SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3la6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A27_A_ESTA350_1
(17-BETA-HYDROXYSTERO
ID-DEHYDROGENASE)		 3la6 TYROSINE-PROTEIN
KINASE WZC
(Escherichia
coli) 		5 / 12 VAL A 690
GLY A 692
MET A 664
TYR A 467
GLU A 677
 None
 1.49A 1a27A-3la6A:
2.5		 1a27A-3la6A:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N5X_A_TEIA3006_1
(XANTHINE
DEHYDROGENASE)		 3la6 TYROSINE-PROTEIN
KINASE WZC
(Escherichia
coli) 		5 / 12 LEU A 573
LEU A 574
SER A 600
VAL A 499
ALA A 548
 None
 1.07A 1n5xA-3la6A:
undetectable		 1n5xA-3la6A:
12.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N5X_B_TEIB4006_1
(XANTHINE
DEHYDROGENASE)		 3la6 TYROSINE-PROTEIN
KINASE WZC
(Escherichia
coli) 		5 / 12 LEU A 573
LEU A 574
SER A 600
VAL A 499
ALA A 548
 None
 1.08A 1n5xB-3la6A:
undetectable		 1n5xB-3la6A:
12.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWJ_B_BAXB1723_2
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 3la6 TYROSINE-PROTEIN
KINASE WZC
(Escherichia
coli) 		3 / 3 ILE A 561
ASP A 605
PHE A 604
 None
 0.66A 1uwjB-3la6A:
undetectable		 1uwjB-3la6A:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F7A_B_BEZB1002_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 3la6 TYROSINE-PROTEIN
KINASE WZC
(Escherichia
coli) 		5 / 9 LEU A 559
LEU A 560
ILE A 641
LEU A 582
ILE A 607
 None
 1.24A 2f7aB-3la6A:
undetectable		 2f7aB-3la6A:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FT9_A_CHDA131_0
(FATTY ACID-BINDING
PROTEIN 2, LIVER)		 3la6 TYROSINE-PROTEIN
KINASE WZC
(Escherichia
coli) 		5 / 11 LEU A 574
LEU A 573
PRO A 502
ASN A 501
LEU A 640
 None
 1.32A 2ft9A-3la6A:
undetectable		 2ft9A-3la6A:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIP_C_MTXC613_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 3la6 TYROSINE-PROTEIN
KINASE WZC
(Escherichia
coli) 		5 / 12 VAL A 639
ALA A 548
LEU A 606
THR A 643
LEU A 582
 None
 1.24A 2oipC-3la6A:
3.7		 2oipC-3la6A:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XAT_A_CLMA301_0
(XENOBIOTIC
ACETYLTRANSFERASE)		 3la6 TYROSINE-PROTEIN
KINASE WZC
(Escherichia
coli) 		3 / 3 GLY A 692
TYR A 467
SER A 465
 None
 0.74A 2xatA-3la6A:
undetectable		 2xatA-3la6A:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CV9_A_VDXA501_1
(CYTOCHROME P450-SU1)		 3la6 TYROSINE-PROTEIN
KINASE WZC
(Escherichia
coli) 		5 / 9 LEU A 513
SER A 465
ILE A 694
ILE A 641
GLY A 656
 None
 1.18A 3cv9A-3la6A:
undetectable		 3cv9A-3la6A:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_B_ROCB201_4
(HIV-1 PROTEASE)		 3la6 TYROSINE-PROTEIN
KINASE WZC
(Escherichia
coli) 		4 / 4 ARG A 657
ASP A 564
GLY A 533
THR A 662
 None
CA  A1001 (-4.6A)
None
None
 1.26A 3k4vB-3la6A:
undetectable		 3k4vB-3la6A:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L2V_A_RLTA397_1
(INTEGRASE)		 3la6 TYROSINE-PROTEIN
KINASE WZC
(Escherichia
coli) 		4 / 7 ASP A 707
GLN A 706
TYR A 710
GLN A 457
 None
 1.06A 3l2vA-3la6A:
undetectable		 3l2vA-3la6A:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TL9_A_ROCA401_4
(PROTEASE)		 3la6 TYROSINE-PROTEIN
KINASE WZC
(Escherichia
coli) 		4 / 4 ASP A 564
ASP A 642
GLY A 533
THR A 662
 CA  A1001 (-4.6A)
CA  A1001 ( 4.0A)
None
None
 1.14A 3tl9B-3la6A:
undetectable		 3tl9B-3la6A:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_B_06XB501_1
(CYTOCHROME P450 2B6)		 3la6 TYROSINE-PROTEIN
KINASE WZC
(Escherichia
coli) 		4 / 7 ILE A 641
ILE A 607
GLU A 627
LEU A 586
 None
 0.88A 3ua5B-3la6A:
undetectable		 3ua5B-3la6A:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CCQ_A_ACTA1317_0
(THIOREDOXIN
REDUCTASE)		 3la6 TYROSINE-PROTEIN
KINASE WZC
(Escherichia
coli) 		3 / 3 LEU A 619
GLU A 618
SER A 622
 None
 0.83A 4ccqA-3la6A:
undetectable		 4ccqA-3la6A:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CCQ_A_ACTA1317_0
(THIOREDOXIN
REDUCTASE)		 3la6 TYROSINE-PROTEIN
KINASE WZC
(Escherichia
coli) 		3 / 3 LEU A 620
GLU A 618
SER A 622
 None
 0.83A 4ccqA-3la6A:
undetectable		 4ccqA-3la6A:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0Q_A_PX9A201_0
(BETA-LACTOGLOBULIN)		 3la6 TYROSINE-PROTEIN
KINASE WZC
(Escherichia
coli) 		5 / 12 LEU A 680
LEU A 513
ILE A 694
GLU A 675
LEU A 529
 None
 1.12A 4y0qA-3la6A:
undetectable		 4y0qA-3la6A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KPC_A_SAMA401_1
(PAVINE
N-METHYLTRANSFERASE)		 3la6 TYROSINE-PROTEIN
KINASE WZC
(Escherichia
coli) 		4 / 5 PHE A 604
SER A 600
GLN A 553
ASP A 504
 None
 1.41A 5kpcA-3la6A:
undetectable		 5kpcA-3la6A:
22.66