / 11 SER A 634
THR A 442
THR A 441
THR A 438
THR A 571
 None
KCX  A 490 ( 3.4A)
None
None
None
 1.44A 4qw0H-3la4A:
undetectable
4qw0N-3la4A:
undetectable		 4qw0H-3la4A:
15.16
4qw0N-3la4A:
14.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW1_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 3la4 UREASE
(Canavalia
ensiformis) 		5 / 11 SER A 634
THR A 442
THR A 441
THR A 438
THR A 571
 None
KCX  A 490 ( 3.4A)
None
None
None
 1.44A 4qw1V-3la4A:
undetectable
4qw1b-3la4A:
undetectable		 4qw1V-3la4A:
15.16
4qw1b-3la4A:
14.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW1_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 3la4 UREASE
(Canavalia
ensiformis) 		5 / 11 SER A 634
THR A 442
THR A 441
THR A 438
THR A 571
 None
KCX  A 490 ( 3.4A)
None
None
None
 1.45A 4qw1H-3la4A:
undetectable
4qw1N-3la4A:
undetectable		 4qw1H-3la4A:
15.16
4qw1N-3la4A:
14.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW3_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 3la4 UREASE
(Canavalia
ensiformis) 		5 / 11 SER A 634
THR A 442
THR A 441
THR A 438
THR A 571
 None
KCX  A 490 ( 3.4A)
None
None
None
 1.44A 4qw3V-3la4A:
undetectable
4qw3b-3la4A:
undetectable		 4qw3V-3la4A:
15.16
4qw3b-3la4A:
14.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW3_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 3la4 UREASE
(Canavalia
ensiformis) 		5 / 11 SER A 634
THR A 442
THR A 441
THR A 438
THR A 571
 None
KCX  A 490 ( 3.4A)
None
None
None
 1.45A 4qw3H-3la4A:
undetectable
4qw3N-3la4A:
undetectable		 4qw3H-3la4A:
15.16
4qw3N-3la4A:
14.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWU_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 3la4 UREASE
(Canavalia
ensiformis) 		5 / 11 SER A 634
THR A 442
THR A 441
THR A 438
THR A 571
 None
KCX  A 490 ( 3.4A)
None
None
None
 1.42A 4qwuV-3la4A:
undetectable
4qwub-3la4A:
undetectable		 4qwuV-3la4A:
15.16
4qwub-3la4A:
14.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWU_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 3la4 UREASE
(Canavalia
ensiformis) 		5 / 11 SER A 634
THR A 442
THR A 441
THR A 438
THR A 571
 None
KCX  A 490 ( 3.4A)
None
None
None
 1.43A 4qwuH-3la4A:
undetectable
4qwuN-3la4A:
undetectable		 4qwuH-3la4A:
15.16
4qwuN-3la4A:
14.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R29_D_SAMD301_0
(UNCHARACTERIZED
PROTEIN)		 3la4 UREASE
(Canavalia
ensiformis) 		5 / 12 GLY A 326
ILE A 194
ALA A 195
GLY A 197
GLU A 395
 None
 1.11A 4r29D-3la4A:
undetectable		 4r29D-3la4A:
13.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_C_377C401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 3la4 UREASE
(Canavalia
ensiformis) 		4 / 6 TYR A  32
ASN A  31
GLU A 742
LEU A 839
 None
 1.31A 4twdB-3la4A:
undetectable
4twdC-3la4A:
undetectable		 4twdB-3la4A:
16.02
4twdC-3la4A:
16.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4UBP_C_HAEC800_1
(PROTEIN (UREASE
(CHAIN C)))		 3la4 UREASE
(Canavalia
ensiformis) 		6 / 6 HIS A 407
HIS A 409
HIS A 492
HIS A 519
HIS A 545
ASP A 633
 NI  A 841 ( 3.3A)
NI  A 841 ( 3.3A)
PO4  A 843 (-4.0A)
NI  A 842 (-3.2A)
NI  A 842 ( 3.4A)
PO4  A 843 ( 2.5A)
 0.19A 4ubpC-3la4A:
61.0		 4ubpC-3la4A:
40.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URN_A_NOVA2000_1
(DNA TOPOISOMERASE
IV, B SUBUNIT)		 3la4 UREASE
(Canavalia
ensiformis) 		5 / 11 ASP A 633
ARG A 639
ILE A 615
ARG A 646
THR A 571
 PO4  A 843 ( 2.5A)
None
None
None
None
 1.36A 4urnA-3la4A:
undetectable		 4urnA-3la4A:
14.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URN_B_NOVB2000_1
(DNA TOPOISOMERASE
IV, B SUBUNIT)		 3la4 UREASE
(Canavalia
ensiformis) 		5 / 11 ASP A 633
ARG A 639
ILE A 615
ARG A 646
THR A 571
 PO4  A 843 ( 2.5A)
None
None
None
None
 1.35A 4urnB-3la4A:
undetectable		 4urnB-3la4A:
14.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URN_C_NOVC2000_1
(DNA TOPOISOMERASE
IV, B SUBUNIT)		 3la4 UREASE
(Canavalia
ensiformis) 		5 / 11 ASP A 633
ARG A 639
ILE A 615
ARG A 646
THR A 571
 PO4  A 843 ( 2.5A)
None
None
None
None
 1.33A 4urnC-3la4A:
undetectable		 4urnC-3la4A:
14.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XT7_A_TOPA302_1
(RV2671)		 3la4 UREASE
(Canavalia
ensiformis) 		5 / 11 ILE A 165
SER A 159
GLY A 161
ARG A 163
GLU A 203
 None
 1.45A 4xt7A-3la4A:
undetectable		 4xt7A-3la4A:
16.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YO9_B_ACTB401_0
(3C-LIKE PROTEINASE)		 3la4 UREASE
(Canavalia
ensiformis) 		3 / 3 ARG A 163
ASP A 162
TYR A 179
 None
 0.92A 4yo9B-3la4A:
undetectable		 4yo9B-3la4A:
16.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BXN_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 3la4 UREASE
(Canavalia
ensiformis) 		5 / 11 SER A 634
THR A 442
THR A 441
THR A 438
THR A 571
 None
KCX  A 490 ( 3.4A)
None
None
None
 1.46A 5bxnV-3la4A:
undetectable
5bxnb-3la4A:
undetectable		 5bxnV-3la4A:
15.16
5bxnb-3la4A:
14.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BXN_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 3la4 UREASE
(Canavalia
ensiformis) 		5 / 11 SER A 634
THR A 442
THR A 441
THR A 438
THR A 571
 None
KCX  A 490 ( 3.4A)
None
None
None
 1.48A 5bxnH-3la4A:
undetectable
5bxnN-3la4A:
undetectable		 5bxnH-3la4A:
15.16
5bxnN-3la4A:
14.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CZ7_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 3la4 UREASE
(Canavalia
ensiformis) 		5 / 9 SER A 634
THR A 442
THR A 441
THR A 438
THR A 571
 None
KCX  A 490 ( 3.4A)
None
None
None
 1.45A 5cz7V-3la4A:
0.0
5cz7b-3la4A:
0.0		 5cz7V-3la4A:
15.16
5cz7b-3la4A:
14.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CZ7_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 3la4 UREASE
(Canavalia
ensiformis) 		5 / 11 SER A 634
THR A 442
THR A 441
THR A 438
THR A 571
 None
KCX  A 490 ( 3.4A)
None
None
None
 1.43A 5cz7H-3la4A:
undetectable
5cz7N-3la4A:
undetectable		 5cz7H-3la4A:
15.16
5cz7N-3la4A:
14.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0X_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 3la4 UREASE
(Canavalia
ensiformis) 		5 / 11 SER A 634
THR A 442
THR A 441
THR A 438
THR A 571
 None
KCX  A 490 ( 3.4A)
None
None
None
 1.44A 5d0xV-3la4A:
undetectable
5d0xb-3la4A:
undetectable		 5d0xV-3la4A:
15.16
5d0xb-3la4A:
14.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0X_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 3la4 UREASE
(Canavalia
ensiformis) 		5 / 11 SER A 634
THR A 442
THR A 441
THR A 438
THR A 571
 None
KCX  A 490 ( 3.4A)
None
None
None
 1.44A 5d0xH-3la4A:
undetectable
5d0xN-3la4A:
undetectable		 5d0xH-3la4A:
15.16
5d0xN-3la4A:
14.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DB5_A_CYSA503_0
(CYSTEINE DESULFURASE)		 3la4 UREASE
(Canavalia
ensiformis) 		4 / 8 ALA A 549
HIS A 593
HIS A 519
THR A 522
 None
PO4  A 844 (-3.3A)
NI  A 842 (-3.2A)
None
 1.26A 5db5A-3la4A:
undetectable
5db5B-3la4A:
undetectable		 5db5A-3la4A:
17.89
5db5B-3la4A:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E5K_B_017B201_1
(HIV-1 PROTEASE)		 3la4 UREASE
(Canavalia
ensiformis) 		6 / 12 GLY A 723
ALA A 703
ASP A 704
ILE A 357
GLY A 700
ILE A 359
 None
 1.40A 5e5kA-3la4A:
undetectable		 5e5kA-3la4A:
8.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JGL_A_SAMA301_1
(UBIE/COQ5 FAMILY
METHYLTRANSFERASE,
PUTATIVE)		 3la4 UREASE
(Canavalia
ensiformis) 		3 / 3 GLY A 310
ASP A 311
ASN A 372
 None
 0.61A 5jglA-3la4A:
2.1		 5jglA-3la4A:
16.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5F_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 3la4 UREASE
(Canavalia
ensiformis) 		5 / 11 SER A 634
THR A 442
THR A 441
THR A 438
THR A 571
 None
KCX  A 490 ( 3.4A)
None
None
None
 1.44A 5l5fV-3la4A:
undetectable
5l5fb-3la4A:
undetectable		 5l5fV-3la4A:
15.16
5l5fb-3la4A:
14.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5F_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 3la4 UREASE
(Canavalia
ensiformis) 		5 / 11 SER A 634
THR A 442
THR A 441
THR A 438
THR A 571
 None
KCX  A 490 ( 3.4A)
None
None
None
 1.45A 5l5fH-3la4A:
undetectable
5l5fN-3la4A:
undetectable		 5l5fH-3la4A:
15.16
5l5fN-3la4A:
14.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L66_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 3la4 UREASE
(Canavalia
ensiformis) 		5 / 11 SER A 634
THR A 442
THR A 441
THR A 438
THR A 571
 None
KCX  A 490 ( 3.4A)
None
None
None
 1.45A 5l66V-3la4A:
undetectable
5l66b-3la4A:
undetectable		 5l66V-3la4A:
15.16
5l66b-3la4A:
14.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L66_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 3la4 UREASE
(Canavalia
ensiformis) 		5 / 11 SER A 634
THR A 442
THR A 441
THR A 438
THR A 571
 None
KCX  A 490 ( 3.4A)
None
None
None
 1.44A 5l66H-3la4A:
undetectable
5l66N-3la4A:
undetectable		 5l66H-3la4A:
15.16
5l66N-3la4A:
14.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MZR_E_PFLE409_1
(PROTON-GATED ION
CHANNEL)		 3la4 UREASE
(Canavalia
ensiformis) 		4 / 8 ILE A 533
VAL A 560
THR A 543
ILE A 518
 None
 0.94A 5mzrE-3la4A:
undetectable		 5mzrE-3la4A:
7.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NWW_A_ACAA18_2
(SCRFP-TAG,GP41)		 3la4 UREASE
(Canavalia
ensiformis) 		3 / 3 LYS A 709
TRP A 708
SER A 711
 None
 1.05A 5nwwA-3la4A:
undetectable		 5nwwA-3la4A:
3.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_B_ACTB306_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 3la4 UREASE
(Canavalia
ensiformis) 		4 / 4 LEU A 491
GLY A 470
SER A 472
SER A 473
 KCX  A 490 ( 4.2A)
KCX  A 490 ( 3.5A)
None
None
 1.31A 5uunB-3la4A:
undetectable		 5uunB-3la4A:
16.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V96_B_ADNB502_2
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE)		 3la4 UREASE
(Canavalia
ensiformis) 		4 / 4 GLU A 618
THR A 571
THR A 522
LEU A 589
 None
 1.41A 5v96B-3la4A:
2.7		 5v96B-3la4A:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V96_C_ADNC502_2
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE)		 3la4 UREASE
(Canavalia
ensiformis) 		4 / 4 GLU A 618
THR A 571
THR A 522
LEU A 589
 None
 1.39A 5v96C-3la4A:
2.8		 5v96C-3la4A:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V96_D_ADND502_2
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE)		 3la4 UREASE
(Canavalia
ensiformis) 		4 / 4 GLU A 618
THR A 571
THR A 522
LEU A 589
 None
 1.37A 5v96D-3la4A:
2.8		 5v96D-3la4A:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_H_CVIH301_1
(REGULATORY PROTEIN
TETR)		 3la4 UREASE
(Canavalia
ensiformis) 		4 / 8 GLN A 327
GLY A 371
ILE A 375
ASP A 311
 None
 0.89A 5vlmH-3la4A:
undetectable		 5vlmH-3la4A:
12.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A7P_A_9SCA601_1
(SERUM ALBUMIN)		 3la4 UREASE
(Canavalia
ensiformis) 		4 / 5 ASN A 688
TYR A 410
VAL A 416
LEU A 415
 None
 1.30A 6a7pA-3la4A:
undetectable		 6a7pA-3la4A:
22.09